Short-term outcomes of micropulse transscleral laser therapy using the revised delivery probe in refractory glaucoma
ConclusionMP-TLT using the revised MicroPulse P3® Delivery Device for the treatment of refractory glaucoma was effective in reducing IOP across glaucoma types with an excellent safety profile and was well-tolerated by the patients. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - August 17, 2022 Category: Opthalmology Source Type: research
Agreement in the detection of chiasmal and postchiasmal visual field defects between imo binocular random single-eye test and Humphrey monocular test
ConclusionBRSET detected VF defects due to C/PCLs as accurately as the HFA monocular test with a shorter test duration. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - August 16, 2022 Category: Opthalmology Source Type: research
Astigmatism profile in the elderly population: Tehran Geriatric Eye Study
ConclusionThe prevalence of astigmatism was high in the elderly population of Tehran. More than half of the participants in this study had anisorule astigmatism, and against the rule-oblique combination was more prevalent than other types. A posterior subcapsular cataract, a history of cataract surgery, and myopia were the associated factors of astigmatism in this study. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - August 10, 2022 Category: Opthalmology Source Type: research
Newly or switching effect of a selective EP2 agonist on intraocular pressure in Japanese patients with open-angle glaucoma
ConclusionsNew administration of OMDI significantly reduced the IOP. Furthermore, the IOP did not change after switching from FP receptor agonists to OMDI, including multidrug therapy. OMDI can be used as a first-line drug and is comparable to FP receptor agonists in Japanese patients with OAG. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - July 30, 2022 Category: Opthalmology Source Type: research
Update on glial antibody-mediated optic neuritis
AbstractOptic neuritis (ON) refers to inflammatory demyelinating lesions of the optic nerve, which can cause acute or subacute vision loss and is a major cause of vision loss in young adults. Much of our understanding of typical ON is from the Optic Neuritis Treatment Trial. Glial autoantibodies to aquaporin-4 immunoglobulin (AQP4-IgG) and myelin oligodendrocyte glycoprotein immunoglobulin (MOG-IgG) are recently established biomarkers of ON that have revolutionized our understanding of atypical ON. The detection of glial antibodies is helpful in the diagnosis, treatment, and follow-up of patients with different types of ON...
Source: Japanese Journal of Ophthalmology - July 27, 2022 Category: Opthalmology Source Type: research
Clinical characteristics and surgical approach in Duane retraction syndrome: a study of 691 patients
ConclusionsAbout two-thirds of DRS patients had AHP, one-third had overshoots, and one-sixth had amblyopia. The results show that different types of DRS are associated with different epidemiological and clinical characteristics. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - July 21, 2022 Category: Opthalmology Source Type: research
Temperature effects on the disappearance and reappearance of corneal-endothelium primary cilia
ConclusionThe findings in this study using rabbit corneas indicate that the primary cilia of corneal endothelium preserved at low temperature disappeared, then reappeared after returning to body temperature, suggesting that temperature has a direct effect on the primary cilia of corneal endothelium. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - July 21, 2022 Category: Opthalmology Source Type: research
Intraocular pressure-lowering effects and safety of brimonidine/brinzolamide fixed combination after switching from other medications
ConclusionBBFC had satisfactory IOP-lowering effects without serious adverse reactions in patients who switched medications. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - July 17, 2022 Category: Opthalmology Source Type: research
The relationship between choroidal blood flow and glaucoma progression in a Japanese study population
ConclusionLSFG-derived choroidal MBR might be a useful biomarker to predict VF defect progression in a Japanese population. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - July 5, 2022 Category: Opthalmology Source Type: research
The optimal cut-off value of non-cycloplegic autorefraction for diagnosing myopia in school-aged children
Conclusion When diagnosing myopia using non-cycloplegic autorefraction alone with a theoretical cut-off SEQ of -0.50 D, the prevalence of myopia will be overestimated, and we need to set the cut-off value lower (more myopic) especially in younger children with low prevalence. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - July 5, 2022 Category: Opthalmology Source Type: research
Clinical features of ocular sarcoidosis: severe, refractory, and prolonged inflammation
ConclusionsAlthough most of the patients with ocular sarcoidosis had a relatively good visual prognosis, some developed severe, refractory, and/or prolonged inflammation related to the development of ocular complications, that resulted in poor visual prognosis. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - June 21, 2022 Category: Opthalmology Source Type: research
Clinical performance of a custom-designed soft contact lens in patients with keratoconus and intolerance to rigid contact lenses
ConclusionsThis study showed the efficacy and acceptable safety of Yousoft for patients with keratoconus and intolerance to rigid CLs. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - June 7, 2022 Category: Opthalmology Source Type: research
Epidemiological characteristics of malignant eyelid tumors at a referral hospital in Japan
ConclusionsSebaceous carcinoma is the major malignant eyelid tumor in Japan and is more frequent in women than in men. Epidemiology of malignant eyelid tumors may be affected by the trend of population age structure associated with the recent population aging. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - June 7, 2022 Category: Opthalmology Source Type: research
Use of systemic corticosteroids in patients newly registered at a claims database with a diagnosis of non-infectious uveitis: results from a real-world claims database analysis
ConclusionsThe systemic corticosteroid dose was highest at month 1 and decreased over time in all disease categories. This database research revealed that some patients with NIU continued being prescribed systemic corticosteroids for at least 1 year. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - June 7, 2022 Category: Opthalmology Source Type: research
Differential gene expression analysis using RNA sequencing: retinal pigment epithelial cells after exposure to continuous-wave and subthreshold micropulse laser
ConclusionsThe results provide insights into the genetic responses and may contribute to the understanding of the molecular mechanisms of laser-induced thermal effects. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - May 31, 2022 Category: Opthalmology Source Type: research
