Associations of Baseline and Changes in Leukocyte Counts with Incident Cardiovascular Events: The Dongfeng-Tongji Cohort Study
CONCLUSION: High baseline total leukocyte count and a 5-year increase in total leukocyte count were related to higher CVD risk.PMID:34305075 | DOI:10.5551/jat.62970 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 26, 2021 Category: Cardiology Authors: Qiuhong Wang Qiang Guo Lue Zhou Wending Li Yu Yuan Wenhui Lei Kang Liu Man Xu Tingyue Diao Hui Gao Meian He Huan Guo Handong Yang Xiaomin Zhang Tangchun Wu Source Type: research

Beta-2-Microglobulin is an Independent Risk Factor for Asymptomatic Carotid Atherosclerosis in Patients with Primary Aldosteronism
CONCLUSION: B2M is an independent risk factor for asymptomatic carotid atherosclerosis in patients with PA.PMID:34305082 | DOI:10.5551/jat.62851 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 26, 2021 Category: Cardiology Authors: Shangyan Liang Qingling Li Qianwei Lai Ying Zhou Hui Zhang Xueyan Chen Bin Yao Wen Xu Xubin Yang Source Type: research

Left Ventricular Abnormality and Covert Atrial Fibrillation in Embolic Stroke of Undetermined Source
CONCLUSIONS: In patients with ESUS after ICMs implantation, the LV characteristics of low LVFS and high E/e' were associated with AF detection.PMID:34305083 | DOI:10.5551/jat.62994 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 26, 2021 Category: Cardiology Authors: Hajime Ikenouchi Junpei Koge Tomotaka Tanaka Eriko Yamaguchi Shuhei Egashira Kazuo Washida Satoshi Nagase Kengo Kusano Kazunori Toyoda Masafumi Ihara Masatoshi Koga Source Type: research

Association of Asymptomatic Low Ankle-Brachial Index with Long-Term Clinical Outcomes in Patients after Acute Myocardial Infarction
CONCLUSIONS: Reduced ABI was significantly associated with long-term adverse events in AMI patients without a history of PAD. Our results suggest the usefulness of ABI as a prognostic marker in AMI patients irrespective of symptomatic PAD.PMID:34305084 | DOI:10.5551/jat.62998 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 26, 2021 Category: Cardiology Authors: Soichiro Ban Kenichi Sakakura Hiroyuki Jinnouchi Yousuke Taniguchi Takunori Tsukui Yusuke Watanabe Kei Yamamoto Masaru Seguchi Hiroshi Wada Hideo Fujita Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y < sub > 12 < /sub > Inhibitor Thereafter
CONCLUSIONS: Our meta-analysis shows that short DAPT ≤ 3 months followed by SAPT reduces bleeding and is not associated with an increase in ST. The results were consistent within the aspirin and P2Y12 SAPT studies.PMID:34248087 | DOI:10.5551/jat.63000 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shqipdona Lahu Peter Bristot Senta Gewalt Alexander Goedel Daniele Giacoppo Stefanie Sch üpke Heribert Schunkert Adnan Kastrati Nikolaus Sarafoff Source Type: research

Finding Importance for Universal Screening of Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Jul 10. doi: 10.5551/jat.ED183. Online ahead of print.NO ABSTRACTPMID:34248088 | DOI:10.5551/jat.ED183 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Shinji Yokoyama Source Type: research

Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes
CONCLUSIONS: Higher triglycerides levels are associated with intracranial artery atherosclerosis. Pemafibrate showed pleiotropic effects not only in ameliorating atherogenic dyslipidemia but also in the reduction of the levels of inflammatory markers and hepatobiliary enzymes.PMID:34248089 | DOI:10.5551/jat.63036 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Takao Hoshino Kentaro Ishizuka Sono Toi Misa Seki Kazuo Kitagawa Source Type: research

Emerging Roles of the Innate Immune System Regulated by DNA Sensors in the Development of Vascular and Metabolic Diseases
J Atheroscler Thromb. 2021 Jul 12. doi: 10.5551/jat.RV17059. Online ahead of print.ABSTRACTSterile chronic inflammation causes cardiometabolic disorders; however, the mechanisms are not fully understood. Previous studies have demonstrated the degradation of cells/tissues in the vasculature and metabolic organs in lifestyle-associated diseases, such as diabetes and hyperlipidemia, suggesting the release and/or accumulation of nucleic acids from damaged cells. DNA is indispensable for life; however, DNA fragments, especially those from pathogens, strongly induce inflammation by the activation of DNA sensors. Growing evidence...
Source: Journal of Atherosclerosis and Thrombosis - July 12, 2021 Category: Cardiology Authors: Daiju Fukuda Phuong Tran Pham Masataka Sata Source Type: research

Differential Impact of Clinical and Genetic Factors on High Platelet Reactivity in Patients with Coronary Artery Disease Treated with Clopidogrel and Prasugrel
CONCLUSIONS: Clinical and genetic factors had a differential effect on a P2Y12 inhibitor reactivity with clopidogrel and prasugrel in patients with coronary artery disease. The severity of the factors also had a different impact on HPR.PMID:34234079 | DOI:10.5551/jat.63035 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - July 8, 2021 Category: Cardiology Authors: Yuichi Saito Takeshi Nishi Shinichi Wakabayashi Yuji Ohno Hideki Kitahara Noritaka Ariyoshi Yoshio Kobayashi Source Type: research