Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research

Application of the log-Logistic Model to Dose Response Relation in Microbial Risk Assessment
Shokuhin Eiseigaku Zasshi. 2021;62(2):37-43. doi: 10.3358/shokueishi.62.37.ABSTRACTMicrobial risk assessment in food safety is a valuable tool to reduce the risks of infection by pathogens. The dose-response relation is aimed to establish the relationship between the dose of a pathogen that populations are exposed to and the probability of the adverse health effect by the pathogen. Among many dose-response models ever proposed, the exponential and beta-Poisson models have been internationally applied, but the decision on which model is selected between them solely depends on the goodness of fit to specific data sets. On th...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Hiroshi Fujikawa Source Type: research

Establishment of Simple and Quick Method to Confirm the Heating History of Milk and Dairy Products
Shokuhin Eiseigaku Zasshi. 2021;62(2):44-50. doi: 10.3358/shokueishi.62.44.ABSTRACTIn Japan, the import quarantine procedure for dairy products was newly introduced in November 2017. The treatment such as 15 sec heating at 72℃ is required for virus inactivation when importing milk or dairy products from the area which is not free from foot and mouth disease. Moreover, the heating history of imported items is also inspected as import quality procedures. The IDF 63 method is known as one of the methods to confirm the heating history of milk by checking the alkaline phosphatase (ALP) activity. However, this procedure is com...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Akihito Endo Asako Kato Masae Yanagisawa Juichi Tanaka Mari Ichikawa Ayumi Shibasaki Yasushi Kawai Tetsuya Masuda Source Type: research

Attempt to Calculate the Efficiency of Methylation Using < sup > 1 < /sup > H-NMR for Analyzing Brominated Vegetable Oil
In this report, we investigated whether 1H-NMR is an applicable method for assessing the efficiency of methylation to analyze BVO. 1H-NMR sufficiently calculated the efficiency of methylation using each integral and the numbers of protons derived from the methyl group, which is characteristic in products, and the methine group, which is characteristic in unreacted substances. Additionally, the efficiency of methylation calculated via 1H-NMR was in good agreement with changes in the peak area of BVO fatty acid methyl esters (BVOFAMEs) after various heating times obtained from GC-FID analysis. Therefore, 1H-NMR is applicable...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Asamoe Ogawa Keiko Iwakoshi Jun'ichi Nakajima Natsumi Takahashi Narue Sakamaki Chigusa Kobayashi Source Type: research

Application of the Benchmark Dose Method to the Incidence Data for Various Pathological Findings and Its Validation Analysis
Shokuhin Eiseigaku Zasshi. 2021;62(2):56-64. doi: 10.3358/shokueishi.62.56.ABSTRACTBenchmark dose (BMD) method have been used in the toxicological assessment of chemical substances so that the point of departure can be derived, as an alternative to the use of no observable adverse effect level (NOAEL), and the method is often applied to the incidence data of histopathological findings in the toxicity studies. In the present study, the BMD method was applied to various patterns of incidence data derived from some toxicity studies as case studies, and the validity of each application was discussed. Five independent applicati...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Kaoru Inoue Yoshiyuki Shigeta Takashi Umemura Hiroshi Nishiura Akihiko Hirose Source Type: research

The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements
This study determined the configuration of the isomers of tadalafil, nortadalafil, and homotadalafil in dietary supplements. The products purchased over the Internet studied included a honey product and a tablet, which contained tadalafil, and a candy, which contained nortadalafil and homotadalafil. Each of the pharmaceutical ingredients isolated from the products was measured with circular dichroism (CD).As a result, the CD spectrum of each isolated pharmaceutical ingredient was found to align with the standard CD spectrum of the 6R,12aR isomer, confirmed that each isolated tadalafil or tadalafil analogue included in a 6R...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 22, 2021 Category: Food Science Authors: Tomohide Fukiwake Midori Yamazaki Kazunaga Takahashi Takahiro Doi Masami Kawaguchi Keigo Enomoto Hiroki Yoshino Katsuya Uchimoto Maki Nishimura Source Type: research