A case of Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-d-aspartate Receptor Encephalitis
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2767-23. Online ahead of print.ABSTRACTA 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et al. Cardiac arrest occurred, which required pacemaker placement. She subsequently showed profound flaccid limb paralysis, with magnetic resonance imaging demonstrating focal necrotic lesions localized in the anterior horn of the longitudinal segments of the spinal cord and in the pontine tegmentu...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroyuki Sumikura Mai Ito Takuma Sato Naoki Hatayama Tomohiro Fujioka Nozomi Nagashima Yuki Shimada Isao Fukasaka Mikito Shimizu Kyoko Higashida Taku Hoshi Keiko Tanaka Manabu Sakaguchi Source Type: research
A case of autoimmune encephalitis in a patient with a solitary intracranial plasmacytoma
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2888-23. Online ahead of print.ABSTRACTA 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy. Additional examinations revealed elevated anti-glutamate receptor antibodies in the cerebrospinal...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Keisuke Mizutani Keita Sakurai Yuto Uchida Ken Hashimoto Tomohiro Kajiguchi Yukitoshi Takahashi Hiroyuki Yuasa Koji Takada Noriyuki Matsukawa Source Type: research
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif
In this study, we showed that the rabies virus matrix protein (RABV-M) used its PPxY motif to interact with the E3 ubiquitin-protein ligase NEDD4. NEDD4 then recruited MAP1LC3/LC3 via its LC3-interacting region (LIR). Interestingly, after binding to the ubiquitinated RABV-M, NEDD4 could bind more LC3 and enhance autophagosome accumulation, while NEDD4 knockdown significantly reduced M-induced autophagosome accumulation. Further study revealed that RABV-M prevented autophagosome-lysosome fusion and facilitated viral budding. Inhibition of RABV-M-induced autophagosome accumulation reduced the production of extracellular viru...
Source: Autophagy - April 3, 2024 Category: Cytology Authors: Yueming Yuan An Fang Zhihui Wang Huanchun Chen Zhen F Fu Ming Zhou Ling Zhao Source Type: research
A case of Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-d-aspartate Receptor Encephalitis
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2767-23. Online ahead of print.ABSTRACTA 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et al. Cardiac arrest occurred, which required pacemaker placement. She subsequently showed profound flaccid limb paralysis, with magnetic resonance imaging demonstrating focal necrotic lesions localized in the anterior horn of the longitudinal segments of the spinal cord and in the pontine tegmentu...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroyuki Sumikura Mai Ito Takuma Sato Naoki Hatayama Tomohiro Fujioka Nozomi Nagashima Yuki Shimada Isao Fukasaka Mikito Shimizu Kyoko Higashida Taku Hoshi Keiko Tanaka Manabu Sakaguchi Source Type: research
A case of autoimmune encephalitis in a patient with a solitary intracranial plasmacytoma
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2888-23. Online ahead of print.ABSTRACTA 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy. Additional examinations revealed elevated anti-glutamate receptor antibodies in the cerebrospinal...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Keisuke Mizutani Keita Sakurai Yuto Uchida Ken Hashimoto Tomohiro Kajiguchi Yukitoshi Takahashi Hiroyuki Yuasa Koji Takada Noriyuki Matsukawa Source Type: research
GSE237915 Single-cell RNA sequencing reveals the landscape of immune cells and the characterization of viral tropism in Japanese encephalitis virus-infected mouse brain
Contributor : ling'en yangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusJEV is a neurotropic pathogen that causes lethal encephalitis in humans. The high susceptibility and massive proliferation of JEV in neurons lead to neuronal damage and dramatical inflammation in central nerves system (CNS). However, the mechanisms by which JEV preferentially infects neurons and induces massive neuroinflammation are largely unknown. Here, we found that JEV mainly distributed in cerebral cortex, striatum and thalamus in brain of infected mice, indicating the tissue or cell type bias. Cells in th...
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Clinical characteristics and outcomes of COVID-19-associated encephalopathy in children
This study aimed to assess the features of COVID-19-associated encephalopathy/encephalitis in children. We retrospectively analyzed a single cohort of 13 hospitalized children with COVID-19-associated encephalopathy. The primary outcome was the descriptive analysis of the clinical characteristics, magnetic resonance imaging and electroencephalography findings, treatment progression, and outcomes. Thirteen children among a total of 275 (5%) children with confirmed COVID-19 developed associated encephalopathy/encephalitis (median age, 35 months; range, 3 –138 months). Autoimmune encephalitis was present in six patients, ac...
Source: Journal of NeuroVirology - April 3, 2024 Category: Neurology Source Type: research
Genetic causes of infection induced encephalitis
CONCLUSION: A case of both DBR1 and NUP214 genetic changes resulting in infection induced encephalitis is presented. This case series raises awareness of this rare group of disorders and provides clues to their identification. Features to prompt clinician consideration of such genetic conditions are also highlighted. Although rare, identification of these patients is important due to implications on treatment, prognosis, and family planning.PMID:38564873 | DOI:10.1016/j.ejpn.2024.03.004 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - April 2, 2024 Category: Neurology Authors: Olivia-Paris Quinn Peter McNaughton Nolette Pereira Kate Riney Source Type: research
Cortical laminar necrosis due to hypoglycemia in anti-CV2/CRMP5 paraneoplastic encephalitis: a curious association
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 2, 2024 Category: Neurology Source Type: research
Elevated levels of serum muscle enzymes in the initial phase of tick-borne encephalitis
. (Source: Infectious Diseases)
Source: Infectious Diseases - April 2, 2024 Category: Infectious Diseases Authors: Petra Bogovi čStanka Lotrič-FurlanKatarina OgrincTatjana Avšič ŽupancMiša KorvaAndrej KastrinAlenka Trampuš BakijaKlemen StrleFranc Strlea Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Sloveniab Institute of Mic Source Type: research
Cortical laminar necrosis due to hypoglycemia in anti-CV2/CRMP5 paraneoplastic encephalitis: a curious association
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 2, 2024 Category: Neurology Source Type: research
Molecular and serological evidence of chikungunya virus infection with high case fatality among pediatric population with acute encephalitis syndrome: first report from Eastern Uttar Pradesh, India
This study advocates constant serological and molecular surveillance of CHIKV in AES endemic regions of India. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 1, 2024 Category: Microbiology Source Type: research
Glucocorticoid receptor and specificity protein 1 (Sp1) or Sp3, but not the antibiotic Mithramycin A, stimulates human alphaherpesvirus 1 (HSV-1) replication
Antiviral Res. 2024 Mar 29:105870. doi: 10.1016/j.antiviral.2024.105870. Online ahead of print.ABSTRACTFollowing acute human alphaherpesvirus 1 (HSV-1) infection of oral-facial mucosal surfaces, sensory neurons in trigeminal ganglia (TG) are important sites for life-long latency. Neurons in the central nervous system, including brainstem, also harbor viral genomes during latency. Periodically, certain cellular stressors trigger reactivation from latency, which can lead to recurrent HSV-1 disease: herpes labialis, herpes stromal keratitis, and encephalitis for example. Activation of the glucocorticoid receptor (GR) by stres...
Source: Herpes - March 31, 2024 Category: Infectious Diseases Authors: Fouad S El-Mayet Vanessa Claire Santos Nishani Wijesekera Sydney Lubbers Kelly S Harrison Hafez Sadeghi Clinton Jones Source Type: research
Glucocorticoid receptor and specificity protein 1 (Sp1) or Sp3, but not the antibiotic Mithramycin A, stimulates human alphaherpesvirus 1 (HSV-1) replication
Antiviral Res. 2024 Mar 29:105870. doi: 10.1016/j.antiviral.2024.105870. Online ahead of print.ABSTRACTFollowing acute human alphaherpesvirus 1 (HSV-1) infection of oral-facial mucosal surfaces, sensory neurons in trigeminal ganglia (TG) are important sites for life-long latency. Neurons in the central nervous system, including brainstem, also harbor viral genomes during latency. Periodically, certain cellular stressors trigger reactivation from latency, which can lead to recurrent HSV-1 disease: herpes labialis, herpes stromal keratitis, and encephalitis for example. Activation of the glucocorticoid receptor (GR) by stres...
Source: Antiviral Research - March 31, 2024 Category: Virology Authors: Fouad S El-Mayet Vanessa Claire Santos Nishani Wijesekera Sydney Lubbers Kelly S Harrison Hafez Sadeghi Clinton Jones Source Type: research
Glucocorticoid receptor and specificity protein 1 (Sp1) or Sp3, but not the antibiotic Mithramycin A, stimulates human alphaherpesvirus 1 (HSV-1) replication
Antiviral Res. 2024 Mar 29:105870. doi: 10.1016/j.antiviral.2024.105870. Online ahead of print.ABSTRACTFollowing acute human alphaherpesvirus 1 (HSV-1) infection of oral-facial mucosal surfaces, sensory neurons in trigeminal ganglia (TG) are important sites for life-long latency. Neurons in the central nervous system, including brainstem, also harbor viral genomes during latency. Periodically, certain cellular stressors trigger reactivation from latency, which can lead to recurrent HSV-1 disease: herpes labialis, herpes stromal keratitis, and encephalitis for example. Activation of the glucocorticoid receptor (GR) by stres...
Source: Herpes - March 31, 2024 Category: Infectious Diseases Authors: Fouad S El-Mayet Vanessa Claire Santos Nishani Wijesekera Sydney Lubbers Kelly S Harrison Hafez Sadeghi Clinton Jones Source Type: research
