How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors
AbstractThe lack of effective chemotherapeutic agents for the treatment of brain tumors is a serious unmet medical need. This can be attributed, in part, to inadequate delivery through the blood-brain barrier (BBB) and the tumor-cell barrier, both of which have active efflux transporters that can restrict the transport of many potentially effective agents for both primary and metastatic brain tumors. This review briefly summarizes the components and function of the normal BBB with respect to drug penetration into the brain and the alterations in the BBB due to brain tumor that could influence drug delivery. Depending on wh...
Source: Pharmaceutical Research - August 17, 2023 Category: Drugs & Pharmacology Source Type: research
The Impact of Post-Processing Temperature on PLGA Microparticle Properties
ConclusionThe study highlights the importance of both the post-treatment process and control during manufacturing to obtain a formulation within the desired product profile. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 17, 2023 Category: Drugs & Pharmacology Source Type: research
How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors
AbstractThe lack of effective chemotherapeutic agents for the treatment of brain tumors is a serious unmet medical need. This can be attributed, in part, to inadequate delivery through the blood-brain barrier (BBB) and the tumor-cell barrier, both of which have active efflux transporters that can restrict the transport of many potentially effective agents for both primary and metastatic brain tumors. This review briefly summarizes the components and function of the normal BBB with respect to drug penetration into the brain and the alterations in the BBB due to brain tumor that could influence drug delivery. Depending on wh...
Source: Pharmaceutical Research - August 17, 2023 Category: Drugs & Pharmacology Source Type: research
An Experimental and Computational Approach to Development of Mixing Processes for Miscible Liquids in Unbaffled Tanks
ConclusionResults of this study establish a practical and reliable methodology to perform mixing studies for miscible liquids with different kinematic viscosities. The methods discussed herein greatly reduce the routine mixing study costs in the biopharmaceutical industry and increase efficiency and accuracy of the results, allowing proactive scale-up of mixing operations. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 11, 2023 Category: Drugs & Pharmacology Source Type: research
The Relationship Between Molecular Symmetry and Physicochemical Properties Involving Boiling and Melting of Organic Compounds
ConclusionThe lack of correlation between the boiling point and the symmetry number reflects the fact that molecules have a high degree of rotational freedom in both the liquid and the vapor. On the other hand, the strong relationship between symmetry and melting point reflects the fact that molecules are rotationally restricted in the crystal but not in the liq uid. Since the symmetry number is equal to the number of ways that the molecule can be properly oriented for incorporation into the crystal lattice, it is a significant determinant of the melting point. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 10, 2023 Category: Drugs & Pharmacology Source Type: research
Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity
ConclusionRitlecitinib does not inhibit BCRP, OATP1B1, and OAT3 and is unlikely to cause a clinically relevant interaction through these transporters. Furthermore, our findings add to the body of evidence supporting the utility of CP-I and PDA as endogenous biomarkers for assessment of OATP1B1 and OAT1/3 transporter activity. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 10, 2023 Category: Drugs & Pharmacology Source Type: research
Correction: Preventive Pharmacovigilance: timely and precise prevention of adverse events through person-level patient screening and dose-level product surveillance
(Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 10, 2023 Category: Drugs & Pharmacology Source Type: research
The Relationship Between Molecular Symmetry and Physicochemical Properties Involving Boiling and Melting of Organic Compounds
ConclusionThe lack of correlation between the boiling point and the symmetry number reflects the fact that molecules have a high degree of rotational freedom in both the liquid and the vapor. On the other hand, the strong relationship between symmetry and melting point reflects the fact that molecules are rotationally restricted in the crystal but not in the liq uid. Since the symmetry number is equal to the number of ways that the molecule can be properly oriented for incorporation into the crystal lattice, it is a significant determinant of the melting point. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 10, 2023 Category: Drugs & Pharmacology Source Type: research
Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity
ConclusionRitlecitinib does not inhibit BCRP, OATP1B1, and OAT3 and is unlikely to cause a clinically relevant interaction through these transporters. Furthermore, our findings add to the body of evidence supporting the utility of CP-I and PDA as endogenous biomarkers for assessment of OATP1B1 and OAT1/3 transporter activity. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 10, 2023 Category: Drugs & Pharmacology Source Type: research
Correction: Preventive Pharmacovigilance: timely and precise prevention of adverse events through person-level patient screening and dose-level product surveillance
(Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 10, 2023 Category: Drugs & Pharmacology Source Type: research
Effect of Material Properties and Variability of Mannitol on Tablet Formulation Development
ConclusionThe study elucidated the linkage between fundamental material attributes and mechanical properties of mannitol, highlighting their impact on tablet defects and compaction performance in compression. A comprehensive understanding of the variability in mannitol properties between vendors and lots is crucial for successful formulation development, particularly when high percentages of mannitol are included as a brittle excipient. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 8, 2023 Category: Drugs & Pharmacology Source Type: research
Challenges and Opportunities for Celecoxib Repurposing
AbstractDrug repositioning, also known as drug repurposing, reprofiling, or rediscovery, is considered to be one of the most promising strategies to accelerate the development of new original drug products. Multiple examples of successful rediscovery or therapeutic switching of old molecules that did not show clinical benefits or safety in initial trials encourage the following of the discovery of new therapeutic pathways for them. This review summarizes the efforts that have been made, mostly over the last decade, to identify new therapeutic targets for celecoxib. To achieve this goal, records gathered in MEDLINE PubMed a...
Source: Pharmaceutical Research - August 8, 2023 Category: Drugs & Pharmacology Source Type: research
Accelerating Drug Product Development and Approval: Early Development and Evaluation
(Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 8, 2023 Category: Drugs & Pharmacology Source Type: research
Drug-Polymer Miscibility and the Overlap Concentration (C*) as Measured by Rheology: Variation of Polymer Structure
ConclusionsOur findings will aid researchers in designing or selecting appropriate polymers to inhibit crystallization of poorly soluble drugs. This research also suggests thatC* as determined by rheology can be used to compare drug-polymer interactions for similar molecular weight polymers.Graphical abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 8, 2023 Category: Drugs & Pharmacology Source Type: research
