The Priority of Non-HDL-C Assessment to Predict New Lesions among Stable Angina Patients with Strong Statins
CONCLUSIONS: Non-HDL-C ≥ 100 mg/dL was determined to be the independent risk factor for the occurrence of new lesions 9 months and ≤ 2 years after PCI among stable angina patients with strong statins. Residual risk after PCI should be considered by assessing not only DM but also non-HDL-C beyond the scope of LDL-C-lowering therapy with strong statins.PMID:34039817 | DOI:10.5551/jat.62908 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Daisuke Kanda Masaaki Miyata Yoshiyuki Ikeda Akihiro Tokushige Takeshi Sonoda Ryo Arikawa Kazuhiro Anzaki Ippei Kosedo Satoshi Yoshino Takuro Takumi Mitsuru Ohish Source Type: research

Response to "Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation have a Risk for Aortogenic Embolizations"
J Atheroscler Thromb. 2021 May 27. doi: 10.5551/jat.62890-R. Online ahead of print.NO ABSTRACTPMID:34039831 | DOI:10.5551/jat.62890-R (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Masayuki Suzuki Shigeru Fujimoto Ryota Tanaka Source Type: research

Ambulatory Status Over Time after Revascularization in Patients with Chronic Limb-Threatening Ischemia
CONCLUSION: Mobility in the overall population gradually decreased, whereas the number of deceased patients increased. Advanced age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI stage 4 were associated with ambulation loss at almost all points after revascularization.PMID:34039832 | DOI:10.5551/jat.62892 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Akio Kodama Mitsuyoshi Takahara Osamu Iida Yoshimitsu Soga Hiroto Terashi Daizo Kawasaki Yuichi Izumi Shinsuke Mii Kimihiro Komori Nobuyoshi Azuma SPINACH investigators. Source Type: research

The Priority of Non-HDL-C Assessment to Predict New Lesions among Stable Angina Patients with Strong Statins
CONCLUSIONS: Non-HDL-C ≥ 100 mg/dL was determined to be the independent risk factor for the occurrence of new lesions 9 months and ≤ 2 years after PCI among stable angina patients with strong statins. Residual risk after PCI should be considered by assessing not only DM but also non-HDL-C beyond the scope of LDL-C-lowering therapy with strong statins.PMID:34039817 | DOI:10.5551/jat.62908 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Daisuke Kanda Masaaki Miyata Yoshiyuki Ikeda Akihiro Tokushige Takeshi Sonoda Ryo Arikawa Kazuhiro Anzaki Ippei Kosedo Satoshi Yoshino Takuro Takumi Mitsuru Ohish Source Type: research

Response to "Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation have a Risk for Aortogenic Embolizations"
J Atheroscler Thromb. 2021 May 27. doi: 10.5551/jat.62890-R. Online ahead of print.NO ABSTRACTPMID:34039831 | DOI:10.5551/jat.62890-R (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Masayuki Suzuki Shigeru Fujimoto Ryota Tanaka Source Type: research

Ambulatory Status Over Time after Revascularization in Patients with Chronic Limb-Threatening Ischemia
CONCLUSION: Mobility in the overall population gradually decreased, whereas the number of deceased patients increased. Advanced age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI stage 4 were associated with ambulation loss at almost all points after revascularization.PMID:34039832 | DOI:10.5551/jat.62892 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Akio Kodama Mitsuyoshi Takahara Osamu Iida Yoshimitsu Soga Hiroto Terashi Daizo Kawasaki Yuichi Izumi Shinsuke Mii Kimihiro Komori Nobuyoshi Azuma SPINACH investigators. Source Type: research

The Priority of Non-HDL-C Assessment to Predict New Lesions among Stable Angina Patients with Strong Statins
CONCLUSIONS: Non-HDL-C ≥ 100 mg/dL was determined to be the independent risk factor for the occurrence of new lesions 9 months and ≤ 2 years after PCI among stable angina patients with strong statins. Residual risk after PCI should be considered by assessing not only DM but also non-HDL-C beyond the scope of LDL-C-lowering therapy with strong statins.PMID:34039817 | DOI:10.5551/jat.62908 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Daisuke Kanda Masaaki Miyata Yoshiyuki Ikeda Akihiro Tokushige Takeshi Sonoda Ryo Arikawa Kazuhiro Anzaki Ippei Kosedo Satoshi Yoshino Takuro Takumi Mitsuru Ohish Source Type: research

Response to "Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation have a Risk for Aortogenic Embolizations"
J Atheroscler Thromb. 2021 May 27. doi: 10.5551/jat.62890-R. Online ahead of print.NO ABSTRACTPMID:34039831 | DOI:10.5551/jat.62890-R (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Masayuki Suzuki Shigeru Fujimoto Ryota Tanaka Source Type: research

Ambulatory Status Over Time after Revascularization in Patients with Chronic Limb-Threatening Ischemia
CONCLUSION: Mobility in the overall population gradually decreased, whereas the number of deceased patients increased. Advanced age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI stage 4 were associated with ambulation loss at almost all points after revascularization.PMID:34039832 | DOI:10.5551/jat.62892 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Akio Kodama Mitsuyoshi Takahara Osamu Iida Yoshimitsu Soga Hiroto Terashi Daizo Kawasaki Yuichi Izumi Shinsuke Mii Kimihiro Komori Nobuyoshi Azuma SPINACH investigators. Source Type: research

The Priority of Non-HDL-C Assessment to Predict New Lesions among Stable Angina Patients with Strong Statins
CONCLUSIONS: Non-HDL-C ≥ 100 mg/dL was determined to be the independent risk factor for the occurrence of new lesions 9 months and ≤ 2 years after PCI among stable angina patients with strong statins. Residual risk after PCI should be considered by assessing not only DM but also non-HDL-C beyond the scope of LDL-C-lowering therapy with strong statins.PMID:34039817 | DOI:10.5551/jat.62908 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Daisuke Kanda Masaaki Miyata Yoshiyuki Ikeda Akihiro Tokushige Takeshi Sonoda Ryo Arikawa Kazuhiro Anzaki Ippei Kosedo Satoshi Yoshino Takuro Takumi Mitsuru Ohish Source Type: research

Response to "Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation have a Risk for Aortogenic Embolizations"
J Atheroscler Thromb. 2021 May 27. doi: 10.5551/jat.62890-R. Online ahead of print.NO ABSTRACTPMID:34039831 | DOI:10.5551/jat.62890-R (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Masayuki Suzuki Shigeru Fujimoto Ryota Tanaka Source Type: research

Ambulatory Status Over Time after Revascularization in Patients with Chronic Limb-Threatening Ischemia
CONCLUSION: Mobility in the overall population gradually decreased, whereas the number of deceased patients increased. Advanced age, impaired mobility before CLTI onset and at revascularization, renal failure on dialysis, and WIfI stage 4 were associated with ambulation loss at almost all points after revascularization.PMID:34039832 | DOI:10.5551/jat.62892 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 27, 2021 Category: Cardiology Authors: Akio Kodama Mitsuyoshi Takahara Osamu Iida Yoshimitsu Soga Hiroto Terashi Daizo Kawasaki Yuichi Izumi Shinsuke Mii Kimihiro Komori Nobuyoshi Azuma SPINACH investigators. Source Type: research

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
CONCLUSION: CEC was not changed by JD education in Japanese patients with dyslipidemia who already had normal CEC at baseline. CEC was suggested to be positively associated with serum α- and γ-tocopherol and HDL ORAC.PMID:34024872 | DOI:10.5551/jat.62832 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 24, 2021 Category: Cardiology Authors: Ariko Umezawa Chizuko Maruyama Yasuhiro Endo Yumiko Suenaga Yuri Shijo Noriko Kameyama Aisa Sato Ai Nishitani Makoto Ayaori Masako Waki Tamio Teramoto Katsunori Ikewaki Source Type: research

Measurement of Nutritional Status as Frailty Severity is Indispensable to Treat Patients with Chronic Limb-Threatening Ischemia
J Atheroscler Thromb. 2021 May 22. doi: 10.5551/jat.ED169. Online ahead of print.NO ABSTRACTPMID:34024873 | DOI:10.5551/jat.ED169 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 24, 2021 Category: Cardiology Authors: Yoshiyuki Ikeda Source Type: research

To be Functional, or not to be Low in Cholesterol, that is the Clinical Concern when Evaluating Anti-Atherosclerotic Actions of High-Density Lipoproteins
J Atheroscler Thromb. 2021 May 22. doi: 10.5551/jat.ED173. Online ahead of print.NO ABSTRACTPMID:34024874 | DOI:10.5551/jat.ED173 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 24, 2021 Category: Cardiology Authors: Hiroshi Yoshida Source Type: research

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial
CONCLUSION: CEC was not changed by JD education in Japanese patients with dyslipidemia who already had normal CEC at baseline. CEC was suggested to be positively associated with serum α- and γ-tocopherol and HDL ORAC.PMID:34024872 | DOI:10.5551/jat.62832 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 24, 2021 Category: Cardiology Authors: Ariko Umezawa Chizuko Maruyama Yasuhiro Endo Yumiko Suenaga Yuri Shijo Noriko Kameyama Aisa Sato Ai Nishitani Makoto Ayaori Masako Waki Tamio Teramoto Katsunori Ikewaki Source Type: research

Measurement of Nutritional Status as Frailty Severity is Indispensable to Treat Patients with Chronic Limb-Threatening Ischemia
J Atheroscler Thromb. 2021 May 22. doi: 10.5551/jat.ED169. Online ahead of print.NO ABSTRACTPMID:34024873 | DOI:10.5551/jat.ED169 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 24, 2021 Category: Cardiology Authors: Yoshiyuki Ikeda Source Type: research

To be Functional, or not to be Low in Cholesterol, that is the Clinical Concern when Evaluating Anti-Atherosclerotic Actions of High-Density Lipoproteins
J Atheroscler Thromb. 2021 May 22. doi: 10.5551/jat.ED173. Online ahead of print.NO ABSTRACTPMID:34024874 | DOI:10.5551/jat.ED173 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 24, 2021 Category: Cardiology Authors: Hiroshi Yoshida Source Type: research

Genetic Analysis of Japanese Children Clinically Diagnosed with Familial Hypercholesterolemia
CONCLUSION: Approximately half of the children clinically diagnosed with FH had pathogenic variants in FH causative genes. The serum LDL-C levels tend to be high in FH children with pathogenic variations, and the levels are by the types of variants. Genetic analysis is useful; however, further study on FH without any variants is required.PMID:34011801 | DOI:10.5551/jat.62807 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Keiko Nagahara Tsuyoshi Nishibukuro Yasuko Ogiwara Kento Ikegawa Hayato Tada Masakazu Yamagishi Masa-Aki Kawashiri Ayako Ochi Junya Toyoda Yuya Nakano Masanori Adachi Katsumi Mizuno Yukihiro Hasegawa Kazushige Dobashi Source Type: research

Association of Flow Parameters and Diameter in the Common Carotid Artery with Impaired Glucose Metabolism
CONCLUSIONS: These findings indicate that all CCA parameters except IMT are associated with impaired glucose metabolism in patients without cardiovascular disease.PMID:34011802 | DOI:10.5551/jat.62790 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Nobuo Sasaki Ryo Maeda Ryoji Ozono Yukiko Nakano Yukihito Higashi Source Type: research

Genetic Analysis of Japanese Children Clinically Diagnosed with Familial Hypercholesterolemia
CONCLUSION: Approximately half of the children clinically diagnosed with FH had pathogenic variants in FH causative genes. The serum LDL-C levels tend to be high in FH children with pathogenic variations, and the levels are by the types of variants. Genetic analysis is useful; however, further study on FH without any variants is required.PMID:34011801 | DOI:10.5551/jat.62807 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Keiko Nagahara Tsuyoshi Nishibukuro Yasuko Ogiwara Kento Ikegawa Hayato Tada Masakazu Yamagishi Masa-Aki Kawashiri Ayako Ochi Junya Toyoda Yuya Nakano Masanori Adachi Katsumi Mizuno Yukihiro Hasegawa Kazushige Dobashi Source Type: research

Association of Flow Parameters and Diameter in the Common Carotid Artery with Impaired Glucose Metabolism
CONCLUSIONS: These findings indicate that all CCA parameters except IMT are associated with impaired glucose metabolism in patients without cardiovascular disease.PMID:34011802 | DOI:10.5551/jat.62790 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Nobuo Sasaki Ryo Maeda Ryoji Ozono Yukiko Nakano Yukihito Higashi Source Type: research

Genetic Analysis of Japanese Children Clinically Diagnosed with Familial Hypercholesterolemia
CONCLUSION: Approximately half of the children clinically diagnosed with FH had pathogenic variants in FH causative genes. The serum LDL-C levels tend to be high in FH children with pathogenic variations, and the levels are by the types of variants. Genetic analysis is useful; however, further study on FH without any variants is required.PMID:34011801 | DOI:10.5551/jat.62807 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Keiko Nagahara Tsuyoshi Nishibukuro Yasuko Ogiwara Kento Ikegawa Hayato Tada Masakazu Yamagishi Masa-Aki Kawashiri Ayako Ochi Junya Toyoda Yuya Nakano Masanori Adachi Katsumi Mizuno Yukihiro Hasegawa Kazushige Dobashi Source Type: research

Association of Flow Parameters and Diameter in the Common Carotid Artery with Impaired Glucose Metabolism
CONCLUSIONS: These findings indicate that all CCA parameters except IMT are associated with impaired glucose metabolism in patients without cardiovascular disease.PMID:34011802 | DOI:10.5551/jat.62790 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Nobuo Sasaki Ryo Maeda Ryoji Ozono Yukiko Nakano Yukihito Higashi Source Type: research

Genetic Analysis of Japanese Children Clinically Diagnosed with Familial Hypercholesterolemia
CONCLUSION: Approximately half of the children clinically diagnosed with FH had pathogenic variants in FH causative genes. The serum LDL-C levels tend to be high in FH children with pathogenic variations, and the levels are by the types of variants. Genetic analysis is useful; however, further study on FH without any variants is required.PMID:34011801 | DOI:10.5551/jat.62807 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Keiko Nagahara Tsuyoshi Nishibukuro Yasuko Ogiwara Kento Ikegawa Hayato Tada Masakazu Yamagishi Masa-Aki Kawashiri Ayako Ochi Junya Toyoda Yuya Nakano Masanori Adachi Katsumi Mizuno Yukihiro Hasegawa Kazushige Dobashi Source Type: research

Association of Flow Parameters and Diameter in the Common Carotid Artery with Impaired Glucose Metabolism
CONCLUSIONS: These findings indicate that all CCA parameters except IMT are associated with impaired glucose metabolism in patients without cardiovascular disease.PMID:34011802 | DOI:10.5551/jat.62790 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 20, 2021 Category: Cardiology Authors: Nobuo Sasaki Ryo Maeda Ryoji Ozono Yukiko Nakano Yukihito Higashi Source Type: research

Genetic Analysis in a Taiwanese Cohort of 750 Index Patients with Clinically Diagnosed Familial Hypercholesterolemia
CONCLUSION: LDLR and APOB, but not PCSK9, mutations were the major genetic causes of FH. Four novel mutations in LDLR or ABCG5 were identified. This genetic screening method using mass spectrometry, targeted NGS, and MLPA analysis provided an efficient algorithm for genetic testing for clinically diagnosed FH in Taiwan.PMID:33994402 | DOI:10.5551/jat.62773 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Chin-Chou Huang Dau-Ming Niu Min-Ji Charng Source Type: research

Can Upstroke Time be a More Significant Predictor for Cardiovascular Disease Than Ankle-Brachial Index?
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED171. Online ahead of print.NO ABSTRACTPMID:33994403 | DOI:10.5551/jat.ED171 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Yasuyoshi Takei Source Type: research

A Risk Prediction Model of Atherosclerotic Cardiovascular Disease in Japan
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED172. Online ahead of print.NO ABSTRACTPMID:33994404 | DOI:10.5551/jat.ED172 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Isao Saito Source Type: research

Current Diagnosis and Management of Abetalipoproteinemia
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.RV17056. Online ahead of print.ABSTRACTAbetalipoproteinemia (ABL) is a rare autosomal recessive disorder caused by biallelic pathogenic mutations in the MTTP gene. Deficiency of microsomal triglyceride transfer protein (MTTP) abrogates the assembly of apolipoprotein (apo) B-containing lipoprotein in the intestine and liver, resulting in malabsorption of fat and fat-soluble vitamins and severe hypolipidemia. Patients with ABL typically manifest steatorrhea, vomiting, and failure to thrive in infancy. The deficiency of fat-soluble vitamins progressively develops into a vari...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Manabu Takahashi Hiroaki Okazaki Ken Ohashi Masatsune Ogura Shun Ishibashi Sachiko Okazaki Satoshi Hirayama Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Dis Source Type: research

Small Dense Low-Density Lipoprotein Cholesterol is a Potential Marker for Predicting Laser Treatment for Retinopathy in Diabetic Patients
CONCLUSIONS: SdLDL-C is a sensitive target marker to predict cardiovascular events as well as the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy.PMID:33994406 | DOI:10.5551/jat.62889 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Atsuko Nakayama Hiroyuki Morita Tatsuyuki Sato Takuya Kawahara Norifumi Takeda Satoshi Kato Hiroshi Itoh Issei Komuro Source Type: research

Current Diagnosis and Management of Tangier Disease
J Atheroscler Thromb. 2021 May 14. doi: 10.5551/jat.RV17053. Online ahead of print.ABSTRACTTangier disease is a genetic disorder characterized by an absence or extremely low level of high-density lipoprotein (HDL)-cholesterol (HDL-C). It is caused by a dysfunctional mutation of the ATP-binding cassette transporter A1 (ABCA1) gene, the mandatory gene for generation of HDL particles from cellular cholesterol and phospholipids, and it appears in an autosomal recessive hereditary profile. To date, 35 cases have been reported in Japan and 109 cases outside Japan. With dysfunctional mutations in both alleles (homozygotes or comp...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Masahiro Koseki Shizuya Yamashita Masatsune Ogura Yasushi Ishigaki Koh Ono Kazuhisa Tsukamoto Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Mi Source Type: research

Genetic Analysis in a Taiwanese Cohort of 750 Index Patients with Clinically Diagnosed Familial Hypercholesterolemia
CONCLUSION: LDLR and APOB, but not PCSK9, mutations were the major genetic causes of FH. Four novel mutations in LDLR or ABCG5 were identified. This genetic screening method using mass spectrometry, targeted NGS, and MLPA analysis provided an efficient algorithm for genetic testing for clinically diagnosed FH in Taiwan.PMID:33994402 | DOI:10.5551/jat.62773 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Chin-Chou Huang Dau-Ming Niu Min-Ji Charng Source Type: research

Can Upstroke Time be a More Significant Predictor for Cardiovascular Disease Than Ankle-Brachial Index?
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED171. Online ahead of print.NO ABSTRACTPMID:33994403 | DOI:10.5551/jat.ED171 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Yasuyoshi Takei Source Type: research

A Risk Prediction Model of Atherosclerotic Cardiovascular Disease in Japan
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED172. Online ahead of print.NO ABSTRACTPMID:33994404 | DOI:10.5551/jat.ED172 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Isao Saito Source Type: research

Current Diagnosis and Management of Abetalipoproteinemia
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.RV17056. Online ahead of print.ABSTRACTAbetalipoproteinemia (ABL) is a rare autosomal recessive disorder caused by biallelic pathogenic mutations in the MTTP gene. Deficiency of microsomal triglyceride transfer protein (MTTP) abrogates the assembly of apolipoprotein (apo) B-containing lipoprotein in the intestine and liver, resulting in malabsorption of fat and fat-soluble vitamins and severe hypolipidemia. Patients with ABL typically manifest steatorrhea, vomiting, and failure to thrive in infancy. The deficiency of fat-soluble vitamins progressively develops into a vari...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Manabu Takahashi Hiroaki Okazaki Ken Ohashi Masatsune Ogura Shun Ishibashi Sachiko Okazaki Satoshi Hirayama Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Dis Source Type: research

Small Dense Low-Density Lipoprotein Cholesterol is a Potential Marker for Predicting Laser Treatment for Retinopathy in Diabetic Patients
CONCLUSIONS: SdLDL-C is a sensitive target marker to predict cardiovascular events as well as the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy.PMID:33994406 | DOI:10.5551/jat.62889 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Atsuko Nakayama Hiroyuki Morita Tatsuyuki Sato Takuya Kawahara Norifumi Takeda Satoshi Kato Hiroshi Itoh Issei Komuro Source Type: research

Current Diagnosis and Management of Tangier Disease
J Atheroscler Thromb. 2021 May 14. doi: 10.5551/jat.RV17053. Online ahead of print.ABSTRACTTangier disease is a genetic disorder characterized by an absence or extremely low level of high-density lipoprotein (HDL)-cholesterol (HDL-C). It is caused by a dysfunctional mutation of the ATP-binding cassette transporter A1 (ABCA1) gene, the mandatory gene for generation of HDL particles from cellular cholesterol and phospholipids, and it appears in an autosomal recessive hereditary profile. To date, 35 cases have been reported in Japan and 109 cases outside Japan. With dysfunctional mutations in both alleles (homozygotes or comp...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Masahiro Koseki Shizuya Yamashita Masatsune Ogura Yasushi Ishigaki Koh Ono Kazuhisa Tsukamoto Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Mi Source Type: research

Genetic Analysis in a Taiwanese Cohort of 750 Index Patients with Clinically Diagnosed Familial Hypercholesterolemia
CONCLUSION: LDLR and APOB, but not PCSK9, mutations were the major genetic causes of FH. Four novel mutations in LDLR or ABCG5 were identified. This genetic screening method using mass spectrometry, targeted NGS, and MLPA analysis provided an efficient algorithm for genetic testing for clinically diagnosed FH in Taiwan.PMID:33994402 | DOI:10.5551/jat.62773 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Chin-Chou Huang Dau-Ming Niu Min-Ji Charng Source Type: research

Can Upstroke Time be a More Significant Predictor for Cardiovascular Disease Than Ankle-Brachial Index?
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED171. Online ahead of print.NO ABSTRACTPMID:33994403 | DOI:10.5551/jat.ED171 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Yasuyoshi Takei Source Type: research

A Risk Prediction Model of Atherosclerotic Cardiovascular Disease in Japan
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED172. Online ahead of print.NO ABSTRACTPMID:33994404 | DOI:10.5551/jat.ED172 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Isao Saito Source Type: research

Current Diagnosis and Management of Abetalipoproteinemia
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.RV17056. Online ahead of print.ABSTRACTAbetalipoproteinemia (ABL) is a rare autosomal recessive disorder caused by biallelic pathogenic mutations in the MTTP gene. Deficiency of microsomal triglyceride transfer protein (MTTP) abrogates the assembly of apolipoprotein (apo) B-containing lipoprotein in the intestine and liver, resulting in malabsorption of fat and fat-soluble vitamins and severe hypolipidemia. Patients with ABL typically manifest steatorrhea, vomiting, and failure to thrive in infancy. The deficiency of fat-soluble vitamins progressively develops into a vari...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Manabu Takahashi Hiroaki Okazaki Ken Ohashi Masatsune Ogura Shun Ishibashi Sachiko Okazaki Satoshi Hirayama Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Dis Source Type: research

Small Dense Low-Density Lipoprotein Cholesterol is a Potential Marker for Predicting Laser Treatment for Retinopathy in Diabetic Patients
CONCLUSIONS: SdLDL-C is a sensitive target marker to predict cardiovascular events as well as the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy.PMID:33994406 | DOI:10.5551/jat.62889 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Atsuko Nakayama Hiroyuki Morita Tatsuyuki Sato Takuya Kawahara Norifumi Takeda Satoshi Kato Hiroshi Itoh Issei Komuro Source Type: research

Current Diagnosis and Management of Tangier Disease
J Atheroscler Thromb. 2021 May 14. doi: 10.5551/jat.RV17053. Online ahead of print.ABSTRACTTangier disease is a genetic disorder characterized by an absence or extremely low level of high-density lipoprotein (HDL)-cholesterol (HDL-C). It is caused by a dysfunctional mutation of the ATP-binding cassette transporter A1 (ABCA1) gene, the mandatory gene for generation of HDL particles from cellular cholesterol and phospholipids, and it appears in an autosomal recessive hereditary profile. To date, 35 cases have been reported in Japan and 109 cases outside Japan. With dysfunctional mutations in both alleles (homozygotes or comp...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Masahiro Koseki Shizuya Yamashita Masatsune Ogura Yasushi Ishigaki Koh Ono Kazuhisa Tsukamoto Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Mi Source Type: research

Genetic Analysis in a Taiwanese Cohort of 750 Index Patients with Clinically Diagnosed Familial Hypercholesterolemia
CONCLUSION: LDLR and APOB, but not PCSK9, mutations were the major genetic causes of FH. Four novel mutations in LDLR or ABCG5 were identified. This genetic screening method using mass spectrometry, targeted NGS, and MLPA analysis provided an efficient algorithm for genetic testing for clinically diagnosed FH in Taiwan.PMID:33994402 | DOI:10.5551/jat.62773 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Chin-Chou Huang Dau-Ming Niu Min-Ji Charng Source Type: research

Can Upstroke Time be a More Significant Predictor for Cardiovascular Disease Than Ankle-Brachial Index?
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED171. Online ahead of print.NO ABSTRACTPMID:33994403 | DOI:10.5551/jat.ED171 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Yasuyoshi Takei Source Type: research

A Risk Prediction Model of Atherosclerotic Cardiovascular Disease in Japan
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.ED172. Online ahead of print.NO ABSTRACTPMID:33994404 | DOI:10.5551/jat.ED172 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Isao Saito Source Type: research

Current Diagnosis and Management of Abetalipoproteinemia
J Atheroscler Thromb. 2021 May 16. doi: 10.5551/jat.RV17056. Online ahead of print.ABSTRACTAbetalipoproteinemia (ABL) is a rare autosomal recessive disorder caused by biallelic pathogenic mutations in the MTTP gene. Deficiency of microsomal triglyceride transfer protein (MTTP) abrogates the assembly of apolipoprotein (apo) B-containing lipoprotein in the intestine and liver, resulting in malabsorption of fat and fat-soluble vitamins and severe hypolipidemia. Patients with ABL typically manifest steatorrhea, vomiting, and failure to thrive in infancy. The deficiency of fat-soluble vitamins progressively develops into a vari...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Manabu Takahashi Hiroaki Okazaki Ken Ohashi Masatsune Ogura Shun Ishibashi Sachiko Okazaki Satoshi Hirayama Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Dis Source Type: research

Small Dense Low-Density Lipoprotein Cholesterol is a Potential Marker for Predicting Laser Treatment for Retinopathy in Diabetic Patients
CONCLUSIONS: SdLDL-C is a sensitive target marker to predict cardiovascular events as well as the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy.PMID:33994406 | DOI:10.5551/jat.62889 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Atsuko Nakayama Hiroyuki Morita Tatsuyuki Sato Takuya Kawahara Norifumi Takeda Satoshi Kato Hiroshi Itoh Issei Komuro Source Type: research

Current Diagnosis and Management of Tangier Disease
J Atheroscler Thromb. 2021 May 14. doi: 10.5551/jat.RV17053. Online ahead of print.ABSTRACTTangier disease is a genetic disorder characterized by an absence or extremely low level of high-density lipoprotein (HDL)-cholesterol (HDL-C). It is caused by a dysfunctional mutation of the ATP-binding cassette transporter A1 (ABCA1) gene, the mandatory gene for generation of HDL particles from cellular cholesterol and phospholipids, and it appears in an autosomal recessive hereditary profile. To date, 35 cases have been reported in Japan and 109 cases outside Japan. With dysfunctional mutations in both alleles (homozygotes or comp...
Source: Journal of Atherosclerosis and Thrombosis - May 17, 2021 Category: Cardiology Authors: Masahiro Koseki Shizuya Yamashita Masatsune Ogura Yasushi Ishigaki Koh Ono Kazuhisa Tsukamoto Mika Hori Kota Matsuki Shinji Yokoyama Mariko Harada-Shiba Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Mi Source Type: research