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Two-year Clinical Outcomes Post Implantation of Epic(TM) Self-Expanding Nitinol Stents for the Aortoiliac Occlusive Disease in Patients with Peripheral Arterial Disease.
CONCLUSION: The Epic(TM) self-expanding nitinol stent was demonstrated to be safe and effectivene for AIOD when tested for two years in patients with PAD. PMID: 28978866 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - October 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases.
Authors: Wu H, Du Q, Dai Q, Ge J, Cheng X Abstract Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a pivotal role in extracellular matrix (ECM) remodeling and have been implicated in the development and progression of atherosclerosis-based cardiovascular diseases. An imbalance in expression between cathepsins (such as cathepsins S, K, L, C) and their inhibitor cystatin C may favor proteolysis of ECM in the pathogenesis of cardiovascular disease such as atherosclerosis, aneurysm formation,...
Source: Journal of Atherosclerosis and Thrombosis - October 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus.
Authors: Katakami N Abstract Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus (DM), causes cerebro-cardiovascular diseases, which are major causes of death in patients with DM and significantly reduce their quality of life. The alterations in vascular homeostasis due to endothelial and vascular smooth muscle cell dysfunction are the main features of diabetic macroangiopathy. Although multiple metabolic abnormalities that characterize diabetes are involved in the progression of atherosclerosis in patients with DM, it may be said that prolonged exposure to hyperglycemia and insulin resistance ...
Source: Journal of Atherosclerosis and Thrombosis - October 3, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms.
Authors: Yamashiro Y, Yanagisawa H Abstract Thoracic aortic aneurysms (TAAs) are common, life-threatening diseases and are a major cause of mortality and morbidity. Over the past decade, genetic approaches have revealed that 1) activation of the transforming growth factor beta (TGF-β) signaling, 2) alterations in the contractile apparatus of vascular smooth muscle cells (SMCs), and 3) defects in the extracellular matrix (ECM) were responsible for development of TAAs. Most recently, a fourth mechanism has been proposed in that dysfunction of mechanosensing in the aortic wall in response to hemodynamic stress ma...
Source: Journal of Atherosclerosis and Thrombosis - September 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Tumor Necrosis Factor- α Gene Expression in Epicardial Adipose Tissue is Related to Coronary Atherosclerosis Assessed by Computed Tomography.
CONCLUSIONS: TNF-α expressed regionally in EAT may exert potent effects on the progression of coronary atherosclerosis, suggesting a contribution of EAT to coronary artery disease through behavior of molecule. PMID: 28931782 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Prediction of Stroke After Cardiac Catheterization: No Reason, No Stroke.
Authors: Tanaka A, Node K PMID: 28931783 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event.
CONCLUSIONS: Pravastatin is likely to reduce atherothrombotic stroke in patients enrolled within 6 months after stroke onset. However, the clinical efficacy for prevention of recurrent stroke was not conclusive with earlier statin treatment. PMID: 28924103 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Relationship between Serum Uric Acid and Vascular Function and Structure Markers and Gender Difference in a Real-World Population of China-From Beijing Vascular Disease Patients Evaluation Study (BEST) Study.
CONCLUSIONS: 1. All vascular parameters were higher in males than females. There was no gender difference in the relationship between UA and vascular markers except in ABI. 2. UA was independently linearly correlated with CAVI. 3. In people with higher UA level, the risk of higher CF-PWV increased. Therefore, higher UA may influence the vascular function mainly instead of vascular structure. PMID: 28904249 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Genetic Variants of RAMP2 and CLR are Associated with Stroke.
CONCLUSIONS: This was the first study to investigate the relationships between ADM receptor genes (RAMP2 and CLR) and stroke in the light of gene-environment interactions in human. PMID: 28904253 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

CIDE Family-Mediated Unique Lipid Droplet Morphology in White Adipose Tissue and Brown Adipose Tissue Determines the Adipocyte Energy Metabolism.
Authors: Nishimoto Y, Tamori Y Abstract White adipose tissue (WAT) stores energy as triacylglycerol in preparation for fasting state. In contrast, brown adipose tissue (BAT) consumes energy and produces heat in a cold environment. One of the major differences between these two adipose tissues is the morphology of the intracellular lipid droplet (LD), which is large and unilocular in WAT and small and multilocular in BAT. Although the fat-specific protein 27 alpha (FSP27α), belonging to the cell death-inducing DNA fragmentation factor A (DFFA)-like effector (Cide) family, was known to be indispensable for larg...
Source: Journal of Atherosclerosis and Thrombosis - September 10, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice.
CONCLUSIONS: These findings suggest that miR-134 accelerates atherogenesis by promoting lipid accumulation and proinflammatory cytokine secretion via the ANGPTL4/LPL pathway. Therefore, targeting miR-134 may offer a promising strategy for the prevention and treatment of atherosclerotic cardiovascular disease. PMID: 28867683 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Prospective Study on the Incidence of Cerebrovascular Disease After Coronary Angiography.
CONCLUSIONS: We suggested that the incidence of cerebral infarction after CAG was not related to the catheterization procedure per se but may be caused by atherosclerosis with CABG. PMID: 28855432 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 2, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of Cardiac Rehabilitation on High-Density Lipoprotein-mediated Cholesterol Efflux Capacity and Paraoxonase-1 Activity in Patients with Acute Coronary Syndrome.
CONCLUSIONS: CR can improve HDL function, and it is beneficial for secondary prevention. PMID: 28855433 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 2, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Additional Value of Brachial-Ankle Pulse Wave Velocity to Single-Photon Emission Computed Tomography in the Diagnosis of Coronary Artery Disease.
CONCLUSIONS: The results of this study suggest that baPWV may have additional value to SPECT for the detection of obstructive CAD, especially in patients with mild ischemia on SPECT. PMID: 28835579 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Epoxyeicosatrienoic Acids are Mediated by EPHX2 Variants and may be a Predictor of Early Neurological Deterioration in Acute Minor Ischemic Stroke.
CONCLUSION: END is fairly common and associated with poor outcomes in acute MIS. EPHX2 variants may mediate EETs levels, and low levels of EETs may be a predictor for END in acute MIS. PMID: 28835580 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Carotid Artery Parameters After Combined Exercise Training in Women with Sarcopenic Obesity.
Authors: Gando Y PMID: 28835581 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

n-3 Polyunsaturated Fatty Acids: Promising Nutrients for Preventing Cardiovascular Disease.
Authors: Yagi S, Fukuda D, Aihara KI, Akaike M, Shimabukuro M, Sata M Abstract The adoption of the Western-style diet, with decreased fish intake and lack of exercise, has increased the prevalence of cardiovascular disease (CVD) in Japan. Statin treatment has been established to reduce the risk of cardiovascular events; however, 60%-70% of these events occur despite its use. Thus, the residual risk for CVD should be identified and resolved to reduce further cardiovascular events. The serum levels of n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid and docosahexaenoic acid, are reportedly ass...
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Lower Level of Low Density Lipoprotein Cholesterol is Associated with a Higher Increase in the Fractional Flow Reserve in Patients with Fixed-dose Rosuvastatin.
CONCLUSIONS: LDL cholesterol level was associated with the change in the FFR value in patients following stent implantation. Lower LDL cholesterol tended to improve in the long-term FFR, underscoring the importance of lowering LDL cholesterol to prevent the progression of coronary atherosclerosis. PMID: 28824048 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders.
Authors: Miyazaki T, Miyazaki A Abstract Chronic vascular diseases such as atherosclerosis, aneurysms, diabetic angiopathy/retinopathy as well as fibrotic and proliferative vascular diseases are generally complicated by the progression of degenerative insults, which are characterized by endothelial dysfunction, apoptotic/necrotic cell death in vascular/immune cells, remodeling of extracellular matrix or breakdown of elastic lamella. Increasing evidence suggests that dysfunctional calpain proteolytic systems and defective calpain protein metabolism in blood vessels contribute to degenerative disorders. In vascular e...
Source: Journal of Atherosclerosis and Thrombosis - August 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Lipid Lowering Therapy and Circulating PCSK9 Concentration.
Authors: Nozue T Abstract Hypercholesterolemia, particularly an increase in low-density lipoprotein cholesterol (LDL-C) levels, contributes substantially to the development of coronary artery disease and the risk for cardiovascular events. As the first-line pharmacotherapy, statins have been shown to reduce both LDL-C levels and cardiovascular events. However, despite intensive statin therapy, a sizable proportion of statin-treated patients are unable to achieve the recommended target LDL-C levels, and not all patients can avoid future cardiovascular events. Proprotein convertase subtilisin/kexin type 9 (PCSK9) pla...
Source: Journal of Atherosclerosis and Thrombosis - August 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Heparin Cofactor II: A Novel Plausible Link of Obesity and Diabetes with Thrombosis.
Authors: Hasegawa Y, Ishigaki Y PMID: 28794345 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 11, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

A Novel Selective PPAR α Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice.
CONCLUSION: K-877 may attenuate PHTG by suppressing the postprandial increase of chylomicrons and the accumulation of chylomicron remnants more effectively than fenofibrate. PMID: 28781340 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Leptin Resistance and Lipolysis of White Adipose Tissue: An Implication to Ectopic Fat Disposition and Its Consequences.
Authors: Shimabukuro M PMID: 28781341 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Knowledge Translation for Cardiovascular Disease Research and Management in Japan.
This article provides an overview of knowledge translation and its importance in the cardiovascular health of the Japanese population, and describes the key steps of a typical knowledge translation strategy. PMID: 28757537 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 1, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases.
Authors: Abe H, Semba H, Takeda N Abstract The circulatory system distributes blood flow to each tissue and transports oxygen and nutrients. Peripheral circulation is required to maintain the physiological function in each tissue. Disturbance of circulation, therefore, decreases oxygen delivery, leading to tissue hypoxia which takes place in several cardiovascular disorders including atherosclerosis, pulmonary arterial hypertension and heart failure. While tissue hypoxia can be induced because of cardiovascular disorders, hypoxia signaling itself has a potential to modulate tissue remodeling processes or the severi...
Source: Journal of Atherosclerosis and Thrombosis - August 1, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men.
CONCLUSION: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men. PMID: 28747590 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 28, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Age-Specific Determinants of Pulse Wave Velocity among Metabolic Syndrome Components, Inflammatory Markers, and Oxidative Stress.
CONCLUSIONS: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y. PMID: 28740031 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Statin Responses in Chinese Patients.
Authors: Tomlinson B, Chan P, Liu ZM PMID: 28740057 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Association between Social Network Betweenness and Coronary Calcium: A Baseline Study of Patients with a High Risk of Cardiovascular Disease.
CONCLUSION: Deficiency in social network betweenness is closely related to coronary calcium in participants with a high risk of CVD. To generalize these results to a general population, further study should be performed. PMID: 28740058 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Exposure to Parental Smoking in Childhood is Associated with High C-Reactive Protein in Adulthood: The Cardiovascular Risk in Young Finns Study.
CONCLUSION: Our findings suggest that children exposed to parental smoking are at increased risk of having high hsCRP in adulthood. Limiting children's exposure to passive smoking may have long-term benefits on general low-grade inflammation. PMID: 28724840 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 21, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Sphingosine 1-Phosphate and Atherosclerosis.
Authors: Kurano M, Yatomi Y Abstract Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P receptors located on the cell membrane. In the circulation, S1P is distributed to HDL, followed by albumin. Since S1P and HDL share several bioactivities, S1P is believed to be responsible for the pleiotropic effects of HDL. Plasma S1P levels are reportedly lower in subjects with coronary artery disease, suggesting that S1P might be deeply involved in the pathogenesis of atherosclerosis. In basic experiments, however, S1P appears to possess both pro-atherosclerotic and anti-atherosclerotic p...
Source: Journal of Atherosclerosis and Thrombosis - July 21, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Is Childhood Exposure to Parental Smoking a Risk Factor for Future Cardiovascular Disease?
Authors: Michikawa T, Okamura T PMID: 28724852 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 21, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

A New Factor for Vascular Calcification in Chronic Kidney Disease:Computed Tomography-Based Renal Parenchymal Volume.
Authors: Nishimura M PMID: 28701626 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 15, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of 24-Week Aerobic and Resistance Training on Carotid Artery Intima-Media Thickness and Flow Velocity in Elderly Women with Sarcopenic Obesity.
CONCLUSION: The 24-week combined exercise effectively decreased CIMT and increased carotid flow velocity and wall shear ratio. Therefore, combined exercise is thought to contribute to the improvement of the risk of CVD in elderly women with SO. PMID: 28674320 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Incremental Prognostic Value of Coronary Computed Tomography Angiography: High-Risk Plaque Characteristics in Asymptomatic Patients.
CONCLUSION: Although the cardiac event rate was low, the evaluation of CCTA plaque characteristics may provide incremental prognostic value to CACS in asymptomatic patients. PMID: 28674321 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Oxidative Stress is Closely Associated with Increased Arterial Stiffness, Especially in Aged Male Smokers without Previous Cardiovascular Events: A Cross-Sectional Study.
CONCLUSIONS: Increased RAI is significantly associated with smoking and, in smokers, with increased d-ROM levels. These results suggest that the effects of oxidative stress on arterial properties differ between smokers and non-smokers and that oxidative stress is closely associated with arterial stiffness, especially in smokers. PMID: 28674322 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder.
CONCLUSIONS: We suggest that our new CKD rat model using SDT rats represents a useful CKD-MBD model, and this model was greatly influenced by paricalcitol administration. Further studies are needed to clarify the detailed mechanisms underlying this model. PMID: 28674323 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Flow Mediated Dilatation as a Biomarker in Vascular Surgery Research.
Authors: Bellamkonda K, Williams M, Handa A, Lee R Abstract Endothelial dysfunction is one of the hallmarks of atherogenesis, and correlates with many cardiovascular risk factors. One of the features of endothelial dysfunction is the loss of nitric oxide (NO) bioavailability, resulting in derangements in the vasodilatory response of the vessel wall. Flow mediated dilatation (FMD) of the brachial artery is an accepted method for non-invasive assessment of systemic endothelial function. FMD is examined extensively in the context of cardiovascular research, and has been utilised as a routine assessment in large cohort...
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Is the Association between Dietary Trans Fatty Acids and Insulin Resistance Remarkable in Japan?
Authors: Tsutsui W, Fujioka Y PMID: 28674325 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Sugar-Sweetened Beverages Consumption Positively Associated with the Risks of Obesity and Hypertriglyceridemia Among Children Aged 7-18 Years in South China.
CONCLUSION: A positive association between SSB consumption and the risks of obesity and hypertriglyceridemia was observed in children living in South China, which suggests that high SSB consumption enhances the risk of cardio-metabolic risk factors and the consequent cardio-metabolic diseases. PMID: 28652525 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 28, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Comprehensive Risk Management for the Prevention of Cerebro- Cardiovascular Diseases in Japan.
Authors: Joint Committee for Comprehensive Risk Management Chart for the Prevention of Cerebro- Cardiovascular Diseases PMID: 28652526 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 28, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Central Hemodynamics for Management of Arteriosclerotic Diseases.
Authors: Hashimoto J Abstract Arteriosclerosis, particularly aortosclerosis, is the most critical risk factor associated with cardiovascular, cerebrovascular, and renal diseases. The pulsatile hemodynamics in the central aorta consists of blood pressure, flow, and stiffness and substantially differs from the peripheral hemodynamics in muscular arteries. Arteriosclerotic changes with age appear earlier in the elastic aorta, and age-dependent increases in central pulse pressure are more marked than those apparent from brachial pressure measurement. Central pressure can be affected by lifestyle habits, metabolic disor...
Source: Journal of Atherosclerosis and Thrombosis - June 14, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Smoking Cessation without Educational Instruction Could Promote the Development of Metabolic Syndrome.
CONCLUSIONS: Smoking cessation without instruction could be followed by the development of metabolic syndrome, and the incidence of metabolic syndrome might reduce the benefit obtained from smoking cessation. Therefore, further educational outreach is needed to prevent the progression of metabolic syndrome during the course of smoking cessation. PMID: 28592705 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 9, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice.
CONCLUSION: Pitavastatin exerts eNOS-independent protective effects against atherogenesis and hind-limb ischemia in mice, which may occur via modifications on key molecules such as AMPK and diverse molecules. PMID: 28592707 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 9, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effect of Thyroxin Treatment on Carotid Intima-Media Thickness (CIMT) Reduction in Patients with Subclinical Hypothyroidism (SCH): a Meta-Analysis of Clinical Trials.
CONCLUSION: This meta-analysis shows that thyroxin therapy in subjects with SCH significantly decreases CIMT and improves lipid profile, modifiable CVD risk factors. Thyroid hormone replacement in subjects with SCH may play a role in slowing down or preventing the progression of atherosclerosis. PMID: 28566564 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 2, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Effect of n-3 PUFA on the Development of Abdominal Aortic Aneurysm.
Authors: Zaima N PMID: 28552852 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 31, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?
Authors: Ohira H, Tsutsui W, Fujioka Y Abstract Intestinal flora (microbiota) have recently attracted attention among lipid and carbohydrate metabolism researchers. Microbiota metabolize resistant starches and dietary fibers through fermentation and decomposition, and provide short chain fatty acids (SCFAs) to the host. The major SCFAs acetates, propionate and butyrate, have different production ratios and physiological activities. Several receptors for SCFAs have been identified as the G-protein coupled receptor 41/free fatty acid receptor 3 (GPR41/FFAR3), GPR43/FFAR2, GPR109A, and olfactory receptor 78, which are...
Source: Journal of Atherosclerosis and Thrombosis - May 31, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Association of a Low Serum Eicosapentaenoic Acid/Arachidonic Acid Ratio with the Risk of Acute Venous Thromboembolism.
Authors: Tani S PMID: 28539547 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Comparison of the OUTBACK( ®) Elite Reentry Catheter and the Bi-directional Approach after Failed Antegrade Approach for Femoro-popliteal Occlusive Disease.
CONCLUSIONS: Endovascular therapy for FP-CTO using the OUTBACK(®) Elite reentry catheter is feasible and safe after a failed antegrade approach. PMID: 28515407 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.
CONCLUSIONS: The present studies provide evidence to support the idea that HCⅡ plays an important role in the maintenance of glucose homeostasis by regulating insulin sensitivity in both humans and mice. Stimulators of HCⅡ production may serve as novel therapeutic tools for the treatment of type 2 diabetes. PMID: 28502917 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research