CNS Viral Infections —What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches
AbstractNeurotropic viruses may cause meningitis, myelitis, encephalitis, or meningoencephalitis. These inflammatory conditions of the central nervous system (CNS) may have serious and devastating consequences if not treated adequately. In this review, we first summarize how neurotropic viruses can enter the CNS by (1) crossing the blood-brain barrier or blood-cerebrospinal fluid barrier; (2) invading the nose via the olfactory route; or (3) invading the peripheral nervous system. Neurotropic viruses may then enter the intracellular space of brain cells via endocytosis and/or membrane fusion. Antiviral drugs are currently ...
Source: CNS Drugs - April 5, 2024 Category: Neurology Source Type: research
YF17D-based vaccines - standing on the shoulders of a giant
Eur J Immunol. 2024 Apr 3:e2250133. doi: 10.1002/eji.202250133. Online ahead of print.ABSTRACTLive-attenuated yellow fever vaccine (YF17D) was developed in the 1930s as the first ever empirically derived human vaccine. Ninety years later, it is still a benchmark for vaccines made today. YF17D triggers a particularly broad and polyfunctional response engaging multiple arms of innate, humoral and cellular immunity. This unique immunogenicity translates into an extraordinary vaccine efficacy and outstanding longevity of protection, possibly by single-dose immunization. More recently, progress in molecular virology and synthet...
Source: European Journal of Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Lorena Sanchez-Felipe Yeranddy A Alpizar Ji Ma Lotte Coelmont Kai Dallmeier Source Type: research
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif
In this study, we showed that the rabies virus matrix protein (RABV-M) used its PPxY motif to interact with the E3 ubiquitin-protein ligase NEDD4. NEDD4 then recruited MAP1LC3/LC3 via its LC3-interacting region (LIR). Interestingly, after binding to the ubiquitinated RABV-M, NEDD4 could bind more LC3 and enhance autophagosome accumulation, while NEDD4 knockdown significantly reduced M-induced autophagosome accumulation. Further study revealed that RABV-M prevented autophagosome-lysosome fusion and facilitated viral budding. Inhibition of RABV-M-induced autophagosome accumulation reduced the production of extracellular viru...
Source: Autophagy - April 3, 2024 Category: Cytology Authors: Yueming Yuan An Fang Zhihui Wang Huanchun Chen Zhen F Fu Ming Zhou Ling Zhao Source Type: research
A case of Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-d-aspartate Receptor Encephalitis
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2767-23. Online ahead of print.ABSTRACTA 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et al. Cardiac arrest occurred, which required pacemaker placement. She subsequently showed profound flaccid limb paralysis, with magnetic resonance imaging demonstrating focal necrotic lesions localized in the anterior horn of the longitudinal segments of the spinal cord and in the pontine tegmentu...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroyuki Sumikura Mai Ito Takuma Sato Naoki Hatayama Tomohiro Fujioka Nozomi Nagashima Yuki Shimada Isao Fukasaka Mikito Shimizu Kyoko Higashida Taku Hoshi Keiko Tanaka Manabu Sakaguchi Source Type: research
A case of autoimmune encephalitis in a patient with a solitary intracranial plasmacytoma
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2888-23. Online ahead of print.ABSTRACTA 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy. Additional examinations revealed elevated anti-glutamate receptor antibodies in the cerebrospinal...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Keisuke Mizutani Keita Sakurai Yuto Uchida Ken Hashimoto Tomohiro Kajiguchi Yukitoshi Takahashi Hiroyuki Yuasa Koji Takada Noriyuki Matsukawa Source Type: research
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif
In this study, we showed that the rabies virus matrix protein (RABV-M) used its PPxY motif to interact with the E3 ubiquitin-protein ligase NEDD4. NEDD4 then recruited MAP1LC3/LC3 via its LC3-interacting region (LIR). Interestingly, after binding to the ubiquitinated RABV-M, NEDD4 could bind more LC3 and enhance autophagosome accumulation, while NEDD4 knockdown significantly reduced M-induced autophagosome accumulation. Further study revealed that RABV-M prevented autophagosome-lysosome fusion and facilitated viral budding. Inhibition of RABV-M-induced autophagosome accumulation reduced the production of extracellular viru...
Source: Autophagy - April 3, 2024 Category: Cytology Authors: Yueming Yuan An Fang Zhihui Wang Huanchun Chen Zhen F Fu Ming Zhou Ling Zhao Source Type: research
A case of Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-d-aspartate Receptor Encephalitis
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2767-23. Online ahead of print.ABSTRACTA 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et al. Cardiac arrest occurred, which required pacemaker placement. She subsequently showed profound flaccid limb paralysis, with magnetic resonance imaging demonstrating focal necrotic lesions localized in the anterior horn of the longitudinal segments of the spinal cord and in the pontine tegmentu...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroyuki Sumikura Mai Ito Takuma Sato Naoki Hatayama Tomohiro Fujioka Nozomi Nagashima Yuki Shimada Isao Fukasaka Mikito Shimizu Kyoko Higashida Taku Hoshi Keiko Tanaka Manabu Sakaguchi Source Type: research
A case of autoimmune encephalitis in a patient with a solitary intracranial plasmacytoma
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2888-23. Online ahead of print.ABSTRACTA 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy. Additional examinations revealed elevated anti-glutamate receptor antibodies in the cerebrospinal...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Keisuke Mizutani Keita Sakurai Yuto Uchida Ken Hashimoto Tomohiro Kajiguchi Yukitoshi Takahashi Hiroyuki Yuasa Koji Takada Noriyuki Matsukawa Source Type: research
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif
In this study, we showed that the rabies virus matrix protein (RABV-M) used its PPxY motif to interact with the E3 ubiquitin-protein ligase NEDD4. NEDD4 then recruited MAP1LC3/LC3 via its LC3-interacting region (LIR). Interestingly, after binding to the ubiquitinated RABV-M, NEDD4 could bind more LC3 and enhance autophagosome accumulation, while NEDD4 knockdown significantly reduced M-induced autophagosome accumulation. Further study revealed that RABV-M prevented autophagosome-lysosome fusion and facilitated viral budding. Inhibition of RABV-M-induced autophagosome accumulation reduced the production of extracellular viru...
Source: Autophagy - April 3, 2024 Category: Cytology Authors: Yueming Yuan An Fang Zhihui Wang Huanchun Chen Zhen F Fu Ming Zhou Ling Zhao Source Type: research
A case of Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-d-aspartate Receptor Encephalitis
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2767-23. Online ahead of print.ABSTRACTA 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et al. Cardiac arrest occurred, which required pacemaker placement. She subsequently showed profound flaccid limb paralysis, with magnetic resonance imaging demonstrating focal necrotic lesions localized in the anterior horn of the longitudinal segments of the spinal cord and in the pontine tegmentu...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroyuki Sumikura Mai Ito Takuma Sato Naoki Hatayama Tomohiro Fujioka Nozomi Nagashima Yuki Shimada Isao Fukasaka Mikito Shimizu Kyoko Higashida Taku Hoshi Keiko Tanaka Manabu Sakaguchi Source Type: research
A case of autoimmune encephalitis in a patient with a solitary intracranial plasmacytoma
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2888-23. Online ahead of print.ABSTRACTA 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy. Additional examinations revealed elevated anti-glutamate receptor antibodies in the cerebrospinal...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Keisuke Mizutani Keita Sakurai Yuto Uchida Ken Hashimoto Tomohiro Kajiguchi Yukitoshi Takahashi Hiroyuki Yuasa Koji Takada Noriyuki Matsukawa Source Type: research
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif
In this study, we showed that the rabies virus matrix protein (RABV-M) used its PPxY motif to interact with the E3 ubiquitin-protein ligase NEDD4. NEDD4 then recruited MAP1LC3/LC3 via its LC3-interacting region (LIR). Interestingly, after binding to the ubiquitinated RABV-M, NEDD4 could bind more LC3 and enhance autophagosome accumulation, while NEDD4 knockdown significantly reduced M-induced autophagosome accumulation. Further study revealed that RABV-M prevented autophagosome-lysosome fusion and facilitated viral budding. Inhibition of RABV-M-induced autophagosome accumulation reduced the production of extracellular viru...
Source: Autophagy - April 3, 2024 Category: Cytology Authors: Yueming Yuan An Fang Zhihui Wang Huanchun Chen Zhen F Fu Ming Zhou Ling Zhao Source Type: research
A case of Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-d-aspartate Receptor Encephalitis
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2767-23. Online ahead of print.ABSTRACTA 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et al. Cardiac arrest occurred, which required pacemaker placement. She subsequently showed profound flaccid limb paralysis, with magnetic resonance imaging demonstrating focal necrotic lesions localized in the anterior horn of the longitudinal segments of the spinal cord and in the pontine tegmentu...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroyuki Sumikura Mai Ito Takuma Sato Naoki Hatayama Tomohiro Fujioka Nozomi Nagashima Yuki Shimada Isao Fukasaka Mikito Shimizu Kyoko Higashida Taku Hoshi Keiko Tanaka Manabu Sakaguchi Source Type: research
A case of autoimmune encephalitis in a patient with a solitary intracranial plasmacytoma
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.2888-23. Online ahead of print.ABSTRACTA 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy. Additional examinations revealed elevated anti-glutamate receptor antibodies in the cerebrospinal...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Keisuke Mizutani Keita Sakurai Yuto Uchida Ken Hashimoto Tomohiro Kajiguchi Yukitoshi Takahashi Hiroyuki Yuasa Koji Takada Noriyuki Matsukawa Source Type: research
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif
In this study, we showed that the rabies virus matrix protein (RABV-M) used its PPxY motif to interact with the E3 ubiquitin-protein ligase NEDD4. NEDD4 then recruited MAP1LC3/LC3 via its LC3-interacting region (LIR). Interestingly, after binding to the ubiquitinated RABV-M, NEDD4 could bind more LC3 and enhance autophagosome accumulation, while NEDD4 knockdown significantly reduced M-induced autophagosome accumulation. Further study revealed that RABV-M prevented autophagosome-lysosome fusion and facilitated viral budding. Inhibition of RABV-M-induced autophagosome accumulation reduced the production of extracellular viru...
Source: Autophagy - April 3, 2024 Category: Cytology Authors: Yueming Yuan An Fang Zhihui Wang Huanchun Chen Zhen F Fu Ming Zhou Ling Zhao Source Type: research
