The neuroimaging mimics of abusive head trauma.
Abstract Abusive head trauma (AHT) is a significant cause of morbidity and mortality in the paediatric population, typically in children under the age of two years. Neuroimaging plays a key role in the diagnostic work up of these patients as information regarding the mechanism of injury is often lacking and the findings on examination can be nonspecific. A number of conditions, both traumatic and atraumatic can mimic AHT based on neuroimaging features alone. The repercussions associated with a diagnosis or misdiagnosis of AHT can be severe and radiologists therefore need to be aware of and familiar with the imagin...
Source: European Journal of Paediatric Neurology - November 22, 2018 Category: Neurology Authors: Mankad K, Chhabda S, Lim W, Oztekin O, Reddy N, Chong WK, Shroff M Tags: Eur J Paediatr Neurol Source Type: research

Bickerstaff Brainstem Encephalitis and overlapping Guillain-Barr é syndrome in children: Report of two cases and review of the literature.
Bickerstaff Brainstem Encephalitis and overlapping Guillain-Barré syndrome in children: Report of two cases and review of the literature. Eur J Paediatr Neurol. 2018 Nov 20;: Authors: Michev A, Musso P, Foiadelli T, Trabatti C, Lozza A, Franciotta D, Simoncelli AM, Savasta S Abstract Bickerstaff Brainstem Encephalitis (BBE) is a rare autoimmune encephalitis, characterized by acute ophthalmoplegia, ataxia and altered state of consciousness. Together with Guillan-Barrè Syndrome (GBS) and Miller-Fisher Syndrome, it forms a spectrum of post-infectious demyelinating diseases. Overlapping form...
Source: European Journal of Paediatric Neurology - November 20, 2018 Category: Neurology Authors: Michev A, Musso P, Foiadelli T, Trabatti C, Lozza A, Franciotta D, Simoncelli AM, Savasta S Tags: Eur J Paediatr Neurol Source Type: research

Efficacy and tolerability of olive oil-based ketogenic diet in children with drug-resistant epilepsy: A single center experience from Turkey.
CONCLUSION: KD is an effective and well-tolerated treatment option for patients with drug-resistant epilepsy. Previous history of ACTH use and constipation during KD treatment are important factors that affect the efficacy of KD treatment. PMID: 30497921 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - November 20, 2018 Category: Neurology Authors: Guzel O, Uysal U, Arslan N Tags: Eur J Paediatr Neurol Source Type: research

Fetal midline anomalies: Diagnosis and counselling part 2: Septal anomalies.
PMID: 30470535 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - November 8, 2018 Category: Neurology Authors: Leombroni M, Khalil A, Liberati M, D'Antonio F Tags: Eur J Paediatr Neurol Source Type: research

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study.
CONCLUSIONS: Fifty percent of caMS reported clinically significant fatigue. Similarities between adolescent and parent cognitive behavioural factors in fatigued caMS and adolescents with CFS suggest important potential targets for intervention. Both fatigued and non-fatigued caMS had cognitive difficulties, suggesting that fatigue may need targeted intervention. PMID: 30455131 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - November 2, 2018 Category: Neurology Authors: Carroll S, Chalder T, Hemingway C, Heyman I, Bear H, Sweeney L, Moss-Morris R Tags: Eur J Paediatr Neurol Source Type: research

A systematic review of comorbidity between cerebral palsy, autism spectrum disorders and Attention Deficit Hyperactivity Disorder.
CONCLUSIONS: Assessing the occurrence of ASD and ADHD would improve the significant cost of healthcare, therapies, and overall daily living for families with children affected by CP. However, psychometric studies are needed in the future to promote development of measures suitable for individuals with CP. In addition, this review highlights the paucity of peer-reviewed studies investigating the occurrence of ASD and ADHD in children with different CP subtypes or functional abilities, and there are still some open questions about pathogenic mechanisms common to CP, ASD and ADHD. PMID: 30446273 [PubMed - as supplied by ...
Source: European Journal of Paediatric Neurology - November 2, 2018 Category: Neurology Authors: Craig F, Savino R, Trabacca A Tags: Eur J Paediatr Neurol Source Type: research

Usefulness of perampanel with concomitant levetiracetam for patients with drug-resistant epilepsy.
CONCLUSION: The present study suggests the utility of PER with concomitant LEV for children with drug-resistant epilepsy. PMID: 30424990 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - November 2, 2018 Category: Neurology Authors: Kanemura H, Sano F, Aihara M Tags: Eur J Paediatr Neurol Source Type: research

Hearing impairment and hypoxia ischaemic encephalopathy: Incidence and associated factors.
CONCLUSION: This study confirms that hearing impairment is common in term infants who have undergone therapeutic hypothermia for moderate/severe HIE. Blood glucose should be monitored carefully in these infants and developmental surveillance should include formal audiology. Further larger studies are needed to clarify the role, if any, of hypothermia per se in causation of hearing loss and to fully identify risk factors for hearing impairment in this population. WHAT IS NEW: The current study confirms that hearing impairment is common in term infants who have undergone therapeutic hypothermia for moderate/severe HIE. ...
Source: European Journal of Paediatric Neurology - October 10, 2018 Category: Neurology Authors: Fitzgerald MP, Reynolds A, Garvey CM, Norman G, King MD, Hayes BC Tags: Eur J Paediatr Neurol Source Type: research

CSF neopterin, a useful biomarker in children presenting with influenza associated encephalopathy?
CONCLUSION: Raised CSF neopterin was present in most cases of encephalopathy, and along with diffusion restriction on MRI, is a useful diagnostic biomarker. Lack of seasonal influenza vaccination represents a missed opportunity to prevent illness in children, including severe neurological disease. PMID: 30316638 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - September 28, 2018 Category: Neurology Authors: Macdonald-Laurs E, Koirala A, Britton PN, Rawlinson W, Hiew CC, Mcrae J, Dale RC, Jones C, Macartney K, McMullan B, Pillai S Tags: Eur J Paediatr Neurol Source Type: research

Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients ( ≥1 to < 4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303.
Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to
Source: European Journal of Paediatric Neurology - September 27, 2018 Category: Neurology Authors: Arzimanoglou A, Ferreira J, Satlin A, Olhaye O, Kumar D, Dhadda S, Bibbiani F Tags: Eur J Paediatr Neurol Source Type: research

Safety, tolerability, and effectiveness of oral zonisamide therapy in comparison with intramuscular adrenocorticotropic hormone therapy in infants with West syndrome.
Abstract West syndrome is a distinct, infantile onset, epileptic encephalopathy, associated with poor neurodevelopmental outcome. The present study was designed as a randomized, open-label, pilot study to evaluate the safety, feasibility, and effectiveness of oral zonisamide therapy in comparison with adrenocorticotropic hormone therapy in infants with West syndrome. Thirty infants with West syndrome were randomized to receive treatment with either synthetic, intramuscular adrenocorticotropic hormone (30-60 IU) or oral zonisamide (4-25 mg/kg/day). The study participants had a long treatment lag and prepo...
Source: European Journal of Paediatric Neurology - September 22, 2018 Category: Neurology Authors: Angappan D, Sahu JK, Malhi P, Singhi P Tags: Eur J Paediatr Neurol Source Type: research

Methylphenidate use in males with Duchenne muscular dystrophy and a comorbid attention-deficit hyperactivity disorder.
Abstract Attention-deficit hyperactivity disorder (ADHD) is a common comorbidity in Duchenne muscular dystrophy (DMD). Until now, treatment with methylphenidate (MPH) has never been systematically assessed and described in this population. Our aim was to evaluate the effectiveness and safety of short acting MPH for learning problems in males with DMD and ADHD. Neuropsychological (cognition and behavior) and medical data of a sample of ten males (mean age = 8.1 years, range 6.3-9.8) with DMD and an ADHD diagnosis was retrospectively analyzed at baseline (T0; without MPH), short-term follow-up (T1; with MP...
Source: European Journal of Paediatric Neurology - September 21, 2018 Category: Neurology Authors: Lionarons JM, Hellebrekers DMJ, Klinkenberg S, Faber CG, Vles JSH, Hendriksen JGM Tags: Eur J Paediatr Neurol Source Type: research

The role of the neuropediatrician in pediatric intensive care unit: Diagnosis, therapeutics and major participation in collaborative multidisciplinary deliberations about life-sustaining treatments' withdrawal.
CONCLUSION: NP are clearly involved in the decision-process of LLST for patients admitted in PICU, claiming for close collaboration to improve current practices and the quality of the care provided to children. PMID: 30262235 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - September 14, 2018 Category: Neurology Authors: Toulouse J, Hully M, Brossier D, Viallard ML, de Saint Blanquat L, Renolleau S, Kossorotoff M, Desguerre I Tags: Eur J Paediatr Neurol Source Type: research

Polysomnographic findings in Rett syndrome.
CONCLUSION: Girls with RS have poor sleep quality with alterations in slow wave and REM sleep stages. Obstructive respiratory events are uncommon in patients without adenotonsillar hypertrophy. Central respiratory events are rare. Longitudinal studies should help understanding the natural history of sleep disturbances in RS and their relationship with the neurocognitive decline. PMID: 30262236 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - September 12, 2018 Category: Neurology Authors: Amaddeo A, De Sanctis L, Arroyo JO, Khirani S, Bahi-Buisson N, Fauroux B Tags: Eur J Paediatr Neurol Source Type: research

Decline in severe spastic cerebral palsy at term in Denmark 1999-2007.
CONCLUSION: The decline in rate of CP seen in 2005-2007 as compared to 1999-2001 was mainly based on fewer cases of severe spastic CP in term infants. We hypothesize that improved neonatal resuscitation in the delivery room may be partly responsible for the decrease. In premature children the decline was not significant in this time period, but has been dramatically decreasing in the years before the time period here analysed. PMID: 30241693 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - September 6, 2018 Category: Neurology Authors: Hoei-Hansen CE, Laursen B, Langhoff-Roos J, Rackauskaite G, Uldall P Tags: Eur J Paediatr Neurol Source Type: research

Prenatal aspects in spinal muscular atrophy: From early detection to early presymptomatic intervention.
Abstract With the recent advances in spinal muscular atrophy therapies, the complete scenario of standard of care and following up is changing not only in the clinical field with new phenotypes emerging but also with new expectations for patients, caregivers and health providers. The actual evidence indicates that early intervention and treatment is crucial for better response and prognosis. Knowledge of the prenatal and pre-symptomatic postnatal stages of the disease are becoming essential to consider the opportunities of timely diagnosis and to decide the earliest therapeutic intervention. PMID: 30219357 [P...
Source: European Journal of Paediatric Neurology - September 3, 2018 Category: Neurology Authors: Tizzano EF, Zafeiriou D Tags: Eur J Paediatr Neurol Source Type: research

The cerebellar "tilted telephone receiver sign" enables prenatal diagnosis of PHACES syndrome.
The cerebellar "tilted telephone receiver sign" enables prenatal diagnosis of PHACES syndrome. Eur J Paediatr Neurol. 2018 Sep 01;: Authors: Leibovitz Z, Guibaud L, Garel C, Massoud M, Karl K, Malinger G, Haratz KK, Gindes L, Tamarkin M, Ben-Sira L, Lev D, Shalev J, Brasseur-Daudruy M, Contreras Gutierrez de Piñeres CA, Lerman-Sagie T Abstract OBJECTIVES: To describe a unique posterior fossa neuroimaging characteristic of prenatal PHACES syndrome (PS): unilateral cerebellar hypoplasia (UCH) and ipsilateral posterior fossa (PF) cyst communicating with an asymmetrically distended 4th ve...
Source: European Journal of Paediatric Neurology - September 1, 2018 Category: Neurology Authors: Leibovitz Z, Guibaud L, Garel C, Massoud M, Karl K, Malinger G, Haratz KK, Gindes L, Tamarkin M, Ben-Sira L, Lev D, Shalev J, Brasseur-Daudruy M, Contreras Gutierrez de Piñeres CA, Lerman-Sagie T Tags: Eur J Paediatr Neurol Source Type: research

Seize the opportunity - Recognition and management of functional seizures in children.
PMID: 30213504 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - September 1, 2018 Category: Neurology Authors: Heyman I, Reilly C Tags: Eur J Paediatr Neurol Source Type: research

Genotype-phenotype correlation: The ultimate challenge in facioscapolohumeral muscular dystrophy.
PMID: 30213505 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - September 1, 2018 Category: Neurology Authors: Tupler R Tags: Eur J Paediatr Neurol Source Type: research

Long-term follow-up in pediatric patients with paroxysmal hypothermia (Shapiro's syndrome).
CONCLUSION: Paroxysmal hypothermia, the core symptom of SS, behaved as a age-dependent feature in our cohort, supporting a good long-term prognosis for SS. A prompt diagnosis of SS is crucial to avoid unnecessary diagnostic investigations. PMID: 30195408 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - August 29, 2018 Category: Neurology Authors: Tambasco N, Paoletti FP, Prato G, Mancardi MM, Prontera P, Giordano L, Grosso S, Romeo A, Pinto F, Savasta S, Peruzzi C, Romoli M, Striano P, Verrotti A, Belcastro V, Società Italiana Neurologia Pediatrica (SINP) Collaborative Network Tags: Eur J Paediatr Neurol Source Type: research

Clinical and magnetic resonance imaging features of children, adolescents, and adults with a clinically isolated syndrome.
CONCLUSION: In this retrospective series, subtle differences between children, adolescents, and adults with a CIS were noted. Larger samples are required in order to establish distinct features of the different age groups. PMID: 30195407 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - August 28, 2018 Category: Neurology Authors: Milos RI, Szimacsek M, Leutmezer F, Rostasy K, Blaschek A, Karenfort M, Schimmel M, Pritsch M, Storm Van's Gravesande K, Weber M, Schmoeger M, Seidl R, Prayer D, Kornek B Tags: Eur J Paediatr Neurol Source Type: research

SLC35A2-related congenital disorder of glycosylation: Defining the phenotype.
ian M Abstract We aim to further delineate the phenotype associated with pathogenic variants in the SLC35A2 gene, and review all published literature to-date. This gene is located on the X chromosome and encodes a UDP-galactose transporter. Pathogenic variants in SLC35A2 cause a congenital disorder of glycosylation. The condition is rare, and less than twenty patients have been reported to-date. The phenotype is complex and has not been fully defined. Here, we present a series of five patients with de novo pathogenic variants in SLC35A2. The patients' phenotype includes developmental and epileptic encephalopathy w...
Source: European Journal of Paediatric Neurology - August 27, 2018 Category: Neurology Authors: Yates TM, Suri M, Desurkar A, Lesca G, Wallgren-Pettersson C, Hammer TB, Raghavan A, Poulat AL, Møller RS, Thuresson AC, Balasubramanian M Tags: Eur J Paediatr Neurol Source Type: research

Functional assessment tools in children with Pompe disease: A pilot comparative study to identify suitable outcome measures for the standard of care.
CONCLUSIONS: The proposed protocol seems to be reliable and should be done every six months, because of the progressive natural history of the disease, the rapid changes typical of developmental age and the need to document ERT effects. About cognitive functions, additional tests to classical intelligence scales (WISC, WPPSI) should be useful to better describe specific neuropsychological profile. PMID: 30166092 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - August 18, 2018 Category: Neurology Authors: Ricci F, Brusa C, Rossi F, Rolle E, Placentino V, Berardinelli A, Pagliardini V, Porta F, Spada M, Mongini T Tags: Eur J Paediatr Neurol Source Type: research

A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy.
Abstract AIM: Despite antiepileptic medication and dietary treatment options available about 45% of children with epilepsy still suffer from uncontrolled seizures. Triheptanoin is an anaplerotic treatment designed to improve energy generation via the Krebs cycle. METHOD: For the first time, we evaluated the feasibility, tolerability and efficacy of add-on triheptanoin in 12 patients with medically refractory epilepsy (seven males, five females; min-max: 3-18yr, median 13.5 yr). RESULTS: Eight out of a total of 12 children (67%), who tested the treatment, finished the trial and tolerated between 30 a...
Source: European Journal of Paediatric Neurology - August 7, 2018 Category: Neurology Authors: Calvert S, Barwick K, Par M, Ni Tan K, Borges K Tags: Eur J Paediatr Neurol Source Type: research

Safety and efficacy of recanalization therapy in pediatric stroke: A systematic review and meta-analysis.
Abstract BACKGROUND AND PURPOSE: Safety and efficacy of intravenous (IV) thrombolysis and endovascular therapy in children with acute ischemic stroke (AIS) are unknown to date. We aimed to review and synthesize currently available evidence on these acute recanalization therapies in pediatric stroke patients. METHODS: We performed a systematic review and meta-analysis of all available data on safety and efficacy of acute treatment including thrombolysis and endovascular therapy in pediatric AIS patients aged
Source: European Journal of Paediatric Neurology - August 7, 2018 Category: Neurology Authors: Pacheco JT, Siepmann T, Barlinn J, Winzer S, Penzlin AI, Puetz V, von der Hagen M, Barlinn K Tags: Eur J Paediatr Neurol Source Type: research

Fetal pericallosal lipomas - Clues to diagnosis in the second trimester.
CONCLUSIONS: Non visualization of a PCL during the 2nd trimester is common, and should not be considered a diagnostic error. An underlying PCL should be included in the differential diagnosis of CC anomalies during this time period, necessitating further follow up into the 3rd trimester. PMID: 30104143 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - August 2, 2018 Category: Neurology Authors: Shinar S, Lerman-Sagie T, Telleria ME, Viñals F, García R, Quiroga H, Bermejo C, Ben-Sira L, Leibovitz Z, Har-Toov J, Malinger G Tags: Eur J Paediatr Neurol Source Type: research

Progressive cerebello-cerebral atrophy and progressive encephalopathy with edema, hypsarrhythmia and optic atrophy may be allelic syndromes.
Abstract In 2003, a new syndrome was described in the Sephardi Jewish population, named progressive cerebello-cerebral atrophy (PCCA) based on the typical neuroradiological findings. Following the identification of the causal genes in 2010 and 2014, two types were defined: PCCA type 1 due to SEPSECS mutations and PCCA type 2 due to VPS53 mutations. Progressive encephalopathy with edema, hypsarrhythmia and optic atrophy (PEHO) was described in 1991 in Finland. The clinical and radiological phenotype resembles PCCA. The genetic background has been elusive for many years. Recently, mutations in multiple genes includi...
Source: European Journal of Paediatric Neurology - July 26, 2018 Category: Neurology Authors: Hady-Cohen R, Ben-Pazi H, Adir V, Yosovich K, Blumkin L, Lerman-Sagie T, Lev D Tags: Eur J Paediatr Neurol Source Type: research

Secondary enuresis and urological manifestations in children with ataxia telangiectasia.
DISCUSSION: Transient secondary enuresis is a frequent finding in AT patients, heralding loss of ambulatory capacity, tough it's pathophysiological mechanism is largely no understood. PMID: 30100180 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 26, 2018 Category: Neurology Authors: Nissenkorn A, Erlich T, Zilberman DE, Sarouk I, Krauthammer A, Kitrey ND, Heimer G, BenZeev B, Mor Y Tags: Eur J Paediatr Neurol Source Type: research

Benefits of hippotherapy in children with cerebral palsy: A narrative review.
CONCLUSIONS: Gains were also observed in postural alignment and the balance of head and trunk. Moreover, there were improvements in quality of life and the activities of daily life, such as jumping, balance, strength and ascending and descending stairs. PMID: 30017618 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 10, 2018 Category: Neurology Authors: Martín-Valero R, Vega-Ballón J, Perez-Cabezas V Tags: Eur J Paediatr Neurol Source Type: research

Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study.
CONCLUSION: This explorative study shows that multifocal activity is associated with generally increased long-distance functional connectivity in the brain. It can be suggested that this pronounced connectivity may represent either a risk to pathological over-synchronization or a consequence of the multifocal epileptic activity. PMID: 30017619 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 5, 2018 Category: Neurology Authors: Siniatchkin M, Moehring J, Kroeher B, Galka A, von Ondarza G, Moeller F, Wolff S, Tagliazucchi E, Steinmann E, Boor R, Stephani U Tags: Eur J Paediatr Neurol Source Type: research

Short-term safety of mTOR inhibitors in infants and very young children with tuberous sclerosis complex (TSC): Multicentre clinical experience.
CONCLUSIONS: Everolimus, and to a lesser extent sirolimus, are increasingly being used to treat TSC infants and very young children for multiple TSC-associated clinical indications. While AEs were common, most were not severe and did not prevent continued treatment in the majority of this younger population. PMID: 30005812 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 4, 2018 Category: Neurology Authors: Krueger DA, Capal JK, Curatolo P, Devinsky O, Ess K, Tzadok M, Koenig MK, Narayanan V, Ramos F, Jozwiak S, de Vries P, Jansen AC, Wong M, Mowat D, Lawson J, Bruns S, Franz DN, TSCure Research Group Tags: Eur J Paediatr Neurol Source Type: research

Brain malformations associated to Aldh7a1 gene mutations: Report of a novel homozygous mutation and literature review.
CONCLUSIONS: ALDH7A1 mutations have been associated to different brain abnormalities, documented by MRI only in few cases. The study cases expand the clinical spectrum of ALDH7A1 associated conditions, suggesting to look for ALDH7A1 mutations not only in classical phenotypes but also in patients with brain malformations, mainly if there is a response to a pyridoxine trial. PMID: 30005813 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - July 3, 2018 Category: Neurology Authors: Toldo I, Bonardi CM, Bettella E, Polli R, Talenti G, Burlina A, Sartori S, Murgia A Tags: Eur J Paediatr Neurol Source Type: research

Developmental outcome in pyridoxine-dependent epilepsy: Better late (onset) than early.
PMID: 29887411 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - June 13, 2018 Category: Neurology Authors: Gospe SM Tags: Eur J Paediatr Neurol Source Type: research

Next generation genetic considerations in paediatric stroke.
PMID: 29887412 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - June 13, 2018 Category: Neurology Authors: Dlamini N Tags: Eur J Paediatr Neurol Source Type: research

Neurological assessment of late-preterm infants during the first year of age.
PMID: 29887413 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - June 13, 2018 Category: Neurology Authors: Romeo DM, Brogna C, Mercuri E Tags: Eur J Paediatr Neurol Source Type: research

Function of the unaffected arms of children with neonatal brachial plexus injuries.
PMID: 29887414 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - June 13, 2018 Category: Neurology Authors: Matthews DJ Tags: Eur J Paediatr Neurol Source Type: research

Trajectories of normal cerebral blood flow development in youth. Commentary on: Liu et  al. Resting state cerebral blood flow with arterial spin labeling MRI in developing human brains.
Trajectories of normal cerebral blood flow development in youth. Commentary on: Liu et al. Resting state cerebral blood flow with arterial spin labeling MRI in developing human brains. Eur J Paediatr Neurol. 2018 Jul;22(4):582-583 Authors: O'Neill J PMID: 29887415 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - June 13, 2018 Category: Neurology Authors: O'Neill J Tags: Eur J Paediatr Neurol Source Type: research

Of pioneers and advancements related to general movement assessment.
PMID: 29887416 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - June 13, 2018 Category: Neurology Authors: Marschik PB, Einspieler C Tags: Eur J Paediatr Neurol Source Type: research

Cognitive behavioral therapy for children with autism spectrum disorder: A prospective observational study.
CONCLUSION: Results indicate that CBT is an effective therapy for children with ASD. Larger studies are needed to give more details about which symptoms respond best in these patients. PMID: 29887491 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 30, 2018 Category: Neurology Authors: Kurz R, Huemer J, Muchitsch E, Feucht M Tags: Eur J Paediatr Neurol Source Type: research

Management of epilepsy associated with tuberous sclerosis complex: Updated clinical recommendations.
iak S Abstract Patients with tuberous sclerosis complex (TSC) are at very high risk for developing epilepsy, and the majority experience seizure onset during the first year of life. Early targeted interventions increase the probability of seizure-freedom and may protect neurodevelopment. In 2012, clinical recommendations for the management of epilepsy in patients with TSC were published by a panel of European experts. Since that time novel studies, reports, and expert opinions in preclinical and clinical TSC-related sciences prompted the need for updated recommendations, including epileptogenesis in TSC, the poten...
Source: European Journal of Paediatric Neurology - May 24, 2018 Category: Neurology Authors: Curatolo P, Nabbout R, Lagae L, Aronica E, Ferreira JC, Feucht M, Hertzberg C, Jansen AC, Jansen F, Kotulska K, Moavero R, O'Callaghan F, Papavasiliou A, Tzadok M, Jóźwiak S Tags: Eur J Paediatr Neurol Source Type: research

Paediatricians' attitudes to and management of functional seizures in children.
CONCLUSION: The findings suggest that introduction of clinical guidelines in this area is highly needed. Such guidelines could promote more formal training of paediatricians in understanding and assessing FS and increased collaboration between paediatrics and CAMHS regarding care for children with this challenging and potentially costly and disabling disorder. PMID: 29871800 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 24, 2018 Category: Neurology Authors: Nielsen ES, Wichaidit BT, Østergaard JR, Rask CU Tags: Eur J Paediatr Neurol Source Type: research

What is new: Talk about status epilepticus in the neonatal period.
Abstract Nowadays, no general consensus was achieved regarding neonatal status epilepticus and its definition. Indeed, different criteria (mainly based on seizure duration) were used. Whereas a recent proposal has been developed to define status epilepticus in older ages, it seems that the peculiar characteristics of neonatal seizures and of the immature brain make difficult to find a tailored definition for this period of life. Achieving a consensus on this entity would mean to make the first step toward a targeted therapeutic strategy of intervention. PMID: 29861333 [PubMed - as supplied by publisher] ...
Source: European Journal of Paediatric Neurology - May 24, 2018 Category: Neurology Authors: Pisani F, Pavlidis E Tags: Eur J Paediatr Neurol Source Type: research

Self-concept and self-esteem in patients with chronic tic disorders: A systematic literature review.
Abstract Chronic tic disorders are neurodevelopmental conditions characterized by the presence of motor and/or phonic tics and often accompanied by co-morbid behavioral problems. Chronic tic disorders can negatively affect the level of functioning of young patients across social and family domains, with possible repercussions on their self-perception. We conducted a systematic literature review to assess the clinical correlates of both components of self-perception (self-concept, i.e. what patients think about themselves, and self-esteem, i.e. how they feel about their self-concept) in patients with chronic tic di...
Source: European Journal of Paediatric Neurology - May 24, 2018 Category: Neurology Authors: Silvestri PR, Baglioni V, Cardona F, Cavanna AE Tags: Eur J Paediatr Neurol Source Type: research

PLA2G6-associated neurodegeneration: Lessons from neurophysiological findings.
CONCLUSIONS: Peripheral involvement is an early feature in PLAN recognizable by EDX at an earlier stage than typical iron accumulation in the brain. Furthermore, the association of West syndrome and axonal motor neuropathy may represent positive clues in favor of PLAN. This results emphasize the interest of early and repeated EDX. PMID: 29859652 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 22, 2018 Category: Neurology Authors: Gitiaux C, Kaminska A, Boddaert N, Barcia G, Guéden S, The Tich SN, De Lonlay P, Quijano-Roy S, Hully M, Péréon Y, Desguerre I Tags: Eur J Paediatr Neurol Source Type: research

Diffusion MRI parameters of corpus callosum and corticospinal tract in neonates: Comparison between region-of-interest and whole tract averaged measurements.
CONCLUSION: Agreement between dMRI measures of neonatal WM microstructure calculated from ROI and whole tract averaged methods is weak. ROI approaches may not provide sufficient representation of tract microstructure at the level of neural systems in newborns. PMID: 29804802 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 16, 2018 Category: Neurology Authors: Sparrow SA, Anblagan D, Drake AJ, Telford EJ, Pataky R, Piyasena C, Semple SI, Bastin ME, Boardman JP Tags: Eur J Paediatr Neurol Source Type: research

Decreasing prevalence and severity of cerebral palsy in Norway among children born 1999 to 2010 concomitant with improvements in perinatal health.
CONCLUSION: We observed a significant decrease in the prevalence and severity of CP subtypes and associated impairments among children with CP in Norway. This coincided with improvements in perinatal health indicators in the general population. These improvements are most likely explained by advancements in obstetric and neonatal care. PMID: 29779984 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 8, 2018 Category: Neurology Authors: Hollung SJ, Vik T, Lydersen S, Bakken IJ, Andersen GL Tags: Eur J Paediatr Neurol Source Type: research

Acute transverse myelitis following an opsoclonus-myoclonus syndrome: An unusual presentation.
Abstract Opso-myoclonus syndrome (OMS) is a very rare and severe condition. Ataxia, opsoclonus, myoclonus and/or behavioral and sleeping disturbances define that autoimmune disorder syndrome which is paraneoplastic or triggered by an infection. Here, we report a 3 year-old immunocompetent boy who developed an atypical OMS which was later complicated by an acute transverse myelitis. Screening for neuroblastoma was negative and extensive infectious screening revealed an active HHV-6 infection confirmed by blood and cerebrospinal fluid PCR. A parainfectious disease was suggested and immunosuppressive treatment was in...
Source: European Journal of Paediatric Neurology - May 8, 2018 Category: Neurology Authors: Simon T, Cheuret E, Fiedler L, Mengelle C, Baudou E, Deiva K Tags: Eur J Paediatr Neurol Source Type: research

A 22-year follow-up reveals a variable disease severity in early-onset facioscapulohumeral dystrophy.
DISCUSSION: Patients with early-onset FSHD generally had a severe phenotype compared to classical onset FSHD. However, after 22 years of follow up they showed a wide variation in severity and, despite these physical limitations, participated socially and economically. These observations are important for patient management and should be taken into account in clinical trials. PMID: 29753614 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 3, 2018 Category: Neurology Authors: Goselink RJM, van Kernebeek CR, Mul K, Lemmers RJLF, van der Maarel SM, Brouwer OF, Voermans N, Padberg GW, Erasmus CE, van Engelen BGM Tags: Eur J Paediatr Neurol Source Type: research

Further expansion of the genetic GABA-A-opathies.
PMID: 29653609 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - April 15, 2018 Category: Neurology Authors: Symonds J Tags: Eur J Paediatr Neurol Source Type: research

Abnormal white matter: Expanding the GLUT1-D phenotype.
PMID: 29653610 [PubMed - in process] (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - April 15, 2018 Category: Neurology Authors: Auvin S Tags: Eur J Paediatr Neurol Source Type: research