European Journal of Clinical Microbiology and Infectious Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Staphylococcus aureus bacteraemia, cardiac implantable electronic device, and the risk of endocarditis: a retrospective population –based cohort study
The objectives were to describe a Swedish population-based cohort of patients with CIED and SAB, to identify risk factors, and to construct a predictive score for IE. Patients over 18  years old in the Stockholm Region identified to have SAB in the Karolinska Laboratory database from January 2015 through December 2019 were matched to the Swedish Pacemaker and Implantable Cardioverter-Defibrillator ICD Registry to identify the study cohort. Data were collected from study of medic al records. A cohort of 274 patients with CIED and SAB was identified and in 38 episodes (14%) IE were diagnosed, 19 with changes on the CIED, an...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 15, 2023 Category: Microbiology Source Type: research

Enhanced bacterial killing with a combination of sulbactam/minocycline against dual carbapenemase-producing Acinetobacter baumannii
AbstractCarbapenem-resistantAcinetobacter baumannii (CRAB) is often difficult to treat. Considering the current circumstances, there is an unquestionable need for new therapeutic options to treat CRAB infections. In the present study, the synergistic activity of sulbactam-based combination was determined against genetically characterized CRAB isolates. Non-duplicate CRAB isolates (n = 150) recovered from blood culture and endotracheal aspirates were included in this study. The minimum inhibitory concentrations (MICs) of tetracyclines (minocycline, tigecycline, eravacycline) and their comparators (meropenem, sulbactam, ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 11, 2023 Category: Microbiology Source Type: research

Rapid diagnostics and ceftazidime/avibactam for KPC-producing Klebsiella pneumoniae bloodstream infections: impact on mortality and role of combination therapy
This study was aimed at investigating risk factors for mortality in patients suffering from KPC-producingKlebsiella pneumoniae (KPC-Kp) bloodstream infections (BSIs), evaluating the impact of rapid diagnostics and ceftazidime/avibactam use. This observational retrospective study (January 2017 –May 2021) included all patients with a KPC-Kp BSI. Uni-multivariable analyses were carried out to evaluate the effect of clinical variables on both in-hospital death (IHD) and 30-day all-cause mortality, and the role of the combination of ceftazidime/avibactam plus polymyxin. One hundred and nine ty-six patients met the study’s i...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 9, 2023 Category: Microbiology Source Type: research

Nasotracheal enterococcal carriage and resistomes: detection of optrA-, poxtA- and cfrD-carrying strains in migratory birds, livestock, pets, and in-contact humans in Spain
This study determined the carriage rates and antimicrobial resistance (AMR) genes of enterococci from nasotracheal  samples of three healthy animal species and in-contact humans. Nasal samples were collected from 27 dog-owning households (34 dogs, 41 humans) and 4 pig-farms (40 pigs, 10 pig-farmers), and they were processed for enterococci recovery (MALDI-TOF–MS identification). Also, a collection of 144 en terococci previously recovered of tracheal/nasal samples from 87 white stork nestlings were characterized. The AMR phenotypes were determined in all enterococci and AMR genes were studied by PCR/sequencing. Multi...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 9, 2023 Category: Microbiology Source Type: research

Incidence and clinical and microbiological features of invasive and probable invasive streptococcal group A infections in children and adults in the Brussels-Capital Region, 2005 –2020
AbstractAssess the incidence, risk factors, clinical and microbiological features, and outcome of both probable invasive and invasive group AStreptococcus (GAS) infections in children and adults in the BrusselsCapital Region between 2005 and 2020. A retrospective, multicentric study was performed in three university hospitals in Brussels. Patients were identified through the centralized laboratory information system. Epidemiological and clinical data were collected from patients ’ hospital records. A total of 467 cases were identified. Incidence has increased from 2.1 to 10.9/100,000 inhabitants between 2009 and 2019 in ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 7, 2023 Category: Microbiology Source Type: research

Staphylococcus aureus hitchhiking from colonization to bacteremia via Candida within ICU infection prevention studies: a proof of concept modelling
AbstractWhetherCandida within the patient microbiome drives the pathogenesis ofStaphylococcus aureus bacteremia, described as microbial hitchhiking, cannot be directly studied. Group-level observations from studies of various decontamination and non-decontamination-based ICU infection prevention interventions and studies without study interventions (observational  groups) collectively enable tests of this interaction within causal models. Candidate models of the propensity forStaphylococcus aureus bacteremia to arise with versus without various antibiotic, anti-septic, and antifungal exposures, each identified as singleto...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 6, 2023 Category: Microbiology Source Type: research

Resistance to ceftazidime-avibactam in a KPC-2 –producing Klebsiella pneumoniae caused by the extended-spectrum beta-lactamase VEB-25
AbstractCarbapenem-resistant Enterobacterales, including KPC-producingKlebsiella pneumoniae, represent a major threat to public health due to their rapid spread. The beta-lactam/beta-lactamase inhibitor (BL/BLI) combination ceftazidime-avibactam (CAZ-AVI) has recently been introduced and shown to exhibit excellent activity toward multidrug-resistant KPC-producing Enterobacterales strains. However, CAZ-AVI-resistantK. pneumoniae isolates are being increasingly reported, mostly corresponding to producers of KPC variants that confer resistance to CAZ-AVI but at a cost of carbapenem resistance. We have characterized here, both...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 6, 2023 Category: Microbiology Source Type: research

Analysis of risk factors associated with healthcare-associated carbapenem-resistant Klebsiella pneumoniae infection in a large general hospital: a case-case-control study
AbstractCarbapenem-resistantKlebsiella pneumoniae (CRKP) infection is a major public health threat in the world. To inform the prevention and control of CRKP infection in hospitals, this study analyzed the factors associated with CRKP infection and resistance to carbapenems inK.pneumoniae. This case-case-control study was carried out in a large general hospital in China from January 2016 to December 2018, comprising 494 hospitalized patients infected with CRKP (case group 1) and 2429 hospitalized patients infected with carbapenem-susceptibleK.pneumoniae (CSKP, case group 2). We selected control groups from hospitalized pat...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 1, 2023 Category: Microbiology Source Type: research

The safety and immunogenicity of inactivated COVID-19 vaccine in old pulmonary tuberculosis patients
This study has been registered at ClinicalTrials.gov (NCT05043246). (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 28, 2023 Category: Microbiology Source Type: research

Antibiotic resistance and resistance mechanism of Corynebacterium kroppenstedtii isolated from patients with mastadenitis
AbstractTo investigate the antibiotic resistance and resistance mechanism ofCorynebacterium kroppenstedtii (C. kroppenstedtii) isolated from patients with mastadenitis. NinetyC. kroppenstedtii clinical isolates were obtained from clinical specimens in 2018 –2019. Species identification was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Antimicrobial susceptibility testing was performed by the broth microdilution method. The resistance genes were detected using PCR and DNA sequencing. The results of anti microbial susceptibility testing indicated that the resistance rates ofC...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 27, 2023 Category: Microbiology Source Type: research

Massive secretions in paragonimiasis pleural effusion: a new finding concerning clinical recognition and treatment
This study aimed to investigate their clinical characteristics, thereby promoting effective treatments. A 3-year retrospective review of paragonimiasis patients who were admitted for nonhomogeneous PEs at Chongqing University Three Gorges Hospital was conducted. Epidemiological data, symptoms, laboratory and imaging findings, treatments, and outcomes were analyzed. Twenty-eight patients were identified, of which 22 (78.6%) were males and 22 (78.6%) were rural residents. Respiratory (85.7%) and constitutional (57.1%) symptoms were common.Paragonimus-specific ELISA was positive in all patients. Eosinophilia was detected in a...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 24, 2023 Category: Microbiology Source Type: research

Norfloxacin prophylaxis effect on multidrug resistance in patients with cirrhosis and bacterial infections
Abstract It is unclear whether norfloxacin predisposes to infections by multidrug-resistant organisms (MDROs). We aimed to evaluate if patients with cirrhosis receiving norfloxacin prophylaxis at the time of the diagnosis of bacterial infections were more likely to present a multidrug-resistant isolate than those without prophylaxis. This is a cross-sectional study of hospitalized patients with cirrhosis and bacterial infections from Argentina and Uruguay (NCT03919032) from September 2018 to December 2020. The outcome variable was a multidrug-resistant bacterial infection. We used inverse probability of treatment weight...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 23, 2023 Category: Microbiology Source Type: research

Genetic and enzymatic characterization of two novel blaNDM-36, -37 variants in Escherichia coli strains
In this study, threeE. coli strains carrying two novelblaNDM variants ofblaNDM-36, -37 were identified from a patient with refractory urinary tract infection (UTI) in China. We conducted antimicrobial susceptibility testing (AST), enzyme kinetics analysis, conjugation experiment, whole-genome sequencing (WGS), and bioinformatics analysis to characterize theblaNDM-36, -37 enzymes and their carrying strains. TheblaNDM-36, -37 harboringE. coli isolates belonged to ST227, O9:H10 serotype and exhibited intermediate or resistance to all β-lactams tested except aztreonam and aztreonam/avibactam. The genes ofblaNDM-36, -37 were l...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 22, 2023 Category: Microbiology Source Type: research

Development of a rapid diagnostic test based on loop-mediated isothermal amplification to identify the most frequent non-typhoidal Salmonella serovars from culture
In this study, a molecular assay based on loop-mediated isothermal amplification (LAMP) targeting specific gene sequences ofSalmonella Enteritidis,S. Typhimurium,S. Infantis,S. Derby, andS. Choleraesuis has been developed for rapid serovar identification from cultured colonies. A total of 318Salmonella strains and 25 isolates of otherEnterobacterales species that served as negative controls were analyzed. AllS. Enteritidis (n = 40),S. Infantis (n = 27), andS. Choleraesuis (n = 11) strains were correctly identified. Seven out of 104S. Typhimurium and 10 out of 38S. Derby strains missed a positive signal. Cross-r...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 22, 2023 Category: Microbiology Source Type: research

Investigation of the presence of Capnophilic bacteria in routine urine cultures
AbstractCapnophilicEscherichia coli (CEC) strains are rarely isolated from urinary tract infections (UTIs). The purpose of this research was to look into the incidence and traits of the CEC strains that cause UTIs. Nine (0.11%) epidemiologically unrelated CEC isolates with varying antibiotic susceptibility patterns were identified from patients with various co-morbidities after the evaluation of 8500 urine samples. Three of these strains belonged to the O25b-ST131 clone, and none of them possessed the yadF gene. Due to adverse incubation conditions, CEC isolation is difficult. Although rare, capnophilic incubation of urine...
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 22, 2023 Category: Microbiology Source Type: research