European Journal of Clinical Microbiology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Antimicrobial activity of ceftibuten-avibactam against a global collection of Enterobacterales from patients with urinary tract infections (2021)
In conclusion, ceftibuten-avibactam was highly active against a large collection of contemporary Enterobacterales isolated from patients with UTI and exhibited a similar spectrum to ceftazidime-avibactam. Ceftibuten-avibactam may represent a valuable option for oral treatment of UTI caused by multidrug-resistant Enterobacterales. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 22, 2023 Category: Microbiology Source Type: research

Positive intrathecal anti-Borrelia antibody synthesis: what are the implications for clinical practice? Clinical features and outcomes of 138 patients in a French multicenter cohort study
AbstractWe aimed to describe the clinical characteristics, management, and residual symptoms (RS) in patients with definite and possible Lyme neuroborreliosis (LNB). We conducted a retrospective French multicenter cohort study (2010 –2020). Cases of LNB were defined as clinical manifestations attributed to LNB and a positiveBorrelia-specific intrathecal antibody index (AI) ( “possible” LNB) and with pleocytosis (“definite” LNB). Risk factors of RS were determined using a logistic regression model. We included 138 adult patients with a positive AI. Mean age was 59.5 years (± 14.7). The median duration of sympt...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 21, 2023 Category: Microbiology Source Type: research

Post-treatment outcomes of ceftriaxone versus antistaphylococcal penicillins or cefazolin for definitive therapy of methicillin-susceptible Staphylococcus aureus bacteremia
AbstractMethicillin-susceptibleStaphylococcus aureus (MSSA) bacteremia is associated with poor outcomes. Ceftriaxone offers logistical advantages over other standard therapies, though in vitro studies have questioned its efficacy and clinical studies of ceftriaxone in MSSA bacteremia are conflicting.We performed a multicenter, retrospective cohort study of adult patients who received ceftriaxone, cefazolin, or antistaphylococcal penicillins as definitive therapy for MSSA bacteremia from 2018 to 2019. Definitive therapy was defined as the antibiotic used in the outpatient setting. Patients were excluded if they received les...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 17, 2023 Category: Microbiology Source Type: research

The use of TNF- α antagonists in tuberculosis to control severe paradoxical reaction or immune reconstitution inflammatory syndrome: a case series and literature review
We report four cases of severe PR or IRIS during tuberculosis treatment who required TNF- α antagonists, and identified 20 additional cases through literature review. They were 14 women and 10 men, with a median age of 36 years (interquartile range, 28–52). Twelve were immunocompromised before tuberculosis: untreated HIV infection (n=6), or immunosuppressive treatment (TNF- α antagonists,n=5; tacrolimus,n=1). Tuberculosis was mostly neuromeningeal (n=15), pulmonary (n=10), lymph node (n=6), and miliary (n=6), multi-susceptible in 23 cases. PR or IRIS started after a median time of 6 weeks (IQR, 4 –9) following anti-t...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 16, 2023 Category: Microbiology Source Type: research

Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study
Abstract Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development. The data of FUO patients hospitalized/followed between 1st July 2016 and 1st July 2021 were collected retrospectively and submitted from referral centers in 21 countries through ID-IRI clinical research platform. The countries were categorized into developing (low-income (LI) and lower middle-income (LMI) economies) and developed countries (upper middle-income (UMI) and high-income (HI) economies). This research inclu...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 15, 2023 Category: Microbiology Source Type: research

Streptococcus pneumoniae serotype 19A from carriers and invasive disease: virulence gene profile and pathogenicity in a Galleria mellonella model
ConclusionsThe occurrence of the investigated virulence genes was similar between HC and IPDS. pneumoniae serotype 19A groups. However, the IPD isolates showed a higher lethality in the alternativeG. mellonella model than the HC isolates, regardless of the virulence gene composition, indicating that other virulence factors may play a decisive role in virulence. Currently, this is the first report using the in vivoG. mellonella model to study the virulence of clinical isolates ofS. pneumoniae. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 15, 2023 Category: Microbiology Source Type: research

A rare class A carbapenemase FRI-11 in Enterobacter clinical strain
AbstractWe found a carbapenem-resistantEnterobacter clinical strain which was susceptible to cefotaxime and ceftazidime. This unusual susceptibility profile promoted the investigation. This strain hadblaFRI-11, a rare carbapenemase-encoding gene, on a 93,864-bp plasmid containing two replicons of IncFII(pECLA) and IncFIA(HI1). FRI-11, FRI-2, FRI-3, FRI-4, FRI-6, FRI-7, and FRI-9 belong to the same group  of FRI β-lactamases based on the amino acid sequence similarity and their encoding genes are carried by plasmids containing an IncFII(pECLA) replicon. Awareness should be raised towards FRI carbapenemases that are plas...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 11, 2023 Category: Microbiology Source Type: research

Evaluation of the Reveal ® rapid AST system to assess the susceptibility of Pseudomonas aeruginosa from blood cultures
This study was set up to assess the performance of the Reveal ® rapid AST system to determine the drug susceptibility ofPseudomonas aeruginosa strains directly from blood cultures. Two hundred fully sequenced clinicalP. aeruginosa strains were selected for the evaluation, of which 26.5% (n = 53) produced transferable β-lactamases, and 2.0 to 33.0% had susceptibility levels close to the EUCAST 2021 breakpoints of 11 commonly used antipseudomonal antibiotics. The Reveal® AST system was run with a commercial MIC microplate designed for fast-growing Gram-negative bacilli (Microscan Neg MDR MIC 1), and was compared to th...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 2, 2023 Category: Microbiology Source Type: research

Predictors of mortality of Staphylococcus aureus bacteremia among patients hospitalized in a Swiss University Hospital and the role of early source control; a retrospective cohort study
AbstractS. aureus bacteremia is associated with high mortality. The aim was to identify predictors of mortality among patients withS. aureus bacteremia and evaluate the role of early source control.  This retrospective study was conducted at the Lausanne University Hospital, Switzerland. All episodes ofS. aureus bacteremia among adult patients from 2015 to 2021 were included.  During the study period, 839 episodes ofS. aureus bacteremia were included, of which 7.9% were due to methicillin-resistant isolates. Bacteremias were related to bone or joint infections (268; 31.9%), followed by bacteremia of unknown origin (158; ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 2, 2023 Category: Microbiology Source Type: research

Clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteraemia
AbstractThis retrospective study, conducted at Lausanne University Hospital (2015 –2021), comparedStaphylococcus aureus bacteraemia (SABA) patients with or without concomitant bacteriuria (SABU). Among 448 included bacteraemic patients, 62 (13.8%) hadS. aureus concurrently isolated from urine. In multivariate analysis, there was a significant difference in the odds of community-onset bacteraemia (P 0.030), malignancy (P 0.002),  >  1 pair of positive blood cultures (P 0.037), and persistent bacteraemia for at least 48  h (P 0.045) in patients with concurrent SABU. No difference concerning mortality was found. On ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 2, 2023 Category: Microbiology Source Type: research

A multi-centre retrospective study of Nocardia speciation and antimicrobial susceptibility in Queensland, Australia
AbstractThe study aims to characterise the species identification and antimicrobial susceptibility testing (AST) results of Nocardial isolates from adult patients across major public hospitals in Queensland, Australia, over a 15-year period. A multi-centre retrospective observational study ofNocardia sp. isolates was conducted from 7 major public hospitals in Queensland, Australia, over a 15-year period. Clinical samples from patients aged  ≥ 18 years that isolatedNocardia sp. were included. Demographic and clinical data were collected, along with species identification and AST results. Overall, 484Nocardia sp. were...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 1, 2023 Category: Microbiology Source Type: research

Clinical characteristics and risk factor analysis of Pneumocystis jirovecii pneumonia in patients with CKD: a machine learning –based approach
AbstractPatients with chronic kidney disease (CKD) who are being treated with immunosuppressive medications are at risk for developingPneumocystis jirovecii pneumonia (PCP). We attempted to characterize the clinical aspects of PCP in CKD patients in order to alert high-risk patients with bad prognosis. A retrospective study of CKD patients was conducted from June 2018 to June 2022. Based on PCP diagnostic criteria, these patients were divided into PCP and non-PCP groups. Using univariate and multivariate logistic regression analysis, risk indicators were evaluated, and nomogram and decision tree were developed. Of the CKD ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 1, 2023 Category: Microbiology Source Type: research

Microbial dynamics with CRC progression: a study of the mucosal microbiota at multiple sites in cancers, adenomatous polyps, and healthy controls
AbstractAccumulating evidence has related the gut microbiota to colorectal cancer (CRC).Fusobacterium nucleatum has repeatedly been linked to colorectal tumorigenesis. The aim of this study was to investigate microbial composition in different sampling sites, in order to profile the microbial dynamics with CRC progression. Further, we characterized the tumor-associatedF. nucleatum subspecies. Here, we conducted Illumina Miseq next-generation sequencing of the 16S rRNA V4 region in biopsy samples, to investigate microbiota alterations in cancer patients, patients with adenomatous polyp, and healthy controls in Norway. Furth...
Source: European Journal of Clinical Microbiology and Infectious Diseases - January 27, 2023 Category: Microbiology Source Type: research

Spread of Mycobacterium tuberculosis in Southern Brazilian persons deprived of liberty: a molecular epidemiology study
AbstractTo evaluate the genetic diversity and clustering rates ofM. tuberculosis strains to better understand transmission among persons deprived of liberty (PDL) in Rio Grande do Sul (RS), southern Brazil. This is a cross-sectional study, including strains ofM. tuberculosis isolated from PDL, stored at the Central Laboratory of RS, in the period from 2013 to 2018. The molecular characterization was performed using the MIRU-VNTR 15loci method. A total of 598  M. tuberculosis strains were genotyped, and 37.5% were grouped into 53 clusters. Cluster sizes ranged from 2 to 34 strains. The largest cluster of the study had stra...
Source: European Journal of Clinical Microbiology and Infectious Diseases - January 26, 2023 Category: Microbiology Source Type: research

Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation
AbstractA clinical strain ofKlebsiella pneumoniae typed as sequence type 307 carrying three different alleles of theflu gene encoding theEscherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. Theflu alleles are located in the chromosome inside putative integrative conjugative elements. The strain displays the phenotypes associated with Ag43, i.e. bi-phasic colony morphology and enhanced biofilm production. Furthermore, the strain produces low amount of capsule known to affect Ag43 function. Analysis of 1431 worldwide deposited genomes revealed that 3.7%Klebsiella pneu...
Source: European Journal of Clinical Microbiology and Infectious Diseases - January 25, 2023 Category: Microbiology Source Type: research