Effectiveness and Safety of Lipid-Lowering Drug Treatments in Japanese Patients with Familial Hypercholesterolemia: Familial Hypercholesterolemia Expert Forum (FAME) Study
CONCLUSION: The prevalence of CAD in Japanese patients with heterozygous FH is still very high. In most of the cases, the target level of serum LDL-C was not achieved for primary and secondary prevention of CAD, suggesting that a more aggressive LDL-C lowering and appropriate management of residual risks are necessary.PMID:33980760 | DOI:10.5551/jat.62764 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 13, 2021 Category: Cardiology Authors: Shizuya Yamashita Daisaku Masuda Mariko Harada-Shiba Hidenori Arai Hideaki Bujo Shun Ishibashi Hiroyuki Daida Nobuhiko Koga Shinichi Oikawa FAME Study Group Source Type: research

Current Diagnosis and Management of Primary Chylomicronemia
J Atheroscler Thromb. 2021 May 13. doi: 10.5551/jat.RV17054. Online ahead of print.ABSTRACTPrimary chylomicronemia (PCM) is a rare and intractable disease characterized by marked accumulation of chylomicrons in plasma. The levels of plasma triglycerides (TGs) typically range from 1,000 - 15,000 mg/dL or higher.PCM is caused by defects in the lipoprotein lipase (LPL) pathway due to genetic mutations, autoantibodies, or unidentified causes. The monogenic type is typically inherited as an autosomal recessive trait with loss-of-function mutations in LPL pathway genes (LPL, LMF1, GPIHBP1, APOC2, and APOA5). Secondary/environmen...
Source: Journal of Atherosclerosis and Thrombosis - May 13, 2021 Category: Cardiology Authors: Hiroaki Okazaki Takanari Gotoda Masatsune Ogura Shun Ishibashi Kyoko Inagaki Hiroyuki Daida Toshio Hayashi Mika Hori Daisaku Masuda Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and I Source Type: research

Cerebrotendinous Xanthomatosis: Molecular Pathogenesis, Clinical Spectrum, Diagnosis, and Disease-Modifying Treatments
J Atheroscler Thromb. 2021 May 8. doi: 10.5551/jat.RV17055. Online ahead of print.ABSTRACTCerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage disorder caused by mutations in the CYP27A1 gene, which encodes the mitochondrial enzyme sterol 27-hydroxylase. Decreased sterol 27-hydroxylase activity results in impaired bile acid synthesis, leading to reduced production of bile acids, especially chenodeoxycholic acid (CDCA), as well as elevated serum cholestanol and urine bile alcohols. The accumulation of cholestanol and cholesterol mainly in the brain, lenses, and tendons results in the characteristic c...
Source: Journal of Atherosclerosis and Thrombosis - May 10, 2021 Category: Cardiology Authors: Shingo Koyama Yoshiki Sekijima Masatsune Ogura Mika Hori Kota Matsuki Takashi Miida Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Ministry of Health, Labour and Welfare of Japan Source Type: research

Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source
CONCLUSIONS: Infratentorial lesions may be independently associated with PFO in patients with ESUS. The presence of infratentorial lesions could predict the presence of PFO in ESUS cases.PMID:33952811 | DOI:10.5551/jat.61200 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Kentaro Ishizuka Sono Toi Takao Hoshino Eiko Higuchi Kazuo Kitagawa Source Type: research

Atorvastatin Reduces Circulating S100A12 Levels in Patients with Carotid Atherosclerotic Plaques - A Link with Plaque Inflammation
CONCLUSIONS: Atorvastatin treatment reduced S100A12/CRP levels, and the changes in these circulating markers mirrored the improvement in arterial inflammation. Our observations suggest that S100A12 may be an emerging therapeutic target for atherosclerosis.PMID:33952812 | DOI:10.5551/jat.61630 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tomohiro Komatsu Makoto Ayaori Harumi Uto-Kondo Katsumi Hayashi Katsumi Tamura Hiroki Sato Makoto Sasaki Takafumi Nishida Shunichi Takiguchi Emi Yakushiji Kazuhiro Nakaya Katsunori Ikewaki Source Type: research

Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol
CONCLUSIONS: LDL-TG levels were more tightly regulated by the number of LDL particles than plasma TG levels were. SdLDL-C was closely associated with metabolic syndrome-related factors, whereas LDL-TG was associated with low-grade systemic inflammation.PMID:33952832 | DOI:10.5551/jat.62789 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tsutomu Hirano Rieko Kodera Takeshi Hirashima Natsuko Suzuki Ema Aoki Mitsuru Hosoya Taito Oshima Toshiyuki Hayashi Shinji Koba Motoko Ohta Noriyuki Satoh Yasuki Ito Source Type: research

Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source
CONCLUSIONS: Infratentorial lesions may be independently associated with PFO in patients with ESUS. The presence of infratentorial lesions could predict the presence of PFO in ESUS cases.PMID:33952811 | DOI:10.5551/jat.61200 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Kentaro Ishizuka Sono Toi Takao Hoshino Eiko Higuchi Kazuo Kitagawa Source Type: research

Atorvastatin Reduces Circulating S100A12 Levels in Patients with Carotid Atherosclerotic Plaques - A Link with Plaque Inflammation
CONCLUSIONS: Atorvastatin treatment reduced S100A12/CRP levels, and the changes in these circulating markers mirrored the improvement in arterial inflammation. Our observations suggest that S100A12 may be an emerging therapeutic target for atherosclerosis.PMID:33952812 | DOI:10.5551/jat.61630 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tomohiro Komatsu Makoto Ayaori Harumi Uto-Kondo Katsumi Hayashi Katsumi Tamura Hiroki Sato Makoto Sasaki Takafumi Nishida Shunichi Takiguchi Emi Yakushiji Kazuhiro Nakaya Katsunori Ikewaki Source Type: research

Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol
CONCLUSIONS: LDL-TG levels were more tightly regulated by the number of LDL particles than plasma TG levels were. SdLDL-C was closely associated with metabolic syndrome-related factors, whereas LDL-TG was associated with low-grade systemic inflammation.PMID:33952832 | DOI:10.5551/jat.62789 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tsutomu Hirano Rieko Kodera Takeshi Hirashima Natsuko Suzuki Ema Aoki Mitsuru Hosoya Taito Oshima Toshiyuki Hayashi Shinji Koba Motoko Ohta Noriyuki Satoh Yasuki Ito Source Type: research

Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source
CONCLUSIONS: Infratentorial lesions may be independently associated with PFO in patients with ESUS. The presence of infratentorial lesions could predict the presence of PFO in ESUS cases.PMID:33952811 | DOI:10.5551/jat.61200 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Kentaro Ishizuka Sono Toi Takao Hoshino Eiko Higuchi Kazuo Kitagawa Source Type: research

Atorvastatin Reduces Circulating S100A12 Levels in Patients with Carotid Atherosclerotic Plaques - A Link with Plaque Inflammation
CONCLUSIONS: Atorvastatin treatment reduced S100A12/CRP levels, and the changes in these circulating markers mirrored the improvement in arterial inflammation. Our observations suggest that S100A12 may be an emerging therapeutic target for atherosclerosis.PMID:33952812 | DOI:10.5551/jat.61630 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tomohiro Komatsu Makoto Ayaori Harumi Uto-Kondo Katsumi Hayashi Katsumi Tamura Hiroki Sato Makoto Sasaki Takafumi Nishida Shunichi Takiguchi Emi Yakushiji Kazuhiro Nakaya Katsunori Ikewaki Source Type: research

Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol
CONCLUSIONS: LDL-TG levels were more tightly regulated by the number of LDL particles than plasma TG levels were. SdLDL-C was closely associated with metabolic syndrome-related factors, whereas LDL-TG was associated with low-grade systemic inflammation.PMID:33952832 | DOI:10.5551/jat.62789 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tsutomu Hirano Rieko Kodera Takeshi Hirashima Natsuko Suzuki Ema Aoki Mitsuru Hosoya Taito Oshima Toshiyuki Hayashi Shinji Koba Motoko Ohta Noriyuki Satoh Yasuki Ito Source Type: research

Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source
CONCLUSIONS: Infratentorial lesions may be independently associated with PFO in patients with ESUS. The presence of infratentorial lesions could predict the presence of PFO in ESUS cases.PMID:33952811 | DOI:10.5551/jat.61200 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Kentaro Ishizuka Sono Toi Takao Hoshino Eiko Higuchi Kazuo Kitagawa Source Type: research

Atorvastatin Reduces Circulating S100A12 Levels in Patients with Carotid Atherosclerotic Plaques - A Link with Plaque Inflammation
CONCLUSIONS: Atorvastatin treatment reduced S100A12/CRP levels, and the changes in these circulating markers mirrored the improvement in arterial inflammation. Our observations suggest that S100A12 may be an emerging therapeutic target for atherosclerosis.PMID:33952812 | DOI:10.5551/jat.61630 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tomohiro Komatsu Makoto Ayaori Harumi Uto-Kondo Katsumi Hayashi Katsumi Tamura Hiroki Sato Makoto Sasaki Takafumi Nishida Shunichi Takiguchi Emi Yakushiji Kazuhiro Nakaya Katsunori Ikewaki Source Type: research

Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol
CONCLUSIONS: LDL-TG levels were more tightly regulated by the number of LDL particles than plasma TG levels were. SdLDL-C was closely associated with metabolic syndrome-related factors, whereas LDL-TG was associated with low-grade systemic inflammation.PMID:33952832 | DOI:10.5551/jat.62789 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 6, 2021 Category: Cardiology Authors: Tsutomu Hirano Rieko Kodera Takeshi Hirashima Natsuko Suzuki Ema Aoki Mitsuru Hosoya Taito Oshima Toshiyuki Hayashi Shinji Koba Motoko Ohta Noriyuki Satoh Yasuki Ito Source Type: research

Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial
CONCLUSIONS: This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.PMID:33907060 | DOI:10.5551/jat.58941 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Takuya Matsumoto Shinichiro Yoshino Tadashi Furuyama Koichi Morisaki Kaku Nakano Jun-Ichiro Koga Yoshihiko Maehara Kimihiro Komori Masaki Mori Kensuke Egashira Source Type: research

Diagnosis and Management of Sitosterolemia 2021
J Atheroscler Thromb. 2021 Apr 28. doi: 10.5551/jat.RV17052. Online ahead of print.ABSTRACTSitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively), both of which play important roles in selective excretion of plant sterols from the liver and intestine, leading to failure to prevent absorption of food plant sterols. This disorder has been considered to be extremely rare. However, accumulated clinical data a...
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Hayato Tada Akihiro Nomura Masatsune Ogura Katsunori Ikewaki Yasushi Ishigaki Kyoko Inagaki Kazuhisa Tsukamoto Kazushige Dobashi Kimitoshi Nakamura Mika Hori Kota Matsuki Shizuya Yamashita Shinji Yokoyama Masa-Aki Kawashiri Mariko Harada-Shiba Committee o Source Type: research

Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial
CONCLUSIONS: This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.PMID:33907060 | DOI:10.5551/jat.58941 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Takuya Matsumoto Shinichiro Yoshino Tadashi Furuyama Koichi Morisaki Kaku Nakano Jun-Ichiro Koga Yoshihiko Maehara Kimihiro Komori Masaki Mori Kensuke Egashira Source Type: research

Diagnosis and Management of Sitosterolemia 2021
J Atheroscler Thromb. 2021 Apr 28. doi: 10.5551/jat.RV17052. Online ahead of print.ABSTRACTSitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively), both of which play important roles in selective excretion of plant sterols from the liver and intestine, leading to failure to prevent absorption of food plant sterols. This disorder has been considered to be extremely rare. However, accumulated clinical data a...
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Hayato Tada Akihiro Nomura Masatsune Ogura Katsunori Ikewaki Yasushi Ishigaki Kyoko Inagaki Kazuhisa Tsukamoto Kazushige Dobashi Kimitoshi Nakamura Mika Hori Kota Matsuki Shizuya Yamashita Shinji Yokoyama Masa-Aki Kawashiri Mariko Harada-Shiba Committee o Source Type: research

Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial
CONCLUSIONS: This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.PMID:33907060 | DOI:10.5551/jat.58941 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Takuya Matsumoto Shinichiro Yoshino Tadashi Furuyama Koichi Morisaki Kaku Nakano Jun-Ichiro Koga Yoshihiko Maehara Kimihiro Komori Masaki Mori Kensuke Egashira Source Type: research

Diagnosis and Management of Sitosterolemia 2021
J Atheroscler Thromb. 2021 Apr 28. doi: 10.5551/jat.RV17052. Online ahead of print.ABSTRACTSitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively), both of which play important roles in selective excretion of plant sterols from the liver and intestine, leading to failure to prevent absorption of food plant sterols. This disorder has been considered to be extremely rare. However, accumulated clinical data a...
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Hayato Tada Akihiro Nomura Masatsune Ogura Katsunori Ikewaki Yasushi Ishigaki Kyoko Inagaki Kazuhisa Tsukamoto Kazushige Dobashi Kimitoshi Nakamura Mika Hori Kota Matsuki Shizuya Yamashita Shinji Yokoyama Masa-Aki Kawashiri Mariko Harada-Shiba Committee o Source Type: research

Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial
CONCLUSIONS: This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.PMID:33907060 | DOI:10.5551/jat.58941 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Takuya Matsumoto Shinichiro Yoshino Tadashi Furuyama Koichi Morisaki Kaku Nakano Jun-Ichiro Koga Yoshihiko Maehara Kimihiro Komori Masaki Mori Kensuke Egashira Source Type: research

Diagnosis and Management of Sitosterolemia 2021
J Atheroscler Thromb. 2021 Apr 28. doi: 10.5551/jat.RV17052. Online ahead of print.ABSTRACTSitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively), both of which play important roles in selective excretion of plant sterols from the liver and intestine, leading to failure to prevent absorption of food plant sterols. This disorder has been considered to be extremely rare. However, accumulated clinical data a...
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Hayato Tada Akihiro Nomura Masatsune Ogura Katsunori Ikewaki Yasushi Ishigaki Kyoko Inagaki Kazuhisa Tsukamoto Kazushige Dobashi Kimitoshi Nakamura Mika Hori Kota Matsuki Shizuya Yamashita Shinji Yokoyama Masa-Aki Kawashiri Mariko Harada-Shiba Committee o Source Type: research

Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial
CONCLUSIONS: This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.PMID:33907060 | DOI:10.5551/jat.58941 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Takuya Matsumoto Shinichiro Yoshino Tadashi Furuyama Koichi Morisaki Kaku Nakano Jun-Ichiro Koga Yoshihiko Maehara Kimihiro Komori Masaki Mori Kensuke Egashira Source Type: research

Diagnosis and Management of Sitosterolemia 2021
J Atheroscler Thromb. 2021 Apr 28. doi: 10.5551/jat.RV17052. Online ahead of print.ABSTRACTSitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively), both of which play important roles in selective excretion of plant sterols from the liver and intestine, leading to failure to prevent absorption of food plant sterols. This disorder has been considered to be extremely rare. However, accumulated clinical data a...
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Hayato Tada Akihiro Nomura Masatsune Ogura Katsunori Ikewaki Yasushi Ishigaki Kyoko Inagaki Kazuhisa Tsukamoto Kazushige Dobashi Kimitoshi Nakamura Mika Hori Kota Matsuki Shizuya Yamashita Shinji Yokoyama Masa-Aki Kawashiri Mariko Harada-Shiba Committee o Source Type: research

Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial
CONCLUSIONS: This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.PMID:33907060 | DOI:10.5551/jat.58941 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Takuya Matsumoto Shinichiro Yoshino Tadashi Furuyama Koichi Morisaki Kaku Nakano Jun-Ichiro Koga Yoshihiko Maehara Kimihiro Komori Masaki Mori Kensuke Egashira Source Type: research

Diagnosis and Management of Sitosterolemia 2021
J Atheroscler Thromb. 2021 Apr 28. doi: 10.5551/jat.RV17052. Online ahead of print.ABSTRACTSitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively), both of which play important roles in selective excretion of plant sterols from the liver and intestine, leading to failure to prevent absorption of food plant sterols. This disorder has been considered to be extremely rare. However, accumulated clinical data a...
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Hayato Tada Akihiro Nomura Masatsune Ogura Katsunori Ikewaki Yasushi Ishigaki Kyoko Inagaki Kazuhisa Tsukamoto Kazushige Dobashi Kimitoshi Nakamura Mika Hori Kota Matsuki Shizuya Yamashita Shinji Yokoyama Masa-Aki Kawashiri Mariko Harada-Shiba Committee o Source Type: research

Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial
CONCLUSIONS: This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.PMID:33907060 | DOI:10.5551/jat.58941 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Takuya Matsumoto Shinichiro Yoshino Tadashi Furuyama Koichi Morisaki Kaku Nakano Jun-Ichiro Koga Yoshihiko Maehara Kimihiro Komori Masaki Mori Kensuke Egashira Source Type: research

Diagnosis and Management of Sitosterolemia 2021
J Atheroscler Thromb. 2021 Apr 28. doi: 10.5551/jat.RV17052. Online ahead of print.ABSTRACTSitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively), both of which play important roles in selective excretion of plant sterols from the liver and intestine, leading to failure to prevent absorption of food plant sterols. This disorder has been considered to be extremely rare. However, accumulated clinical data a...
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2021 Category: Cardiology Authors: Hayato Tada Akihiro Nomura Masatsune Ogura Katsunori Ikewaki Yasushi Ishigaki Kyoko Inagaki Kazuhisa Tsukamoto Kazushige Dobashi Kimitoshi Nakamura Mika Hori Kota Matsuki Shizuya Yamashita Shinji Yokoyama Masa-Aki Kawashiri Mariko Harada-Shiba Committee o Source Type: research

New Risk Stratification in Patients with Femoropopliteal PAD. Can We Fight Against the Poor Prognosis?
J Atheroscler Thromb. 2021 Apr 21. doi: 10.5551/jat.ED168. Online ahead of print.NO ABSTRACTPMID:33883346 | DOI:10.5551/jat.ED168 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 22, 2021 Category: Cardiology Authors: Yoshinori Tsubakimoto Source Type: research

Efficacy and Safety of Ticagrelor Versus Prasugrel in Women and Men with Acute Coronary Syndrome: A Pre-specified, Sex-Specific Analysis of the ISAR-REACT 5 Trial
CONCLUSIONS: Although there was no significant interaction between sex and treatment effect of study drugs, the superior efficacy of prasugrel was more evident among men. No difference in bleeding between the two study groups was seen for both women and men.PMID:33867409 | DOI:10.5551/jat.62776 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Senta Gewalt Shqipdona Lahu Gjin Ndrepepa Costanza Pellegrini Isabell Bernlochner Franz-Josef Neumann Maurizio Menichelli Tanja Morath Bernhard Witzenbichler Jochen W öhrle Katharina Hoppe Gert Richardt Karl-Ludwig Laugwitz Heribert Schunkert Adnan Kastr Source Type: research

Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT
CONCLUSION: We demonstrated a marginal effect of probucol on cerebrocardiovascular events in Asian patients with CAD, with reasonable safety profiles. A larger study may be needed to support the effect of probucol for cardiovascular prevention.PMID:33867420 | DOI:10.5551/jat.62821 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Hidenori Arai Hideaki Bujo Daisaku Masuda Toshiyuki Ishibashi Satoshi Nakagawa Kenichiro Tanabe Tatsuo Kagimura Hyun-Jae Kang Moo Hyun Kim Jidong Sung Sang-Hyun Kim Cheol-Ho Kim Jeong Euy Park Junbo Ge Byung-Hee Oh Toru Kita Yasushi Saito Masanori Fukushi Source Type: research

Homozygous Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17050. Online ahead of print.ABSTRACTFamilial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated pathway and most of them exhibit autosomal dominant inheritance. Homozygotes of FH (HoFH) may have plasma LDL-C levels, which are at least twice as high as those of heterozygous FH (HeFH) and therefore four times higher than normal levels. Prevalence of HoFH had been estimated as 1 in 1,000,000 before but more recent genetic analysis surveys predict 1 in 170,000 to 30...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Atsushi Nohara Hayato Tada Masatsune Ogura Sachiko Okazaki Koh Ono Hitoshi Shimano Hiroyuki Daida Kazushige Dobashi Toshio Hayashi Mika Hori Kota Matsuki Tetsuo Minamino Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Resea Source Type: research

Current Status of Familial LCAT Deficiency in Japan
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17051. Online ahead of print.ABSTRACTLecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial LCAT deficiency is an intractable autosomal recessive disorder caused by inherited dysfunction of the LCAT enzyme. The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) that...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Masayuki Kuroda Hideaki Bujo Koutaro Yokote Takeyoshi Murano Takashi Yamaguchi Masatsune Ogura Katsunori Ikewaki Masahiro Koseki Yasuo Takeuchi Atsuko Nakatsuka Mika Hori Kota Matsuki Takashi Miida Shinji Yokoyama Jun Wada Mariko Harada-Shiba Committee on Source Type: research

Efficacy and Safety of Ticagrelor Versus Prasugrel in Women and Men with Acute Coronary Syndrome: A Pre-specified, Sex-Specific Analysis of the ISAR-REACT 5 Trial
CONCLUSIONS: Although there was no significant interaction between sex and treatment effect of study drugs, the superior efficacy of prasugrel was more evident among men. No difference in bleeding between the two study groups was seen for both women and men.PMID:33867409 | DOI:10.5551/jat.62776 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Senta Gewalt Shqipdona Lahu Gjin Ndrepepa Costanza Pellegrini Isabell Bernlochner Franz-Josef Neumann Maurizio Menichelli Tanja Morath Bernhard Witzenbichler Jochen W öhrle Katharina Hoppe Gert Richardt Karl-Ludwig Laugwitz Heribert Schunkert Adnan Kastr Source Type: research

Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT
CONCLUSION: We demonstrated a marginal effect of probucol on cerebrocardiovascular events in Asian patients with CAD, with reasonable safety profiles. A larger study may be needed to support the effect of probucol for cardiovascular prevention.PMID:33867420 | DOI:10.5551/jat.62821 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Hidenori Arai Hideaki Bujo Daisaku Masuda Toshiyuki Ishibashi Satoshi Nakagawa Kenichiro Tanabe Tatsuo Kagimura Hyun-Jae Kang Moo Hyun Kim Jidong Sung Sang-Hyun Kim Cheol-Ho Kim Jeong Euy Park Junbo Ge Byung-Hee Oh Toru Kita Yasushi Saito Masanori Fukushi Source Type: research

Homozygous Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17050. Online ahead of print.ABSTRACTFamilial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated pathway and most of them exhibit autosomal dominant inheritance. Homozygotes of FH (HoFH) may have plasma LDL-C levels, which are at least twice as high as those of heterozygous FH (HeFH) and therefore four times higher than normal levels. Prevalence of HoFH had been estimated as 1 in 1,000,000 before but more recent genetic analysis surveys predict 1 in 170,000 to 30...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Atsushi Nohara Hayato Tada Masatsune Ogura Sachiko Okazaki Koh Ono Hitoshi Shimano Hiroyuki Daida Kazushige Dobashi Toshio Hayashi Mika Hori Kota Matsuki Tetsuo Minamino Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Resea Source Type: research

Current Status of Familial LCAT Deficiency in Japan
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17051. Online ahead of print.ABSTRACTLecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial LCAT deficiency is an intractable autosomal recessive disorder caused by inherited dysfunction of the LCAT enzyme. The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) that...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Masayuki Kuroda Hideaki Bujo Koutaro Yokote Takeyoshi Murano Takashi Yamaguchi Masatsune Ogura Katsunori Ikewaki Masahiro Koseki Yasuo Takeuchi Atsuko Nakatsuka Mika Hori Kota Matsuki Takashi Miida Shinji Yokoyama Jun Wada Mariko Harada-Shiba Committee on Source Type: research

Efficacy and Safety of Ticagrelor Versus Prasugrel in Women and Men with Acute Coronary Syndrome: A Pre-specified, Sex-Specific Analysis of the ISAR-REACT 5 Trial
CONCLUSIONS: Although there was no significant interaction between sex and treatment effect of study drugs, the superior efficacy of prasugrel was more evident among men. No difference in bleeding between the two study groups was seen for both women and men.PMID:33867409 | DOI:10.5551/jat.62776 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Senta Gewalt Shqipdona Lahu Gjin Ndrepepa Costanza Pellegrini Isabell Bernlochner Franz-Josef Neumann Maurizio Menichelli Tanja Morath Bernhard Witzenbichler Jochen W öhrle Katharina Hoppe Gert Richardt Karl-Ludwig Laugwitz Heribert Schunkert Adnan Kastr Source Type: research

Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT
CONCLUSION: We demonstrated a marginal effect of probucol on cerebrocardiovascular events in Asian patients with CAD, with reasonable safety profiles. A larger study may be needed to support the effect of probucol for cardiovascular prevention.PMID:33867420 | DOI:10.5551/jat.62821 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Hidenori Arai Hideaki Bujo Daisaku Masuda Toshiyuki Ishibashi Satoshi Nakagawa Kenichiro Tanabe Tatsuo Kagimura Hyun-Jae Kang Moo Hyun Kim Jidong Sung Sang-Hyun Kim Cheol-Ho Kim Jeong Euy Park Junbo Ge Byung-Hee Oh Toru Kita Yasushi Saito Masanori Fukushi Source Type: research

Homozygous Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17050. Online ahead of print.ABSTRACTFamilial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated pathway and most of them exhibit autosomal dominant inheritance. Homozygotes of FH (HoFH) may have plasma LDL-C levels, which are at least twice as high as those of heterozygous FH (HeFH) and therefore four times higher than normal levels. Prevalence of HoFH had been estimated as 1 in 1,000,000 before but more recent genetic analysis surveys predict 1 in 170,000 to 30...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Atsushi Nohara Hayato Tada Masatsune Ogura Sachiko Okazaki Koh Ono Hitoshi Shimano Hiroyuki Daida Kazushige Dobashi Toshio Hayashi Mika Hori Kota Matsuki Tetsuo Minamino Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Resea Source Type: research

Current Status of Familial LCAT Deficiency in Japan
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17051. Online ahead of print.ABSTRACTLecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial LCAT deficiency is an intractable autosomal recessive disorder caused by inherited dysfunction of the LCAT enzyme. The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) that...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Masayuki Kuroda Hideaki Bujo Koutaro Yokote Takeyoshi Murano Takashi Yamaguchi Masatsune Ogura Katsunori Ikewaki Masahiro Koseki Yasuo Takeuchi Atsuko Nakatsuka Mika Hori Kota Matsuki Takashi Miida Shinji Yokoyama Jun Wada Mariko Harada-Shiba Committee on Source Type: research

The TIMI Study Group's Contributions to the Advancement of Cardiology -With Focus on Atherosclerotic Cardiovascular Disease
J Atheroscler Thromb. 2021 Apr 13. doi: 10.5551/jat.RV17049. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality across the world, warranting continuous research in this field. The elucidation of the atherogenesis mechanism is considered one of the most relevant scientific accomplishments of the last century. This has led to the clinical development of various novel therapeutic interventions for patients with or at risk of ASCVD, in which randomized clinical trials played a crucial role.The Thrombolysis in Myocardial Infarction (TIMI) Study Group was ...
Source: Journal of Atherosclerosis and Thrombosis - April 15, 2021 Category: Cardiology Authors: Eri Toda Kato Shinya Goto Source Type: research