Macular atrophy after aflibercept therapy for neovascular age-related macular degeneration: outcomes of Japanese multicenter study
ConclusionsOur study determined the incidence and rate of growth of macular atrophy after IVAs for neovascular AMD in clinical settings. Eyes with vision reduction and intraretinal fluid at the baseline develop macular atrophy more frequently after IVAs for neovascular AMD. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - May 24, 2020 Category: Opthalmology Source Type: research

Comparison of intravitreal melphalan with and without topotecan in the management of vitreous disease in retinoblastoma
ConclusionThe combined use of intravitreal melphalan and topotecan provides significantly better results in terms of avoiding enucleation and vitreal and subretinal seed control. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - May 23, 2020 Category: Opthalmology Source Type: research

What is glaucomatous optic neuropathy?
AbstractGlaucomatous optic neuropathy (GON) is the pathohistological feature of glaucoma in the optic nerve. The pathogenesis of GON has been hypothesized, to either originate from compromised mechanical conditions at the lamina cribrosa or as associated with pathological vascular involvement. From a historical perspective, glaucoma is the degeneration of retinal ganglion cells (RGC) due to the elevation of intraocular pressure (IOP). The consensus of glaucoma treatment is generally accepted as sufficient IOP reduction. Is there an additional option to treat GON from the perspective of the vascular theory? In this section,...
Source: Japanese Journal of Ophthalmology - May 12, 2020 Category: Opthalmology Source Type: research

Management of diabetic macular edema: experts ’ consensus in Taiwan
This article was composed with the intention to provide recommendations for practicing clinicians to improve the management and, through it the outcomes of DME. Drawing from current guideline recommendations, clinical trial findings and local clinical experiences, these consensus recommendations for the management of DME were formed by an expert panel through iterations of discussion and voting. First, the treatment goal of DME is to achieve best visual outcome with edema improvement while minimizing treatment burden. Second, anti-VEGF therapy should be considered as the first-line treatment for patients with center-involv...
Source: Japanese Journal of Ophthalmology - April 28, 2020 Category: Opthalmology Source Type: research

Toxicity profiles of fixed-combination eye drops for glaucoma therapy using cultivated human corneal epithelial sheets
ConclusionGlaucoma fixed-combination eye drops demonstrated a different toxic effect on the cell viability, barrier function, and morphologic changes of HCES. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 27, 2020 Category: Opthalmology Source Type: research

Correction to: Current practice in the management of branch retinal vein occlusion in Japan: Survey results of retina specialists in Japan
In the original publication, under section, BRVO treatment practice pattern, the sentence in p. 369 was published as. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 22, 2020 Category: Opthalmology Source Type: research

Pachychoroid disease: a new perspective on exudative maculopathy
ConclusionPachychoroid is an important cause of exudative maculopathies. Both drusen and pachychoroid are increasingly recognized as important causes of macular neovascularization, and eyes formally categorized as typical nAMD or PCV can be further sub-categorized based on the presence or absence of pachychoroid and drusen. There is a need to develop a consensus definition, which will greatly enhance our understanding of pachychoroid and facilitate the development of individual interventions in pachychoroid diseases. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 21, 2020 Category: Opthalmology Source Type: research

Changes in intraocular pressure and aqueous flare in eyes with multiple evanescent white dot syndrome
ConclusionIOP values mildly decreased in association with aqueous flare values in the acute phase in eyes with MEWDS. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 25, 2020 Category: Opthalmology Source Type: research

Effectiveness of polypoidal lesion-selective photodynamic therapy with intravitreal antivascular endothelial growth factor for polypoidal choroidal vasculopathy
ConclusionPolypoidal lesion-selective PDT with aflibercept was effective for relatively large, fovea-involved PCV, with significant visual improvement at 24 months. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 23, 2020 Category: Opthalmology Source Type: research

Impact of vitrectomy and air tamponade on aspheric intraocular lens tilt and decentration and ocular higher-order aberrations: phacovitrectomy versus cataract surgery
ConclusionAlthough largely decentered IOLs were occasionally found in Group B, aspheric IOLs could be effectively used in phacovitrectomy. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 21, 2020 Category: Opthalmology Source Type: research

A founder Alu insertion in RP1 gene in Japanese patients with retinitis pigmentosa
ConclusionThe founderAlu insertion inRP1 is an important cause of autosomal recessive RP in Japanese patients and can be missed in standard targeted resequencing. Screening optimized for this mutation is warranted, particularly in patients with a heterozygous deleterious mutation outside the defined region in exon 4 ofRP1. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 19, 2020 Category: Opthalmology Source Type: research

Prevalence and associations of myopia in Hong Kong primary school students
AbstractPurposeTo examine the prevalence of myopia in primary school children in Hong Kong, and the risk factors for myopia development.Study designA cross-sectional study.MethodsSubjective refraction and axial length were measured in all participants. Structured questionnaire was completed by the parents to assess risk factors of myopia.ResultsA total of 1396 children (491 boys) from Grade 1 to Grade 6 from 4 primary schools in Sham Shui Po district of Hong Kong participated. All participants underwent non-cycloplegic refraction. The overall prevalence of myopia (spherical equivalent, SE ≤ -0.5 diopter [D]) was 37.7%, ...
Source: Japanese Journal of Ophthalmology - March 16, 2020 Category: Opthalmology Source Type: research

Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration
ConclusionThe SIRT1 activator SRT2104 exerts axonal protection in TNF-induced optic nerve degeneration. This effect may be associated with upregulated autophagic status in the optic nerve. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 10, 2020 Category: Opthalmology Source Type: research

Ability of Swept source OCT technology to detect neurodegeneration in patients with type 2 diabetes mellitus without diabetic retinopathy
AbstractPurposeTo evaluate neurodegeneration in patients with type 2 Diabetes Mellitus (DM2) without diabetic retinopathy, and to assess the possible role of chronic systemic ischaemia and disease duration in retinal changes.Study designObservational cross sectional study.MethodsSixty eyes of 60 patients with DM2 without signs of diabetic retinopathy (DR), and 60 eyes of 60 healthy controls underwent retinal (ganglion cell layer (GCL), and retinal nerve fiber layer (RNFL) and choroidal evaluation using Swept source Optical coherence tomography, which allows high quality analysis of the different retinal layers and the chor...
Source: Japanese Journal of Ophthalmology - March 10, 2020 Category: Opthalmology Source Type: research

Features of neovascularization in pachychoroid neovasculopathy compared with type 1 neovascular age-related macular degeneration on optical coherence tomography angiography
AbstractPurposeTo compare neovascular membrane features of pachychoroid neovasculopathy (PNV) and type 1 neovascular age-related macular degeneration (nAMD) using optical coherence tomography angiography (OCTA).DesignRetrospective study.MethodsWe assessed 34 treatment-na ïve eyes with a diagnosis of PNV and 36 treatment-naïve eyes with a diagnosis of type 1 nAMD. Morphological patterns of neovascular membranes were categorized, and lesion sizes and flow areas were calculated by using en face images on the AngioVue (Optovue) OCTA system.ResultsStatistically significant differences were found between groups in age ...
Source: Japanese Journal of Ophthalmology - March 10, 2020 Category: Opthalmology Source Type: research

Foveal avascular zone area analysis in juvenile-onset type 1 diabetes using optical coherence tomography angiography
ConclusionPatients with juvenile-onset T1DM and no diabetic retinopathy had increased FAZ, but no significant difference in parafoveal vessel density compared to healthy controls. Larger FAZ area was associated with higher annual HbA1c, more episodes of severe hypoglycemic attacks, and older onset age. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 3, 2020 Category: Opthalmology Source Type: research

Characteristic of slow growth in cell culture of adenovirus type 54 causing nationwide outbreak epidemic keratoconjunctivitis in Japan
ConclusionThe propagation of Ad54 in A549 is slow compared with Ad37, Ad64 and Ad5. This slow propagation could have been caused by slow genomic replication resulting from delayed viral entry or E1 transcription initiation. The EKC caused by Ad54 needs more attention because the slow propagation of Ad54 may contribute to prolonged disease duration. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 3, 2020 Category: Opthalmology Source Type: research

Systemic and ocular determinants of mean ocular perfusion pressure in a population-based sample
AbstractPurposeTo investigate the associations between mean ocular perfusion pressure (MOPP) and several variables including body mass index (BMI), comorbid medical conditions and various ocular parameters in a population-based sample.Study designCross-sectional.MethodsData of 2091 healthy participants from a previous population based cross-sectional study were reviewed. Inclusion criteria were adults ≥40 years of age who were screened on-site for glaucoma. Data on medical history, height, weight, systolic and diastolic blood pressures (SBP and DBP, respectively) were obtained. A basic ocular examination was performed w...
Source: Japanese Journal of Ophthalmology - February 28, 2020 Category: Opthalmology Source Type: research

Keratoconus detection by novel indices in patients with Down syndrome: a cohort population-based study
ConclusionThe prevalence of KC in Down syndrome patients is significantly higher than that reported in non-Down syndrome individuals of the same age groups. The progression rate is approximately similar to that of the non-Down syndrome population. Screening programs should be applied to prohibit serious visual impairment in these populations. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 27, 2020 Category: Opthalmology Source Type: research

Risk factors for spontaneous consecutive exotropia in children with refractive and nonrefractive accommodative esotropia
ConclusionScXT can be found in AET with faster reduction in hyperopia per year, accompanied by DVD, or in eyes with esodeviation corrected in relatively shorter time. It can be noted even in patients with good alignment over a long-term, so long-term follow-up is recommended. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 27, 2020 Category: Opthalmology Source Type: research

Correlation between anterior chamber flare changes and diabetic macular edema after intravitreal injection of ranibizumab and aflibercept
AbstractPurposeTo evaluate aqueous flare change patterns following anti-vascular endothelial growth factor therapy for diabetic macular edema (DME) and investigate the relationship between changes in flare values and central macular thickness (CMT).Study designRetrospective, interventional case seriesMethodsA total of 84 eyes of 62 patients with DME received either intravitreal ranibizumab (IVR; n  = 62) or aflibercept (IVA; n = 22). A laser flare photometer (Kowa FM500, Kowa Company, Ltd) was used to measure flare values, and CMT was assessed using optical coherence tomography. Flare values and...
Source: Japanese Journal of Ophthalmology - February 27, 2020 Category: Opthalmology Source Type: research

A scoping review and network meta-analysis for efficacy and safety of glaucoma medication in Japanese patients
ConclusionThe efficacy and safety of glaucoma medications were assessed by NMA as reference to those of timolol maleate 0.5% in Japanese patients. PG analogs were the most efficacious in reducing IOP. However, PG analogs were also associated with higher rates of adverse reactions and conjunctival hyperemia. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 24, 2020 Category: Opthalmology Source Type: research

Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure
AbstractPurposeTo quantitatively analyze the topographic features of localized retinal nerve fiber layer (RNFL) defects according to baseline intraocular pressure (IOP) level in cases of early primary open-angle glaucoma (POAG).Study designRetrospective comparative study.MethodsPOAG patients meeting the following conditions were consecutively included: (1) baseline office-hour diurnal IOP ≤ 21 mmHg, (2) 1 localized RNFL defect as observed on red-free fundus photography, and (3) corresponding visual field defect. Defects’ approximations to the macula (angle α) and width (angle ß) as well as the angle be...
Source: Japanese Journal of Ophthalmology - February 15, 2020 Category: Opthalmology Source Type: research

Transient changes in refractive error and corneal tomography after 24-h continuous monitoring of intraocular pressure patterns with a contact lens sensor
The objective spherical equivalent (SE) refractive error was measured using automated refraction and keratometry. The axial power, instantaneous power, and corneal thickness at the central, paracentral, midperipheral, and peripheral cornea were measured with swept-source anterior-segment optical coherence tomography. Measurements were performed at baseline, immediately after monitoring, and at follow-up visits 2 –4 days after monitoring.ResultsThe myopic SE increased significantly (P 
Source: Japanese Journal of Ophthalmology - February 13, 2020 Category: Opthalmology Source Type: research

Posterior vitreous detachment in patients with diabetes mellitus
AbstractPurposeTo compare the progression of posterior vitreous detachment (PVD) during aging among eyes of diabetics with diabetic retinopathy (DR), eyes of diabetics without DR, and eyes of nondiabetics.Study designProspective cross-sectional study.MethodsOne-hundred thirty-three diabetic eyes with DR (DR group), 254 diabetic eyes without DR (non-DR group), and 577 nondiabetic eyes (nondiabetic group) were divided into four age categories: 1) 40-49 years, 2) 50-59 years, 3) 60-69 years, and 4) 70-79 years. The PVD state was examined using swept source-optical coherence tomography and classified into five stages: 0 (non P...
Source: Japanese Journal of Ophthalmology - February 11, 2020 Category: Opthalmology Source Type: research

Analysis of macular curvature in normal eyes using swept-source optical coherence tomography
AbstractPurposeTo evaluate macular shape in normal eyes using swept-source optical coherence tomography (SS-OCT).Study designRetrospective cross-sectional study.MethodsWe retrospectively evaluated 77 normal eyes of 48 subjects. Curvature of retinal pitment epithelium (RPE) and choroid/scleral interface (CSI) was measured in vertical and horizontal SS-OCT 16-mm scanned images. After correcting the optical distortion of OCT images, curvatures of superior, central, and inferior sectors in the vertical scan, and temporal, central, and nasal sectors in the horizontal scan (each 4-mm length) were compared. Factors associated wit...
Source: Japanese Journal of Ophthalmology - February 10, 2020 Category: Opthalmology Source Type: research

Interocular symmetry of the foveal avascular zone area in healthy eyes: a swept-source optical coherence tomography angiography study
We examined 236 healthy eyes of 118 consecutive subjects (mean age, 39.1  ± 18.9 years). We used swept-source optical coherence tomography angiography (OCTA) images of the FAZ to measure its area from both the superficial capillary plexus (SCP-FAZ) and the whole retinal capillary plexus (WCP-FAZ). We also investigated the relationship between interocular differenc es in SCP-FAZ and other factors such as: axial length, spherical equivalent, central retinal thickness, and retinal vascular density.ResultsThere was no significant difference in the FAZ area between the right and left eyes in eithe...
Source: Japanese Journal of Ophthalmology - February 3, 2020 Category: Opthalmology Source Type: research

One-year outcomes of half-fluence photodynamic therapy combined with intravitreal injection of aflibercept for pachychoroid neovasculopathy without polypoidal lesions
AbstractPurposeTo evaluate the 1-year efficacy of half-fluence photodynamic therapy (HFPDT) combined with intravitreal aflibercept injection on treatment-na ïve pachychoroid neovasculopathy (PNV) without polypoidal lesions.Study designRetrospective, interventional case seriesPatients and methodsWe retrospectively studied 21 eyes with treatment-na ïve PNV and assessed the best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), pachyvessel vertical diameter, and choroidal neovascularization thickness (CNVT) at the fovea over a 12-month period.ResultsThe median BCVA w...
Source: Japanese Journal of Ophthalmology - February 3, 2020 Category: Opthalmology Source Type: research

Two sisters with microphthalmia and anterior segment dysgenesis secondary to a PAX6 pathogenic variant with clinically healthy parents: a case of gonadal mosaicism?
ConclusionsThe description of the variant inPAX6 in two siblings with clinically healthy parents who are negative for the mutation in DNA from leukocytes and buccal cells represents the possibility of parental gonadal mosaicism. Detection of germ cell mosaicism in the parents is essential to provide genetic counseling to the family regarding the risk of reoccurrence. Furthermore, we also report a pathogenic variant inPAX6 that to our knowledge has not so far been reported in patients with partial aniridia and therefore broadens the spectrum of the variants associated with aniridia. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 3, 2020 Category: Opthalmology Source Type: research

Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis
AbstractPurposeRetinal vasculitis and occlusive changes are important signs of posterior uveitis and are possible diagnostic markers for uveitis. However, the frequency of arteritis and phlebitis in various uveitis entities, including infectious uveitis (IU) and non-infectious uveitis (NIU), have not been systematically investigated.Study designRetrospective.MethodsWe investigated the frequency of retinal vascular inflammatory and occlusive changes in patients with IU and NIU. The study included 283 patients with intermediate, posterior, or pan-uveitis who were diagnosed with IU (presumed tuberculous uveitis, acute retinal...
Source: Japanese Journal of Ophthalmology - February 3, 2020 Category: Opthalmology Source Type: research

Safety of retrocorneal plaque aspiration for managing fungal keratitis
ConclusionRetrocorneal plaque aspiration may be useful for the precise diagnosis of fungal keratitis. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 28, 2020 Category: Opthalmology Source Type: research

Duration of room air tamponade after vitrectomy
ConclusionThe data suggest that room air tamponade remains in the vitreous cavity for an average of 11.1  days. Axial length and posterior capsule status were associated with duration. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 27, 2020 Category: Opthalmology Source Type: research

Spatial distribution of macular pigment estimated by autofluorescence imaging in elderly Japanese individuals
ConclusionsThe present characteristics of the different distribution patterns could be explained by the hypothesis that MP presents mainly in the M üller cell cone within 0.5° and in Müller cells in the outer and inner plexiform layers in the area outside 0.5°. The anatomic characteristics of Müller cells at the fovea and parafovea likely affect the MP distribution. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 27, 2020 Category: Opthalmology Source Type: research

Measurement of the volume of the vitrectomized space during vitrectomy in myopic patients with retinal detachment
We present a novel technique for measuring volume of space replaced by air during fluid-air exchange in vitrectomy (vitrectomized space) for intravitreal gas injection. To confirm the feasibility of this technique, we assessed postoperative intraocular pressure (IOP) and the duration of injected gas. Using this technique, we found remarkable differences in volume between high myopic eyes with retinal detachment caused by peripheral break (PB-RD group) and those with macular hole retinal detachment (MH-RD group). We studied the relationships between the volume and biometric values, axial length (AL) and corneal curvature ra...
Source: Japanese Journal of Ophthalmology - January 6, 2020 Category: Opthalmology Source Type: research

Comparisons of photopic negative responses elicited by different conditions from glaucomatous eyes
ConclusionThe PhNR1 and PhNR2 elicited by the W/W and R/B stimuli are suitable measures to assess the function of the RGCs in eyes with OAG. The PhNR2 elicited by R/B stimuli at higher stimulus intensities is most effective in detecting functional and structural changes of the RGCs with the highest diagnostic capacity in discriminating advanced glaucoma. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 3, 2020 Category: Opthalmology Source Type: research

Prediction of severe retinopathy of prematurity using the weight gain, insulin-like growth factor 1, and neonatal retinopathy of prematurity algorithm in a Japanese population of preterm infants
ConclusionThe WINROP algorithm could be used for preterm infants (gestational age of
Source: Japanese Journal of Ophthalmology - January 3, 2020 Category: Opthalmology Source Type: research

The effects of intravitreal triamcinolone acetonide in diabetic macular edema refractory to anti-VEGF treatment
AbstractPurposeTo investigate the efficacy and safety of primary intravitreal triamcinolone acetonide (IVTA) in eyes affected by diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (VEGF) therapy.Study designRetrospective observational studyMethodsThe medical records of patients who attended our clinic from March 2013 to September 2018 with refractory macular were reviewed. We included the patients who were injected at least one IVTA and completed 6 months of observation. Best-corrected Snellen visual acuity (VA), central macular thickness (CMT), intraocular pressure (IOP), and adverse events...
Source: Japanese Journal of Ophthalmology - January 3, 2020 Category: Opthalmology Source Type: research

Results of a clinical evaluation of a trifocal intraocular lens in Japan
ConclusionsThis new trifocal IOL provides equally good uncorrected VAs at distance, intermediate, and near, and decreases spectacle dependence in daily life. Patients frequently report mild-to-moderate glare and halos, and patients should be informed about these before implantation. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 3, 2020 Category: Opthalmology Source Type: research

Long-term results of focal laser photocoagulation and photodynamic therapy for the treatment of central serous chorioretinopathy
ConclusionsPDT showed early resolution of the SRF compared to focal laser. In CSC patients, both the CMT and BCVA remained stable for 3 years after treatment. After 3 or more years of follow-up, PDT showed a lower recurrence rate than focal laser. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - December 20, 2019 Category: Opthalmology Source Type: research

Surgical management of pediatric patients with congenital fibrosis of the extraocular muscles
ConclusionsBilateral IR recession in pediatric patients with CFEOM was effective in improving AHP, but postoperative exotropia appeared to be inevitable owing to the diminished adducted function caused by IR recession. Thus, horizontal strabismus surgery should be planned after the results of IR recession become evident. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - December 17, 2019 Category: Opthalmology Source Type: research

Machine learning classifiers-based prediction of normal-tension glaucoma progression in young myopic patients
AbstractPurposeTo assess the performance of machine learning classifiers for prediction of progression of normal-tension glaucoma (NTG) in young myopic patients.Study designCross-sectional study.MethodsOne hundred and fifty-five eyes of 155 myopic NTG patients (axial length [AL]  ≥ 24.00 mm and refractive error ≤ − 3.0 D) between the ages of 20 and 40 were enrolled and divided into training (110) and test (45) sets. Sixty-five eyes showed glaucoma progression as defined by standard automated perimetry, while 91 eyes (nonprogressors) had been stable over th e course o...
Source: Japanese Journal of Ophthalmology - December 17, 2019 Category: Opthalmology Source Type: research

Characteristics of tear abnormalities associated with benign essential blepharospasm and amelioration by means of botulinum toxin type A treatment
ConclusionTear abnormalities seen in BEB correspond to short BUT-type dry eye (DE), subclassified into decreased wettability DE in view of FBUPs. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - December 10, 2019 Category: Opthalmology Source Type: research

Effectiveness of intraoperative iodine in cataract surgery: cleanliness of the surgical field without preoperative topical antibiotics
ConclusionsThe cleanliness of the operative field without using topical antibiotics was revealed to be equivalent to that of the conventional method (using preoperative antibiotics without intraoperative iodine) as long as intraoperative iodine was used. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - November 27, 2019 Category: Opthalmology Source Type: research

Japan-Retinal Detachment Registry Report I: preoperative findings in eyes with primary retinal detachment
AbstractPurposeTo report the demographics and clinical characteristics of patients with a primary retinal detachment (RD).DesignProspective cohort study by a registry design.ParticipantsPatients with RD treated at vitreoretinal sub-specialty institutions in Japan from February 2016 to March 2017.MethodsDescriptive statistics for the primary RD, and multivariable ordered logistic regression and multiple linear regression analyses were performed.Results3178 eyes of 3178 cases were analyzed. The interval from onset to surgery was significantly shorter in patients in the 40-year age group than in other age groups except for th...
Source: Japanese Journal of Ophthalmology - November 23, 2019 Category: Opthalmology Source Type: research

Autologous transplantation of conjunctiva by modifying simple limbal epithelial transplantation for limbal stem cell deficiency
ConclusionThis is the first report of ocular surface reconstruction using autologous conjunctival epithelial transplants from the affected eye. Transplantation by modifying SLET effectively restored a clear corneal surface with minimal neovascularization in 4 patients with LSCD. Autologous conjunctival transplants combined with AM transplantation could be a practical option for treating bilateral LSCD in patients without symblepharon or severe keratinization. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - November 23, 2019 Category: Opthalmology Source Type: research

Association between axial length and in vivo human crystalline lens biometry during accommodation: a swept-source optical coherence tomography study
AbstractPurposeTo evaluate the association between axial length and crystalline lens biometry with and without accommodation using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment.Study designIntervention study.MethodsIndividuals aged 20 to 39 years were enrolled for SS-OCT imaging at 2 separate visits within 1 week. Each eye was imaged under accommodation stimuli with different amplitudes (0 D, -1 D, -3 D, -5 D, and -7 D). The anterior and posterior lens curvature radii and lens thicknesses were measured. The participants were divided into 4 groups according to axial length.Re...
Source: Japanese Journal of Ophthalmology - November 23, 2019 Category: Opthalmology Source Type: research

Insufficient accommodation during binocular near viewing in eyes with intermittent exotropia
AbstractPurposeTo investigate the changes in spherical equivalent and pupil response during near viewing in patients with intermittent exotropia (IXT) who have complaints of blurred vision or asthenopia from near viewing in daily life using a novel binocular wavefront aberrometer.Study designA cross-sectional study.MethodsTen IXT patients and ten healthy subjects wearing full-correction lenses at far sight (5 m) were instructed to fixate on a near target at 67 cm, which was then moved to 40 cm three times. Serial changes in the spherical equivalent (SE) refractive error (SE) were measured during this task using a laborator...
Source: Japanese Journal of Ophthalmology - November 9, 2019 Category: Opthalmology Source Type: research

Predictability of intraocular lens power calculation in eyes after phototherapeutic keratectomy
ConclusionsThe TCRP provides the highest predictability of IOL power calculation in post-PTK eyes. This result suggests that the use of the TCRP, rather than of conventional anterior keratometry, may be clinically helpful for improving the refractive accuracy of post-PTK eyes. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - November 5, 2019 Category: Opthalmology Source Type: research

Fovea-sparing internal limiting membrane peeling versus complete internal limiting membrane peeling for myopic traction maculopathy
ConclusionsFSIP resulted in significant improvement in MTM and prevented postoperative macular hole development. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - November 4, 2019 Category: Opthalmology Source Type: research

Scientific Reviewers
(Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - November 1, 2019 Category: Opthalmology Source Type: research