European Journal of Clinical Microbiology and Infectious Diseases 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Three separate acquisitions of blaNDM-1 in three different bacterial species from a single patient
AbstractTo investigate the acquisition and relatedness of New Delhi Metallo-beta-lactamase among multiple separate species from one patient. Five isolates from three species (Pseudomonas aeruginosa; Pa,Acinetobacter baumannii; Ab andProteus mirabilis; Pm) suspected of harbouring a carbapenemase were investigated by phenotype (antimicrobial susceptibilities) and whole genome sequencing. Epidemiological data was collected on this patient. Three different carbapenemase genes were detected;blaVIM-1 (Pa; ST773),blaOXA-23 (Ab, ST499) andblaNDM-1 identified in all isolates. NDM regions were found chromosomally integrated in all i...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 9, 2023 Category: Microbiology Source Type: research
Ertapenem plus meropenem combination treatment in carbapenem-resistant Klebsiella pneumoniae bacteremia: an analysis of 53 cases
AbstractHerein, we aimed to describe the outcomes of patients with blood stream infections due to carbapenem-resistantKlebsiella pneumoniae (CR-Kp) who received ertapenem plus meropenem combination treatment (EMCT). A total of 53 patients with culture proven CR-Kp bacteremia treated with ertapenem + meropenem were included. The patients with secondary bacteremia due to urinary tract infection exhibited a significantly lower 1-month mortality (OMM), particularly in those with microbiological eradication and those with end-of-treatment success. Salvage EMCT resulted in 49% 1-month survival. (Source: European Journal of Clini...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 7, 2023 Category: Microbiology Source Type: research
Cryptococcal meningitis and cerebral vasculitis in a patient with primary intestinal lymphangiectasia: a case report
We report the case of a 49-year-old male patient with meningitis and cerebral vasculitis due toCryptococcus neoformans complicating Waldmann ’s disease diagnosed 12 years ago. The treatment combined liposomal amphotericin B, 3 mg/kg daily plus flucytosine 25 mg/kg/6 h, both intravenously during 15 days, then fluconazole 800 mg daily during 8 weeks, and finally 200 mg daily indefinitely. Dexamethasone 0.4 mg/kg daily during the first week was gradually decreased over 2 months. The outcome was good, and the patient is still followed 3 years later without any recurrence. (Source: European Journal of Clinical Micr...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 5, 2023 Category: Microbiology Source Type: research
A novel lytic phage exhibiting a remarkable in vivo therapeutic potential and higher antibiofilm activity against Pseudomonas aeruginosa
ConclusionBased on these findings, isolated phage vB_PaeM_PS3 could be potentially considered for treating ofP. aeruginosa infections. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 23, 2023 Category: Microbiology Source Type: research
Development and validation of a machine learning model to predict prognosis in HIV-negative cryptococcal meningitis patients: a multicenter study
ConclusionA ML model for predicting prognosis in HIV-negative CM patients was built and validated, and the model might provide a reference for personalized treatment of HIV-negative CM patients. The change in the CSF cryptococcal count in the early phase of HIV-negative CM treatment can reflect the prognosis of the disease. In addition, utilizing AI to detect and count CSF cryptococci in HIV-negative CM patients can eliminate the interference of human factors in detecting cryptococci in CSF samples and reduce the workload of the examiner. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 22, 2023 Category: Microbiology Source Type: research
Tenofovir disoproxil fumarate mediates neuronal injury by inducing neurotoxicity
ConclusionOur findings indicated that TDF may induce neuronal cell apoptosis through increasing the intracellular ROS and the expression level of caspase-3, which may be related to the increasing prevalence of HAND. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 22, 2023 Category: Microbiology Source Type: research
Prevention of ICU-acquired infection with decontamination regimen in immunocompromised patients: a pre/post observational study
ConclusionIn conclusion, MSD appeared to be associated with improved outcomes in critically ill immunocompromised patients. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 19, 2023 Category: Microbiology Source Type: research
The impact of COVID on bacterial sepsis
ConclusionConcurrent COVID-19 infection is associated with a significant increase in morbidity and mortality in patients with GP and GN BSIs. Patients withS. aureus BSIs with COVID-19 are more likely to develop shock and respiratory failure and have higher rates and odds of mortality than those without COVID-19. These findings provide an essential insight into the care of these patients, especially those co-infected withStaphylococcus aureus. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 19, 2023 Category: Microbiology Source Type: research
A comparative study for optimization of MALDI-TOF MS identification of filamentous fungi
ConclusionThe results of our study show the necessity of using selective culture media (IDFP and SGC2) for fungal identification with MALDI-TOF MS and demonstrate no significant benefit of the formic acid-ethanol protein extraction technique in these media. Given the relative strengths and weaknesses of the MBT library and the MSI database, it might currently be beneficial to consider these libraries as complementary and employ both databases to achieve optimal fungal identification. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 17, 2023 Category: Microbiology Source Type: research
Efficacy of ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam combinations against carbapenemase-producing Enterobacterales in Switzerland
AbstractCarbapenemase-producing in Enterobacterales (CPE) represent a critical health concern worldwide, including in Switzerland, leading to very limited therapeutic options. Therefore, our aim was to evaluate the susceptibility to the novel ß-lactam/ß-lactamase inhibitor combinations ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam of CPE isolates recovered in Switzerland from 2018 to 2020. A total of 150 clinical CPE were studied including mainlyKlebsiella pneumoniae (n = 61, 40.3%) andEscherichia coli (n = 53, 35.3%). The distribution of carbapenemases was as follows: KPC-like (32%), OXA-48-like ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 11, 2023 Category: Microbiology Source Type: research
In vitro activity of aztreonam –avibactam against Enterobacterales isolates collected in Latin America, Africa/Middle East, Asia, and Eurasia for the ATLAS Global Surveillance Program in 2019–2021
This study aimed to report reference method antimicrobial susceptibility results for 24,937 recent (2019 –2021) clinical isolates of Enterobacterales from 27 countries in Latin America, Eurasia, Africa/Middle East, and Asia with a focus on the investigational combination aztreonam–avibactam against metallo-β-lactamase (MBL) isolates. Antimicrobial susceptibility testing was performed by the CLSI b roth microdilution methodology. Minimum inhibitory concentrations (MICs) were interpreted using the CLSI (2022) breakpoints for all agents except aztreonam–avibactam (provisional pharmacokinetic/pharmacodynamic susceptible...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 1, 2023 Category: Microbiology Source Type: research
Phenotypic and genomic characteristics of oxacillin-susceptible mecA-positive Staphylococcus aureus, rapid selection of high-level resistance to beta-lactams
AbstractThe aim of this study is to describe the phenotypic and genetic properties of oxacillin-susceptible methicillin-resistantStaphylococcus aureus (OS-MRSA) isolates and their beta-lactam resistant derivatives obtained after selection with oxacillin. A collection of hospital- (HA-) and community-acquired (CA-) MRSA was screened for oxacillin susceptibility. Antibiotic susceptibility testing, population analysis profile (PAP),mecA expression analysis, and whole genome sequencing (WGS) were performed for 60mecA-positive OS-MRSA isolates. Twelve high-level beta-lactam resistant derivatives selected during PAP were also su...
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 29, 2023 Category: Microbiology Source Type: research
High carriage rate of extended ‐spectrum β‐lactamase Enterobacterales and diarrheagenic Escherichia coli in healthy donor screening for fecal microbiota transplantation
This study aimed to demonstrate the outcomes of our strict donor screening program. This study was conducted at our FMT center between January 2019 and June 2022. Our donor screening program included an initial questionnaire and subsequent blood and stool testing. We further used selective culture for third-generation cephalosporin-resistant (3GCR)Enterobacterales and multiplex PCR to detect diarrheagenicE. coli in stools. The resistance mechanisms and sequence type of 3GCREnterobacterales were determined. A total of 742 individuals were assessed, and 583 participants (78.6%) were excluded after questionnaire. Of the remai...
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 20, 2023 Category: Microbiology Source Type: research
The aetiology and incidence of infective endocarditis in people living with rheumatic heart disease in tropical Australia
ConclusionAlthough RHD predisposes individuals to IE, the absolute risk of IE in native valve disease in tropical Australia is low and might be reduced further by improved adherence to secondary BPG prophylaxis. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 20, 2023 Category: Microbiology Source Type: research
Dissemination of ArmA- and OXA-23-co-producing Acinetobacter baumannii Global Clone 2 in Switzerland, 2020 –2021
AbstractFollowing the observation of an increased number of isolation of OXA-23- and ArmA-producingAcinetobacter baumannii at the national level, our aim was to evaluate whether some given clone(s) might actually be spreading and/or emerging in Switzerland. To evaluate this possibility, our study investigated and characterized allA. baumannii isolates harboring both theblaOXA-23 andarmA genes that had been collected at the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) from 2020 to 2021. Most isolates were obtained from infections rather than colonization with the majority being obtained from res...
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 20, 2023 Category: Microbiology Source Type: research
