C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
Comparison of Short ‑Term Outcomes and 3-Year Overall Survival between Robotic and Laparoscopic Gastrectomy for Gastric Cancer: A Propensity Score Matching Analysis
Conclusion: Our findings suggest that RG may offer advantages in terms of blood loss, surgical complications, recovery time, and pain management compared to LG while maintaining similar overall survival rates. However, RG is associated with higher hospital costs, potentially limiting its wider adoption. Further research, including large, multi-center randomized controlled trials with longer patient follow-up, particularly for advanced gastric cancer, is needed to confirm these findings.PMID:38693890 | DOI:10.1080/00015458.2024.2348256 (Source: Acta Chirurgica Belgica)
Source: Acta Chirurgica Belgica - May 2, 2024 Category: Surgery Authors: Li Zhang Jingli Cui Mingzhi Cai Bin Li Gang Ma Xuejun Wang Yong Liu Jingyu Deng Rupeng Zhang Han Liang Jilong Yang Source Type: research
Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis
We examined the association between intra-peritoneal exosomes, particularly exosomal micro-RNAs (exo-miRNAs), and IP-chemo sensitivity. MKN45 cells that were cultured with intra-peritoneal exosomes from patients who did not respond to IP therapy with PTX (IPnon-respond group) exhibited resistance to PTX compared with exosomes from responding patients (IPrespond group) (p = 0.002). A comprehensive search for exo-miRNAs indicated that miR-493 was significantly up-regulated in exosomes from the IPnon-respond group compared with those collected from the IPrespond group. The expression of miR-493 in PTX-resistant MKN45 cells (M...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Masahiro Makinoya Kozo Miyatani Yoshiaki Matsumi Yu Sakano Shota Shimizu Yuji Shishido Takehiko Hanaki Kyoichi Kihara Tomoyuki Matsunaga Manabu Yamamoto Naruo Tokuyasu Shuichi Takano Teruhisa Sakamoto Toshimichi Hasegawa Hiroaki Saito Yuji Nakayama Mitsuh Source Type: research
The effects of resistance exercise and leucine-enriched essential amino acid supplementation on muscle mass and physical function in post-gastrectomy patients: a pilot randomized controlled trial
Conclusion] We failed to detect a significant difference in muscle mass due to resistance exercise with LEAA supplementation in post-gastrectomy patients. However, resistance exercise with LEAA supplementation might be beneficial for muscle strength recovery and QOL improvements.PMID:38694013 | PMC:PMC11060767 | DOI:10.1589/jpts.36.218 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Atsushi Sawada Kentaro Yoneta Eri Togashi Shogo Asaka Riho Tada Takaaki Asada Seiichi Son Makoto Tayama Masami Kimura Satoshi Fujita Source Type: research
Identification of Helicobacter pylori-carcinogenic TNF-alpha-inducing protein inhibitors via daidzein derivatives through computational approaches
In this study, a total of 45 daidzein derivatives were investigated and the best 10 molecules were comprehensively investigated using in silico approaches for drug development, namely pass prediction, quantum calculations, molecular docking, molecular dynamics simulations, Lipinski rule evaluation, and prediction of pharmacokinetics. The molecular docking study was performed to evaluate the binding affinity between the target protein and the ligands. In addition, the stability of ligand-protein complexes was investigated by molecular dynamics simulations. Various parameters were analysed, including root-mean-square deviati...
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Jehad Zuhair Tayyeb Shibam Mondal Md Anisur Rahman Swapon Kumar Imren Bay ıl Shopnil Akash Md Sarowar Hossain Taha Alqahtani Magdi E A Zaki Jonas Ivan Nobre Oliveira Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
The effects of resistance exercise and leucine-enriched essential amino acid supplementation on muscle mass and physical function in post-gastrectomy patients: a pilot randomized controlled trial
Conclusion] We failed to detect a significant difference in muscle mass due to resistance exercise with LEAA supplementation in post-gastrectomy patients. However, resistance exercise with LEAA supplementation might be beneficial for muscle strength recovery and QOL improvements.PMID:38694013 | PMC:PMC11060767 | DOI:10.1589/jpts.36.218 (Source: Health Physics)
Source: Health Physics - May 2, 2024 Category: Physics Authors: Atsushi Sawada Kentaro Yoneta Eri Togashi Shogo Asaka Riho Tada Takaaki Asada Seiichi Son Makoto Tayama Masami Kimura Satoshi Fujita Source Type: research
Identification of Helicobacter pylori-carcinogenic TNF-alpha-inducing protein inhibitors via daidzein derivatives through computational approaches
In this study, a total of 45 daidzein derivatives were investigated and the best 10 molecules were comprehensively investigated using in silico approaches for drug development, namely pass prediction, quantum calculations, molecular docking, molecular dynamics simulations, Lipinski rule evaluation, and prediction of pharmacokinetics. The molecular docking study was performed to evaluate the binding affinity between the target protein and the ligands. In addition, the stability of ligand-protein complexes was investigated by molecular dynamics simulations. Various parameters were analysed, including root-mean-square deviati...
Source: J Cell Mol Med - May 2, 2024 Category: Molecular Biology Authors: Jehad Zuhair Tayyeb Shibam Mondal Md Anisur Rahman Swapon Kumar Imren Bay ıl Shopnil Akash Md Sarowar Hossain Taha Alqahtani Magdi E A Zaki Jonas Ivan Nobre Oliveira Source Type: research
Comparison of Short ‑Term Outcomes and 3-Year Overall Survival between Robotic and Laparoscopic Gastrectomy for Gastric Cancer: A Propensity Score Matching Analysis
Conclusion: Our findings suggest that RG may offer advantages in terms of blood loss, surgical complications, recovery time, and pain management compared to LG while maintaining similar overall survival rates. However, RG is associated with higher hospital costs, potentially limiting its wider adoption. Further research, including large, multi-center randomized controlled trials with longer patient follow-up, particularly for advanced gastric cancer, is needed to confirm these findings.PMID:38693890 | DOI:10.1080/00015458.2024.2348256 (Source: Acta Chirurgica Belgica)
Source: Acta Chirurgica Belgica - May 2, 2024 Category: Surgery Authors: Li Zhang Jingli Cui Mingzhi Cai Bin Li Gang Ma Xuejun Wang Yong Liu Jingyu Deng Rupeng Zhang Han Liang Jilong Yang Source Type: research
The effects of resistance exercise and leucine-enriched essential amino acid supplementation on muscle mass and physical function in post-gastrectomy patients: a pilot randomized controlled trial
Conclusion] We failed to detect a significant difference in muscle mass due to resistance exercise with LEAA supplementation in post-gastrectomy patients. However, resistance exercise with LEAA supplementation might be beneficial for muscle strength recovery and QOL improvements.PMID:38694013 | PMC:PMC11060767 | DOI:10.1589/jpts.36.218 (Source: Cancer Control)
Source: Cancer Control - May 2, 2024 Category: Cancer & Oncology Authors: Atsushi Sawada Kentaro Yoneta Eri Togashi Shogo Asaka Riho Tada Takaaki Asada Seiichi Son Makoto Tayama Masami Kimura Satoshi Fujita Source Type: research
Impact of Health Education Based on Protective Motivation Theory on the Mood State, Cancer-Related Fatigue, and Hope Level of Gastric Cancer Patients
CONCLUSION: Health education based on the theory of protective motivation effectively enhances the mood state, reduces cancer-related fatigue, and increases hope levels among gastric cancer patients, thereby improving their medication compliance and overall quality of life.PMID:38694853 | PMC:PMC11058386 | DOI:10.18502/ijph.v53i1.14689 (Source: Cancer Control)
Source: Cancer Control - May 2, 2024 Category: Cancer & Oncology Authors: Xinlong Zhang Shaolei Lang Fei Liu Source Type: research
A physiologically ‐based pharmacokinetic precision dosing approach to manage dasatinib drug–drug interactions
AbstractDasatinib, a second-generation tyrosine kinase inhibitor, is approved for treating chronic myeloid and acute lymphoblastic leukemia. As a sensitive cytochrome P450 (CYP) 3A4 substrate and weak base with strong pH-sensitive solubility, dasatinib is susceptible to enzyme-mediated drug –drug interactions (DDIs) with CYP3A4 perpetrators and pH-dependent DDIs with acid-reducing agents. This work aimed to develop a whole-body physiologically-based pharmacokinetic (PBPK) model of dasatinib to describe and predict enzyme-mediated and pH-dependent DDIs, to evaluate the impact of stron g and moderate CYP3A4 inhibitors and ...
Source: CPT: Pharmacometrics and Systems Pharmacology - May 2, 2024 Category: Drugs & Pharmacology Authors: Christina Kovar,
Helena Leonie Hanae Loer,
Simeon R üdesheim,
Laura Maria Fuhr,
Fatima Zahra Marok,
Dominik Selzer,
Matthias Schwab,
Thorsten Lehr Tags: ARTICLE Source Type: research
Real ‐world safety and effectiveness of anamorelin for cancer cachexia: Interim analysis of post‐marketing surveillance in Japan
ConclusionThe overall safety of anamorelin raised no new safety concerns, although continued caution may be required for hyperglycemia and nausea. Improvements in BW and appetite were also observed in real-world clinical settings. (Source: Cancer Medicine)
Source: Cancer Medicine - May 2, 2024 Category: Cancer & Oncology Authors: Koichi Takayama,
Ai Kojima,
Chikara Honda,
Masahiro Nakayama,
Satomi Kanemata,
Toshimitsu Endo,
Kei Muro Tags: RESEARCH ARTICLE Source Type: research
LncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer
LncRNA PCED1B-AS1 is abnormally expressed in multiple cancers and has been confirmed as an oncogene. Our study aimed to investigate the regulatory mechanism of lncRNA PCED1B-AS1 in gastric cancer. (Source: Biology Direct)
Source: Biology Direct - May 2, 2024 Category: Biology Authors: Jia Cao, Yicheng Yang, Bensong Duan, Haibin Zhang, Qinwei Xu, Junyi Han and Bing Lu Tags: Research Source Type: research
