Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease
ConclusionsIntravitreal delivery of the PEG-ELNP ofpGRK1-ABCA4-S/MAR is a promising approach for gene therapy of Stargardt Disease, which can also be a delivery platform for gene therapy of other inherited retinal diseases. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Clinical Investigation of Large Volume Subcutaneous Delivery up to 25 mL for Lean and Non-Lean Subjects
ConclusionSC injection of 25 mL is feasible and tolerable using a low-pain formulation for abdomen injection irrespective of subcutaneous thickness and injection depths at a delivery rate of 0.5 mL/min. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms
ConclusionsIn clinical practice, the impact of genotyping on thein vivo disposition process of VEN should be considered to ensure the safety and efficacy of treatment. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Healthcare Systems and Artificial Intelligence: Focus on Challenges and the International Regulatory Framework
ConclusionsThe challenges in regulatory processes to facilitate the integration of AI in healthcare are significant. However, overcoming them is essential to ensure that AI-based technologies are adopted safely and effectively. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution
ConclusionIn the present study, hMN1300S showed effective solution delivery into an intradermal site. In particular, a micropillar can be effective for depth control of the injected solution as well as preventing contact between the hMN pedestal and the deformed membrane. The obtained results will help in the design and development of hMNs that ensure successful injection of an administered drug. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease
ConclusionsIntravitreal delivery of the PEG-ELNP ofpGRK1-ABCA4-S/MAR is a promising approach for gene therapy of Stargardt Disease, which can also be a delivery platform for gene therapy of other inherited retinal diseases. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Clinical Investigation of Large Volume Subcutaneous Delivery up to 25 mL for Lean and Non-Lean Subjects
ConclusionSC injection of 25 mL is feasible and tolerable using a low-pain formulation for abdomen injection irrespective of subcutaneous thickness and injection depths at a delivery rate of 0.5 mL/min. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms
ConclusionsIn clinical practice, the impact of genotyping on thein vivo disposition process of VEN should be considered to ensure the safety and efficacy of treatment. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
Healthcare Systems and Artificial Intelligence: Focus on Challenges and the International Regulatory Framework
ConclusionsThe challenges in regulatory processes to facilitate the integration of AI in healthcare are significant. However, overcoming them is essential to ensure that AI-based technologies are adopted safely and effectively. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 5, 2024 Category: Drugs & Pharmacology Source Type: research
An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat
ConclusionThe drying process is a critical factor in anhydrous form conservation. FBG and FBD yielded better preservation of the initial anhydrous forms. HSG could be an acceptable granulation method for API susceptible to hydrate formation if the API solubility is low. Selecting an FBG+FBD process minimizes API hydrate formation and preserves the original anhydrous form. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
Research Landscape of Physiologically Based Pharmacokinetic Model Utilization in Different Fields: A Bibliometric Analysis (1999 –2023)
ConclusionWe first visualize the research landscape and hotspots of the PBPK modeling through bibliometric methods. Our study provides a better understanding for researchers, especially beginners about the dynamization of PBPK modeling and presents the relevant trend in the future. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng
ConclusionsThis study presents a simple and feasible approach for achieving the targeted delivery of complex active ingredient clusters in TCM. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat
ConclusionThe drying process is a critical factor in anhydrous form conservation. FBG and FBD yielded better preservation of the initial anhydrous forms. HSG could be an acceptable granulation method for API susceptible to hydrate formation if the API solubility is low. Selecting an FBG+FBD process minimizes API hydrate formation and preserves the original anhydrous form. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
Research Landscape of Physiologically Based Pharmacokinetic Model Utilization in Different Fields: A Bibliometric Analysis (1999 –2023)
ConclusionWe first visualize the research landscape and hotspots of the PBPK modeling through bibliometric methods. Our study provides a better understanding for researchers, especially beginners about the dynamization of PBPK modeling and presents the relevant trend in the future. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng
ConclusionsThis study presents a simple and feasible approach for achieving the targeted delivery of complex active ingredient clusters in TCM. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - February 21, 2024 Category: Drugs & Pharmacology Source Type: research
