< em > Angelica sinensis < /em > extract induces telomere dysfunction, cell cycle arrest, and mitochondria-mediated apoptosis in human glioblastoma cells
This study aimed to investigate the effect of AS-acetone extract (AS-A) on the progression of GB and the potential mechanisms underlying its effects. The results indicated that AS-A used in this study showed potency in growth inhibition of GB cells and reduction of telomerase activity. In addition, AS-A blocked the cell cycle at the G0/G1 phase by regulating the expression of p53 and p16. Furthermore, apoptotic morphology, such as chromatin condensation, DNA fragmentation, and apoptotic bodies, was observed in AS-A-treated cells, induced by the activation of the mitochondria-mediated pathway. In an animal study, AS-A reduc...
Source: The Chinese Journal of Physiology - June 16, 2023 Category: Physiology Authors: Tsung-Liang Ma Kai-Fu Chang Xiao-Fan Huang Hung-Chih Lai Chih-Yen Hsiao Nu-Man Tsai Source Type: research
Ligustilide, a novel SIRT1 agonist, alleviates lipopolysaccharide-induced acute lung injury through deacetylation of NICD
Int Immunopharmacol. 2023 Jun 14;121:110486. doi: 10.1016/j.intimp.2023.110486. Online ahead of print.ABSTRACTDevelopment and progression of sepsis-induced acute lung injury (ALI) involve apoptosis and oxidative stress in lung epithelial cells. Ligustilide (LIG) is one of the main bioactive constituents derived from the Angelica sinensis. As a novel SIRT1 agonist, LIG owns powerful anti-inflammatory and antioxidative properties, exerting remarkable therapeutic effects on cancers, neurological disorders, and diabetes mellitus. However, whether LIG could protect against lipopolysaccharide (LPS)-induced ALI by activating SIRT...
Source: International Immunopharmacology - June 16, 2023 Category: Allergy & Immunology Authors: Guang Li Chunxiao Hu Yan Liu Huiqing Lin Source Type: research
< em > Angelica sinensis < /em > extract induces telomere dysfunction, cell cycle arrest, and mitochondria-mediated apoptosis in human glioblastoma cells
This study aimed to investigate the effect of AS-acetone extract (AS-A) on the progression of GB and the potential mechanisms underlying its effects. The results indicated that AS-A used in this study showed potency in growth inhibition of GB cells and reduction of telomerase activity. In addition, AS-A blocked the cell cycle at the G0/G1 phase by regulating the expression of p53 and p16. Furthermore, apoptotic morphology, such as chromatin condensation, DNA fragmentation, and apoptotic bodies, was observed in AS-A-treated cells, induced by the activation of the mitochondria-mediated pathway. In an animal study, AS-A reduc...
Source: The Chinese Journal of Physiology - June 16, 2023 Category: Physiology Authors: Tsung-Liang Ma Kai-Fu Chang Xiao-Fan Huang Hung-Chih Lai Chih-Yen Hsiao Nu-Man Tsai Source Type: research
