A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution

ConclusionThe study demonstrated the potential of the radial diffusion-based model to describe dissolution of drug powders. In contrast, the classic Nernst-Brunner equation could under-estimate drug dissolution rate, largely due to the underlying assumption of translational diffusion. Moreover, the study indicated that not all surfaces on a drug particle contribute to dissolution. Therefore, relying on the experimentally-determined specific surface area for predicting drug dissolution is not advisable.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research