WANTED DEAD OR ALIVE: New Thinking to Incentivize Drug Development
AbstractDespite unprecedented advancements in our understanding of disease process and targeting opportunities, our continued ability to discover and develop new medicines is fundamentally in doubt. These challenges reflect a growing recognition of the escalating risks of drug development (in terms of dollars and time) by established pharmaceutical companies and investors. Such hurdles are surmountable and require new thinking. This opinion piece conveys an overview of the challenge and an example of how we might overcome these challenges with constructive and forward-looking incentives for drug discovery. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 30, 2024 Category: Drugs & Pharmacology Source Type: research
Keratinocyte Exosomes for Topical Delivery of Tofacitinib in Treatment of Psoriasis: an In Vitro/ In Vivo Study in Animal Model of Psoriasis
ConclusionsThis method of drug delivery for TFC may be effective on enhancing its therapeutic effects and reduction its side effects favorably in chronic administration.Graphical abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 23, 2024 Category: Drugs & Pharmacology Source Type: research
Time-Lapse Macro Imaging with Dissolution Tests for Exploring the Interrelationship Between Disintegration and Dissolution Behaviors of Solid Dosages
ConclusionFVDS offers an alternative to traditional dissolution methods by integrating imaging analysis as a complementary tool to disintegration and dissolution testing methods. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Correction: Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
(Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Time-Lapse Macro Imaging with Dissolution Tests for Exploring the Interrelationship Between Disintegration and Dissolution Behaviors of Solid Dosages
ConclusionFVDS offers an alternative to traditional dissolution methods by integrating imaging analysis as a complementary tool to disintegration and dissolution testing methods. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Correction: Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
(Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Development of an Accelerated Rotator-based Drug Release Method for the Evaluation of Bupivacaine Multivesicular Liposomes
ConclusionsAn accelerated rotator-based IVRT method for bupivacaine MVLs was developed in this study, with the discriminatory ability to distinguish between formulations of different qualities. The developed IVRT method was a robust tool for generic development of MVL based formulations. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 11, 2024 Category: Drugs & Pharmacology Source Type: research
IVIVC Revised
ConclusionsThe consideration of Levy plots and IVIVC in the light of the F.A.T. and F.D.T. concepts allows a better physiological insight of thein vitro andin vivo drug dissolution/absorption processes. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 8, 2024 Category: Drugs & Pharmacology Source Type: research
The Osmolality and Hemolysis of High-Concentration Monoclonal Antibody Formulations
ConclusionsHigh osmolality for high-concentration mAb formulations would not affect product safety and the excipients could be added at relatively high levels to maintain product stability, especially for labile products. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - January 3, 2024 Category: Drugs & Pharmacology Source Type: research
Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
ConclusionsdOFM pig model is a robust and reproducible method to directly determine topical drug concentration in dermal interstitial fluid. Dermal biopsies were a less reliable measure of dermal exposure due to possible contributions from drug bound to tissue and drug associated with skin appendages. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - December 29, 2023 Category: Drugs & Pharmacology Source Type: research
Correction: Effect of Buffer Salts on Physical Stability of Lyophilized and Spray-Dried Protein Formulations Containing Bovine Serum Albumin and Trehalose
(Source: Pharmaceutical Research)
Source: Pharmaceutical Research - December 29, 2023 Category: Drugs & Pharmacology Source Type: research
