C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
Commun Biol. 2024 Apr 24;7(1):494. doi: 10.1038/s42003-024-06178-6.ABSTRACTInflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2 deficiency substantially reduces iMO recruitment for most, but not all encephalitic viruses. Here we show CCR7 acts synergistically with CCR2 to control this process. Following Herpes simplex virus type-1 (HSV-1), or La Crosse virus (LACV) infection, we find iMO proportions are reduced by approximately half in either Ccr2 or Ccr7 knockout mice compared to control mice. However, Ccr2/Ccr7 double knockouts elimin...
Source: Herpes - April 24, 2024 Category: Infectious Diseases Authors: Clayton W Winkler Alyssa B Evans Aaron B Carmody Justin B Lack Tyson A Woods Karin E Peterson Source Type: research
Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties
We report about a patient with the clinical presentation of a psychotic depression, who was diagnosed with anti-NMDA receptor encephalitis only after a thorough diagnostic work-up. Neurological symptoms were wrongly attributed to the psychiatric syndrome or considered as side-effects of its treatment. We present an overview of clinical aspects of the disorder, distinctive psychiatric symptoms, diagnostic tools, treatment and prognosis.PMID:38650533 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - April 23, 2024 Category: Psychiatry Authors: S Wouters K Van Laere F-L De Winter Source Type: research
Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties
We report about a patient with the clinical presentation of a psychotic depression, who was diagnosed with anti-NMDA receptor encephalitis only after a thorough diagnostic work-up. Neurological symptoms were wrongly attributed to the psychiatric syndrome or considered as side-effects of its treatment. We present an overview of clinical aspects of the disorder, distinctive psychiatric symptoms, diagnostic tools, treatment and prognosis.PMID:38650533 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - April 23, 2024 Category: Psychiatry Authors: S Wouters K Van Laere F-L De Winter Source Type: research
Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties
We report about a patient with the clinical presentation of a psychotic depression, who was diagnosed with anti-NMDA receptor encephalitis only after a thorough diagnostic work-up. Neurological symptoms were wrongly attributed to the psychiatric syndrome or considered as side-effects of its treatment. We present an overview of clinical aspects of the disorder, distinctive psychiatric symptoms, diagnostic tools, treatment and prognosis.PMID:38650533 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - April 23, 2024 Category: Psychiatry Authors: S Wouters K Van Laere F-L De Winter Source Type: research
Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties
We report about a patient with the clinical presentation of a psychotic depression, who was diagnosed with anti-NMDA receptor encephalitis only after a thorough diagnostic work-up. Neurological symptoms were wrongly attributed to the psychiatric syndrome or considered as side-effects of its treatment. We present an overview of clinical aspects of the disorder, distinctive psychiatric symptoms, diagnostic tools, treatment and prognosis.PMID:38650533 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - April 23, 2024 Category: Psychiatry Authors: S Wouters K Van Laere F-L De Winter Source Type: research
Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties
We report about a patient with the clinical presentation of a psychotic depression, who was diagnosed with anti-NMDA receptor encephalitis only after a thorough diagnostic work-up. Neurological symptoms were wrongly attributed to the psychiatric syndrome or considered as side-effects of its treatment. We present an overview of clinical aspects of the disorder, distinctive psychiatric symptoms, diagnostic tools, treatment and prognosis.PMID:38650533 (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - April 23, 2024 Category: Psychiatry Authors: S Wouters K Van Laere F-L De Winter Source Type: research
Sheep abortions associated with Neospora caninum and Toxoplasma gondii infections in multiple flocks from Southern Brazil
This study verified the occurrence of these diseases in sheep fetuses from Santa Catarina State, Southern Brazil from 2015 to 2022. Sheep fetuses were necropsied with organ sampling for histopathology, and polymerase chain reaction (PCR) forNeospora caninum andToxoplasma gondii using the Nc5 and SAG2 targets, respectively, in frozen brain tissue. Microbiological culture and RT-PCR forPestivirus were conducted to discard other abortion causes. One positive fetus for toxoplasmosis was genotyped using multiplex multilocus nested PCR-RFLP (Mn-PCR-RFLP) with ten genetic markers. Fifty-five sheep fetuses were evaluated, with 10 ...
Source: Veterinary Research Communications - April 23, 2024 Category: Veterinary Research Source Type: research
Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Infection with Angiostrongylus cantonensis (AC) in humans or mice can lead to severe eosinophilic meningitis or encephalitis, resulting in various neurological impairments. Developing effective neuroprotective dr... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 23, 2024 Category: Microbiology Authors: Hui Huang, Zhongyuan Zhang, Mengdan Xing, Zihan Jin, Yue Hu, Minyu Zhou, Hang Wei, Yiwen Liang and Zhiyue Lv Tags: Research Source Type: research
Prevalence and Molecular Analysis of Encephalomyocarditis Virus-2 in the Hazel Dormouse
In this study, we firstly investigated cause of death in seven hazel dormice found dead in England, through next-generation sequencing identifyin g a virus closely related to a wood mouse encephalomyocarditis virus-2 (EMCV-2). Subsequently, lung tissue samples from 35 out of 44 hazel dormice tested positive for EMCV-2 RNA using a reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and Sanger sequencing methods developed in this study. Formalin-fixed tissues available for nine hazel dormice which tested positive for EMCV-2 RNA were examined microscopically. Three cases showed moderate interstitial pneumon...
Source: EcoHealth - April 23, 2024 Category: Environmental Health Source Type: research
Intravenous immunoglobulin alleviates Japanese encephalitis virus-induced peripheral neuropathy by inhibiting the ASM/ceramide pathway
In this study, we found that high doses of intravenous immunoglobulin, a function inhibitor of acid sphingomyelinase (FIASMA), inhibited acid sphingomyelinase (ASM) and ceramide activity in the serum and sciatic nerve of JEV-infected rats, reduced disease severity, reversed electrophysiological and histological abnormalities, significantly reduced circulating proinflammatory cytokine levels, inhibited Th1 and Th17 cell proliferation, and suppressed the infiltration of inflammatory CD4 + cells into the sciatic nerve. It also maintained the peripheral nerve-blood barrier without causing severe clinical side effects. In terms...
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Na Zhang Guowei Wang Liping Yang Jinyuan Zhang YanPing Yuan Lijun Ma Zhenhai Wang Source Type: research
Intravenous immunoglobulin alleviates Japanese encephalitis virus-induced peripheral neuropathy by inhibiting the ASM/ceramide pathway
In this study, we found that high doses of intravenous immunoglobulin, a function inhibitor of acid sphingomyelinase (FIASMA), inhibited acid sphingomyelinase (ASM) and ceramide activity in the serum and sciatic nerve of JEV-infected rats, reduced disease severity, reversed electrophysiological and histological abnormalities, significantly reduced circulating proinflammatory cytokine levels, inhibited Th1 and Th17 cell proliferation, and suppressed the infiltration of inflammatory CD4 + cells into the sciatic nerve. It also maintained the peripheral nerve-blood barrier without causing severe clinical side effects. In terms...
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Na Zhang Guowei Wang Liping Yang Jinyuan Zhang YanPing Yuan Lijun Ma Zhenhai Wang Source Type: research
Predictors of mortality and poor outcome for patients with severe infectious encephalitis in the intensive care unit: a cross-sectional study
There are few thorough studies assessing predictors of severe encephalitis, despite the poor prognosis and high mortality associated with severe encephalitis. The study aims to evaluate the clinical predictors... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 22, 2024 Category: Infectious Diseases Authors: WenYan Zhao, YuLiang Zhou, YingYing Hu, WenJing Luo, Jing Wang, Hong Zhu and ZhiPeng Xu Tags: Research Source Type: research
Dabrafenib mitigates the neuroinflammation caused by ferroptosis in experimental autoimmune encephalomyelitis by up regulating Axl receptor
In this study, we preliminarily studied the possible mechanism of dabrafenib in the treatment of multiple sclerosis from the perspective of ferroptosis. First, we observed that dabrafenib significantly improved symptoms of gait abnormalities, limb weakness or paralysis, and down-regulated levels of spinal cord inflammation in an experimental autoimmune encephalitis (EAE) model. Meanwhile, we also observed that dabrafenib could inhibit the proteins of ferroptosis in spinal cord tissue of EAE mice by western blot. The results of immunohistochemical analysis showed that the effect of dabrafenib on ferroptosis mainly occurred ...
Source: European Journal of Pharmacology - April 21, 2024 Category: Drugs & Pharmacology Authors: Ning Liu Wuhan Yu Mengjiao Sun Xiaoling Li Wenjing Zhang Manxia Wang Source Type: research
Japanese encephalitis virus E protein domain III immunization mediates cross-protection against Zika virus in mice via antibodies and CD8 < sup > + < /sup > T cells
Virus Res. 2024 Apr 19:199376. doi: 10.1016/j.virusres.2024.199376. Online ahead of print.ABSTRACTZika virus (ZIKV) and Japanese encephalitis virus (JEV) are antigenically related flaviviruses that co-circulate in many countries/territories. The interaction between the two viruses needs to be determined. Recent findings by ourselves and other labs showed that JEV-elicited antibodies (Abs) and CD8+ T cells exacerbate and protect against subsequent ZIKV infection, respectively. However, the impact of JEV envelope (E) protein domain III (EDIII)-induced immune responses on ZIKV infection is unclear. We show here that sera from...
Source: Virus Research - April 21, 2024 Category: Virology Authors: Zhi-Liang Duan Wei-Wei Zou Dong Chen Jia-Yang Zhu Jin-Sheng Wen Source Type: research
