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Dapagliflozin Reduces Fat Mass without Affecting Muscle Mass in Type 2 Diabetes.
CONCLUSIONS: Treatment with dapagliflozin for six months significantly improved glycemic control and reduced body weight without reducing muscle mass in T2DM patients. PMID: 29225209 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 12, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study.
CONCLUSIONS: Cilnidipine promoted the regression of common carotid IMT in post-stroke hypertensive patients, especially in the thick group. Cilnidipine also reduced the IAD in both normal and thick groups. PMID: 29225324 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 12, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Omentin-1 is Associated with Carotid Plaque Instability among Ischemic Stroke Patients.
CONCLUSIONS: Among ischemic stroke patients, higher omentin-1 levels were inversely associated with carotid plaque instability, but not associated with moderate-severe carotid stenosis or occlusion. Omentin-1 may represent a biomarker for predicting carotid plaque instability of acute ischemic stroke patients. PMID: 29225325 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 12, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Noninvasive Coronary Plaque Imaging.
Authors: Noguchi T, Nakao K, Asaumi Y, Morita Y, Otsuka F, Kataoka Y, Hosoda H, Miura H, Fukuda T, Yasuda S Abstract Early identification of high-risk or vulnerable atherosclerotic plaques prone to rupture and performing preemptive therapy prior to catastrophic cardiovascular events are optimal goals of plaque imaging. Despite the advances in imaging modalities to identify vulnerable characteristics, the predictive value of the imaging techniques in the clinical setting is still developing. In this regard, reliable and high-sensitive imaging modalities identifying vulnerable plaque characters that may lead to futur...
Source: Journal of Atherosclerosis and Thrombosis - December 12, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effect of PEAR1 Genetic Variants on 1-Year Outcomes in Chinese Patients with Acute Myocardial Infarction After Percutaneous Coronary Intervention.
CONCLUSIONS: Genetic testing for PEAR1 variants can be helpful in predicting adverse ischemic events in Chinese patients with acute myocardial infarction after percutaneous coronary intervention. PMID: 29212986 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 9, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).
CONCLUSIONS: In a community-based sample of Japanese men free of CHD and stroke, CAC score ≥100 was significantly associated with higher estimated CHD risk by prediction models. This finding supports the potential utility of CAC as a biomarker for CHD in a general Japanese male population. PMID: 29212987 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 9, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Age Stratification and Impact of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid Ratios in Ischemic Stroke Patients.
CONCLUSIONS: The ratios of EPA/AA and DHA/AA could be specific markers for younger stroke patients. The EPA/AA ratio may be related to aortic arch calcification for elderly stroke patients and to multiple infarctions and cerebral white matter disease for middle-aged stroke patients. PMID: 29199200 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of a Dipeptidyl Peptidase 4 Inhibitor Sitagliptin on Glycemic Control and Lipoprotein Metabolism in Patients with Type 2 Diabetes Mellitus (GLORIA Trial).
CONCLUSIONS: These findings indicated that sitagliptin administration ameliorated the lipid and lipoprotein profiles in patients with diabetes, which may be due to the decrease in atherogenic remnant lipoproteins (UMIN#000013218). PMID: 29199201 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Influence of the Japanese Nationwide Cardiovascular Prevention System Health Guidance on Smoking Cessation Among Smokers: A Propensity Score Matching Analysis.
CONCLUSIONS: In the Japanese cardiovascular prevention system, repeated counseling may promote smoking cessation among male smokers. PMID: 29199202 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Efficacy and Safety of Pitavastatin in Children and Adolescents with Familial Hypercholesterolemia in Japan and Europe.
CONCLUSION: There were no significant differences between the efficacy or safety of pitavastatin in Japanese and European children and adolescents with FH, suggesting no relevant ethnic differences in the safety or efficacy of pitavastatin. PMID: 29187694 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - December 2, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Reduced Vitamin D Receptor on Circulating Endothelial Progenitor Cells: A New Risk Factor of Coronary Artery Diseases.
CONCLUSION: A significant decrease of VDR expression on circulating EPCs was observed among CAD patients, particularly among those also with diabetes. VDR expression on EPCs was independently negatively correlated with HbA1c and high glucose decreased EPCs' VDR expression. Low levels of VDR expression on circulating EPCs might serve as a potential risk factor of CAD. PMID: 29176261 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 29, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats.
CONCLUSIONS: SHRSP5/Dmcr rats may be a suitable animal model for elucidating the organ interaction between NASH and cardiac or vascular dysfunction. PMID: 29162773 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Modulation of High-Density Lipoprotein Function via Cardiac Rehabilitation.
Authors: Satomi-Kobayashi S, Ishida T PMID: 29142155 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 18, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Usefulness of a Short Dietary Propensity Questionnaire in Japan.
CONCLUSION: The SDPQ may be useful for assessment of dietary propensities for alcohol, starchy foods, and milk and dairy products in Japan. PMID: 29142179 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 18, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Update on the Therapeutic Strategy of Type B Aortic Dissection.
Authors: Kaji S Abstract Stanford type B aortic dissection (TBAD) is a life-threatening disease. Current therapeutic guidelines recommend medical therapy with aggressive blood pressure lowering for patients with acute TBAD unless they have fatal complications. Although patients with uncomplicated TBAD have relatively low early mortality, aorta-related adverse events during the chronic phase worsen the long-term clinical outcome. Recent advances in thoracic endovascular aortic repair (TEVAR) can improve clinical outcomes in patients with both complicated and uncomplicated TBAD. According to present guidelines, compl...
Source: Journal of Atherosclerosis and Thrombosis - November 15, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Manifestation of Coronary Atherosclerosis in Klang Valley, Malaysia: An Autopsy Study.
CONCLUSION: Cardiovascular diseases were the most significant natural cause of sudden death with a staggering figure of 75%. CAD was the single most commonly encountered pathology within the SCD. Most cases presented with single and double-vessel diseases, observed in all subjects, as well as the young adult population. PMID: 29118310 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 11, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study.
CONCLUSION: Baseline mean and maximum values of carotid IMT in Japanese noncardioembolic stroke patients with hyperlipidemia were 0.89±0.15 mm and 1.19±0.32 mm, respectively, which were similar to those previously reported from Western countries. Age, smoking, hypertension, HDL cholesterol, and diabetes mellitus were associated with mean IMT, and those, except for hypertension, were associated with maximum IMT. PMID: 29118311 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 11, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function.
CONCLUSION: Serum α2MG levels might reflect endothelial dysfunction evaluated by FMD in patients with chronic stroke or cardiovascular risk factors. PMID: 29093276 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 3, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Coronary Artery Running Pattern is One of the Causes of Individual Differences in the Progression of Coronary Atherosclerosis in WHHLMI Rabbits, an Animal Model for Coronary Atherosclerosis.
CONCLUSIONS: Individual differences were observed in the angle of the main curvature of the LCX, which affected the occurrence and extension of atherosclerotic lesions. PMID: 29093277 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - November 3, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Social Network Structure and Atherosclerotic Cardiovascular Disease.
Authors: Nishi N PMID: 29057761 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - October 24, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Principles and Applications of Rabbit Models for Atherosclerosis Research.
Authors: Fan J, Chen Y, Yan H, Niimi M, Wang Y, Liang J Abstract Rabbits are one of the most used experimental animals for biomedical research, particularly as a bioreactor for the production of antibodies. However, many unique features of the rabbit have also made it as an excellent species for examining a number of aspects of human diseases such as atherosclerosis. Rabbits are phylogenetically closer to humans than rodents, in addition to their relatively proper size, tame disposition, and ease of use and maintenance in the laboratory facility. Due to their short life spans, short gestation periods, high numbers ...
Source: Journal of Atherosclerosis and Thrombosis - October 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Correlation between Thyroid Stimulating Hormone and Renal Function in Euthyroid Residents of Japan: Results from the Kyushu and Okinawa Population Study (KOPS).
CONCLUSIONS: Our findings demonstrated a significant correlation between serum TSH levels and eGFR in high-normal TSH participants. In healthy individuals, high-normal TSH levels indicate increased the risk of chronic kidney disease. PMID: 29046502 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - October 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator K-877 (Pemafibrate) on Postprandial hyperlipidemia.
Effects of a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator K-877 (Pemafibrate) on Postprandial hyperlipidemia. J Atheroscler Thromb. 2017 Oct 18;: Authors: Fujioka Y PMID: 29046503 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - October 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Two-year Clinical Outcomes Post Implantation of Epic(TM) Self-Expanding Nitinol Stents for the Aortoiliac Occlusive Disease in Patients with Peripheral Arterial Disease.
CONCLUSION: The Epic(TM) self-expanding nitinol stent was demonstrated to be safe and effectivene for AIOD when tested for two years in patients with PAD. PMID: 28978866 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - October 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases.
Authors: Wu H, Du Q, Dai Q, Ge J, Cheng X Abstract Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a pivotal role in extracellular matrix (ECM) remodeling and have been implicated in the development and progression of atherosclerosis-based cardiovascular diseases. An imbalance in expression between cathepsins (such as cathepsins S, K, L, C) and their inhibitor cystatin C may favor proteolysis of ECM in the pathogenesis of cardiovascular disease such as atherosclerosis, aneurysm formation,...
Source: Journal of Atherosclerosis and Thrombosis - October 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus.
Authors: Katakami N Abstract Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus (DM), causes cerebro-cardiovascular diseases, which are major causes of death in patients with DM and significantly reduce their quality of life. The alterations in vascular homeostasis due to endothelial and vascular smooth muscle cell dysfunction are the main features of diabetic macroangiopathy. Although multiple metabolic abnormalities that characterize diabetes are involved in the progression of atherosclerosis in patients with DM, it may be said that prolonged exposure to hyperglycemia and insulin resistance ...
Source: Journal of Atherosclerosis and Thrombosis - October 3, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms.
Authors: Yamashiro Y, Yanagisawa H Abstract Thoracic aortic aneurysms (TAAs) are common, life-threatening diseases and are a major cause of mortality and morbidity. Over the past decade, genetic approaches have revealed that 1) activation of the transforming growth factor beta (TGF-β) signaling, 2) alterations in the contractile apparatus of vascular smooth muscle cells (SMCs), and 3) defects in the extracellular matrix (ECM) were responsible for development of TAAs. Most recently, a fourth mechanism has been proposed in that dysfunction of mechanosensing in the aortic wall in response to hemodynamic stress ma...
Source: Journal of Atherosclerosis and Thrombosis - September 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Tumor Necrosis Factor- α Gene Expression in Epicardial Adipose Tissue is Related to Coronary Atherosclerosis Assessed by Computed Tomography.
CONCLUSIONS: TNF-α expressed regionally in EAT may exert potent effects on the progression of coronary atherosclerosis, suggesting a contribution of EAT to coronary artery disease through behavior of molecule. PMID: 28931782 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Prediction of Stroke After Cardiac Catheterization: No Reason, No Stroke.
Authors: Tanaka A, Node K PMID: 28931783 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event.
CONCLUSIONS: Pravastatin is likely to reduce atherothrombotic stroke in patients enrolled within 6 months after stroke onset. However, the clinical efficacy for prevention of recurrent stroke was not conclusive with earlier statin treatment. PMID: 28924103 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Relationship between Serum Uric Acid and Vascular Function and Structure Markers and Gender Difference in a Real-World Population of China-From Beijing Vascular Disease Patients Evaluation Study (BEST) Study.
CONCLUSIONS: 1. All vascular parameters were higher in males than females. There was no gender difference in the relationship between UA and vascular markers except in ABI. 2. UA was independently linearly correlated with CAVI. 3. In people with higher UA level, the risk of higher CF-PWV increased. Therefore, higher UA may influence the vascular function mainly instead of vascular structure. PMID: 28904249 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Genetic Variants of RAMP2 and CLR are Associated with Stroke.
CONCLUSIONS: This was the first study to investigate the relationships between ADM receptor genes (RAMP2 and CLR) and stroke in the light of gene-environment interactions in human. PMID: 28904253 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

CIDE Family-Mediated Unique Lipid Droplet Morphology in White Adipose Tissue and Brown Adipose Tissue Determines the Adipocyte Energy Metabolism.
Authors: Nishimoto Y, Tamori Y Abstract White adipose tissue (WAT) stores energy as triacylglycerol in preparation for fasting state. In contrast, brown adipose tissue (BAT) consumes energy and produces heat in a cold environment. One of the major differences between these two adipose tissues is the morphology of the intracellular lipid droplet (LD), which is large and unilocular in WAT and small and multilocular in BAT. Although the fat-specific protein 27 alpha (FSP27α), belonging to the cell death-inducing DNA fragmentation factor A (DFFA)-like effector (Cide) family, was known to be indispensable for larg...
Source: Journal of Atherosclerosis and Thrombosis - September 10, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice.
CONCLUSIONS: These findings suggest that miR-134 accelerates atherogenesis by promoting lipid accumulation and proinflammatory cytokine secretion via the ANGPTL4/LPL pathway. Therefore, targeting miR-134 may offer a promising strategy for the prevention and treatment of atherosclerotic cardiovascular disease. PMID: 28867683 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Prospective Study on the Incidence of Cerebrovascular Disease After Coronary Angiography.
CONCLUSIONS: We suggested that the incidence of cerebral infarction after CAG was not related to the catheterization procedure per se but may be caused by atherosclerosis with CABG. PMID: 28855432 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 2, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of Cardiac Rehabilitation on High-Density Lipoprotein-mediated Cholesterol Efflux Capacity and Paraoxonase-1 Activity in Patients with Acute Coronary Syndrome.
CONCLUSIONS: CR can improve HDL function, and it is beneficial for secondary prevention. PMID: 28855433 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 2, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Additional Value of Brachial-Ankle Pulse Wave Velocity to Single-Photon Emission Computed Tomography in the Diagnosis of Coronary Artery Disease.
CONCLUSIONS: The results of this study suggest that baPWV may have additional value to SPECT for the detection of obstructive CAD, especially in patients with mild ischemia on SPECT. PMID: 28835579 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Epoxyeicosatrienoic Acids are Mediated by EPHX2 Variants and may be a Predictor of Early Neurological Deterioration in Acute Minor Ischemic Stroke.
CONCLUSION: END is fairly common and associated with poor outcomes in acute MIS. EPHX2 variants may mediate EETs levels, and low levels of EETs may be a predictor for END in acute MIS. PMID: 28835580 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Carotid Artery Parameters After Combined Exercise Training in Women with Sarcopenic Obesity.
Authors: Gando Y PMID: 28835581 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

n-3 Polyunsaturated Fatty Acids: Promising Nutrients for Preventing Cardiovascular Disease.
Authors: Yagi S, Fukuda D, Aihara KI, Akaike M, Shimabukuro M, Sata M Abstract The adoption of the Western-style diet, with decreased fish intake and lack of exercise, has increased the prevalence of cardiovascular disease (CVD) in Japan. Statin treatment has been established to reduce the risk of cardiovascular events; however, 60%-70% of these events occur despite its use. Thus, the residual risk for CVD should be identified and resolved to reduce further cardiovascular events. The serum levels of n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid and docosahexaenoic acid, are reportedly ass...
Source: Journal of Atherosclerosis and Thrombosis - August 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Lower Level of Low Density Lipoprotein Cholesterol is Associated with a Higher Increase in the Fractional Flow Reserve in Patients with Fixed-dose Rosuvastatin.
CONCLUSIONS: LDL cholesterol level was associated with the change in the FFR value in patients following stent implantation. Lower LDL cholesterol tended to improve in the long-term FFR, underscoring the importance of lowering LDL cholesterol to prevent the progression of coronary atherosclerosis. PMID: 28824048 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders.
Authors: Miyazaki T, Miyazaki A Abstract Chronic vascular diseases such as atherosclerosis, aneurysms, diabetic angiopathy/retinopathy as well as fibrotic and proliferative vascular diseases are generally complicated by the progression of degenerative insults, which are characterized by endothelial dysfunction, apoptotic/necrotic cell death in vascular/immune cells, remodeling of extracellular matrix or breakdown of elastic lamella. Increasing evidence suggests that dysfunctional calpain proteolytic systems and defective calpain protein metabolism in blood vessels contribute to degenerative disorders. In vascular e...
Source: Journal of Atherosclerosis and Thrombosis - August 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Lipid Lowering Therapy and Circulating PCSK9 Concentration.
Authors: Nozue T Abstract Hypercholesterolemia, particularly an increase in low-density lipoprotein cholesterol (LDL-C) levels, contributes substantially to the development of coronary artery disease and the risk for cardiovascular events. As the first-line pharmacotherapy, statins have been shown to reduce both LDL-C levels and cardiovascular events. However, despite intensive statin therapy, a sizable proportion of statin-treated patients are unable to achieve the recommended target LDL-C levels, and not all patients can avoid future cardiovascular events. Proprotein convertase subtilisin/kexin type 9 (PCSK9) pla...
Source: Journal of Atherosclerosis and Thrombosis - August 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Heparin Cofactor II: A Novel Plausible Link of Obesity and Diabetes with Thrombosis.
Authors: Hasegawa Y, Ishigaki Y PMID: 28794345 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 11, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

A Novel Selective PPAR α Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice.
CONCLUSION: K-877 may attenuate PHTG by suppressing the postprandial increase of chylomicrons and the accumulation of chylomicron remnants more effectively than fenofibrate. PMID: 28781340 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Leptin Resistance and Lipolysis of White Adipose Tissue: An Implication to Ectopic Fat Disposition and Its Consequences.
Authors: Shimabukuro M PMID: 28781341 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Knowledge Translation for Cardiovascular Disease Research and Management in Japan.
This article provides an overview of knowledge translation and its importance in the cardiovascular health of the Japanese population, and describes the key steps of a typical knowledge translation strategy. PMID: 28757537 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 1, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases.
Authors: Abe H, Semba H, Takeda N Abstract The circulatory system distributes blood flow to each tissue and transports oxygen and nutrients. Peripheral circulation is required to maintain the physiological function in each tissue. Disturbance of circulation, therefore, decreases oxygen delivery, leading to tissue hypoxia which takes place in several cardiovascular disorders including atherosclerosis, pulmonary arterial hypertension and heart failure. While tissue hypoxia can be induced because of cardiovascular disorders, hypoxia signaling itself has a potential to modulate tissue remodeling processes or the severi...
Source: Journal of Atherosclerosis and Thrombosis - August 1, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men.
CONCLUSION: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men. PMID: 28747590 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 28, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Age-Specific Determinants of Pulse Wave Velocity among Metabolic Syndrome Components, Inflammatory Markers, and Oxidative Stress.
CONCLUSIONS: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y. PMID: 28740031 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research