Comparative analyses on radical scavenging and cytotoxic activity of phenolic and flavonoid content from selected medicinal plants.
This study aimed to compare the total phenolic (TPC), flavonoid (TFC), radical scavenging and cytotoxic activities in the aqueous methanolic extracts of Angelica sinensis, Dioscorea polystachya, Ginkgo biloba, Glycyrrhiza uralensis and Lycium barbarum with two dietary plants: Brassica oleracea and Zingiber officinale. The TPC and TFC in medicinal plant extracts were 12-93% lower than Z. officinale as follows: L. barbarum > G. uralensis > A. sinensis > G. biloba > D. polystachya. The decreasing radical scavenging activity in medicinal plant extracts shared similar trend: G. uralensis > L. barbarum > A. sin...
Source: Natural Product Research - April 13, 2020 Category: Biochemistry Authors: Ng ZX, Koick YTT, Yong PH Tags: Nat Prod Res Source Type: research
Inhibition of Dextran Sodium Sulfate-Induced Experimental Colitis in Mice by Angelica Sinensis Polysaccharide
Journal of Medicinal Food, Ahead of Print. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - April 12, 2020 Category: Nutrition Authors: Fang Cheng Yu Zhang Qiang Li Fang Zeng Kaiping Wang Source Type: research
Polysaccharide from Angelica Sinensis Suppresses Inflammation and Reverses Anemia in Complete Freund ’s Adjuvant-induced Rats
SummaryThe anti-inflammatory and antianemic activities ofAngelica sinensis polysaccharide (ASP) isolated from roots ofAngelica sinensis (AS) was investigated in a complete Freund ’s adjuvant (CFA)-induced arthritic rat model. It was observed that serum iron (SI) and total iron binding capacity (TIBC) levels were elevated after 4-week oral administration of ASP. Red blood cell (RBC) count and hemoglobin (Hb) concentrations were ameliorated as well. Moreover, inflammatory cy tokines IL-6 and TNF-a were decreased strikingly in CFA-induced arthritic rats after treatment of ASP. Evidence also showed that ASP strongly inhibite...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - March 31, 2020 Category: Research Source Type: research
Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF- κB, MAPK and AKT pathways.
Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF-κB, MAPK and AKT pathways.
J Cell Mol Med. 2020 Mar 17;:
Authors: Zhi X, Fang C, Gu Y, Chen H, Chen X, Cui J, Hu Y, Weng W, Zhou Q, Wang Y, Wang Y, Jiang H, Li X, Cao L, Chen X, Su J
Abstract
Angelica sinensis (AS; Dang Gui), a traditional Chinese herb, has for centuries been used for the treatment of bone diseases, including osteoporosis and osteonecrosis. However, the effective ingredient and underlying mechanisms remain elusive. Here, we identified guaiacol as the act...
Source: J Cell Mol Med - March 16, 2020 Category: Molecular Biology Authors: Zhi X, Fang C, Gu Y, Chen H, Chen X, Cui J, Hu Y, Weng W, Zhou Q, Wang Y, Wang Y, Jiang H, Li X, Cao L, Chen X, Su J Tags: J Cell Mol Med Source Type: research
Knowledge Mapping of Angelica sinensis (Oliv.) Diels (Danggui) Research: A Scientometric Study
ConclusionThe present scientometric study provides an overview of the development of AS research over the previous decade using quantitative and qualitative methods, and this overview can provide references for researchers focusing on AS. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 12, 2020 Category: Drugs & Pharmacology Source Type: research
In vitro/vivo evaluation of novel mitochondrial targeting charge-reversal polysaccharide-based antitumor nanoparticle
This study aims to overcome the biological barrier while improving the mitochondria-targeted effect of nanoparticles based on natural polysaccharides. Novel polysaccharide-based nanoparticles, with tumor microenvironment-responsive charge-reversal and mitochondrial targeting abilities, were prepared in our study. Curcumin (Cur) was loaded into the core of a positively charged chitosan oligosaccharide (COS) derivative with mitochondrial targeting ability, and a negatively charged shell based on angelica sinensis polysaccharide (AS) derivative was wrapped in the surface of the core. At the same time, the pH-sensitive borate ...
Source: Carbohydrate Polymers - February 17, 2020 Category: Biomedical Science Source Type: research
Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice.
In this study, we used an aging model, SAMP8 mice to investigate the neuroprotective effect of ligustilide. The behavioral tests (Morris water maze, object recognition task, open field test and elevated plus maze) results showed that ligustilide could improve the memory deficit in SAMP8 mice. For mechanism study, we found that the protein level of P-Drp1 (fission) was decreased and the levels of Mfn1 and Mfn2 (fusion) were increased after ligustilide treatment in animals and cells. Ligustilide increased P-AMPK and ATP levels. Malondialdehyde and superoxide dismutase activity results indicated that ligustilide exerts antiox...
Source: Aging - February 15, 2020 Category: Biomedical Science Authors: Zhu WL, Zheng JY, Cai WW, Dai Z, Li BY, Xu TT, Liu HF, Liu XQ, Wei SF, Luo Y, Wang H, Pan HF, Wang Q, Zhang SJ Tags: Aging (Albany NY) Source Type: research
Pharmacokinetics, tissue distribution, and safety evaluation of a ligustilide derivative (LIGc)
Publication date: Available online 31 January 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Yanxia Zhang, Yaming Zhang, Yanming Han, Ye Tian, Pengcheng Wu, Aiyi Xin, Xiaoning Wei, Yanbin Shi, Zhenchang Zhang, Gang Su, Yanping Shi, Junxi LiuAbstractLigustilide (LIG) is the main active ingredient of Angelica sinensis (Oliv.) Diels and has a neuroprotective effect against ischemic stroke. However, owing to its multi-conjugated unstable structure, the compound has poor drug-forming properties. Therefore, we synthesized highly stable colorless needle crystals (known as ligusticum cycloprolactam, LIGc) ...
Source: Journal of Pharmaceutical and Biomedical Analysis - February 1, 2020 Category: Drugs & Pharmacology Source Type: research
Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury through inhibiting the mincle maintained macrophage inflammation
ConclusionOur findings indicated that A&P protected kidney from inhibiting inflammation through down-regulating of Mincle pathway in macrophage in AKI. It provides a potential medicine compound for the treatment of AKI.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 28, 2020 Category: Drugs & Pharmacology Source Type: research
Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats
ConclusionsDG-0.5g and DG-1g treatments exerted neuroprotective effects on I/R injury by activating p38 MAPK-mediated p90RSK/p-Bad-induced anti-apoptotic-Cytc/caspase-3-related and p90RSK/CREB/BDNF survival signaling in the hippocampus 7 d after transient GCI.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 25, 2020 Category: Drugs & Pharmacology Source Type: research
Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection
Publication date: Available online 3 January 2020Source: International Journal of PharmaceuticsAuthor(s): Kaiping Wang, Jingya Xu, Yan Liu, Zheng Cui, Zihao He, Ziming Zheng, Xiao Huang, Yu ZhangAbstractThe present work aimed to study the feasibility of Angelica sinensis polysaccharide (ASP) as an instinctive liver-targeting drug delivery carrier with applications in acute alcoholic liver damage (ALD). Amphipathic cholesteryl hemisuccinate-ASP (ASP-CHEMS) conjugate was synthesized by an esterification reaction and characterized by conventional methods. ASP-CHEMS self-assembled nanoparticles (ACNPs) and Curcumin-loaded ACNP...
Source: International Journal of Pharmaceutics - January 4, 2020 Category: Drugs & Pharmacology Source Type: research
Integrated chemical and transcriptomic analyses unveils synthetic characteristics of different medicinal root parts of Angelica sinensis
ConclusionChemical and transcriptomic analyses revealed the distribution contents and pivotal transcripts of the ferulic acid biosynthesis-related pathways. The spatial gene expression pattern partially explained the discrepancy of integral medicinal activities of three medicinal root parts. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research
A review of traditional Chinese medicine for treatment of glioblastoma.
Authors: Wang J, Qi F, Wang Z, Zhang Z, Pan N, Huai L, Qu S, Zhao L
Abstract
Glioblastoma (GBM) is the most common primary malignant intracranial tumor. Due to its high morbidity, high mortality, high recurrence rate, and low cure rate, it has brought great difficulty for treatment. Although the current treatment is multimodal, including surgical resection, radiotherapy, and chemotherapy, it does not significantly improve survival time. The dismal prognosis and inevitable recurrence as well as resistance to chemoradiotherapy may be related to its highly cellular heterogeneity and multiple subclonal populat...
Source: BioScience Trends - December 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research
The Combination of Astragalus membranaceus and Angelica sinensis Inhibits Lung Cancer and Cachexia through Its Immunomodulatory Function.
In this study, we report the inhibitory effect of the combined therapy of Astragalus membranaceus and Angelica sinensis, on tumor growth and cachexia in tumor-bearing mice. Lewis lung carcinoma cells were inoculated into male C57BL/6 and CAnN.Cg-Foxn1nu nude mice. After tumor inoculation, mice were fed orally by the combination of AM and AS in different doses. In C57BL/6 mice, the combination of AM and AS significantly inhibited the growth of cancer tumor and prevented the loss of body weight and skeletal muscle. It also diminished the formation of free radicals and cytokines, stimulated the differentiation of NK and Tc ce...
Source: Journal of Oncology - November 30, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research
Studies on the potential link between antidepressant effect of Xiaoyao San and its pharmacological activity of hepatoprotection based on multi-platform metabolomics
ConclusionsXYS could significantly improve the depressive and liver injury symptoms induced by CUMS. The metabolomics results indicate that the regulation of glutamine and glutamate metabolism to maintain the balance of ammonia and promote energy metabolism is a potential junction between the antidepressant and hepatoprotective effects of XYS.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 30, 2019 Category: Drugs & Pharmacology Source Type: research
