European Journal of Clinical Microbiology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Analysis of risk factors associated with fatal outcome among severe fever with thrombocytopenia syndrome patients from 2015 to 2019 in Shandong, China
AbstractTo better understand the progression of severe fever with thrombocytopenia syndrome (SFTS), identify early predictors of mortality, and improve the cure rate, the present study aimed to analyze the demographic feature, clinical characteristics, and laboratory parameters of patients with SFTS and to explore the risk factors associated with fatal outcome. We retrospectively analyzed demographic feature, clinical characteristics, and laboratory parameters of 216 laboratory-confirmed SFTS patients in Shandong province between January 2015 and December 2019. Univariate analysis was used to assess the relevance between t...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 11, 2022 Category: Microbiology Source Type: research

Clinical and molecular epidemiology of invasive group B Streptococcus infections in adults in a referral center in Korea
This study investigated the molecular characteristics and antimicrobial resistance of invasive GBS in Korean adults. GBS isolates from patients with invasive diseases during 2006 –2015 were investigated for capsular serotype, multilocus sequence type (ST), antimicrobial susceptibility, and resistance genes. Among the 74 isolates analyzed, the most common serotype was Ib (31.1%), followed by III (21.6%), V (20.3%), Ia (12.2%), and VI (12.2%). Thirteen STs were detected, wit h ST1, ST10, ST19, and ST23 as the most prevalent. The dominant capsular serotype exhibited by ST1 was V, and those expressed by ST10, ST19, and ST23 ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 8, 2022 Category: Microbiology Source Type: research

Gastrointestinal colonization by OXA-48-producing Enterobacterales: risk factors for persistent carriage
AbstractCarbapenem-resistant Enterobacterales (CRE) infections are a major health problem. Intestinal colonization is a key factor in developing infection. However, factors associated with persistent colonization by CRE are unknown. The aim of the study was to identify factors associated with persistent CRE gut colonization. This is a retrospective, single-centre, observational study of adult patients with CRE gut colonization between January 2015 and January 2020. Epidemiologic characteristics, comorbidities, infectious events, duration of hospitalization and antimicrobial treatment received in the follow-up period were c...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 7, 2022 Category: Microbiology Source Type: research

Candida auris, a singular emergent pathogenic yeast: its resistance and new therapeutic alternatives
AbstractNowadays, fungal infections affect millions of people across the world.Candida auris, a new emergent yeast, is a worrisome pathogen because it associates with a high rate of incidence and prevalence, including in the nosocomial environment. The hard identification, the phenotypic plasticity, and the easy adaptation to stressful conditions are some of theC. auris traits that render this latest yeast singular challenging.C. auris infections have already been reported from more than 30 countries and are associated with high mortality rates. This is the result from rapid transmission and the difficulty of prevention, c...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 6, 2022 Category: Microbiology Source Type: research

In vitro and in vivo efficacy of cefiderocol plus tigecycline, colistin, or meropenem against carbapenem-resistant Acinetobacter baumannii
Abstract We investigated activities of cefiderocol combination therapy against carbapenem-resistantAcinetobacter baumannii (CR-AB). A total of 123 clinical isolates of CR-AB, including 44 cefiderocol-resistant isolates were tested. Cefiderocol functioned synergistically with tigecycline in most cefiderocol-susceptible isolates (84.8%, 67/79), but not with colistin or meropenem by checkerboard method. Cefiderocol functioned synergistically with tigecycline, colistin, and meropenem in 90.9% (40/44), 47.7% (21/44), and 79.5% (35/44) cefiderocol-resistant isolates, respectively. The time-kill assay and the in vivoGalleria m...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 6, 2022 Category: Microbiology Source Type: research

Comparison of infections with respiratory syncytial virus between children and adults: a multicenter surveillance from 2015 to 2019 in Beijing, China
The objective of this study is to investigate the epidemiological and clinical characteristics of the acute respiratory tract infections (ARTI) caused by respiratory syncytial virus (RSV) among the population of all age categories in Beijing, China. Outpatients and inpatients with ARTI were enrolled from 35 sentinel hospitals in Beijing between March 2015 and February 2019. They were interviewed and their medical records were collected using a standardized form. Their respiratory specimens were collected and tested for the nucleic acid of RSV. The RSV-positive specimens were further genotyped into RSV-A and RSV-B groups. A...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 5, 2022 Category: Microbiology Source Type: research

Determinants and outcomes of bloodstream infections related to obesity
AbstractAlthough obesity is a major healthcare problem that is increasing in many populations worldwide, there are limited studies that have examined its contribution to infectious diseases morbidity and mortality. The aim of this study was to examine the clinical determinants and outcomes of bloodstream infections among patients with obesity. All adults within the publicly funded healthcare system in Queensland, Australia, identified with a BSI during 2017 –2019 were included and the presence of obesity was based on discharge International Classification of Diseases (ICD-10) codes. Clinical features, microbiology, and o...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 4, 2022 Category: Microbiology Source Type: research

The effect of selective decontamination on the intestinal microbiota as measured with IS-pro: a taxonomic classification tool applicable for direct evaluation of intestinal microbiota in clinical routine
This study shows that SDD not only decreases colonization of the gastrointestinal tract with potential pathogenic Gram-negative microorganisms, but also reduces the abundance of normal colonizers of our gastrointestinal system and leads to a shift in total microbiota composition. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 1, 2022 Category: Microbiology Source Type: research

A longitudinal analysis of nosocomial bloodstream infections among preterm neonates
AbstractNosocomial bloodstream infections (NBSIs), commonly due to central-line associated bloodstream infections (CLABSI), contribute substantially to neonatal morbidity and mortality. We aimed to identify longitudinal changes in incidence of NBSI, microbiological-spectrum, and antibiotic exposure in a large cohort of preterm neonates admitted to the neonatal intensive care unit. We retrospectively assessed differences in annual rates of NBSI (per 1000 patient-days), CLABSI (per 1000 central-line days), and antibiotic consumption (per 1000 patient-days) among preterm neonates (<  32 weeks’ gestation) hospitalized ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 30, 2022 Category: Microbiology Source Type: research

Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study
In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 30, 2022 Category: Microbiology Source Type: research

A longitudinal study of Candida bloodstream infections in a Japanese university hospital: species distribution, drug susceptibility, clinical features, and mortality predictors
AbstractWe aimed to detect possible changes inCandida species distribution over time and to know the antifungal susceptibility profile of isolates obtained from patients with bloodstream infection (BSI) due to this pathogen. Risk factors associated with 30-day mortality were also assessed. We conducted a retrospective cohort study of patients diagnosed withCandida BSI at a Japanese university hospital from 2013 to 2021. The change in the distribution pattern of theCandida spp. isolated was examined by considering three successive sub-periods of 3  years each. Risk factors for 30-day mortality were determined using Cox reg...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 26, 2022 Category: Microbiology Source Type: research

Epidemiology, aetiology and clinical characteristics of clostridial bacteraemia: a 6-year population-based observational study of 386 patients
We present the highest incidence rate of clostridial bacteraemia to date. Clostridial bacteraemia is a severe condition with acute onset, affecting elderly with co-morbidities, most pronounced malignancies. Mortality is related to acute manifestations rather than to background factors. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 22, 2022 Category: Microbiology Source Type: research

Racemose neurocysticercosis simulating tuberculous meningitis
We report a patient with racemose neurocysticercosis, highlighting the diagnostic and management issues. A 37-year-old male had headaches, fever, and seizures for 8  months. He had a positive tuberculin test, cerebrospinal fluid pleocytosis, and hydrocephalus and exudates on MRI. His symptoms rapidly resolved following antitubercular and prednisolone treatment. After 2 months, he was readmitted with headache and vomiting, and his brain MRI revealed communicat ing hydrocephalus with a cyst in the lateral ventricle and subarachnoid space, which was confirmed as neurocysticercosis on the third ventriculostomy. The patient w...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 22, 2022 Category: Microbiology Source Type: research

Ancient DNA confirmation of lepromatous leprosy in a skeleton with concurrent osteosarcoma, excavated from the leprosarium of St. Mary Magdalen in Winchester, Hants., UK
AbstractTo establish a biological profile and disease aetiologies for one of four burials recovered during a Time Team dig at the St. Mary Magdalenleprosarium, Winchester, UK in AD 2000. Osteological techniques were applied to estimate age at death, biological sex, stature and pathology. Visual assessment of the material was supplemented by radiographic examination. Evidence for leprosy DNA was sought using ancient DNA (aDNA) analysis. The remains are those of a male individual excavated from a west –east aligned grave. The skeleton shows signs of two pathologies. Remodelling of the rhino-maxillary area and degenerative ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 17, 2022 Category: Microbiology Source Type: research

Comparison between culture-positive and culture-negative septic shock in patients in the emergency department
This study aimed to compare clinical characteristics and outcomes of patients with culture-negative septic shock (CNSS) and culture-positive septic shock (CPSS) in the emergency department. We also assessed the differences in duration and de-escalation timing of antibiotic administration between the two groups. This single-center, retrospective, case –control study included adult patients diagnosed with septic shock in the emergency department between January 1, 2019 and March 31, 2020. They were divided into the CNSS and CPSS groups based on their culture results. The baseline characteristics, infection sites, culture t...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 15, 2022 Category: Microbiology Source Type: research