European Journal of Clinical Microbiology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

HIV-1 Vif protein sequence variations in South African people living with HIV and their influence on Vif-APOBEC3G interaction
ConclusionsThese results provide insights into Vif sequence diversity in HIV-1C prevalent regions and shed light on differential pathogenesis observed in different geographical areas. The identified Vif amino acid residues warrant further investigation for their diagnostic, prognostic, and therapeutic potential. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 11, 2023 Category: Microbiology Source Type: research

Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan
In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN,iucABCD,rmpA,rmpA2, andiutA), while KP2683-1 acquired an IncL type plasmid harboringblaOXA-48. (Source: European Journal of Clinical Mi...
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 7, 2023 Category: Microbiology Source Type: research

Insidious transmission of Mycobacterium tuberculosis in Ordos, China: a molecular epidemiology study
ConclusionTo conclude, the present study demonstrates the extensive recent transmission of Beijing genotype strains in the community of Ordos. The failure to provide a comprehensive pattern of transmission indicated the missed diagnosis of active TB within the community. A substantial proportion of subclinical TB cases are recognized in the bacteria-positive cases, emphasizing that we must interrupt transmission by finding people with active TB before they infect others. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 6, 2023 Category: Microbiology Source Type: research

Performance evaluation of core genome multilocus sequence typing for genotyping of Mycobacterium tuberculosis strains in China: based on multicenter, population-based collection
Conclusion cgMLST showed a discriminatory power comparable to whole-genome SNP typing and could be used to genotype clinicalM.tuberculosis strains in different regions of China. The discriminative power of cgMLST was significantly correlated with strain genetic diversity and was slightly lower with strains from regions with low genetic diversity. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 2, 2023 Category: Microbiology Source Type: research

Deciphering mechanisms affecting cefepime-taniborbactam in vitro activity in carbapenemase-producing Enterobacterales and carbapenem-resistant Pseudomonas spp. isolates recovered during a surveillance study in Spain
ConclusionsThe reduced cefepime-taniborbactam activity among the minority of isolates with elevated cefepime-taniborbactam MICs is not only due to IMP carbapenemases but also to the accumulation of multiple resistance mechanisms, including PBP and porin mutations in CPE and chromosomal mutations leading to efflux pumps up-regulation, AmpC overexpression, and PBP modifications inP. aeruginosa. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 2, 2023 Category: Microbiology Source Type: research

Clinical and molecular characteristics of Klebsiella pneumoniae infection in a tertiary general hospital of Wuhan, China
ConclusionIn this study, ST11-KPC-2 was responsible for most of theK. pneumoniae infection cases. Carbapenem resistance rather than the co-occurrence of the virulence genesrmpA,rmpA2,iroN andiucA was associated withK. pneumoniae infection-related mortality during hospitalisation. Furthermore, a high proportion of ST11-KPC-2 isolates carried all of the four virulence genes. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 1, 2023 Category: Microbiology Source Type: research

Core genome multilocus sequence typing of Clostridioides difficile to investigate transmission in the hospital setting
ConclusionAmong clusters determined by cgMLST analysis, roughly 40% included unexplained HA-CDI acquisitions, which may be explained by unidentified epidemiological links, asymptomatic colonization, and/or shared common community reservoirs. The use of DLST, followed by whole genome sequencing analysis, is a promising and cost-effective stepwise approach for the investigation of CDI transmission in the hospital setting. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 1, 2023 Category: Microbiology Source Type: research

Severe acute herpes virus type 2 primo-infection and its association with anti-type 1 interferon autoantibodies
AbstractHerpes simplex virus type 2 (HSV-2) is a common cause of infection, which is usually self-limited and asymptomatic. A 71-year-old patient with HSV-2 primo-infection developed acute hepatitis and secondary hemophagocytic lymphohistiocytosis. The patient had high levels of autoantibodies against type I interferon (IFN) (> 1000 ng/mL), neutralizing high concentration (10 ng/mL) of both IFN-α and IFN-ω but not IFN-β. Anti-IFN-I auto-antibodies are rarely observed in healthy individuals; however, their prevalence increases in individuals over 70 years of age and have been identified as a cause of some severe vi...
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 1, 2023 Category: Microbiology Source Type: research

Effectiveness of a multimodal intervention to improve blood culture collection in an adult emergency department
AbstractWe investigated the impact of a multimodal intervention to improve the compliance of BC collections as a composite outcome, taking into account both blood volume collected and absence of solitary BC. We performed a quasi-experimental study using a before-after design (5 months for pre- and post-intervention evaluation) in an adult emergency department at a tertiary care hospital that showed that a multimodal intervention was associated with a dramatic increase in the proportion of blood cultures that were collected as recommended per national guidelines, from 17. 3% (328/1896) to 68.9% (744/1080),P < 0.00...
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 1, 2023 Category: Microbiology Source Type: research

Prevalence of Ureaplasma species among patients at a tertiary hospital in China: a 10-year retrospective study from 2013 to 2022
ConclusionsOur study has shown thatUreaplasma species have reached a significant prevalence in China and demands adequate attention. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 1, 2023 Category: Microbiology Source Type: research

Persistent headaches one year after bacterial meningitis: prevalence, determinants and impact on quality of life
ConclusionPersistent headaches are frequent one year after meningitis and are associated with quality of life alteration.Clinical trialNCT01730690. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - December 1, 2023 Category: Microbiology Source Type: research