The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid

AbstractFungal infections due toApiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection byApiotrichum mycotoxinivorans in a girl with B-cell acute lymphoblastic leukemia. This is the first report of the isolation ofApiotrichum mycotoxinivorans from human cerebrospinal fluid. MRI features of meningitis caused by this fungus are presented. Three small isoquinoline alkaloids inhibited the growth of this rare fungusin vitro, providing a starting point for the application of natural products to treat this highly fatal fungal infection. Our case presentation confirmsApiotrichum mycotoxinivorans as a potential emerging pathogen in patients with hematological malignancy undergoing chemotherapy.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research