European Journal of Clinical Microbiology and Infectious Diseases 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020
This study describes the epidemiology of OXA-48-producingE. coli isolates submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) between January 2019 and December 2020. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 14, 2022 Category: Microbiology Source Type: research
Bordetella pertussis population changes under whole-cell and acellular pertussis vaccines-induced immunity selection pressure in Poland
(Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 14, 2022 Category: Microbiology Source Type: research
Follow-up blood cultures in Staphylococcus aureus bacteremia: a probability-based optimization
AbstractStaphylococcusaureus bacteremia (SAB) is a relevant finding which prompts a thorough diagnostic work-up. Follow-up blood cultures (BC) are essential in this work-up. We investigate the probability of detecting an ongoing bacteremia after initiation of active therapy according to the number of BC taken at key time points. A retrospective analysis of all patients with SAB in a 6-year period was performed. Total number of BCs taken and the positivity was registered for each day after start of therapy. A positivity-rate was corrected using a logistic mixed effects model. Observed detection frequencies were applied to c...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 6, 2022 Category: Microbiology Source Type: research
Safety and efficacy of phage therapy in difficult-to-treat infections: studies in Chinese literature
(Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 6, 2022 Category: Microbiology Source Type: research
VanA-Enterococcus faecalis in Poland: hospital population clonal structure and vanA mobilome
AbstractThe aim of our study was to characterize the epidemiological situation concerning nosocomial vancomycin-resistantEnterococcus faecalis of VanA-phenotype (VREfs-VanA) in Poland by investigating their clonal relationships and thevanA-associated mobilome. One-hundred twenty-five clinical isolates of VREfs-VanA collected between 2004 and 2016 were studied by phenotypic assays, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), PCR detection of plasmid-specific genes, and Tn1546 structure and localization mapping. Selected isolates were subjected to PFGE-S1, Southern hybridization, genomic seque...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 3, 2022 Category: Microbiology Source Type: research
Retrospective analysis of a large single cohort of Enterobacteriaceae producing extended-spectrum B-lactamase (E-ESBL) patients: incidence, microbiology, and mortality
AbstractWe conducted a retrospective study from 2005 to 2019 to describe the epidemiology and mortality of enterobacterial producing extended-spectrum β-lactamase (E-ESBL) infections in our university hospital over a 17-year period of time. Clinical and microbiological data were extracted from different software used for continuous surveillance. Stool samples from systematic screening for E-ESBL colonization were excluded from the study. The inci dence rate of infected patient was calculated by E-ESBL species and by year. A comparison of mortality rate in patients with bloodstream infections versus other types of infectio...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 2, 2022 Category: Microbiology Source Type: research
Missed pertussis diagnosis during co-infection with Bordetella holmesii
AbstractThe purpose of this study is to identify predictive factors associated with missed diagnosis ofB. pertussis–B. holmesii co-infection by assessing the analytical performance of a commercially available multiplexed PCR assay and by building a prediction model based on clinical signs and symptoms for detecting co-infections. This is a retrospective study on the electronic health records of all clinical samples that tested positive to eitherB. pertussis orB. holmesii from January 2015 to January 2018 at Geneva University Hospitals. Multivariate logistic regression was used to build a model for co-infection prediction...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 1, 2022 Category: Microbiology Source Type: research
Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China
AbstractInvasiveSalmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoidSalmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasiveSalmonella infections in hospitalized children in China during 2016 –2018. A total of 130 children with invasiveSalmonella infections were included with the median age of 1...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 30, 2022 Category: Microbiology Source Type: research
Community-acquired hypervirulent Klebsiella pneumoniae invasive infection in critically ill patients who dramatically improved
(Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 27, 2022 Category: Microbiology Source Type: research
Development of the invasive candidiasis discharge [I Can discharge] model: a mixed methods analysis
This study aimed to assess echinocandin use at hospital discharge and develop a transition of care (TOC) model to facilitate discharge for patients with IC. This was a mixed method study design that used epidemiologic assessment to better understand echinocandin use at hospital discharge TOC. Using grounded theory methodology focused on patients given echinocandins during their last day of hospitalization, a TOC model for patients with IC, the invasive candidiasis [I Can] discharge model was developed to better understand discharge barriers. A total of 33% (1405/4211) echinocandin courses were continued until the last day ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 25, 2022 Category: Microbiology Source Type: research
Metagenomic next-generation sequencing restores the diagnosis of a rare infectious complication of B cell depletion
AbstractA 45-year-old female patient receiving rituximab for B cell non-Hodgkin follicular lymphoma presented unexplained recurrent fever, abdominal discomfort, and pollakiuria. We performed shotgun metagenomic sequencing from peri-kidney collection that identified a co-infection withMycoplasma hominis andUreaplasma urealyticum. The patient recovered with sequelae after appropriate antibiotic treatment was given. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 24, 2022 Category: Microbiology Source Type: research
A systematic review and meta-analysis on the accuracy of rapid immunochromatographic tests for dengue diagnosis
AbstractRapid immunochromatographic tests are frequently used to diagnose dengue due to their easy use, low cost, and fast response. A high level of accuracy is essential for rapid diagnostic tests to support their large-scale use. Thus, this systematic review aims to evaluate the accuracy of rapid dengue diagnostic tests. The investigation was run through the following databases: LILACS, Medline (Pubmed), CRD, The Cochrane Library, Trip Medical Database, and Google Scholar. To solve difficulties, two independent reviewers performed document screening and selection. ELISA assay was adopted as a reference test because of se...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 20, 2022 Category: Microbiology Source Type: research
Impact of therapeutic drug monitoring of antibiotics in the management of infective endocarditis
AbstractTreatment of infective endocarditis (IE) is based on high doses of antibiotics with a prolonged duration. Therapeutic drug monitoring (TDM) allows antibiotic prescription optimization and leads to a personalized medicine, but no study evaluates its interest in the management of IE. We conducted a retrospective, bicentric, descriptive study, from January 2007 to December 2019. We included patients cared for IE, defined according to Duke ’s criteria, for whom a TDM was requested. Clinical and microbiological data were collected after patients’ charts review. We considered a trough or steady-state concentration ta...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 19, 2022 Category: Microbiology Source Type: research
Ceftazidime –avibactam treatment in bacteremia caused by OXA-48 carbapenemase-producing Klebsiella pneumoniae
The objective of this study was to analyze clinical success of CAZ-AVI compared with best available therapy (BAT) in patients withKlebsiella pneumoniae carbapenemase-producing OXA-48-type bacteremia (CRKp-OXA-48). We conducted a retrospective, single-center observational study in adult patients with CRKp-OXA-48 between December 2015 and May 2019. We collected the patients ’ clinical and epidemiological characteristics, antibiotic treatment (CAZ-AVI vs. BAT), and evolution. Factors associated with clinical success were analyzed using binary logistic regression. The study included 76 patients with CRKp-OXA-48-type bacterem...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 8, 2022 Category: Microbiology Source Type: research
Implementation of Chromatic Super CAZ/AVI ® medium for active surveillance of ceftazidime-avibactam resistance: preventing the loop from becoming a spiral
AbstractAcquired resistance towards ceftazidime-avibactam (CAZ-AVI) is increasingly reported. Several mechanisms can be involved, but mutations in the Ω-loop region of β-lactamases are the most described. Herein, we assessed the implementation of Chromatic Super CAZ/AVI® medium in rectal swab surveillance cultures in a geographic area with endemic distribution of KPC-producingKlebsiella pneumoniae. Routine rectal swabs collected from the intensive care unit (ICU) and non-ICU patients were screened for carbapenemase-producing Enterobacterales (CPE), carbapenem-resistant Gram-negative organisms (CR-GN) and CAZ-AVI-resista...
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 6, 2022 Category: Microbiology Source Type: research
