Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Agreements between GLIM using left calf circumference as criterion for reduced muscle mass and PG-SGA, and GLIM using ASMI for the diagnosis of malnutrition in gastric cancer patients
CONCLUSION: the agreements were both acceptable between GLIM using left CC and PG-SGA, and GLIM using ASMI. Left calf circumference can be one of the credible references indicating a reduced muscle mass in patients with gastric cancer.PMID:38666329 | DOI:10.20960/nh.05024 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Liang Fu Xiaoqian Xu Yaoqi Zhang Jianxiang Jin Sha Zhu Haixia Shi Qiaohui Guan Lijun Zhang Yanting Hu Bo Zhuang Lushan Zheng Xianghong Ye Source Type: research
Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Agreements between GLIM using left calf circumference as criterion for reduced muscle mass and PG-SGA, and GLIM using ASMI for the diagnosis of malnutrition in gastric cancer patients
CONCLUSION: the agreements were both acceptable between GLIM using left CC and PG-SGA, and GLIM using ASMI. Left calf circumference can be one of the credible references indicating a reduced muscle mass in patients with gastric cancer.PMID:38666329 | DOI:10.20960/nh.05024 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Liang Fu Xiaoqian Xu Yaoqi Zhang Jianxiang Jin Sha Zhu Haixia Shi Qiaohui Guan Lijun Zhang Yanting Hu Bo Zhuang Lushan Zheng Xianghong Ye Source Type: research
Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Agreements between GLIM using left calf circumference as criterion for reduced muscle mass and PG-SGA, and GLIM using ASMI for the diagnosis of malnutrition in gastric cancer patients
CONCLUSION: the agreements were both acceptable between GLIM using left CC and PG-SGA, and GLIM using ASMI. Left calf circumference can be one of the credible references indicating a reduced muscle mass in patients with gastric cancer.PMID:38666329 | DOI:10.20960/nh.05024 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Liang Fu Xiaoqian Xu Yaoqi Zhang Jianxiang Jin Sha Zhu Haixia Shi Qiaohui Guan Lijun Zhang Yanting Hu Bo Zhuang Lushan Zheng Xianghong Ye Source Type: research
Coordination environment dependence of anticancer activity in cyclometalated bismuth(III) complexes with C,O-chelating ligands
J Inorg Biochem. 2024 Apr 21;256:112571. doi: 10.1016/j.jinorgbio.2024.112571. Online ahead of print.ABSTRACTIn this paper, a series of cyclometalated bismuth(III) complexes bearing C,O-bidentate ligands were synthesized and characterized by techniques such as UV-vis, NMR, HRMS, and single crystal X-ray diffraction. Meanwhile, their cytotoxicities against various human cell lines, including colon cancer cells (HCT-116), breast cancer cells (MDA-MB-231), lung cancer cells (A549), gastric cancer cells (SGC-7901), and normal embryonic kidney cells (HEK-293) were assessed in vitro. Compared with the clinical cisplatin, most of...
Source: Journal of Inorganic Biochemistry - April 26, 2024 Category: Biochemistry Authors: Jian Lei Yongping Liu Mingming Yin Shan Li Zixiu Wang Yi Chen Source Type: research
Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Agreements between GLIM using left calf circumference as criterion for reduced muscle mass and PG-SGA, and GLIM using ASMI for the diagnosis of malnutrition in gastric cancer patients
CONCLUSION: the agreements were both acceptable between GLIM using left CC and PG-SGA, and GLIM using ASMI. Left calf circumference can be one of the credible references indicating a reduced muscle mass in patients with gastric cancer.PMID:38666329 | DOI:10.20960/nh.05024 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Liang Fu Xiaoqian Xu Yaoqi Zhang Jianxiang Jin Sha Zhu Haixia Shi Qiaohui Guan Lijun Zhang Yanting Hu Bo Zhuang Lushan Zheng Xianghong Ye Source Type: research
Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer
Cancer Res Commun. 2024 Apr 25. doi: 10.1158/2767-9764.CRC-23-0639. Online ahead of print.ABSTRACTAnticancer drug-tolerant persister (DTP) cells at an early phase of chemotherapy reshape refractory tumors. Aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is commonly upregulated by various anticancer drugs in gastric cancer patient-derived cells (PDCs) and promotes tumor growth. However, the mechanism underlying the generation of ALDH1A3-positive DTP cells remains elusive. Here, we investigated the mechanism of ALDH1A3 expression and a combination therapy targeting gastric cancer DTP cells. We found that gastric cancer t...
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Jin Lee Tetsuo Mashima Naomi Kawata Noriko Yamamoto Shun Morino Saori Inaba Ayane Nakamura Koshi Kumagai Takeru Wakatsuki Kengo Takeuchi Kensei Yamaguchi Hiroyuki Seimiya Source Type: research
Stool protein mass spectrometry identifies biomarkers for the early detection of diffuse-type gastric cancer
We examined whether the stool proteome of mouse models of GC or individuals with hereditary diffuse GC (HDGC) have utility as biomarkers for early detection. Proteomic mass spectrometry of stool from a genetically engineered mouse model driven by oncogenic KrasG12D and loss of p53 and Cdh1 in gastric parietal cells (known as TCON mice) identified differentially abundant proteins compared to littermate controls. Immunoblot assays validated a panel of proteins including actinin alpha 4 (ACTN4), N-acylsphingosine amidohydrolase 2 (ASAH2), dipeptidyl peptidase 4 (DPP4), and valosin-containing protein (VCP) as enriched in TCON ...
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Chi-Lee C Ho Michael B Gilbert Guillaume Urtecho Hyoungjoo Lee David A Drew Samuel J Klempner Jin S Cho Thomas J Ryan Naryan Rustgi Hyuk Lee Jeeyun Lee Alexander Caraballo Marina V Magicheva-Gupta Carmen Rios Alice E Shin Yuen-Yi Tseng Jeremy L Davis Dani Source Type: research
Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Coordination environment dependence of anticancer activity in cyclometalated bismuth(III) complexes with C,O-chelating ligands
J Inorg Biochem. 2024 Apr 21;256:112571. doi: 10.1016/j.jinorgbio.2024.112571. Online ahead of print.ABSTRACTIn this paper, a series of cyclometalated bismuth(III) complexes bearing C,O-bidentate ligands were synthesized and characterized by techniques such as UV-vis, NMR, HRMS, and single crystal X-ray diffraction. Meanwhile, their cytotoxicities against various human cell lines, including colon cancer cells (HCT-116), breast cancer cells (MDA-MB-231), lung cancer cells (A549), gastric cancer cells (SGC-7901), and normal embryonic kidney cells (HEK-293) were assessed in vitro. Compared with the clinical cisplatin, most of...
Source: Journal of Inorganic Biochemistry - April 26, 2024 Category: Biochemistry Authors: Jian Lei Yongping Liu Mingming Yin Shan Li Zixiu Wang Yi Chen Source Type: research
Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Selenochemical modification of low molecular weight polysaccharides from Grifola frondosa and the mechanism of their inhibitory effects on gastric cancer cells
In this study, Se-LMW-GFP was prepared by the HNO3-Na2SeO3 method, and the structures of LMW-GFP and Se-LMW-GFP were characterized by UV-visible spectroscopy of absorption, FTIR spectroscopy, and electron scanning microscopy, and these structural analyses showed that selenium was successfully complexed to LMW-GFP. The selenium content of Se-LMW-GFP was measured to be 2.08 % ± 0.08 % by ICP-MS. The anti-tumor activity of LMW-GFP before and after selenium modification was compared by cellular experiments, and the findings indicated that the anti-tumor activity of Se-LMW-GFP was considerably improved over that of LMW-GFP, an...
Source: International Journal of Biological Macromolecules - April 26, 2024 Category: Biochemistry Authors: Yao Huo Wen-Jie Ding Yan-Ru Liu Zhen-Tong Li Ke-Yao Dai Chao Liu Hai-Yu Ji An-Jun Liu Source Type: research
