European Journal of Clinical Microbiology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The implication of infection with respiratory syncytial virus in pediatric recurrent wheezing and asthma: knowledge expanded post-COVID-19 era
ConclusionIn conclusion, this study offers a comprehensive perspective to better understand how the RSV infection interacts in the control of the host ’s pulmonary immune system, causing recurrent wheezing and the development of asthma, and it sheds fresh light on potential avenues for pharmaceutical therapy in the future. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 28, 2023 Category: Microbiology Source Type: research

Semi-quantitative assessment of gastrointestinal viruses in stool samples with Seegene Allplex gastrointestinal panel assays: a solution to the interpretation problem of multiple pathogen detection?
ConclusionBy omitting very high Ct values and reporting semi-quantitatively, value was added to the syndromic reports, leading to an easier to read lab report, especially in mixed infections. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 26, 2023 Category: Microbiology Source Type: research

An improved protocol for bacteria identification by MALDI-TOF MS directly from positive blood cultures
AbstractFASTinov ® developed a rapid antimicrobial susceptibility test that includes the purification of a bacterial suspension directly from positive blood cultures (BC). In order to streamline laboratory workflow, the use of the bacterial suspension obtained through FASTinov® sampleprep was tested for identification (ID) by matrix absorption laser deionization –time of flight mass spectrometry (MALDI-TOF MS) (Bruker) in 364 positive BC, and its accuracy assessed comparing with the MALDI-TOF MS ID of the next-day subcultured colonies. FASTinov sample prep was highly reliable for rapid ID directly from BC with propo...
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 19, 2023 Category: Microbiology Source Type: research

Clinical characteristics and antimicrobial susceptibility of Fusobacterium species isolated over 10 years at a Japanese university hospital
ConclusionWe show a link betweenFusobacterium species and solid organ malignancies. We observed resistance to penicillin, cefmetazole, clindamycin, and moxifloxacin, warranting caution in their clinical use. This study offers valuable insights for managingFusobacterium infections and guiding empirical treatments. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 19, 2023 Category: Microbiology Source Type: research

The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid
AbstractFungal infections due toApiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection byApiotrichum mycotoxinivorans in a girl with B-cell acute lymphoblastic leukemia. This is the first report of the isolation ofApiotrichum mycotoxinivorans from human cerebrospinal fluid. MRI features of meningitis caused by this fungus are presented. Three small isoquinoline alkaloids inhibited the growth of this rare fungusin vitro, providing a starting point for the application of natural products to treat this highly fatal fungal infection. Our case presentation co...
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 16, 2023 Category: Microbiology Source Type: research

Physician-directed microbiological testing versus syndromic multiplex PCR in gastroenteritis
ConclusionThis study suggests that syndromic multiplex PCR assays are a better strategy for pathogen detection in patients with gastroenteritis than physician-directed laboratory testing based on the clinical presentation. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 16, 2023 Category: Microbiology Source Type: research

Genotyping of European Toxoplasma gondii strains by a new high-resolution next-generation sequencing-based method
ConclusionThe new method can distinguish differentT. gondii genotypes and detect intra-genotype variability among European type IIT. gondii strains. Furthermore, with WGS data additional target regions can be added to the method to potentially increase typing resolution. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 15, 2023 Category: Microbiology Source Type: research

Cutibacterium namnetense osteosynthetic cervical spine infections: experience with two cases
We report two uncommon cases of osteosynthetic cervical spine infection. Clinical patient features, microbiological strain characteristics, diagnostic methods, and treatment were analyzed. Both patients were male, and one had risk factors for surgical site infection. During surgery, perioperative samples were positive yielding an anaerobic microorganism identified asCutibacterium namnetense by MALDI-TOF MS and confirmed by 16S rRNA/gyrB genes sequencing. All isolates were fully susceptible.C. namnetense osteosynthetic cervical spine infections are rare. Both cases were early surgical site infections. Bruker MALDI-TOF MS ap...
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 14, 2023 Category: Microbiology Source Type: research

Multidrug-resistant Gram-negative clinical isolates with reduced susceptibility/resistance to cefiderocol: which are the best present and future therapeutic alternatives?
ConclusionsZidebactam- and nacubactam-containing combinations showed a significant in vitro activity against multidrug-resistant Enterobacterales clinical isolates with reduced susceptibility to cefiderocol. On the other hand, imipenem-relebactam and meropenem-vaborbactam showed the highest susceptibility rates againstP. aeruginosa isolates. Finally, sulbactam-durlobactam and cefiderocol combined with a BLI were the only effective options againstA. baumannii tested isolates. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 14, 2023 Category: Microbiology Source Type: research

Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in Clostridioides difficile infection
ConclusionBy modifying the thresholds for assay positivity, the measurement of FC and FL at diagnosis is useful to predict recurrence and severity in CDI. Adding these biomarkers to current clinical scores may help to individualize CDI management. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 11, 2023 Category: Microbiology Source Type: research