Cancers, Vol. 16, Pages 1636: Heterocellular Adhesion in Cancer Invasion and Metastasis: Interactions between Cancer Cells and Cancer-Associated Fibroblasts
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Cancer invasion is a requisite for the most malignant progression of cancer, that is, metastasis. The mechanisms of cancer invasion were originally studied using in vitro cell culture systems, in which cancer cells were cultured using artificial extracellular matrices (ECMs). However, conventional culture systems do not precisely recapitulate in vivo cancer invasion because the phenotypes of cancer cells in tumor tissues are strongly affected by the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are the most abundant cell type in the TME and accelerate cancer progression through invasion, metast...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Hideki Yamaguchi Makoto Miyazaki Tags: Review Source Type: research
Pancreatitis after Percutaneous Transhepatic Biliary Intervention
A 50-year-old man who had undergone distal gastrectomy and adjuvant chemotherapy for gastric adenocarcinoma presented with new hyperbilirubinemia and biliary ductal dilation (Fig 1a, black arrow) secondary to a common bile duct (CBD) mass (Fig 1a, white arrow). Owing to his gastrojejunostomy (Fig 1a, open arrow), he was not a candidate for endoscopic retrograde cholangiopancreatography. A percutaneous transhepatic cholangiogram confirmed abrupt truncation of the CBD (Fig 1b, white arrow), and a brush biopsy (Cellebrity Cytology Brush; Boston Scientific, Marlborough, Massachsetts) was performed (Fig 1b, black arrow) bef...
Source: Journal of Vascular and Interventional Radiology : JVIR - April 23, 2024 Category: Radiology Authors: Jacob DePolo, Alexander Miller, Joseph Buchholz, James Ronald Tags: Lessons in IR: M & Source Type: research
GSE173219 High-throughput sequencing of oxidative stress for Human gastric cancer cell lines treatment with Bioactive polypeptide chelating selenium (ACBP-S-Se)
Contributor : Xiulan SuSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThe functional gene analyses revealed 911 upregulated genes and 1122 downregulated genes after ACBP-S-Se treatment in MKN-45 cells. From the functional enrichment analyses of oxidative stress-related genes, a total of 75 genes with significant differences were selected . From the gene interaction mapping, CDKN1A, CCNB1, TXN and MAP3K5 were extracted due to the roles of most genes with which they associate and to the significantly enriched pathways, which can...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells
Cell Death & Disease, Published online: 23 April 2024; doi:10.1038/s41419-024-06673-yCMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells (Source: Cell death and disease)
Source: Cell death and disease - April 23, 2024 Category: Internal Medicine Authors: Ruinan Zhao Xiangyu Guo Guohao Zhang Sen Liu Ranran Ma Mengqi Wang Shiming Chen Wenjie Zhu Yuan Liu Peng Gao Haiting Liu Source Type: research
Outcomes of endoscopic submucosal dissection of early gastric cancer neoplasia in the West and change in the absolute indications
Endoscopy 2024; 56: 390-390 DOI: 10.1055/a-2215-5644 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Endoscopy)
Source: Endoscopy - April 23, 2024 Category: Gastroenterology Authors: Fern ández-Esparrach, Glòria Mar ín-Gabriel, José C. Tags: Letter to the editor Source Type: research
Causal relationships of Helicobacter pylori and related gastrointestinal diseases on Type 2 diabetes: Univariable and Multivariable Mendelian randomization
ConclusionOur study found that H. pylori IgG antibody, H. pylori GroEL antibody, gastroduodenal ulcer and chronic gastritis are all related to t T2DM, and blood glucose level and obesity mediate the development of H. pylori GroEL antibody and gastroduodenal ulcer on T2DM, respectively. These findings may inform new prevention and intervention strategies for T2DM. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Mei Sun Source Type: research
Improving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid
Oncogene, Published online: 23 April 2024; doi:10.1038/s41388-024-03034-zImproving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastases: tumor-guided cell-free DNA analysis of peritoneal fluid (Source: Oncogene)
Source: Oncogene - April 23, 2024 Category: Cancer & Oncology Authors: Karen van der Sluis Johanna W. van Sandick Marieke A. Vollebergh Jolanda M. van Dieren Niek Hugen Koen J. Hartemink Alexander A. F. A. Veenhof Els Verhoeven Jos é G. van den Berg Petur Snaebjornsson Michael Noe Tom van Wezel Mirjam C. Boelens Liudmila L. Source Type: research
Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan
ConclusionsThe GNRI is a promising predictor of both short- and long-term outcomes in older patients with RGC. (Source: Surgery Today)
Source: Surgery Today - April 23, 2024 Category: Surgery Source Type: research
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
ConclusionThese findings provide new insights into reconstruction methods after proximal gastrectomy by assessing postoperative hypoglycemia in non-diabetic patients with gastric cancer. (Source: Surgery Today)
Source: Surgery Today - April 23, 2024 Category: Surgery Source Type: research
Cancers, Vol. 16, Pages 1620: Short-Term Outcomes Analysis Comparing Open, Laparoscopic, Laparoscopic-Assisted, and Robotic Distal Gastrectomy for Locally Advanced Gastric Cancer: A Randomized Trials Network Analysis
Conclusions. LapAs-DG, Lap-DG, and Rob-DG performed in referral centers by dedicated surgeons have comparable short-term outcomes to Op-DG for locally AGC. (Source: Cancers)
Source: Cancers - April 23, 2024 Category: Cancer & Oncology Authors: Michele Manara Alberto Aiolfi Andrea Sozzi Matteo Cal ì Federica Grasso Emanuele Rausa Gianluca Bonitta Luigi Bonavina Davide Bona Tags: Systematic Review Source Type: research
Correction: Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
Int J Clin Oncol. 2024 Apr 22. doi: 10.1007/s10147-024-02525-z. Online ahead of print.ABSTRACTThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several tr...
Source: Clinical Colorectal Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Koji Kono Shotaro Nakajima Kosaku Mimura Source Type: research
Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants
CONCLUSIONS: In this largest prospective study to date on family history and gastric cancer, a familial background of gastric cancer increased the risk of gastric cancer in the Asian population. Targeted education, screening, and intervention in these high-risk groups may reduce the burden of gastric cancer.PMID:38649672 | DOI:10.1007/s10120-024-01499-1 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Dan Huang Minkyo Song Sarah Krull Abe Md Shafiur Rahman Md Rashedul Islam Eiko Saito Katherine De la Torre Norie Sawada Akiko Tamakoshi Xiao-Ou Shu Hui Cai Atsushi Hozawa Seiki Kanemura Jeongseon Kim Yu Chen Hidemi Ito Yumi Sugawara Sue K Park Myung-Hee S Source Type: research
Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring
CONCLUSION: These findings provide new insights into reconstruction methods after proximal gastrectomy by assessing postoperative hypoglycemia in non-diabetic patients with gastric cancer.PMID:38649530 | DOI:10.1007/s00595-024-02845-7 (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Katsutoshi Shoda Takeshi Kubota Yoshihiko Kawaguchi Hidenori Akaike Suguru Maruyama Yudai Higuchi Takashi Nakayama Ryo Saito Koichi Takiguchi Shinji Furuya Kensuke Shiraishi Hidetake Amemiya Hiromichi Kawaida Daisuke Ichikawa Source Type: research
Biomarker-oriented chemo-immunotherapy for advanced gastric cancer
Int J Clin Oncol. 2024 Apr 22. doi: 10.1007/s10147-024-02525-z. Online ahead of print.ABSTRACTThe biomarker-oriented chemo-immunotherapy is useful and promising in the development of new anticancer agents, since the responders can be enriched by selecting patients with biomarkers. Compared to colorectal and lung cancers, the development of biomarker-driven molecular-targeted therapeutics for gastric cancers has been straggled. However, several new biomarkers in gastric cancers have been discovered and clinical trials in enrichment design with certain biomarkers have been conducted. Therefore, there are currently several tr...
Source: Clinical Lung Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Koji Kono Shotaro Nakajima Kosaku Mimura Source Type: research
