Coordination environment dependence of anticancer activity in cyclometalated bismuth(III) complexes with C,O-chelating ligands
J Inorg Biochem. 2024 Apr 21;256:112571. doi: 10.1016/j.jinorgbio.2024.112571. Online ahead of print.ABSTRACTIn this paper, a series of cyclometalated bismuth(III) complexes bearing C,O-bidentate ligands were synthesized and characterized by techniques such as UV-vis, NMR, HRMS, and single crystal X-ray diffraction. Meanwhile, their cytotoxicities against various human cell lines, including colon cancer cells (HCT-116), breast cancer cells (MDA-MB-231), lung cancer cells (A549), gastric cancer cells (SGC-7901), and normal embryonic kidney cells (HEK-293) were assessed in vitro. Compared with the clinical cisplatin, most of...
Source: Journal of Inorganic Biochemistry - April 26, 2024 Category: Biochemistry Authors: Jian Lei Yongping Liu Mingming Yin Shan Li Zixiu Wang Yi Chen Source Type: research
Role of Filamin A in Growth and Migration of Breast Cancer-Review
Curr Issues Mol Biol. 2024 Apr 17;46(4):3408-3423. doi: 10.3390/cimb46040214.ABSTRACTDespite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Patryk Zawadka Wioletta Zieli ńska Maciej Gagat Magdalena Izdebska Source Type: research
Selenochemical modification of low molecular weight polysaccharides from Grifola frondosa and the mechanism of their inhibitory effects on gastric cancer cells
In this study, Se-LMW-GFP was prepared by the HNO3-Na2SeO3 method, and the structures of LMW-GFP and Se-LMW-GFP were characterized by UV-visible spectroscopy of absorption, FTIR spectroscopy, and electron scanning microscopy, and these structural analyses showed that selenium was successfully complexed to LMW-GFP. The selenium content of Se-LMW-GFP was measured to be 2.08 % ± 0.08 % by ICP-MS. The anti-tumor activity of LMW-GFP before and after selenium modification was compared by cellular experiments, and the findings indicated that the anti-tumor activity of Se-LMW-GFP was considerably improved over that of LMW-GFP, an...
Source: International Journal of Biological Macromolecules - April 26, 2024 Category: Biochemistry Authors: Yao Huo Wen-Jie Ding Yan-Ru Liu Zhen-Tong Li Ke-Yao Dai Chao Liu Hai-Yu Ji An-Jun Liu Source Type: research
Agreements between GLIM using left calf circumference as criterion for reduced muscle mass and PG-SGA, and GLIM using ASMI for the diagnosis of malnutrition in gastric cancer patients
CONCLUSION: the agreements were both acceptable between GLIM using left CC and PG-SGA, and GLIM using ASMI. Left calf circumference can be one of the credible references indicating a reduced muscle mass in patients with gastric cancer.PMID:38666329 | DOI:10.20960/nh.05024 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Liang Fu Xiaoqian Xu Yaoqi Zhang Jianxiang Jin Sha Zhu Haixia Shi Qiaohui Guan Lijun Zhang Yanting Hu Bo Zhuang Lushan Zheng Xianghong Ye Source Type: research
Nanoparticle Polymeric Micellar Paclitaxel Versus Paclitaxel for Patients with Advanced Gastric Cancer
CONCLUSIONS: NPMP combined chemotherapy offers a new, active, and safe treatment for patients with AGC.PMID:38668776 | DOI:10.1007/s12029-024-01058-y (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Fei-Yu Wang Xiang-Ming Huang Yu-Qing Cao Jie Cao Jie Ni Ke Li Min Lu Xin-En Huang Source Type: research
Creatinine-to-cystatin C ratio and body composition predict response to PD-1 inhibitors-based combination treatment in metastatic gastric cancer
CONCLUSIONS: Low pre-treatment CCR and SATI were independently associated with lower response rates and worse survival in patients with metastatic GC receiving PD-1 inhibitors-based combination therapy.PMID:38665913 | PMC:PMC11043572 | DOI:10.3389/fimmu.2024.1364728 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Hongjuan Ji Bona Liu Peng Jin Yingchun Li Lili Cui Shanxiu Jin Jingran Wu Yongqi Shan Zhenyong Zhang Jian Ming Liang Zhang Cheng Du Source Type: research
The Impact of Infectious Mononucleosis History on the Risk of Developing Lymphoma and Nasopharyngeal Carcinoma: a Retrospective Large-Scale Cohort Study using National Health Insurance Data in South Korea
CONCLUSION: This study suggests that individuals with a history of IM have an elevated risk of developing lymphoma and NPC in South Korea, emphasizing the importance of vigilant follow-up and monitoring. The results advocate for heightened awareness and potential national monitoring policies to address the long-term health implications of EBV infection and to implement preventive measures.PMID:38665055 | DOI:10.4143/crt.2023.1356 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: So Hee Kang Yun-Hee Lee Jun-Pyo Myong Minsu Kwon Source Type: research
Nanoparticle Polymeric Micellar Paclitaxel Versus Paclitaxel for Patients with Advanced Gastric Cancer
ConclusionsNPMP combined chemotherapy offers a new, active, and safe treatment for patients with AGC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 26, 2024 Category: Cancer & Oncology Source Type: research
Risk factors and a nomogram for predicting local recurrence in adult patients with early gastric cancer after endoscopic submucosal dissection
Endoscopic submucosal dissection (ESD) is an effective treatment method for early gastric cancers. The aim of this study was to evaluate the risk factors of recurrence for patients with early gastric cancer after ESD and construct a nomogram for predicting recurrence. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 26, 2024 Category: Gastroenterology Authors: Shaoya Li, Ainun Nahar, Qian Zhang, Jie Xing, Peng Li, Shutian Zhang, Xiujing Sun Tags: Oncology Source Type: research
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7
Cell Death & Disease, Published online: 26 April 2024; doi:10.1038/s41419-024-06666-xACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7 (Source: Cell death and disease)
Source: Cell death and disease - April 26, 2024 Category: Internal Medicine Authors: Mengmeng Zhang Fenglin Cai Jiamei Guo Siya Liu Gang Ma Mingzhi Cai Rupeng Zhang Jingyu Deng Source Type: research
Impact of abdominal compression on heart and stomach motion for stereotactic arrhythmia radioablation
CONCLUSIONS: AC was not a consistent motion management method for STAR, nor does not uniformly affect the separation distance between LVCs and the stomach. If AC is employed in future STAR protocols, the motion of the target volume and its relative distance to the stomach should be compared on two 4DCTs: one while the patient is FB and one under AC.PMID:38661250 | DOI:10.1002/acm2.14346 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 25, 2024 Category: Information Technology Authors: Daniel David Cecchi Nicolas Paul Ploquin Salman Faruqi Hali Morrison Source Type: research
Comparison of the Efficacy of 12-day Concomitant Quadruple Therapy versus 14-day High dose Dual Therapy as a First-line < em > H. pylori < /em > Eradication Regimen
CONCLUSIONS: Twelve-day concomitant therapy seems to be an acceptable regimen for first-line H. pylori eradication in Iran, a country with a high rate of antibiotic resistance. Although, high dose dual therapy did not result in an ideal eradication rate, but it had fewer drug side effects than the 12-day concomitant regimen.PMID:38659251 | DOI:10.4166/kjg.2024.012 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - April 25, 2024 Category: Gastroenterology Authors: Seyed Mohammad Valizadeh Toosi Sahar Feyzi Arash Kazemi Source Type: research
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression
Int Rev Cell Mol Biol. 2024;385:41-99. doi: 10.1016/bs.ircmb.2023.11.006. Epub 2024 Jan 15.ABSTRACTGastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in i...
Source: International Review of Cell and Molecular Biology - April 25, 2024 Category: Cytology Authors: Afza Ahmad Rohit Kumar Tiwari Saleha Siddiqui Muskan Chadha Ratnakar Shukla Vivek Srivastava Source Type: research
Impact of abdominal compression on heart and stomach motion for stereotactic arrhythmia radioablation
CONCLUSIONS: AC was not a consistent motion management method for STAR, nor does not uniformly affect the separation distance between LVCs and the stomach. If AC is employed in future STAR protocols, the motion of the target volume and its relative distance to the stomach should be compared on two 4DCTs: one while the patient is FB and one under AC.PMID:38661250 | DOI:10.1002/acm2.14346 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 25, 2024 Category: Information Technology Authors: Daniel David Cecchi Nicolas Paul Ploquin Salman Faruqi Hali Morrison Source Type: research
Comparison of the Efficacy of 12-day Concomitant Quadruple Therapy versus 14-day High dose Dual Therapy as a First-line < em > H. pylori < /em > Eradication Regimen
CONCLUSIONS: Twelve-day concomitant therapy seems to be an acceptable regimen for first-line H. pylori eradication in Iran, a country with a high rate of antibiotic resistance. Although, high dose dual therapy did not result in an ideal eradication rate, but it had fewer drug side effects than the 12-day concomitant regimen.PMID:38659251 | DOI:10.4166/kjg.2024.012 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - April 25, 2024 Category: Gastroenterology Authors: Seyed Mohammad Valizadeh Toosi Sahar Feyzi Arash Kazemi Source Type: research
