Secondary Packages cannot Protect Liquid Biopharmaceutical Formulations from Dropping-Induced Degradation
ConclusionsOur study is the first real-world data showing that the secondary package system has little to no effect on the liquid biopharmaceutical formulation quality during dropping. On the contrary, the stability of liquid biopharmaceutical formulations during dropping is more relevant to formulation compositions and primary packages. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 19, 2021 Category: Drugs & Pharmacology Source Type: research

Rational Development of Stable PYY3 –36 Peptide Y2 Receptor Agonists
ConclusionsBy rational design, a chemically and physically stable Y2-receptor selective, half-life extended PYY3 –36 peptide has been developed. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 16, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Development of Halofluorochromic Polymer Nanoassemblies for the Potential Detection of Liver Metastatic Colorectal Cancer Tumors Using Experimental and Computational Approaches
(Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 16, 2021 Category: Drugs & Pharmacology Source Type: research

Size-Dependent Absorption through Stratum Corneum by Drug-Loaded Liposomes
ConclusionsGel phase liposomes with sizes under 100  nm improved encapsulated drug absorption and distribution into the epidermis and dermis tissues. A size dependent mechanism for liposome penetration of the stratum corneum was proposed. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 12, 2021 Category: Drugs & Pharmacology Source Type: research

Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models:  Increasing the Predictability of Poor Metabolism in Humans
ABSTRACTPurposeA dataset of fraction excreted unchanged in the urine (fe) values was developed and used to evaluate the ability of preclinical animal species to predict high urinary excretion, and corresponding poor metabolism, in humans.MethodsA literature review of fe values in rats, dogs, and monkeys was conducted for all Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3 and 4 drugs (n=352) and a set of Class 1 and 2 drugs (n=80). The final dataset consisted of 202 total fe values for 135 unique drugs. Human and animal data were compared through correlations, two-fold analysis, and binary classific...
Source: Pharmaceutical Research - July 12, 2021 Category: Drugs & Pharmacology Source Type: research

Multi-Electrode Array of Sensory Neurons as an In Vitro Platform to Identify the Nociceptive Response to Pharmaceutical Buffer Systems of Injectable Biologics
ConclusionIncreased activity/firing of DRG sensory neurons has been suggested as a key feature underlying nociception. Our results support the utility of anin vitro MEA assay with cultured DRG sensory neurons to probe the nociceptive potential of clinically relevant buffer components used in injectable biologics. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 9, 2021 Category: Drugs & Pharmacology Source Type: research

Co-Delivery Using pH-Sensitive Liposomes to Pancreatic Cancer Cells: the Effects of Curcumin on Cellular Concentration and Pharmacokinetics of Gemcitabine
AbstractPurposePEGylated pH-sensitive liposomes (PSL) dual-loaded with gemcitabine and curcumin were investigated for the potential application in gemcitabine-resistant pancreatic ductal adenocarcinoma (PDAC) treatment. Curcumin was employed as an inhibitor of the efflux transporter, multidrug resistance protein 5 (MRP5) in PDAC cells.MethodsLiposomes were prepared with gemcitabine in the core and curcumin in the bilayers. The effects of curcumin on pH-sensitivity and ‘endosome escape’ of PSL with different PEGylation were investigated using a calcein self-quench assay. The effects of curcumin on intracellular ...
Source: Pharmaceutical Research - June 29, 2021 Category: Drugs & Pharmacology Source Type: research

Use of Bead Mixtures as a Novel Process Optimization Approach to Nanomilling of Drug Suspensions
ConclusionsWe demonstrated the feasibility of CPS –YSZ bead mixtures and rationalized its optimal use in WSMM through their modulation of breakage kinetics, energy utilization, and heat dissipation. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 24, 2021 Category: Drugs & Pharmacology Source Type: research

Scipion PKPD: an Open-Source Platform for Biopharmaceutics, Pharmacokinetics and Pharmacodynamics Data Analysis
ConclusionsWe show that the package successfully addresses these kinds of analyses. Scipion PKPD is freely available athttps://github.com/cossorzano/scipion-pkpd. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 23, 2021 Category: Drugs & Pharmacology Source Type: research

Gel Strength of Hydrophilic Matrix Tablets in Terms of In Vitro Robustness
ConclusionSufficient gel strength of swollen tablets is an important prerequisite for unchangedin vitro performance in consideration of mechanical stress. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 21, 2021 Category: Drugs & Pharmacology Source Type: research

Prediction of Free Drug Absorption in Cyclodextrin Formulation by a Modified Physiologically Based Pharmacokinetic Model and Phase Solubility 3-D Surface Graph
ConclusionThis PBPK model and 3-D surface graph can predict the absorption and determine the optimal concentration ratio of CD formulation, which could accelerate the R&D of CD formulation. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 18, 2021 Category: Drugs & Pharmacology Source Type: research

Epicutaneous Allergen Administration with Microneedles as a Novel Method of Immunotherapy for House Dust Mite (HDM) Allergic Rhinitis
ConclusionsEffective immunotherapy can be achieved by precision delivery of the allergen into the skin layer, and microneedles can provide effective immunological therapy by delivering the appropriate amount of allergen. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 18, 2021 Category: Drugs & Pharmacology Source Type: research

Effect of Pulsed Direct Current on Iontophoretic Delivery of Pramipexole across Human Epidermal Membrane In Vitro
ConclusionsThe results indicate that PDC iontophoresis can benefit transdermal delivery of PXCl in terms of controlling its permeation but does not enhance iontophoretic transport compared to continuous DC iontophoresis under the conditions studied. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 16, 2021 Category: Drugs & Pharmacology Source Type: research

Development of a Prototype, Once-Daily, Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772
ConclusionsMT-12  h and MM-12 h provided a QD pharmacokinetic profile in the fasted state, however when MT-12 h was dosed with a high-fat meal a QD profile was not maintained. (ClinicalTrials.gov Identifier: NCT03266172). (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 16, 2021 Category: Drugs & Pharmacology Source Type: research

Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies
AbstractA method to reproducibly mill abuse deterrent oxycodone hydrochloride (HCl) extended release (ER) tablets was developed for a nasal insufflation pharmacokinetic (PK) study. Several comminution methods were explored before determining that a conical mill resulted in controlled milling of tablets to a size range equal to or below 1000  μm. However, milling resulted in significant loss of oxycodone from abuse deterrent oxycodone HCl ER tablets compared to minimal oxycodone loss from oxycodone HCl immediate release (IR) tablets. Characterization of milled tablet powder showed that loss of oxycodone was not attr...
Source: Pharmaceutical Research - June 14, 2021 Category: Drugs & Pharmacology Source Type: research

Glutathione-Conjugated Hydrogels: Flexible Vehicles for Personalized Treatment of Bacterial Infections
ConclusionGSH ligands within GSH-PEG hydrogels allow loading and effective delivery of charged therapeutic agents, in addition to biologic therapeutics.Graphical abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 11, 2021 Category: Drugs & Pharmacology Source Type: research

Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products
AbstractChimeric antigen receptor T (CAR-T) cell therapy has been increasingly conducted for cancer patients in clinical settings. Progress in this therapeutic approach is hampered by the lack of a solid manufacturing process, T lymphocytes, and tumor-specific antigens. T cell source used in CAR-T cell therapy is derived predominantly from the patient ’s own T lymphocytes, which makes this approach impracticable to patients with progressive diseases and T leukemia. The generation of autologous CAR-T cells is time-consuming due to the lack of readily available T lymphocytes and is not applicable for third-party patien...
Source: Pharmaceutical Research - June 10, 2021 Category: Drugs & Pharmacology Source Type: research

Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose
ConclusionsNaloxone released from the three selected formulations could inhibit DAMGO-induced β-arrestin 2 recruitment. This indicates that the proposed naloxone delivery system is adequate for opioid reversal during the naloxone release duration. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 10, 2021 Category: Drugs & Pharmacology Source Type: research

Spray-Congealing and Wet-Sieving as Alternative Processes for Engineering of Inhalation Carrier Particles: Comparison of Surface Properties, Blending and In Vitro Performance
ConclusionsThe wet-sieving process and the related aerosolization performance are strongly dependent on the topography and structure of the starting material. Spray-congealing, has shown to be a potential process for generating smooth spherical particles of D-mannitol that enhance thein vitro aerosolization performance in binary blends of the carrier with a low drug dose. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 10, 2021 Category: Drugs & Pharmacology Source Type: research

Development of CD133 Targeting Multi-Drug Polymer Micellar Nanoparticles for Glioblastoma - In Vitro Evaluation in Glioblastoma Stem Cells
ConclusionsThis work has provided a potential clinical application for targeting GBM CSCs with simultaneous diagnostic imaging. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 7, 2021 Category: Drugs & Pharmacology Source Type: research

Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide
ConclusionThe combination of LS and LBF enhanced thein vivo oral absorption of OCT primarily via the protective effect of LBF sheltering the peptide from gastrointestinal degradation. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 7, 2021 Category: Drugs & Pharmacology Source Type: research

Enhanced Dermal Delivery of Flurbiprofen Nanosuspension Based Gel: Development and Ex Vivo Permeation, Pharmacokinetic Evaluations
ConclusionFB-NSs were successfully prepared with a wet milling method and optimized with the DoE approach. The optimized FB nanosuspension gel provided better permeation and pharmacokinetic performance compared to FB coarse suspension gel. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 4, 2021 Category: Drugs & Pharmacology Source Type: research

Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Sensitivity Analysis
ConclusionThe sensitivity analysis study may shed light on the product development of an mAb formulation, as well as on the future development of the simulation method. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 2, 2021 Category: Drugs & Pharmacology Source Type: research

Conditional Non-parametric Bootstrap for Non-linear Mixed Effect Models
ConclusionsThe conditional bootstrap provided better coverage rate than the traditional residual bootstrap, while preserving the structure of the data generating process. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - June 1, 2021 Category: Drugs & Pharmacology Source Type: research

Ethosomes as Nanocarriers for the Development of Skin Delivery Formulations
AbstractThe use of nanotechnology has been extensively explored for developing  efficient drug delivery systems towards topical and transdermal applications. Ethosomes constitute a vesicular nanocarrier containing a relatively high concentration of ethanol (20–45%). Ethanol is a well-known permeation enhancer, which confers ethosomes unique features, including high elastici ty and deformability, allowing them to penetrate deeply across the skin and enhance drug permeation and deposition. The improved composition of ethosomes offer, thereby, significant advantages in the delivery of therapeutic agents over partic...
Source: Pharmaceutical Research - May 25, 2021 Category: Drugs & Pharmacology Source Type: research

Population Pharmacokinetic Analysis and Dosing Optimization Based on Unbound Daptomycin Concentration and Cystatin C in Nonobese Elderly Patients with Hypoalbuminemia and Chronic Kidney Disease
ConclusionThese results suggest that establishing the dose using total concentrations may result in under- or overestimation caused by alterations in fu. The optimal dose for nonobese elderly patients with hypoalbuminemia and CKD depends on eGFRcys and age, and a standard dose may be insufficient for some patients. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 19, 2021 Category: Drugs & Pharmacology Source Type: research

Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties
ConclusionInter-relationship between molecular, solid-state and surface structures of the polymorphic forms of ritonavir are quantified in relation to their physical-chemical properties. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 19, 2021 Category: Drugs & Pharmacology Source Type: research

Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment
ConclusionsThe mathematical model adding UWL compartment well explained non-linear pharmacokinetics of apparent permeability of P-gp substrate in the microfluidic device. The model also has a potential to be applied to P-gp substrate permeability analysisin vivo. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 19, 2021 Category: Drugs & Pharmacology Source Type: research

Surfactant-Free Glibenclamide Nanoparticles: Formulation, Characterization and Evaluation of Interactions with Biological Barriers
ConclusionTaking into consideration these findings, polyethylene glycol is a useful polymer for stabilizing these surfactant-free glibenclamide nanoparticles and represent a promising alternative to improve the treatment of non-insulin dependent diabetes. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 17, 2021 Category: Drugs & Pharmacology Source Type: research

The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke
ConclusionAs support of our hypothesis, as expected, NL-1 failed to reduce stroke infarct in a permanent photothrombotic occlusion model of stroke. This report demonstrates the potential therapeutic benefits of using mitoNEET ligands like NL-1 as novel mitoceuticals for treating reperfusion-injury with cerebral stroke. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 12, 2021 Category: Drugs & Pharmacology Source Type: research

Novel Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells
This study was designed to investigate the feasibility of a topical delivery system, using a solid lipid nanoparticles (SLNs) loaded delivery systems, that can enhance the skin penetration and anti-cancer efficacy of combination of these polyphenols. Negatively charged Cur-Res SLNs with a mean diameter of 180.2  ± 7.7 nm were prepared using high shear homogenization method. Cur-Res SLNs were found to be stable up to 2 weeks under 4°C. The in vitro release study showed that Res was released five time more than curcumin. The permeability of resveratrol was about 1.67 times that of curcumin ...
Source: Pharmaceutical Research - May 12, 2021 Category: Drugs & Pharmacology Source Type: research

Application of blood microsampling in cynomolgus monkey and demonstration of equivalent monoclonal antibody PK parameters compared to conventional sampling
ConclusionThis study confirmed that PK parameters obtained from samples using microsampling were comparable to that of serum samples in cynomolgus monkeys. Therefore, the microsampling procedure described can be used as a substitute for conventional sampling procedure to support PK/TK studies of biotherapeutics in non-clinical product developments. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 12, 2021 Category: Drugs & Pharmacology Source Type: research

Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets
ConclusionsOwing to its objectivity and reproducibility, this technique is suitable for the design and evaluation of palatability in 3D printed IDT development. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 11, 2021 Category: Drugs & Pharmacology Source Type: research

Parametric Optimization of 3D Printed Hydrogel-Based Cardiovascular Stent
ConclusionThe printed stents had sufficient mechanical strength and were stable against pseudo-physiological wall shear stress. An addition of nanofibers to alginate hydrogel significantly enhanced the biodegradation rates of the stents.In vitro cell culture studies revealed that stents had no cytotoxic effects on human umbilical vein endothelial cells (HUVECs) and Raw 264.7 cells (i.e., Monocyte/macrophage-like cells), supporting that stents are biocompatible and can be explored for future clinical applications. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 10, 2021 Category: Drugs & Pharmacology Source Type: research

A Liposomal Gemcitabine, FF-10832, Improves Plasma Stability, Tumor Targeting, and Antitumor Efficacy of Gemcitabine in Pancreatic Cancer Xenograft Models
ConclusionThis study found that FF-10832 had favorable pharmacokinetic properties. The liposomal formulation was more effective and tolerable than unencapsulated GEM in mouse xenograft tumor models. Hence, FF-10832 is a promising candidate for the treatment of pancreatic cancer. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 7, 2021 Category: Drugs & Pharmacology Source Type: research

Subcutaneous Injection Site Pain of Formulation Matrices
ConclusionsThis systematic study via orthogonal analyses demonstrated that subcutaneous ISP is significantly influenced by solution composition. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 3, 2021 Category: Drugs & Pharmacology Source Type: research

Opportunities in an Evolving Pharmaceutical Development Landscape: Product Differentiation of Biopharmaceutical Drug Products
AbstractThe current perspective reviews the biopharmaceutical market until end of 2020 and highlights the transforming biopharmaceutical landscape during the recent decade. In particular, the rise of biosimilars and the development of new therapeutic modalities through recent advancement in molecular biology research sustainably change the product scenery. The present manuscript describes opportunities for pharmaceutical technical development, highlighting concepts such as product differentiation to succeed in a competitive product landscape. Product differentiation offers the opportunity for numerous life-cycle options an...
Source: Pharmaceutical Research - April 26, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmaceutical Excipients Enhance Iron-Dependent Photo-Degradation in Pharmaceutical Buffers by near UV and Visible Light: Tyrosine Modification by Reactions of the Antioxidant Methionine in Citrate Buffer
ConclusionsCommonly used excipients enhance the light-induced oxidation of amino acids in model peptides. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 21, 2021 Category: Drugs & Pharmacology Source Type: research

Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration
ConclusionThis study established the ability of two film casting screening methods to predict the in vitro and in vivo performance of corresponding SDDs, provided that the films are fully amorphous. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 20, 2021 Category: Drugs & Pharmacology Source Type: research

Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption
ConclusionThese analyses indicate that inhibition of efflux transporters appears to have negligible, clinically insignificant effects on the rivaroxaban absorption process, which is consistent with the concern that predictions based onin vitro measures may not translate to a clinically relevant interactionin vivo. We emphasize the need to evaluate gastric emptying, dissolution and other processes related to absorption when usingMAT changes to indicate efflux transporter inhibition. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 13, 2021 Category: Drugs & Pharmacology Source Type: research

Dried Blood Spot Technique Applied in Therapeutic Drug Monitoring of Anticancer Drugs: a Review on Conversion Methods to Correlate Plasma and Dried Blood Spot Concentrations
AbstractBackgroundAnticancer drugs are notoriously characterized by a low therapeutic index, the introduction of therapeutic drug monitoring (TDM) in oncologic clinical practice could therefore be fundamental to improve treatment efficacy. In this context, an attractive technique to overcome the conventional venous sampling limits and simplify TDM application is represented by dried blood spot (DBS). Despite the significant progress made in bioanalysis exploiting DBS, there is still the need to tackle some challenges that limit the application of this technology: one of the main issues is the comparison of drug concentrati...
Source: Pharmaceutical Research - April 12, 2021 Category: Drugs & Pharmacology Source Type: research

BSA/Silver Nanoparticle-Loaded Hydrogel Film for Local Photothermal Treatment of Skin Cancer
ConclusionsOverall, the results of this study demonstrated that the BSA/AgNP-loaded hydrogel films may serve as an effective but safe topical PTT agent for the treatment of skin cancer. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 9, 2021 Category: Drugs & Pharmacology Source Type: research

Characterization of Biological Material Adsorption to the Surface of Nanoparticles without a Prior Separation Step: a Case Study of Glioblastoma-Targeting Peptide and Lipid Nanocapsules
ConclusionsUsed only as a characterization tool, the process using chromatographic apparatus is less time and solvent consuming than classical Size-Exclusion Chromatography columns only used for separation. It could be a promising tool for the scientific community for characterizing the interactions of other combinations of nanosystems and active biological agents.Graphical abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 7, 2021 Category: Drugs & Pharmacology Source Type: research

Effect of pH on Iontophoretic Transport of Pramipexole Dihydrochloride across Human Epidermal Membrane
ConclusionsSkin permselectivity is a significant factor for iontophoretic transport of PXCl, and reducing formulation pH to increase the positive charges on PX ions did not enhance PXCl delivery. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 7, 2021 Category: Drugs & Pharmacology Source Type: research

Chiral Transplacental Pharmacokinetics of Fexofenadine: Impact of P-Glycoprotein Inhibitor Fluoxetine Using the Human Placental Perfusion Model
ConclusionsOur study showed a low extent, slow rate of non-enantioselective placental transfer of fexofenadine enantiomers, indicating a limited fetal fexofenadine exposure mediated by placental P-gp and/or OATP2B1. The fluoxetine interaction did not affect the non-enantioselective transplacental transfer of fexofenadine. The ex vivo placental perfusion model accurately predictsin vivo placental transfer of fexofenadine enantiomers with remarkably similar values (~0.17), and thus estimates the limited fetal exposure. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 6, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides
A Correction to this paper has been published:https://doi.org/10.1007/s11095-021-03033-9 (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 5, 2021 Category: Drugs & Pharmacology Source Type: research

Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Model Development
ConclusionsA bottom-up method was developed to simulate drug transport and absorption of protein solutions in skin tissue base on physical principles. The results appear to match experimental observations. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 2, 2021 Category: Drugs & Pharmacology Source Type: research

A Photopolymerized Semi-Interpenetrating Polymer Networks-Based Hydrogel Incorporated with Nanoparticle for Local Chemotherapy of Tumors
ConclusionsThis study demonstrated that the PEGDA-HA/PLGA-PTX hydrogel is a promising local drug delivery system in future clinical applications for tumor therapy.Graphical abstractA photopolymerized semi-interpenetrating polymer networks-based hydrogel incorporated with paclitaxel-loaded nanoparticles was fabricated by in situ UV photopolymerization, providing a promised nanoplatform for local chemotherapy of tumors. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2021 Category: Drugs & Pharmacology Source Type: research

Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue
AbstractThe epidemic of overweight and obesity underlies many common metabolic diseases. Approaches aimed to reduce energy intake and/or stimulate energy expenditure represent potential strategies to control weight gain. Adipose tissue is a major energy balancing organ. It can be classified as white adipose tissue (WAT) and brown adipose tissue (BAT). While WAT stores excess metabolic energy, BAT dissipates it as heat via adaptive thermogenesis. WAT also participates in thermogenesis by providing thermogenic fuels and by directly generating heat after browning. Browned WAT resembles BAT morphologically and metabolically an...
Source: Pharmaceutical Research - March 30, 2021 Category: Drugs & Pharmacology Source Type: research

Performance of Area under the Concentration-Time Curve Estimations of Vancomycin with Limited Sampling by a Newly Developed Web Application
ConclusionsThe new application using two concentrations was appropriately validated and might be efficient in popularizing the AUC-guided TDM of vancomycin. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 29, 2021 Category: Drugs & Pharmacology Source Type: research