Short-term results for brolucizumab in treatment-na ïve neovascular age-related macular degeneration: a Japanese multicenter study
ConclusionsIVBr for treatment-na ïve neovascular AMD was effective in the short-term, achieving significantly improved BCVA, good retinal fluid resolution, and a high rate of polypoidal lesion regression. However, iritis was noted in 14% of patients which may limit use of this drug. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - May 21, 2022 Category: Opthalmology Source Type: research
Novel corneal morphological alterations in Vogt-Koyanagi-Harada disease
ConclusionsThis study was the first to reveal morphological changes in the anterior segment of the eye in VKH using CASIA-2, which may affect visual acuity and the astigmatic axis. It is vital to assess corneal morphology to determine the cause of visual function deterioration in patients with VKH. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - May 5, 2022 Category: Opthalmology Source Type: research
Risk factors for early-onset high myopia after treatment for retinopathy of prematurity
ConclusionThe number of laser shots is an independent risk factor for early onset high myopia, and preterm infants who have undergone laser treatment for severe ROP should be considered for early optical correction with cycloplegic refractive examination. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 30, 2022 Category: Opthalmology Source Type: research
Changes in optic nerve head and macula optical coherence tomography angiography parameters before and after trabeculectomy
ConclusionsWe found that reducing IOP by trabeculectomy did not affect the microcirculation of the peripapillary region and macular SCP, while there was a significant increase in the DCP parameters of the macular region. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 21, 2022 Category: Opthalmology Source Type: research
Features and changes in retinal nerve fiber layer thickness in high myopic ocular hypertension: a 1-year prospective follow-up
ConclusionsAfter ocular magnification correction, the HM-OHT group did not have thinner pRNFL thickness than the other two groups. However, the thickness decreased significantly over time. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 19, 2022 Category: Opthalmology Source Type: research
Exophthalmos associated with chronic progressive external ophthalmoplegia
ConclusionsAlthough exophthalmos may not be recognized by either the patient or the clinician, it may be one of the common features of CPEO. A large multiethnic study should be performed. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 19, 2022 Category: Opthalmology Source Type: research
Factors predicting the treatment frequency of ranibizumab injections during the second year in diabetic macular edema
ConclusionsThe cumulative doses of ranibizumab injections, CST, and hyperreflective walls in the foveal cystoid spaces at the 12-month visit are designated predictors of the treatment frequency of ranibizumab injections during the second year in DME. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 19, 2022 Category: Opthalmology Source Type: research
Risk factors for intraocular pressure elevation during the early period post cataract surgery
ConclusionsThe findings in this study reveal that male sex, high myopia, a history of glaucoma treatment, poor mydriasis, IFIS and baseline high IOP are risk factors for IOP elevation during the early period post cataract surgery. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 17, 2022 Category: Opthalmology Source Type: research
Efficacy of scleral imbrication on all quadrants in enucleated pig eyes
ConclusionsScleral imbrication on all quadrants induced a shorter AL and less corneal astigmatism than did a standard scleral imbrication on 2 quadrants. Therefore, the former could be a more effective operation for retinal disorders associated with high myopia, including macular hole retinal detachment and myopic foveoschisis. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 17, 2022 Category: Opthalmology Source Type: research
Potential participation of CTRP6, a complement regulator, in the pathology of age related macular degeneration
ConclusionThe localized expression of CTRP6 in the drusen of AMD eyes may open a new insight into the possible involvement of APC regulatory factors in the pathogenesis of AMD, together with the known CFH so far analyzed solely as an APC inhibitor. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 9, 2022 Category: Opthalmology Source Type: research
Correction to: Effectiveness of a photoscreener in identifying undiagnosed unilateral amblyopia at vision screening of 3-year-old children in Japan
(Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 9, 2022 Category: Opthalmology Source Type: research
Multicenter prospective observational study of fungal keratitis in Japan: analyses of in vitro susceptibility tests for combinations of drugs
ConclusionsThe combination of drugs prescribed for fungal keratitis incurs a possibility of synergistic, additive, indifferent, or antagonistic effects, depending on drug combinations and fungal strains. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 29, 2022 Category: Opthalmology Source Type: research
Multicenter prospective observational study of fungal keratitis in Japan: analyses of culture-positive cases
ConclusionFungal keratitis is caused by various species of fungi and can become refractory due to poor prognosis factors. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 29, 2022 Category: Opthalmology Source Type: research
Vitreoretinal interface anomalies in patients with a history of toxoplasmosis retinochoroiditis
ConclusionsVitreoretinal interface anomalies are common in patients diagnosed with TRC, including those with incomplete PVD. We observed no progression of vitreoretinal interface anomalies during the follow-up of patients diagnosed with TRC. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 28, 2022 Category: Opthalmology Source Type: research
Association between peripheral visual field defects and focal lamina cribrosa defects in highly myopic eyes
ConclusionsOur findings indicate an important relationship between HM-pVFDs and fLCDs, suggesting fLCD involvement in peripheral VF abnormality pathogenesis in highly myopic patients. Furthermore, microperimetry is reproducible for evaluating HM-pVFDs. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - March 20, 2022 Category: Opthalmology Source Type: research
