Heritability of cancers in Japanese population: Estimation from recent cohort data
Clin Genet. 2024 Apr 29. doi: 10.1111/cge.14535. Online ahead of print.ABSTRACTCancers are genetically categorized into common diseases showing a so-called multifactorial inheritance except for rare familial cancers. And as a measure to estimate the strength of genetic factors in the multifactorial diseases, heritability (h2) is generally used. However, there have been few reports on the estimation of heritability for cancers. We calculated the heritability from the incidence in subject population and the familial recurrence rate in first-degree relatives of the affected for cancers quoting the data from a large-scale pros...
Source: Clinical Genetics - April 30, 2024 Category: Genetics & Stem Cells Authors: Yoshiro Nagao Kei Takeshita Source Type: research
Heritability of cancers in Japanese population: Estimation from recent cohort data
Clin Genet. 2024 Apr 29. doi: 10.1111/cge.14535. Online ahead of print.ABSTRACTCancers are genetically categorized into common diseases showing a so-called multifactorial inheritance except for rare familial cancers. And as a measure to estimate the strength of genetic factors in the multifactorial diseases, heritability (h2) is generally used. However, there have been few reports on the estimation of heritability for cancers. We calculated the heritability from the incidence in subject population and the familial recurrence rate in first-degree relatives of the affected for cancers quoting the data from a large-scale pros...
Source: Clinical Lung Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Yoshiro Nagao Kei Takeshita Source Type: research
PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs; approval of elranatamab for multiple myeloma, CPX-351 for myeloid leukemia, inotuzumab ozogamicin for lymphoblastic leukemia, capivasertib for breast cancer, and zolbetuximab for gastric cancer in Japan
Int J Clin Oncol. 2024 Apr 30. doi: 10.1007/s10147-024-02531-1. Online ahead of print.NO ABSTRACTPMID:38687406 | DOI:10.1007/s10147-024-02531-1 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Noriomi Matsumura Masaki Mandai Source Type: research
PMDA regulatory update on approval and revision of the precautions for use of anticancer drugs; approval of elranatamab for multiple myeloma, CPX-351 for myeloid leukemia, inotuzumab ozogamicin for lymphoblastic leukemia, capivasertib for breast cancer, and zolbetuximab for gastric cancer in Japan
Int J Clin Oncol. 2024 Apr 30. doi: 10.1007/s10147-024-02531-1. Online ahead of print.NO ABSTRACTPMID:38687406 | DOI:10.1007/s10147-024-02531-1 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Noriomi Matsumura Masaki Mandai Source Type: research
Successful treatment with nivolumab in a patient with gastric cancer with severe liver failure resulting from multiple liver metastases: A case report
Oncol Lett. 2024 Apr 18;27(6):271. doi: 10.3892/ol.2024.14404. eCollection 2024 Jun.ABSTRACTGastric cancer (GC) is a globally prevalent and deadly malignancy often diagnosed at advanced stages, which can be accompanied by liver metastases. Conventional chemotherapy is contraindicated in patients with severe liver failure because several chemotherapeutic agents are metabolized by the liver. The present study reports on the successful use of nivolumab in a patient with advanced GC and severe liver failure owing to multiple liver metastases. A 57-year-old man was admitted to Shimane Prefectural Central Hospital (Izumo, Japan)...
Source: Oncology Letters - April 30, 2024 Category: Cancer & Oncology Authors: Fumiyoshi Ikejiri Kanako Yokomizo Kenji Tamura Source Type: research
Free TcO4- in 99mTc-PSMA Scan: A Case Report and Review of an Old Pitfall in the New Era of Modern Imaging
Clin Nucl Med. 2024 Apr 30. doi: 10.1097/RLU.0000000000005240. Online ahead of print.ABSTRACTIn a recent 99mTc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO4- in the injected vial. The scans were repeated after confirming acceptable radiopharmaceutical purity of 97% (normal range, 95%-100%). Interestingly, 1 patient had liver metastases at presentation, which remained non-PSMA-avid after repeating the scan. We...
Source: Clinical Prostate Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Pegah Sahafi Kamran Aryana Soroush Zarehparvar Moghadam Kayvan Sadri Emran Askari Source Type: research
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF- β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells
CONCLUSION: In this study, we found that EBV-miRNA-BART6-5p can target SMAD4, effectively increasing glycolysis in gastric cancer cells by regulating the TGF-β/SMAD4 signaling pathway, thereby enhancing the proliferation and metastasis of gastric cancer cells. Our findings may offer new insights into the metabolic aspects of gastric cancer.PMID:38686046 | PMC:PMC11055990 | DOI:10.32604/or.2024.046679 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Xuhui Zhao Xiaomin Huang Chunyan Dang Xia Wang Yujiao Qi Hongling Li Source Type: research
Circ_PABPC1 promotes the malignancy of gastric cancer through interacting with ILK to activate NF- κB pathway
CONCLUSION: circ_PABPC1 promotes the malignancy of GC cells through binding to ILK to activate NF-κB signaling pathway .PMID:38688434 | DOI:10.1016/j.yexcr.2024.114058 (Source: Experimental Cell Research)
Source: Experimental Cell Research - April 30, 2024 Category: Cytology Authors: Siqi Yan Zhu Wang Dongqiang Lan Junjie Niu Xiaolan Jian Fengjiao He Weizhi Tang Chunhong Hu Wei Liu Source Type: research
Retraction of: PHTF2 regulates lipids metabolism in gastric cancer
Aging (Albany NY). 2024 Apr 30;16(8):7507. doi: 10.18632/aging.205842. Epub 2024 Apr 30.NO ABSTRACTPMID:38688693 | DOI:10.18632/aging.205842 (Source: Aging)
Source: Aging - April 30, 2024 Category: Biomedical Science Authors: Yuhua Chi Haiyan Wang Fengsong Wang Mingcui Ding Source Type: research
Circ_PABPC1 promotes the malignancy of gastric cancer through interacting with ILK to activate NF- κB pathway
CONCLUSION: circ_PABPC1 promotes the malignancy of GC cells through binding to ILK to activate NF-κB signaling pathway .PMID:38688434 | DOI:10.1016/j.yexcr.2024.114058 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Siqi Yan Zhu Wang Dongqiang Lan Junjie Niu Xiaolan Jian Fengjiao He Weizhi Tang Chunhong Hu Wei Liu Source Type: research
Exploring the Antitumor Efficacy of PEGylated Liposomes Loaded with Licorice Extract for Cancer Therapy
CONCLUSION: These results have been corroborated by apoptosis assays, which have demonstrated GA PEG-Lip and Lic PEG-Lip to induce stronger apoptotic effects compared to free GA and Lic on both PC-3 and AGS cells. This study has underscored the potential of encapsulating GA and Lic in PEG-Lip as a promising strategy to augment their anticancer efficacy against prostate and gastric cancers.PMID:38685810 | DOI:10.2174/0115680096292153240416115744 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - April 30, 2024 Category: Cancer & Oncology Authors: Zeinab Azizi Haghighat Aliakbar Safekordi Mehdi Ardjmand Azim Akbarzadeh Source Type: research
EBV-Associated Gastric Cancer; An In Situ Hybridization Assay on Tissue Microarray: A Multi-Region Study from Four Major Provinces of Iran
CONCLUSION: EBV-associated gastric adenocarcinoma has a low prevalence in Iran. This finding can be due to epidemiologic differences in risk factors and exposures, and the low number of gastric medullary carcinomas in the population. It may also be related to gastric tumor heterogeneity not detected with the TMA technique.PMID:38685845 | DOI:10.34172/aim.2024.28 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Maryam Abolhasani Ata Ollah Mohseni Ramin Shakeri Ali Khavanin Mehrdad Khajehei Abbasali Omidi Bita Geramizadeh Ensieh Shafigh Farshad Naghshvar Payam Fathizadeh Leyla Taghizadehgan Atoosa Gharib Margaret L Gulley Sanford M Dawsey Reza Malekzadeh Charles Source Type: research
Heritability of cancers in Japanese population: Estimation from recent cohort data
Clin Genet. 2024 Apr 29. doi: 10.1111/cge.14535. Online ahead of print.ABSTRACTCancers are genetically categorized into common diseases showing a so-called multifactorial inheritance except for rare familial cancers. And as a measure to estimate the strength of genetic factors in the multifactorial diseases, heritability (h2) is generally used. However, there have been few reports on the estimation of heritability for cancers. We calculated the heritability from the incidence in subject population and the familial recurrence rate in first-degree relatives of the affected for cancers quoting the data from a large-scale pros...
Source: Clinical Genetics - April 30, 2024 Category: Genetics & Stem Cells Authors: Yoshiro Nagao Kei Takeshita Source Type: research
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF- β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells
CONCLUSION: In this study, we found that EBV-miRNA-BART6-5p can target SMAD4, effectively increasing glycolysis in gastric cancer cells by regulating the TGF-β/SMAD4 signaling pathway, thereby enhancing the proliferation and metastasis of gastric cancer cells. Our findings may offer new insights into the metabolic aspects of gastric cancer.PMID:38686046 | PMC:PMC11055990 | DOI:10.32604/or.2024.046679 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Xuhui Zhao Xiaomin Huang Chunyan Dang Xia Wang Yujiao Qi Hongling Li Source Type: research
Free TcO4- in 99mTc-PSMA Scan: A Case Report and Review of an Old Pitfall in the New Era of Modern Imaging
Clin Nucl Med. 2024 Apr 30. doi: 10.1097/RLU.0000000000005240. Online ahead of print.ABSTRACTIn a recent 99mTc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO4- in the injected vial. The scans were repeated after confirming acceptable radiopharmaceutical purity of 97% (normal range, 95%-100%). Interestingly, 1 patient had liver metastases at presentation, which remained non-PSMA-avid after repeating the scan. We...
Source: Clinical Prostate Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Pegah Sahafi Kamran Aryana Soroush Zarehparvar Moghadam Kayvan Sadri Emran Askari Source Type: research
