Three cases of brolucizumab-associated retinal vasculitis treated with systemic and local steroid therapy
ConclusionBrolucizumab-associated IOI, including retinal vasculitis and retinal occlusion, is a rare but important adverse event that can cause severe vision loss. Prompt diagnosis with FA and treatment with systemic or local steroids should be considered. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 5, 2021 Category: Opthalmology Source Type: research
Three Japanese cases of intraocular inflammation after intravitreal brolucizumab injections in one clinic
AbstractIntroductionTo report the development of intraocular inflammation (IOI) in three Japanese patients in the same clinic after intravitreal injections (IVI) of brolucizumab to treat neovascular age-related macular degeneration.Cases reportsThe major findings were: (1) all three eyes had a history of treatment with multiple anti-vascular endothelial growth factor (VEGF) agents; (2) the time to the onset of IOI after the first IVI of brolucizumab varied, i.e., onset occurred after the first IVI in two cases and after the second IVI in one case; (3) the degree of vitreous opacities resulting from the IOI varied among the...
Source: Japanese Journal of Ophthalmology - February 5, 2021 Category: Opthalmology Source Type: research
Characteristics and treatment responses of cystoid retina associated with central serous chorioretinopathy
ConclusionCystoid retinal changes can be associated with patchy retinal pigment epithelial atrophy and with peripapillary atrophy in CSC eyes. Laser treatment is beneficial for resolving cystoid retina as well as subretinal fluid. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 3, 2021 Category: Opthalmology Source Type: research
Effect of internal limiting membrane peeling on visual field sensitivity in eyes with epiretinal membrane accompanied by glaucoma with hemifield defect and myopia
ConclusionVisual field sensitivity reduction occurred mainly in the nasal region of the glaucomatous hemifield. Differences in axial length alone were not a prominent risk factor for reduced visual field sensitivity after ILM peeling in eyes with ERM. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - February 3, 2021 Category: Opthalmology Source Type: research
Influence of posterior corneal astigmatism on the outcomes of toric intraocular lens implantation in eyes with oblique astigmatism
ConclusionIncorporation of posterior corneal astigmatism measured with AS-OCT can significantly improve the outcomes of toric IOL implantation in eyes with WTR and ATR astigmatism, but not in eyes with oblique astigmatism. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 28, 2021 Category: Opthalmology Source Type: research
Quality of view through extended depth of focus intraocular lens in a model eye
ConclusionOur results suggest that vitreous surgeons can accomplish a clearer view during vitrectomy in EDF IOL-implanted eyes with a wide-angle viewing contact lens and a flat contact lens than in multifocal IOL-implanted eyes. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 26, 2021 Category: Opthalmology Source Type: research
Efficacy and safety of intravitreal aflibercept for polypoidal choroidal vasculopathy: 96-week outcomes in the Japanese subgroup of the PLANET study
ConclusionIVT-AFL monotherapy was efficacious for the treatment of Japanese patients with PCV, and the addition of rescue PDT did not show additional benefits. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 20, 2021 Category: Opthalmology Source Type: research
Intravenous immunoglobulin treatment for steroid-resistant optic neuritis: a multicenter, double-blind, randomized, controlled phase III study
ConclusionOur results suggest that intravenous immunoglobulin could be a safe and efficacious therapeutic option for prompt treatment of steroid-resistant acute ON. Trial registration: JapicCTI-132080. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 20, 2021 Category: Opthalmology Source Type: research
A multicenter cross-sectional survey of dry eye clinical characteristics and practice patterns in Korea: the DECS-K study
ConclusionThe study showed high concordance between Korean and ADES diagnostic guidelines, with most patients having tear film instability. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 19, 2021 Category: Opthalmology Source Type: research
Investigation of causative factors for unusual shape of macula in eyes with macula-off rhegmatogenous retinal detachment
ConclusionsThe anterior protrusion in eyes with macula-off RRD is associated with the presence of ICCs. The presence of ICCs can affect preoperative function and morphology but does not affect postoperative function and morphology. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 10, 2021 Category: Opthalmology Source Type: research
Influence of intermittent exotropia surgery on general health-related quality of life: different perception by children and parents
ConclusionsThe general health-related QOL significantly improved by surgery in pediatric patients with IXT, while the improvement was considerably underestimated by the parents. The children reported the greatest improvement in the school functioning subscale, whereas parents failed to discern this improvement. The discrepancy in children ’ and parents’ views can be an important factor when considering indication of corrective surgery and evaluating surgical outcomes. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 10, 2021 Category: Opthalmology Source Type: research
Evaluation of fornix-based trabeculectomy outcomes in Japanese glaucoma patients based on concrete long-term preoperative data
ConclusionsFornix-based trabeculectomy is an acceptable procedure for initial surgical management of glaucoma, especially for maintenance of superior VF. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 9, 2021 Category: Opthalmology Source Type: research
Practical use of multiplex and broad-range PCR in ophthalmology
ConclusionWe have established and developed the multiplex PCR, broad-range PCR, Strip PCR, and Direct Strip PCR methods and have reported the efficacy of such tests in multicenter studies. Our goal is “rapid and simple comprehensive PCR diagnosis anywhere and by anyone” for ocular infections. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 9, 2021 Category: Opthalmology Source Type: research
Corneal topographic changes after blepharoptosis surgery in patients with deepening of the upper eyelid sulcus
ConclusionIt is expected that in eyes with DUES blepharoptosis surgery can reduce AveK, CYL and HOAs in association with postoperative corneal flattening, and that will contribute to improvements in visual function. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 9, 2021 Category: Opthalmology Source Type: research
Efficient measurements for the dynamic range of human lightness perception
ConclusionsThis measurement technique detects an abnormality of the DRL. The results support our hypothesis that the DRL abnormality characterizes lightness-relevant symptoms that may elucidate the causes of nyctalopia, hemeralopia, and photophobia. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - January 9, 2021 Category: Opthalmology Source Type: research
