Homozygous Familial Hypercholesterolemia
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17050. Online ahead of print.ABSTRACTFamilial hypercholesterolemia (FH) is an inherited disorder with retarded clearance of plasma LDL caused by mutations of the genes involved in the LDL receptor-mediated pathway and most of them exhibit autosomal dominant inheritance. Homozygotes of FH (HoFH) may have plasma LDL-C levels, which are at least twice as high as those of heterozygous FH (HeFH) and therefore four times higher than normal levels. Prevalence of HoFH had been estimated as 1 in 1,000,000 before but more recent genetic analysis surveys predict 1 in 170,000 to 30...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Atsushi Nohara Hayato Tada Masatsune Ogura Sachiko Okazaki Koh Ono Hitoshi Shimano Hiroyuki Daida Kazushige Dobashi Toshio Hayashi Mika Hori Kota Matsuki Tetsuo Minamino Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Resea Source Type: research

Current Status of Familial LCAT Deficiency in Japan
J Atheroscler Thromb. 2021 Apr 18. doi: 10.5551/jat.RV17051. Online ahead of print.ABSTRACTLecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester and lysolecithin. Familial LCAT deficiency is an intractable autosomal recessive disorder caused by inherited dysfunction of the LCAT enzyme. The disease appears in two different phenotypes depending on the position of the gene mutation: familial LCAT deficiency (FLD, OMIM 245900) that...
Source: Journal of Atherosclerosis and Thrombosis - April 19, 2021 Category: Cardiology Authors: Masayuki Kuroda Hideaki Bujo Koutaro Yokote Takeyoshi Murano Takashi Yamaguchi Masatsune Ogura Katsunori Ikewaki Masahiro Koseki Yasuo Takeuchi Atsuko Nakatsuka Mika Hori Kota Matsuki Takashi Miida Shinji Yokoyama Jun Wada Mariko Harada-Shiba Committee on Source Type: research

The TIMI Study Group's Contributions to the Advancement of Cardiology -With Focus on Atherosclerotic Cardiovascular Disease
J Atheroscler Thromb. 2021 Apr 13. doi: 10.5551/jat.RV17049. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality across the world, warranting continuous research in this field. The elucidation of the atherogenesis mechanism is considered one of the most relevant scientific accomplishments of the last century. This has led to the clinical development of various novel therapeutic interventions for patients with or at risk of ASCVD, in which randomized clinical trials played a crucial role.The Thrombolysis in Myocardial Infarction (TIMI) Study Group was ...
Source: Journal of Atherosclerosis and Thrombosis - April 15, 2021 Category: Cardiology Authors: Eri Toda Kato Shinya Goto Source Type: research

Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound
CONCLUSION: H-type hypertension is expressly connected with the degree of plaque enhancement and may facilitate plaque vulnerability. Our findings may offer a new insight for treating vulnerable plaque, lowering blood pressure, and lowering homocysteine equally crucial.PMID:33827997 | DOI:10.5551/jat.61275 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Yuting Tan Fang Nie Guode Wu Fangzhou Guo Yanqing Wang Longli Wang Source Type: research

Does Mild-to-Moderate Salt-Restricted Diet Based on Japanese Cuisine Contribute to Hypertension Treatment for the Japanese Population?
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED166. Online ahead of print.NO ABSTRACTPMID:33828003 | DOI:10.5551/jat.ED166 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Koutatsu Maruyama Saori Miyazaki Satomi Minato-Inokawa Source Type: research

Changes in the Association between Blood Pressure Indices and Subclinical Cerebrovascular Diseases
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED167. Online ahead of print.NO ABSTRACTPMID:33828004 | DOI:10.5551/jat.ED167 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Michihiro Satoh Source Type: research

Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound
CONCLUSION: H-type hypertension is expressly connected with the degree of plaque enhancement and may facilitate plaque vulnerability. Our findings may offer a new insight for treating vulnerable plaque, lowering blood pressure, and lowering homocysteine equally crucial.PMID:33827997 | DOI:10.5551/jat.61275 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Yuting Tan Fang Nie Guode Wu Fangzhou Guo Yanqing Wang Longli Wang Source Type: research

Does Mild-to-Moderate Salt-Restricted Diet Based on Japanese Cuisine Contribute to Hypertension Treatment for the Japanese Population?
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED166. Online ahead of print.NO ABSTRACTPMID:33828003 | DOI:10.5551/jat.ED166 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Koutatsu Maruyama Saori Miyazaki Satomi Minato-Inokawa Source Type: research

Changes in the Association between Blood Pressure Indices and Subclinical Cerebrovascular Diseases
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED167. Online ahead of print.NO ABSTRACTPMID:33828004 | DOI:10.5551/jat.ED167 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Michihiro Satoh Source Type: research

Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound
CONCLUSION: H-type hypertension is expressly connected with the degree of plaque enhancement and may facilitate plaque vulnerability. Our findings may offer a new insight for treating vulnerable plaque, lowering blood pressure, and lowering homocysteine equally crucial.PMID:33827997 | DOI:10.5551/jat.61275 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Yuting Tan Fang Nie Guode Wu Fangzhou Guo Yanqing Wang Longli Wang Source Type: research

Does Mild-to-Moderate Salt-Restricted Diet Based on Japanese Cuisine Contribute to Hypertension Treatment for the Japanese Population?
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED166. Online ahead of print.NO ABSTRACTPMID:33828003 | DOI:10.5551/jat.ED166 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Koutatsu Maruyama Saori Miyazaki Satomi Minato-Inokawa Source Type: research

Changes in the Association between Blood Pressure Indices and Subclinical Cerebrovascular Diseases
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED167. Online ahead of print.NO ABSTRACTPMID:33828004 | DOI:10.5551/jat.ED167 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Michihiro Satoh Source Type: research

Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound
CONCLUSION: H-type hypertension is expressly connected with the degree of plaque enhancement and may facilitate plaque vulnerability. Our findings may offer a new insight for treating vulnerable plaque, lowering blood pressure, and lowering homocysteine equally crucial.PMID:33827997 | DOI:10.5551/jat.61275 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Yuting Tan Fang Nie Guode Wu Fangzhou Guo Yanqing Wang Longli Wang Source Type: research

Does Mild-to-Moderate Salt-Restricted Diet Based on Japanese Cuisine Contribute to Hypertension Treatment for the Japanese Population?
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED166. Online ahead of print.NO ABSTRACTPMID:33828003 | DOI:10.5551/jat.ED166 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Koutatsu Maruyama Saori Miyazaki Satomi Minato-Inokawa Source Type: research

Changes in the Association between Blood Pressure Indices and Subclinical Cerebrovascular Diseases
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED167. Online ahead of print.NO ABSTRACTPMID:33828004 | DOI:10.5551/jat.ED167 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Michihiro Satoh Source Type: research

Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound
CONCLUSION: H-type hypertension is expressly connected with the degree of plaque enhancement and may facilitate plaque vulnerability. Our findings may offer a new insight for treating vulnerable plaque, lowering blood pressure, and lowering homocysteine equally crucial.PMID:33827997 | DOI:10.5551/jat.61275 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Yuting Tan Fang Nie Guode Wu Fangzhou Guo Yanqing Wang Longli Wang Source Type: research

Does Mild-to-Moderate Salt-Restricted Diet Based on Japanese Cuisine Contribute to Hypertension Treatment for the Japanese Population?
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED166. Online ahead of print.NO ABSTRACTPMID:33828003 | DOI:10.5551/jat.ED166 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Koutatsu Maruyama Saori Miyazaki Satomi Minato-Inokawa Source Type: research

Changes in the Association between Blood Pressure Indices and Subclinical Cerebrovascular Diseases
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED167. Online ahead of print.NO ABSTRACTPMID:33828004 | DOI:10.5551/jat.ED167 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Michihiro Satoh Source Type: research

Impact of H-Type Hypertension on Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasound
CONCLUSION: H-type hypertension is expressly connected with the degree of plaque enhancement and may facilitate plaque vulnerability. Our findings may offer a new insight for treating vulnerable plaque, lowering blood pressure, and lowering homocysteine equally crucial.PMID:33827997 | DOI:10.5551/jat.61275 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Yuting Tan Fang Nie Guode Wu Fangzhou Guo Yanqing Wang Longli Wang Source Type: research

Does Mild-to-Moderate Salt-Restricted Diet Based on Japanese Cuisine Contribute to Hypertension Treatment for the Japanese Population?
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED166. Online ahead of print.NO ABSTRACTPMID:33828003 | DOI:10.5551/jat.ED166 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Koutatsu Maruyama Saori Miyazaki Satomi Minato-Inokawa Source Type: research

Changes in the Association between Blood Pressure Indices and Subclinical Cerebrovascular Diseases
J Atheroscler Thromb. 2021 Apr 7. doi: 10.5551/jat.ED167. Online ahead of print.NO ABSTRACTPMID:33828004 | DOI:10.5551/jat.ED167 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 8, 2021 Category: Cardiology Authors: Michihiro Satoh Source Type: research

Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation have a Risk for Aortogenic Embolizations
J Atheroscler Thromb. 2021 Apr 3. doi: 10.5551/jat.62890. Online ahead of print.ABSTRACTWe have a great interest in the article in Journal of Atherosclerosis and Thrombosis by Suzuki et al. titled Complex Aortic Arch Atherosclerosis in Acute Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation. The authors demonstrated that 38.7% transesophageal echocardiography-derived complex aortic arch plaques (CAPs) among 106 patients with acute ischemic strokes with atrial fibrillation (AF), suggesting that patients with acute ischemic stroke and AF often had CAPs. The atheromatous lesions at the aortic arch are one of the ...
Source: Journal of Atherosclerosis and Thrombosis - April 5, 2021 Category: Cardiology Authors: Keisuke Kojima Daisuke Fukamachi Yasuo Okumura Source Type: research

Trends, Treatment Approaches, and In-Hospital Mortality for Acute Coronary Syndrome in Japan During the Coronavirus Disease 2019 Pandemic
CONCLUSIONS: We demonstrated the characteristics and trends of ACS cases in a Japanese population by applying interrupted time series analyses. Our findings provide significant insights into the association between COVID-19 and decreases in ACS hospitalisations during the pandemic.PMID:33790127 | DOI:10.5551/jat.62746 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Tetsuji Morishita Daisuke Takada Jung-Ho Shin Takuya Higuchi Susumu Kunisawa Yuichi Imanaka Source Type: research

Pitavastatin versus Atorvastatin: Potential Differences in their Effects on Serum Lipoprotein Lipase and Cardiovascular Disease
J Atheroscler Thromb. 2021 Apr 1. doi: 10.5551/jat.ED170. Online ahead of print.NO ABSTRACTPMID:33790128 | DOI:10.5551/jat.ED170 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Junji Kobayashi Source Type: research

Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle-Brachial Index
CONCLUSIONS: Increased serum ALP levels are significantly associated with a low ABI. These indicators are independent prognostic factors for poor stroke outcomes at 3 months.PMID:33790143 | DOI:10.5551/jat.62795 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Hiroyuki Naito Tomohisa Nezu Naohisa Hosomi Daisuke Kuzume Shiro Aoki Yuko Morimoto Takeshi Yoshida Teppei Kamimura Yuji Shiga Naoto Kinoshita Hiroki Ueno Hiroyuki Morino Hirofumi Maruyama Source Type: research

Trends, Treatment Approaches, and In-Hospital Mortality for Acute Coronary Syndrome in Japan During the Coronavirus Disease 2019 Pandemic
CONCLUSIONS: We demonstrated the characteristics and trends of ACS cases in a Japanese population by applying interrupted time series analyses. Our findings provide significant insights into the association between COVID-19 and decreases in ACS hospitalisations during the pandemic.PMID:33790127 | DOI:10.5551/jat.62746 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Tetsuji Morishita Daisuke Takada Jung-Ho Shin Takuya Higuchi Susumu Kunisawa Yuichi Imanaka Source Type: research

Pitavastatin versus Atorvastatin: Potential Differences in their Effects on Serum Lipoprotein Lipase and Cardiovascular Disease
J Atheroscler Thromb. 2021 Apr 1. doi: 10.5551/jat.ED170. Online ahead of print.NO ABSTRACTPMID:33790128 | DOI:10.5551/jat.ED170 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Junji Kobayashi Source Type: research

Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle-Brachial Index
CONCLUSIONS: Increased serum ALP levels are significantly associated with a low ABI. These indicators are independent prognostic factors for poor stroke outcomes at 3 months.PMID:33790143 | DOI:10.5551/jat.62795 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Hiroyuki Naito Tomohisa Nezu Naohisa Hosomi Daisuke Kuzume Shiro Aoki Yuko Morimoto Takeshi Yoshida Teppei Kamimura Yuji Shiga Naoto Kinoshita Hiroki Ueno Hiroyuki Morino Hirofumi Maruyama Source Type: research

Trends, Treatment Approaches, and In-Hospital Mortality for Acute Coronary Syndrome in Japan During the Coronavirus Disease 2019 Pandemic
CONCLUSIONS: We demonstrated the characteristics and trends of ACS cases in a Japanese population by applying interrupted time series analyses. Our findings provide significant insights into the association between COVID-19 and decreases in ACS hospitalisations during the pandemic.PMID:33790127 | DOI:10.5551/jat.62746 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Tetsuji Morishita Daisuke Takada Jung-Ho Shin Takuya Higuchi Susumu Kunisawa Yuichi Imanaka Source Type: research

Pitavastatin versus Atorvastatin: Potential Differences in their Effects on Serum Lipoprotein Lipase and Cardiovascular Disease
J Atheroscler Thromb. 2021 Apr 1. doi: 10.5551/jat.ED170. Online ahead of print.NO ABSTRACTPMID:33790128 | DOI:10.5551/jat.ED170 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Junji Kobayashi Source Type: research

Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle-Brachial Index
CONCLUSIONS: Increased serum ALP levels are significantly associated with a low ABI. These indicators are independent prognostic factors for poor stroke outcomes at 3 months.PMID:33790143 | DOI:10.5551/jat.62795 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Hiroyuki Naito Tomohisa Nezu Naohisa Hosomi Daisuke Kuzume Shiro Aoki Yuko Morimoto Takeshi Yoshida Teppei Kamimura Yuji Shiga Naoto Kinoshita Hiroki Ueno Hiroyuki Morino Hirofumi Maruyama Source Type: research

Trends, Treatment Approaches, and In-Hospital Mortality for Acute Coronary Syndrome in Japan During the Coronavirus Disease 2019 Pandemic
CONCLUSIONS: We demonstrated the characteristics and trends of ACS cases in a Japanese population by applying interrupted time series analyses. Our findings provide significant insights into the association between COVID-19 and decreases in ACS hospitalisations during the pandemic.PMID:33790127 | DOI:10.5551/jat.62746 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Tetsuji Morishita Daisuke Takada Jung-Ho Shin Takuya Higuchi Susumu Kunisawa Yuichi Imanaka Source Type: research

Pitavastatin versus Atorvastatin: Potential Differences in their Effects on Serum Lipoprotein Lipase and Cardiovascular Disease
J Atheroscler Thromb. 2021 Apr 1. doi: 10.5551/jat.ED170. Online ahead of print.NO ABSTRACTPMID:33790128 | DOI:10.5551/jat.ED170 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Junji Kobayashi Source Type: research

Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle-Brachial Index
CONCLUSIONS: Increased serum ALP levels are significantly associated with a low ABI. These indicators are independent prognostic factors for poor stroke outcomes at 3 months.PMID:33790143 | DOI:10.5551/jat.62795 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - April 1, 2021 Category: Cardiology Authors: Hiroyuki Naito Tomohisa Nezu Naohisa Hosomi Daisuke Kuzume Shiro Aoki Yuko Morimoto Takeshi Yoshida Teppei Kamimura Yuji Shiga Naoto Kinoshita Hiroki Ueno Hiroyuki Morino Hirofumi Maruyama Source Type: research

Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice
CONCLUSION: Pemafibrate diminished the levels of vasoconstrictive eicosanoids and free fatty acids accompanied by a reduction of triglyceride. These effects may be associated with the improvement of endothelial function by pemafibrate in diabetic mice.PMID:33775978 | DOI:10.5551/jat.61101 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 29, 2021 Category: Cardiology Authors: Kumiko Suto Daiju Fukuda Masakazu Shinohara Byambasuren Ganbaatar Shusuke Yagi Kenya Kusunose Hirotsugu Yamada Takeshi Soeki Ken-Ichi Hirata Masataka Sata Source Type: research

Group V Secretory Phospholipase A < sub > 2 < /sub > Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line
CONCLUSIONS: Nuclear sPLA2-V binds to the Pgk1 gene promoter region and increases its transcriptional activity. sPLA2-V regulates AcLDL endocytosis through PGK1-Beclin1 in a manner that is independent of its enzymatic activity in RAW264.7 cells.PMID:33775979 | DOI:10.5551/jat.62216 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 29, 2021 Category: Cardiology Authors: Daisuke Fujioka Yosuke Watanabe Takamitsu Nakamura Takashi Yokoyama Keiji Miyazawa Makoto Murakami Kiyotaka Kugiyama Source Type: research

Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice
CONCLUSION: Pemafibrate diminished the levels of vasoconstrictive eicosanoids and free fatty acids accompanied by a reduction of triglyceride. These effects may be associated with the improvement of endothelial function by pemafibrate in diabetic mice.PMID:33775978 | DOI:10.5551/jat.61101 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 29, 2021 Category: Cardiology Authors: Kumiko Suto Daiju Fukuda Masakazu Shinohara Byambasuren Ganbaatar Shusuke Yagi Kenya Kusunose Hirotsugu Yamada Takeshi Soeki Ken-Ichi Hirata Masataka Sata Source Type: research

Group V Secretory Phospholipase A < sub > 2 < /sub > Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line
CONCLUSIONS: Nuclear sPLA2-V binds to the Pgk1 gene promoter region and increases its transcriptional activity. sPLA2-V regulates AcLDL endocytosis through PGK1-Beclin1 in a manner that is independent of its enzymatic activity in RAW264.7 cells.PMID:33775979 | DOI:10.5551/jat.62216 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 29, 2021 Category: Cardiology Authors: Daisuke Fujioka Yosuke Watanabe Takamitsu Nakamura Takashi Yokoyama Keiji Miyazawa Makoto Murakami Kiyotaka Kugiyama Source Type: research

Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice
CONCLUSION: Pemafibrate diminished the levels of vasoconstrictive eicosanoids and free fatty acids accompanied by a reduction of triglyceride. These effects may be associated with the improvement of endothelial function by pemafibrate in diabetic mice.PMID:33775978 | DOI:10.5551/jat.61101 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 29, 2021 Category: Cardiology Authors: Kumiko Suto Daiju Fukuda Masakazu Shinohara Byambasuren Ganbaatar Shusuke Yagi Kenya Kusunose Hirotsugu Yamada Takeshi Soeki Ken-Ichi Hirata Masataka Sata Source Type: research

Group V Secretory Phospholipase A < sub > 2 < /sub > Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line
CONCLUSIONS: Nuclear sPLA2-V binds to the Pgk1 gene promoter region and increases its transcriptional activity. sPLA2-V regulates AcLDL endocytosis through PGK1-Beclin1 in a manner that is independent of its enzymatic activity in RAW264.7 cells.PMID:33775979 | DOI:10.5551/jat.62216 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 29, 2021 Category: Cardiology Authors: Daisuke Fujioka Yosuke Watanabe Takamitsu Nakamura Takashi Yokoyama Keiji Miyazawa Makoto Murakami Kiyotaka Kugiyama Source Type: research

Serum HDL-Cholesterol Level Does Not Influence Cardiovascular Event Rate under Sufficient Lowering of LDL-Cholesterol by Pitavatatin in Patients with Stable Coronary Artery Disease
J Atheroscler Thromb. 2021 Mar 24. doi: 10.5551/jat.ED165. Online ahead of print.NO ABSTRACTPMID:33762513 | DOI:10.5551/jat.ED165 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 25, 2021 Category: Cardiology Authors: Daisaku Masuda Shizuya Yamashita Source Type: research

Familial Hypercholesterolemia in Asia Pacific: A Review of Epidemiology, Diagnosis, and Management in the Region
J Atheroscler Thromb. 2021 Mar 19. doi: 10.5551/jat.56762. Online ahead of print.ABSTRACTFamilial hypercholesterolemia (FH) is a common genetic disease that is estimated to affect at least 15 million people in the Asia Pacific region. Affected individuals are at significantly increased risk of premature atherosclerotic cardiovascular disease. A literature review was undertaken to provide an overview of the epidemiology, diagnosis, and management of FH across the region.Currently, epidemiological data relating to FH are lacking across the Asia Pacific. Of the 15 countries and regions considered, locally conducted studies to...
Source: Journal of Atherosclerosis and Thrombosis - March 22, 2021 Category: Cardiology Authors: Sanjay Kalra Zhenyue Chen Chaicharn Deerochanawong Kou-Gi Shyu Ru San Tan Brian Tomlinson Hung-I Yeh Source Type: research