European Journal of Clinical Microbiology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Metabolomics unveil key pathways underlying the synergistic activities of aztreonam and avibactam against multidrug-resistant Escherichia coli
ConclusionThe findings indicate that the aztreonam/avibactam combination accelerates structural damage to the bacterial membrane structure and their actions were immediate and sustained compared to aztreonam or avibactam alone. By inhibiting the production of crucial cell wall precursors, the combination may have inflicted damages on bacterial DNA. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - May 9, 2024 Category: Microbiology Source Type: research

Novel Providencia xianensis sp. nov.: A multidrug-resistant species identified in clinical infections
AbstractProvidencia genus is known to harbor certain opportunistic pathogens capable of causing human infections. Here, we report two strains of multidrug-resistant bacteria initially identified as Providencia rettgeri by mass spectrometry, but genome analysis revealed their ANI (79.84–84.20%) and dDDH (21.1–25.6%) values to fall below the accepted species threshold for knownProvidencia species. We therefore propose that these isolates be recognized as a novel  species, Providencia xianensis sp. nov. Alarmingly, both strains, isolated from locations far apart, exhibited resistance to last-resort antibiotics, in...
Source: European Journal of Clinical Microbiology and Infectious Diseases - May 7, 2024 Category: Microbiology Source Type: research

In vitro and in vivo activity of ceftazidime/avibactam and aztreonam alone or in combination against mcr-9, serine- and metallo- β-lactamases–co-producing carbapenem-resistant Enterobacter cloacae complex
ConclusionTo our knowledge, this study represents the first report on the in vitro and in vivo antibacterial activity of CZA plus ATM against CRECC isolates co-harboringmcr-9, MBL and TEM. Our findings suggest that the combination regimen of CZA  + ATM provides a valuable reference for clinicians to address the increasingly complex antibiotic resistance situation observed in clinical microorganisms. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - May 3, 2024 Category: Microbiology Source Type: research

Antimicrobial susceptibility testing reveals reduced susceptibility to azithromycin and other antibiotics in Legionella pneumophila serogroup 1 isolates from Portugal
ConclusionsWe report, for the first time, elevated MICs against first-line and other antibiotics (including azithromycin, fluoroquinolones and amoxicillin/clavulanic acid commonly used to treat pneumonia patients in Portugal) in PortugueseL. pneumophila strains. Results point towards decreased susceptibility in circulating strains, justifying further investigation. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - May 2, 2024 Category: Microbiology Source Type: research

Epidemiology and antimicrobial resistance patterns of bacterial meningitis among hospitalized patients at a tertiary care hospital in Saudi Arabia: a six-year retrospective study
ConclusionThe study highlights the substantial burden of bacterial meningitis among hospitalized patients, especially among high-risk groups. Emerging antimicrobial resistance emphasizes the need for optimized surveillance and stewardship. Future prospective research employing molecular techniques across multiple centers in the country is warranted to enhance understanding and guide public health strategies in Saudi Arabia. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 29, 2024 Category: Microbiology Source Type: research

Tick-Borne Bacterial Diseases in Europe: Threats to public health
ConclusionsBy integrating various pieces of information on these bacterial species, the paper aims to provide a comprehensive  resource for researchers and healthcare professionals addressing the impact of bacterial tick-borne diseases in Europe. This review underscores the importance of understanding the complex details influencing bacterial prevalence and transmission dynamics to better combat these emerging public he alth threats. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 27, 2024 Category: Microbiology Source Type: research

Evolution, control and success of combination therapy with Ampicilin-sulbactam/Ceftazidime-Avibactam during a Carbapenem-Resistant Acinetobacter baumannii outbreak in burn Intensive Care Unit
We present our findings on interpatient transmission, epidemic control measures, and the outcomes of a series of ten critically ill burn patients who were either colonized or infected with carbapenem-resistantAcinetobacter baumannii (CRAB). None of the five infected patients achieved clinical cure, and all experienced relapses. Microbiological failure was observed in 40% of the infected patients. The isolated CRAB strains were found to carry blaOXA −23 and armA resistance genes. Despite the lack of clinical cure, all five infected patients survived and were discharged from the Burn Intensive Care Unit. (Source: European ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 27, 2024 Category: Microbiology Source Type: research

Oligella spp.: A systematic review on an uncommon urinary pathogen
ConclusionOligella is an uncommon pathogen that can be underrecognized. Microbiologists should be prompt to prolong the incubation of agar media plated with urines when the direct examination showed Gram-negative coccobacilli. Carbapenems should probably be given for the empirical treatment. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 26, 2024 Category: Microbiology Source Type: research

MAST ® D72C test: a novel option for ESBL, AmpC and carbapenemase detection
ConclusionThese results show that the MAST ® D72C test can be a useful tool for the detection of ESBL- and AmpC-production in clinical laboratories. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 25, 2024 Category: Microbiology Source Type: research

Development and validation of an online dynamic nomogram system for pulmonary consolidation in children with Mycoplasma pneumoniae pneumonia
ConclusionsWe developed a dynamic online nomogram for predicting combined pulmonary consolidation in children with MP based on 7 variables for the first time. The predictive value and clinical benefit of the nomogram model were acceptable. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 24, 2024 Category: Microbiology Source Type: research

In vitro activity of cefiderocol against carbapenem-resistant Acinetobacter baumannii carrying various β-lactamase encoding genes
ConclusionsCefiderocol susceptibility was 60.7% in CRAB isolates. MIC50, MIC90 ofblaPER −1 positive andblaPER −1 negative groups were>  128/>128 and 0.25/>128  mg/L. A correlation between the presence ofblaPER −1 and cefiderocol resistance was observed (p <  0.0001). Among colistin-resistant isolates, the presence ofblaPER −1 was 47.1% and 75% of them were resistant to cefiderocol respectively. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 23, 2024 Category: Microbiology Source Type: research

Rubella virus-associated cutaneous granulomatous disease in an immunocompetent woman
(Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 22, 2024 Category: Microbiology Source Type: research

Molecular epidemiological and clinical infection characteristics analysis of Ralstonia
ConclusionWe established a sequence typing system with a relatively fine resolution and the PCR assay is a faster and more sensitive method for clinical identification ofRalstonia pickettii. ST9 is the most common sequence types ofRalstonia pickettii. The most common clinical characteristics ofRalstonia pickettii infected patients were cough, sputum, shortness of breath and pulmonary rales. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 19, 2024 Category: Microbiology Source Type: research

Clinical effectiveness of cefiderocol for the treatment of bloodstream infections due to carbapenem-resistant Acinetobacter baumannii during the COVID-19 era: a single center, observational study
ConclusionsCFDC could represent an effective and safe treatment option for CRAB BSI, especially in patients with bacteremic HAP/VAP and frail patients where the risk of acute renal failure during therapy should be avoided. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 18, 2024 Category: Microbiology Source Type: research

Evaluation of the JF5-based Aspergillus galactomannoprotein lateral flow device for diagnosing invasive aspergillosis in cancer patients
ConclusionThe AspLFD demonstrated good performance in diagnosing IA in cancer patients, especially those with solid tumours. The AspLFD is thus an alternative POCT, particularly when GM evaluations are not readily available. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 16, 2024 Category: Microbiology Source Type: research