Treatment Approaches in Pediatric Relapsing Autoimmune Encephalitis
AbstractPurpose of reviewAutoimmune encephalitis (AE) is increasingly recognized as a treatable cause of encephalitis in children. While prior observational studies demonstrate improved motor outcomes with early immunotherapy, less is known about long-term management and treatment for relapsing disease. In this review, we present current treatment approaches to pediatric AE, in particular relapse risk and treatment for relapsing AE in children.Recent findingsA recent meta-analysis of anti-NMDAR encephalitis demonstrated that disease onset in adolescence was associated with an increased odds of relapse whereas treatment wit...
Source: Current Treatment Options in Neurology - March 21, 2024 Category: Neurology Source Type: research
Gait instability, ophthalmoplegia, and chorea with orofacial dyskinesia in a man with anti-Ri antibodies: a case report
We report the rare manifestation of anti-Ri antibody-associated paraneoplastic neurological syndrome (PNS), and this case can alert us to the importance of respiratory management in this diverse neurologic disease. Furthermore, PNSs positive for anti-Ri antibodies should be added to the list of differential diagnoses of chorea with orofacial dyskinesia. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 20, 2024 Category: Neurology Source Type: research
IgLON5 autoimmunity in a patient with Creutzfeldt –Jakob disease: case report and review of literature
ConclusionIgLON5 Abs may be observed in patients with a diagnosis of CJD; it is unknown whether a synergistic effect of IgLON5 Abs with CJD exists, increasing neurodegenerative changes. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 20, 2024 Category: Neurology Source Type: research
High Frequency of Autoantibodies in COVID-19 Patients with Central Nervous System Complications: a Multicenter Observational Study
We present a panel of central nervous system (CNS) complications associated with coronavirus disease 2019 (COVID-19) and their clinical characteristics. We aim to investigate associations between neurological autoantibodies and COVID-19 patients with predominant CNS complications. In this retrospective multi-center study, we analyze neurologic complications associated with COVID-19 patients from Dec. 2022 to Feb. 2023 at four tertiary hospitals in China. CSF and/or serum in the enrolled patients were tested for autoantibodies using tissue-based assays (TBAs) and cell-based assays (CBAs). A total of 34 consecutive patients ...
Source: Molecular Neurobiology - March 20, 2024 Category: Neurology Source Type: research
Cytomegalovirus Treatment in Solid Organ Transplantation: An Update on Current Approaches
CONCLUSIONS: Selection of CMV antiviral treatment should be determined by patient-specific factors, including severity of illness, resistant or refractory disease, dose-limiting adverse effects, and the preferred route of administration.PMID:38501850 | DOI:10.1177/10600280241237534 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 19, 2024 Category: Drugs & Pharmacology Authors: Karen L Hardinger Daniel C Brennan Source Type: research
CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - March 18, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
