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Disseminated Enterovirus Infection in a Patient Affected by Follicular Lymphoma Treated with Obinutuzumab: A Case Report and a Narrative Review of the Literature
Conclusions: onco-hematological patients who receive immune-chemotherapy with a combination of treatments which depress adaptative immunity, which includes the antiCD20 obinutuzumab, could be at higher risk of disseminated EV infection, including CNS and cardiac involvement.PMID:38541221 | PMC:PMC10972032 | DOI:10.3390/medicina60030495 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Tommaso Lupia Silvia Corcione Elena Staffilano Roberta Bosio Antonio Curtoni Alessandro Busca Francesco Giuseppe De Rosa Source Type: research

Viruses, Vol. 16, Pages 524: Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles
In this study, the cells that harbor subgenomic replicon derived from the Japanese encephalitis virus and dengue virus without producing any replication-competent viruses were employed as the EV donor. It was demonstrated that the EVs in the culture supernatants of those cells were able to transfer the replicon genome to other cells of various types. It was also shown that the EVs were incorporated by the recipient cells primarily through macropinocytosis after interaction with CD33 and Tim-1/Tim-4 on HeLa and K562 cells, respectively. Since the methods used in this study are free from contamination with infectious viral p...
Source: Viruses - March 28, 2024 Category: Virology Authors: Tomohiro Ishikawa Kentaro Narita Kinichi Matsuyama Michiaki Masuda Tags: Article Source Type: research

Brain magnetic resonance imaging findings in children with neurological complications of coronavirus disease 2019 (Omicron variant): a multicenter retrospective observational study
ConclusionsOverall, these data highlighted five neuroimaging patterns associated with the outbreak of the SARS-CoV-2 Omicron variant, with acute necrotizing encephalopathy being the most common of these neuroimaging findings. Rarely, the brain MRI of these pediatric COVID-19 patients also demonstrate hippocampal atrophy.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - March 28, 2024 Category: Radiology Source Type: research