High Frequency of Autoantibodies in COVID-19 Patients with Central Nervous System Complications: a Multicenter Observational Study
We present a panel of central nervous system (CNS) complications associated with coronavirus disease 2019 (COVID-19) and their clinical characteristics. We aim to investigate associations between neurological autoantibodies and COVID-19 patients with predominant CNS complications. In this retrospective multi-center study, we analyze neurologic complications associated with COVID-19 patients from Dec. 2022 to Feb. 2023 at four tertiary hospitals in China. CSF and/or serum in the enrolled patients were tested for autoantibodies using tissue-based assays (TBAs) and cell-based assays (CBAs). A total of 34 consecutive patients ...
Source: Molecular Neurobiology - March 20, 2024 Category: Neurology Source Type: research
Cytomegalovirus Treatment in Solid Organ Transplantation: An Update on Current Approaches
CONCLUSIONS: Selection of CMV antiviral treatment should be determined by patient-specific factors, including severity of illness, resistant or refractory disease, dose-limiting adverse effects, and the preferred route of administration.PMID:38501850 | DOI:10.1177/10600280241237534 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 19, 2024 Category: Drugs & Pharmacology Authors: Karen L Hardinger Daniel C Brennan Source Type: research
CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - March 18, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
GSE254432 CCR2 and CCR7 promote inflammatory monocyte recruitment through synergistic roles during encephalitic virus infection, but the monocyte response in the brain is dependent on the infecting virus
Contributors : Clayton W Winkler ; Alyssa B Evans ; Aaron B Carmody ; Justin B Lack ; Tyson A Woods ; Karin E PetersonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory monocytes (iMO) migrate from the bone marrow to the brain during viral encephalitis. For many viruses, including Herpes simplex virus type-1 (HSV), iMO recruitment is dependent on the chemokine receptor CCR2. However, La Crosse virus (LACV) induces iMO recruitment independent of CCR2. Comparison of iMOs from HSV and LACV-infected mice showed higher expression of the g protein-coupled receptor CCR7 in LACV-ind...
Source: GEO: Gene Expression Omnibus - March 18, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Type I interferon signaling, cognition and neurodegeneration following COVID-19: update on a mechanistic pathogenetic model with implications for Alzheimer ’s disease
COVID-19’s effects on the human brain reveal a multifactorial impact on cognition and the potential to inflict lasting neuronal damage. Type I interferon signaling, a pathway that represents our defense against pathogens, is primarily affected by COVID-19. Type I interferon signaling, however, is known to mediate cognitive dysfunction upon its dysregulation following synaptopathy, microgliosis and neuronal damage. In previous studies, we proposed a model of outside-in dysregulation of tonic IFN-I signaling in the brain following a COVID-19. This disruption would be mediated by the crosstalk between central and peripheral...
Source: Frontiers in Human Neuroscience - March 18, 2024 Category: Neuroscience Source Type: research
B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential
Autoimmune encephalitis (AE) broadly refers to inflammation of the brain parenchyma mediated by autoimmune mechanisms. In most patients with AE, autoantibodies against neuronal cell surface antigens are produced by B-cells and induce neuronal dysfunction through various mechanisms, ultimately leading to disease progression. In recent years, B-cell targeted therapies, including monoclonal antibody (mAb) therapy and chimeric antigen receptor T-cell (CAR-T) therapy, have been widely used in autoimmune diseases. These therapies decrease autoantibody levels in patients and have shown favorable results. This review summarizes th...
Source: Frontiers in Immunology - March 18, 2024 Category: Allergy & Immunology Source Type: research
Bickerstaff brain stem encephalitis preceding recurrent myelin oligodendrocyte glycoprotein antibody-associated disease
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - March 18, 2024 Category: Neurology Source Type: research
Sequential onset of anti-HU-related paraneoplastic sensory polyneuropathy and limbic encephalitis in pancreatic neuroendocrine tumour: a case report
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - March 18, 2024 Category: Neurology Source Type: research
Magnetic Resonance Imaging Characteristics of LGI1-Antibody and CASPR2-Antibody Encephalitis
This cross-sectional study examines findings from brain magnetic resonance imaging to identify the characteristics than can distinguish LGI1-antibody and CASPR2-antibody autoimmune encephalitis from viral encephalitis and Creutzfeldt-Jakob disease (Source: JAMA Neurology)
Source: JAMA Neurology - March 18, 2024 Category: Neurology Source Type: research
Movement disorders associated with pediatric encephalitis
Handb Clin Neurol. 2024;200:229-238. doi: 10.1016/B978-0-12-823912-4.00018-9.ABSTRACTNew onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required. Movement disorders...
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Russell C Dale Shekeeb S Mohammad Source Type: research
Safety and immunogenicity of a novel trivalent recombinant MVA-based equine encephalitis virus vaccine: A Phase 1 clinical trial
CONCLUSION: The study demonstrated that MVA-BN-WEV is well tolerated, induces immune responses, and is suitable for further development.CLINICAL TRIAL REGISTRY NUMBER: NCT04131595.PMID:38494412 | DOI:10.1016/j.vaccine.2024.03.011 (Source: Vaccine)
Source: Vaccine - March 17, 2024 Category: Allergy & Immunology Authors: Carlos Fierro Heinz Weidenthaler Sanja Vidojkovic Darja Schmidt Zarina Gafoor Daria Stroukova Susan Zwiers Jutta M üller Ariane Volkmann Source Type: research
Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Breast Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Genitourinary Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Movement disorders associated with pediatric encephalitis
Handb Clin Neurol. 2024;200:229-238. doi: 10.1016/B978-0-12-823912-4.00018-9.ABSTRACTNew onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required. Movement disorders...
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Russell C Dale Shekeeb S Mohammad Source Type: research
