Causal relationships of Helicobacter pylori and related gastrointestinal diseases on Type 2 diabetes: Univariable and Multivariable Mendelian randomization
ConclusionOur study found that H. pylori IgG antibody, H. pylori GroEL antibody, gastroduodenal ulcer and chronic gastritis are all related to t T2DM, and blood glucose level and obesity mediate the development of H. pylori GroEL antibody and gastroduodenal ulcer on T2DM, respectively. These findings may inform new prevention and intervention strategies for T2DM. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Mei Sun Source Type: research
Improving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid
Oncogene, Published online: 23 April 2024; doi:10.1038/s41388-024-03034-zImproving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid (Source: Oncogene)
Source: Oncogene - April 23, 2024 Category: Cancer & Oncology Authors: Karen van der Sluis Johanna W. van Sandick Marieke A. Vollebergh Jolanda M. van Dieren Niek Hugen Koen J. Hartemink Alexander A. F. A. Veenhof Els Verhoeven Jos é G. van den Berg Petur Snaebjornsson Michael Noe Tom van Wezel Mirjam C. Boelens Liudmila L. Source Type: research
Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan
ConclusionsThe GNRI is a promising predictor of both short- and long-term outcomes in older patients with RGC. (Source: Surgery Today)
Source: Surgery Today - April 23, 2024 Category: Surgery Source Type: research
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
ConclusionThese findings provide new insights into reconstruction methods after proximal gastrectomy by assessing postoperative hypoglycemia in non-diabetic patients with gastric cancer. (Source: Surgery Today)
Source: Surgery Today - April 23, 2024 Category: Surgery Source Type: research
Cancers, Vol. 16, Pages 1620: Short-Term Outcomes Analysis Comparing Open, Laparoscopic, Laparoscopic-Assisted, and Robotic Distal Gastrectomy for Locally Advanced Gastric Cancer: A Randomized Trials Network Analysis
Conclusions. LapAs-DG, Lap-DG, and Rob-DG performed in referral centers by dedicated surgeons have comparable short-term outcomes to Op-DG for locally AGC. (Source: Cancers)
Source: Cancers - April 23, 2024 Category: Cancer & Oncology Authors: Michele Manara Alberto Aiolfi Andrea Sozzi Matteo Cal ì Federica Grasso Emanuele Rausa Gianluca Bonitta Luigi Bonavina Davide Bona Tags: Systematic Review Source Type: research
Correction: Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
Int J Clin Oncol. 2024 Apr 22. doi: 10.1007/s10147-024-02525-z. Online ahead of print.ABSTRACTThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several tr...
Source: Clinical Colorectal Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Koji Kono Shotaro Nakajima Kosaku Mimura Source Type: research
Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants
CONCLUSIONS: In this largest prospective study to date on family history and gastric cancer, a familial background of gastric cancer increased the risk of gastric cancer in the Asian population. Targeted education, screening, and intervention in these high-risk groups may reduce the burden of gastric cancer.PMID:38649672 | DOI:10.1007/s10120-024-01499-1 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Dan Huang Minkyo Song Sarah Krull Abe Md Shafiur Rahman Md Rashedul Islam Eiko Saito Katherine De la Torre Norie Sawada Akiko Tamakoshi Xiao-Ou Shu Hui Cai Atsushi Hozawa Seiki Kanemura Jeongseon Kim Yu Chen Hidemi Ito Yumi Sugawara Sue K Park Myung-Hee S Source Type: research
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
CONCLUSION: These findings provide new insights into reconstruction methods after proximal gastrectomy by assessing postoperative hypoglycemia in non-diabetic patients with gastric cancer.PMID:38649530 | DOI:10.1007/s00595-024-02845-7 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Katsutoshi Shoda Takeshi Kubota Yoshihiko Kawaguchi Hidenori Akaike Suguru Maruyama Yudai Higuchi Takashi Nakayama Ryo Saito Koichi Takiguchi Shinji Furuya Kensuke Shiraishi Hidetake Amemiya Hiromichi Kawaida Daisuke Ichikawa Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
Int J Clin Oncol. 2024 Apr 22. doi: 10.1007/s10147-024-02525-z. Online ahead of print.ABSTRACTThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several tr...
Source: Clinical Lung Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Koji Kono Shotaro Nakajima Kosaku Mimura Source Type: research
Changing Fate: How EGFRs "Pit" Cell Versus Cell in the Stomach
The mammalian gastric epithelium comprises several major cell types, including mucus-secreting foveolar/pit cells, mucus neck cells, gastric-pumping parietal cells, and digestive enzyme-secreting chief cells.1,2 These cells largely originate from isthmus progenitors within the gastric mucosa (although during homeostasis, chief cells mostly autoduplicate3). The stem cells give rise to mature cells via progenitors known as prepit, preparietal, preneck, and so on. Understanding the differentiation process of parietal cells from preparietal cells is particularly important owing to their role in various gastric diseases, rangin...
Source: Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Sumimasa Arimura, Sarah To, Jason C. Mills Tags: Editorials Source Type: research
Management of malignant Gastric Outlet Obstruction (mGOO) due to pancreatic cancer in the era of EUS-Gastrojejunostomy: an international practice survey and case vignette study by Pancreas 2000 from the European Pancreatic Club
ConclusionsThis survey revealed significant differences in the management of mGOO, depending on specialties, local expertise and treatment volume, suggesting the lack of standardized algorithms. Life expectancy and patients ’ frailty are the main decision drivers. Regarding EUS-GJ, its availability remains suboptimal, with learning curve as the main perceived barrier. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 22, 2024 Category: Surgery Source Type: research
Gastritis cystica profunda presenting as an ulcerated lesion
A 57-year-old man was referred to our hospital due to repeated upper abdominal discomfort for more than 1 year. Endoscopy was performed 4 times in the past and gastric cancer was suspected, but biopsy showed inflammation. In our hospital, endoscopy showed a 2.5 cm diameter depressed lesion on the gastric angle (Fig. 1A) and magnifying narrow band imaging observed the central surface structure of the lesion disappeared (Fig. 1B). Endoscopic ultrasound (EUS) revealed a 0.8 × 0.7 cm anechoic area in the submucosa (Fig. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 22, 2024 Category: Gastroenterology Authors: Yang Li, Ruide Liu, Ziqiang Wang, Yi Mou Tags: Image of the Month Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
AbstractThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several treatment options to treat gastric cancer patients based on individual biomarker-oriente...
Source: International Journal of Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1611: An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer
We present the potential molecular mechanisms responsible for the effectivity of a given seasoning substance and their impact on GC cells. We discuss their potential effects on proliferation, apoptosis, and migration. For most of the spices discussed, we also outline the unavailability and side effects of their use. (Source: Cancers)
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Katarzyna Kostelecka Łukasz Bryliński Olga Komar Justyna Michalczyk Agata Mi łosz Jan Bi łogras Filip Woli ński Alicja Forma Jacek Baj Tags: Review Source Type: research
