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Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders.
Authors: Miyazaki T, Miyazaki A Abstract Chronic vascular diseases such as atherosclerosis, aneurysms, diabetic angiopathy/retinopathy as well as fibrotic and proliferative vascular diseases are generally complicated by the progression of degenerative insults, which are characterized by endothelial dysfunction, apoptotic/necrotic cell death in vascular/immune cells, remodeling of extracellular matrix or breakdown of elastic lamella. Increasing evidence suggests that dysfunctional calpain proteolytic systems and defective calpain protein metabolism in blood vessels contribute to degenerative disorders. In vascular e...
Source: Journal of Atherosclerosis and Thrombosis - August 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Lipid Lowering Therapy and Circulating PCSK9 Concentration.
Authors: Nozue T Abstract Hypercholesterolemia, particularly an increase in low-density lipoprotein cholesterol (LDL-C) levels, contributes substantially to the development of coronary artery disease and the risk for cardiovascular events. As the first-line pharmacotherapy, statins have been shown to reduce both LDL-C levels and cardiovascular events. However, despite intensive statin therapy, a sizable proportion of statin-treated patients are unable to achieve the recommended target LDL-C levels, and not all patients can avoid future cardiovascular events. Proprotein convertase subtilisin/kexin type 9 (PCSK9) pla...
Source: Journal of Atherosclerosis and Thrombosis - August 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Heparin Cofactor II: A Novel Plausible Link of Obesity and Diabetes with Thrombosis.
Authors: Hasegawa Y, Ishigaki Y PMID: 28794345 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 11, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

A Novel Selective PPAR α Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice.
CONCLUSION: K-877 may attenuate PHTG by suppressing the postprandial increase of chylomicrons and the accumulation of chylomicron remnants more effectively than fenofibrate. PMID: 28781340 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Leptin Resistance and Lipolysis of White Adipose Tissue: An Implication to Ectopic Fat Disposition and Its Consequences.
Authors: Shimabukuro M PMID: 28781341 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Knowledge Translation for Cardiovascular Disease Research and Management in Japan.
This article provides an overview of knowledge translation and its importance in the cardiovascular health of the Japanese population, and describes the key steps of a typical knowledge translation strategy. PMID: 28757537 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 1, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases.
Authors: Abe H, Semba H, Takeda N Abstract The circulatory system distributes blood flow to each tissue and transports oxygen and nutrients. Peripheral circulation is required to maintain the physiological function in each tissue. Disturbance of circulation, therefore, decreases oxygen delivery, leading to tissue hypoxia which takes place in several cardiovascular disorders including atherosclerosis, pulmonary arterial hypertension and heart failure. While tissue hypoxia can be induced because of cardiovascular disorders, hypoxia signaling itself has a potential to modulate tissue remodeling processes or the severi...
Source: Journal of Atherosclerosis and Thrombosis - August 1, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men.
CONCLUSION: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men. PMID: 28747590 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 28, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Age-Specific Determinants of Pulse Wave Velocity among Metabolic Syndrome Components, Inflammatory Markers, and Oxidative Stress.
CONCLUSIONS: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y. PMID: 28740031 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Statin Responses in Chinese Patients.
Authors: Tomlinson B, Chan P, Liu ZM PMID: 28740057 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Association between Social Network Betweenness and Coronary Calcium: A Baseline Study of Patients with a High Risk of Cardiovascular Disease.
CONCLUSION: Deficiency in social network betweenness is closely related to coronary calcium in participants with a high risk of CVD. To generalize these results to a general population, further study should be performed. PMID: 28740058 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Exposure to Parental Smoking in Childhood is Associated with High C-Reactive Protein in Adulthood: The Cardiovascular Risk in Young Finns Study.
CONCLUSION: Our findings suggest that children exposed to parental smoking are at increased risk of having high hsCRP in adulthood. Limiting children's exposure to passive smoking may have long-term benefits on general low-grade inflammation. PMID: 28724840 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 21, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Sphingosine 1-Phosphate and Atherosclerosis.
Authors: Kurano M, Yatomi Y Abstract Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P receptors located on the cell membrane. In the circulation, S1P is distributed to HDL, followed by albumin. Since S1P and HDL share several bioactivities, S1P is believed to be responsible for the pleiotropic effects of HDL. Plasma S1P levels are reportedly lower in subjects with coronary artery disease, suggesting that S1P might be deeply involved in the pathogenesis of atherosclerosis. In basic experiments, however, S1P appears to possess both pro-atherosclerotic and anti-atherosclerotic p...
Source: Journal of Atherosclerosis and Thrombosis - July 21, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Is Childhood Exposure to Parental Smoking a Risk Factor for Future Cardiovascular Disease?
Authors: Michikawa T, Okamura T PMID: 28724852 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 21, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

A New Factor for Vascular Calcification in Chronic Kidney Disease:Computed Tomography-Based Renal Parenchymal Volume.
Authors: Nishimura M PMID: 28701626 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 15, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of 24-Week Aerobic and Resistance Training on Carotid Artery Intima-Media Thickness and Flow Velocity in Elderly Women with Sarcopenic Obesity.
CONCLUSION: The 24-week combined exercise effectively decreased CIMT and increased carotid flow velocity and wall shear ratio. Therefore, combined exercise is thought to contribute to the improvement of the risk of CVD in elderly women with SO. PMID: 28674320 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Incremental Prognostic Value of Coronary Computed Tomography Angiography: High-Risk Plaque Characteristics in Asymptomatic Patients.
CONCLUSION: Although the cardiac event rate was low, the evaluation of CCTA plaque characteristics may provide incremental prognostic value to CACS in asymptomatic patients. PMID: 28674321 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Oxidative Stress is Closely Associated with Increased Arterial Stiffness, Especially in Aged Male Smokers without Previous Cardiovascular Events: A Cross-Sectional Study.
CONCLUSIONS: Increased RAI is significantly associated with smoking and, in smokers, with increased d-ROM levels. These results suggest that the effects of oxidative stress on arterial properties differ between smokers and non-smokers and that oxidative stress is closely associated with arterial stiffness, especially in smokers. PMID: 28674322 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder.
CONCLUSIONS: We suggest that our new CKD rat model using SDT rats represents a useful CKD-MBD model, and this model was greatly influenced by paricalcitol administration. Further studies are needed to clarify the detailed mechanisms underlying this model. PMID: 28674323 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Flow Mediated Dilatation as a Biomarker in Vascular Surgery Research.
Authors: Bellamkonda K, Williams M, Handa A, Lee R Abstract Endothelial dysfunction is one of the hallmarks of atherogenesis, and correlates with many cardiovascular risk factors. One of the features of endothelial dysfunction is the loss of nitric oxide (NO) bioavailability, resulting in derangements in the vasodilatory response of the vessel wall. Flow mediated dilatation (FMD) of the brachial artery is an accepted method for non-invasive assessment of systemic endothelial function. FMD is examined extensively in the context of cardiovascular research, and has been utilised as a routine assessment in large cohort...
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Is the Association between Dietary Trans Fatty Acids and Insulin Resistance Remarkable in Japan?
Authors: Tsutsui W, Fujioka Y PMID: 28674325 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 5, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Sugar-Sweetened Beverages Consumption Positively Associated with the Risks of Obesity and Hypertriglyceridemia Among Children Aged 7-18 Years in South China.
CONCLUSION: A positive association between SSB consumption and the risks of obesity and hypertriglyceridemia was observed in children living in South China, which suggests that high SSB consumption enhances the risk of cardio-metabolic risk factors and the consequent cardio-metabolic diseases. PMID: 28652525 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 28, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Comprehensive Risk Management for the Prevention of Cerebro- Cardiovascular Diseases in Japan.
Authors: Joint Committee for Comprehensive Risk Management Chart for the Prevention of Cerebro- Cardiovascular Diseases PMID: 28652526 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 28, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Central Hemodynamics for Management of Arteriosclerotic Diseases.
Authors: Hashimoto J Abstract Arteriosclerosis, particularly aortosclerosis, is the most critical risk factor associated with cardiovascular, cerebrovascular, and renal diseases. The pulsatile hemodynamics in the central aorta consists of blood pressure, flow, and stiffness and substantially differs from the peripheral hemodynamics in muscular arteries. Arteriosclerotic changes with age appear earlier in the elastic aorta, and age-dependent increases in central pulse pressure are more marked than those apparent from brachial pressure measurement. Central pressure can be affected by lifestyle habits, metabolic disor...
Source: Journal of Atherosclerosis and Thrombosis - June 14, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Smoking Cessation without Educational Instruction Could Promote the Development of Metabolic Syndrome.
CONCLUSIONS: Smoking cessation without instruction could be followed by the development of metabolic syndrome, and the incidence of metabolic syndrome might reduce the benefit obtained from smoking cessation. Therefore, further educational outreach is needed to prevent the progression of metabolic syndrome during the course of smoking cessation. PMID: 28592705 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 9, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice.
CONCLUSION: Pitavastatin exerts eNOS-independent protective effects against atherogenesis and hind-limb ischemia in mice, which may occur via modifications on key molecules such as AMPK and diverse molecules. PMID: 28592707 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 9, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effect of Thyroxin Treatment on Carotid Intima-Media Thickness (CIMT) Reduction in Patients with Subclinical Hypothyroidism (SCH): a Meta-Analysis of Clinical Trials.
CONCLUSION: This meta-analysis shows that thyroxin therapy in subjects with SCH significantly decreases CIMT and improves lipid profile, modifiable CVD risk factors. Thyroid hormone replacement in subjects with SCH may play a role in slowing down or preventing the progression of atherosclerosis. PMID: 28566564 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - June 2, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Effect of n-3 PUFA on the Development of Abdominal Aortic Aneurysm.
Authors: Zaima N PMID: 28552852 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 31, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?
Authors: Ohira H, Tsutsui W, Fujioka Y Abstract Intestinal flora (microbiota) have recently attracted attention among lipid and carbohydrate metabolism researchers. Microbiota metabolize resistant starches and dietary fibers through fermentation and decomposition, and provide short chain fatty acids (SCFAs) to the host. The major SCFAs acetates, propionate and butyrate, have different production ratios and physiological activities. Several receptors for SCFAs have been identified as the G-protein coupled receptor 41/free fatty acid receptor 3 (GPR41/FFAR3), GPR43/FFAR2, GPR109A, and olfactory receptor 78, which are...
Source: Journal of Atherosclerosis and Thrombosis - May 31, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Association of a Low Serum Eicosapentaenoic Acid/Arachidonic Acid Ratio with the Risk of Acute Venous Thromboembolism.
Authors: Tani S PMID: 28539547 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 26, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Comparison of the OUTBACK( ®) Elite Reentry Catheter and the Bi-directional Approach after Failed Antegrade Approach for Femoro-popliteal Occlusive Disease.
CONCLUSIONS: Endovascular therapy for FP-CTO using the OUTBACK(®) Elite reentry catheter is feasible and safe after a failed antegrade approach. PMID: 28515407 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.
CONCLUSIONS: The present studies provide evidence to support the idea that HCⅡ plays an important role in the maintenance of glucose homeostasis by regulating insulin sensitivity in both humans and mice. Stimulators of HCⅡ production may serve as novel therapeutic tools for the treatment of type 2 diabetes. PMID: 28502917 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Ability of the Ankle Brachial Index and Brachial-Ankle Pulse Wave Velocity to Predict the 3-Month Outcome in Patients with Non-Cardioembolic Stroke.
CONCLUSION: Our study suggests that the stroke outcome can be predicted using ABI and to an extent using baPWV when ABI ≥ 0.9 in patients with non-cardioembolic stroke. PMID: 28502918 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Adiponectin and T-Cadherin: a Tree for Biomarkers in ST-Elevation or Non-ST-Elevation Myocardial Infarction.
Authors: Shimabukuro M PMID: 28502919 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Endostatin as a Biomarker of Basement Membrane Degradation.
Authors: Sato Y PMID: 28502920 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 16, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs.
CONCLUSION: To our knowledge, this is the first large animal model, in which visceral obesity, NAFLD and atherosclerosis are concomitantly induced by dietary manipulation. These data suggest the detrimental effects of CA, potentially through local and systemic activation of oxidative stress-induced signaling to macrophage mobilization, on the acceleration of visceral adiposity, atherosclerosis and NAFLD. PMID: 28496045 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 13, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Soluble Vascular Cell Adhesion Molecule and Cardiovascular Disease: An Epidemiological View.
Authors: Yamagishi K, Iso H PMID: 28496046 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 13, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Histopathology of Asymptomatic Iliac Atherosclerosis: From Autopsy to Practice.
Authors: Nishihira K, Yasuda S PMID: 28496047 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 13, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Determination of Fasting and Non-Fasting Cholesterol Levels of Low- and High-Density Lipoproteins with Homogenous Assays: A Promising Reliable Way to Assessment of Dyslipidemia.
Authors: Yoshida H PMID: 28496075 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 13, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Association between Serum Elaidic acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles.
CONCLUSIONS: These results suggest that excessive TFA intake worsens insulin resistance and increases the risk of developing DM even in the native Japanese, whose intakes of animal fat and simple carbohydrates were presumed to be lower than those of the Japanese-Americans. PMID: 28484112 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 10, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Association of High-Density Lipoprotein Subclasses with Carotid Intima-Media Thickness: Shimane CoHRE Study.
CONCLUSIONS: Neither HDL3-C nor HDL2-C was significantly associated with carotid atherosclerosis in the Japanese population in this study. PMID: 28450678 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 30, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Combination Therapy of Fenofibrate and Ezetimibe Improved Lipid Profile and Vascular Function Compared with Statins in Patients with Type 2 Diabetes.
CONCLUSIONS: Compared with the treatment with statins, the treatment with the combination of fenofibrate and ezetimibe effectively controlled the LDL cholesterol and TG levels, increased the HDL cholesterol level, especially in its small fraction, and improved vascular function of patients with type 2 diabetes. PMID: 28450679 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 30, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Progression of Carotid Atherosclerosis in Two Japanese Populations with Different Lifestyles.
CONCLUSIONS: According to surveys conducted in 2012 and 2014, carotid IMT was still greater in Japanese Americans than in native Japanese. However, a comparison with data from the 1998 survey showed that current native Japanese had higher serum lipid levels and more advanced atherosclerosis. PMID: 28450680 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 30, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

HDL3 Cholesterol Levels in an Elderly Population.
Authors: Inazu A PMID: 28450681 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 30, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

LOX-1 in Ischemic Stroke.
Authors: Sawamura T, Fujita Y, Horiuchi S, Kakino A PMID: 28442661 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 27, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The Relation between Serum Endostatin Level and Carotid Atherosclerosis in Healthy Residents of Japan: Results from the Kyushu and Okinawa Population Study (KOPS).
CONCLUSIONS: A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population. PMID: 28428451 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDL Biogenesis in Hepatocytes.
CONCLUSIONS: It is suggested that localization of ABCA1 to the cell surface is decreased in hepatocytes in hyperglycemic condition to cause decrease of HDL biogenesis. PMID: 28428480 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Serum Tartrate-resistant Acid Phosphatase-5b Levels are Associated with the Severity and Extent of Coronary Atherosclerosis in Patients with Coronary Artery Disease.
CONCLUSIONS: These data indicate that the TRACP-5b level is significantly associated with the OPG level and with the severity and extent of coronary atherosclerosis in CAD patients. PMID: 28428481 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation.
Authors: Takahashi S Abstract Very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. It binds triglyceride rich lipoprotein (TGRL) but not LDL, because it recognizes apolipoprotein (apo)E only but not apoB. The VLDL receptor functions as a peripheral lipoprotein receptor in concert with lipoprotein lipase (LPL) in heart, muscle, adipose tissue and macrophages. In contrast to the LDL receptor, VLDL receptor binds apo E2/2 VLDL and apoE3/3 VLDL particles, and its expression is not down-regulated by intracellular lipoproteins. It has been reported that both LDL-c...
Source: Journal of Atherosclerosis and Thrombosis - April 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering.
CONCLUSIONS: We clarify for the first time the role of HSL in leptin's effect using a genetic model: leptin-promoted fat loss and glucose-lowering are at least in part mediated via HSL-mediated lipolysis. Further studies to define the pathophysiological role of adipocyte lipases in leptin action may lead to a new therapeutic approach to circumvent leptin resistance. PMID: 28413180 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research