Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review
Biomed Pharmacother. 2024 Mar 13;173:116429. doi: 10.1016/j.biopha.2024.116429. Online ahead of print.ABSTRACTFibrosis-related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern anti-fibrosis drugs in clinical practice. However, Chinese medicine has a certain beneficial effect on the treatment of such diseases. Angelica sinensis, with its considerable medi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Zhi Chunzhen Ren Qianrong Li Huaqing Xi Dong Li Qilin Chen Xinfang Lv Xiang Gao Xue Wu Chunling Wang Bing Jiang Zhongnan Mao Hugang Jiang Kai Liu Xinke Zhao Yingdong Li Source Type: research
Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review
Biomed Pharmacother. 2024 Mar 13;173:116429. doi: 10.1016/j.biopha.2024.116429. Online ahead of print.ABSTRACTFibrosis-related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern anti-fibrosis drugs in clinical practice. However, Chinese medicine has a certain beneficial effect on the treatment of such diseases. Angelica sinensis, with its considerable medi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Zhi Chunzhen Ren Qianrong Li Huaqing Xi Dong Li Qilin Chen Xinfang Lv Xiang Gao Xue Wu Chunling Wang Bing Jiang Zhongnan Mao Hugang Jiang Kai Liu Xinke Zhao Yingdong Li Source Type: research
Screening of polysaccharides from the differently processed products of Angelica sinensis with the best liver protection effect on chicken and the intervention mechanism study based on tandem mass tag proteomics and multiple reaction monitoring approach
This study aims to investigate the protective effect of PDPPAS on chicken liver injury caused by CS combined with LPS buildup and further identify the polysaccharides with the highest hepatoprotective activity in chickens. Furthermore, the study elucidates polysaccharides' intervention mechanism using tandem mass tag (TMT) proteomics and multiple reaction monitoring (MRM) methods. A total of 190 1-day-old layer chickens were randomly assigned into 12 groups, of which 14 chickens were in the control group and 16 in other groups, for a 10-day trial. The screening results showed that charred A. sinensis polysaccharide (CASP) ...
Source: Biomedical Chromatography : BMC - February 25, 2024 Category: Biomedical Science Authors: Chen-Chen Li Peng Ji Jian He You-Sheng Peng Fan-Lin Wu Yong-Li Hua Wan-Ling Yao Zi-Wen Yuan Yan-Ming Wei Source Type: research
Screening of polysaccharides from the differently processed products of Angelica sinensis with the best liver protection effect on chicken and the intervention mechanism study based on tandem mass tag proteomics and multiple reaction monitoring approach
This study aims to investigate the protective effect of PDPPAS on chicken liver injury caused by CS combined with LPS buildup and further identify the polysaccharides with the highest hepatoprotective activity in chickens. Furthermore, the study elucidates polysaccharides' intervention mechanism using tandem mass tag (TMT) proteomics and multiple reaction monitoring (MRM) methods. A total of 190 1-day-old layer chickens were randomly assigned into 12 groups, of which 14 chickens were in the control group and 16 in other groups, for a 10-day trial. The screening results showed that charred A. sinensis polysaccharide (CASP) ...
Source: Biomedical Chromatography : BMC - February 25, 2024 Category: Biomedical Science Authors: Chen-Chen Li Peng Ji Jian He You-Sheng Peng Fan-Lin Wu Yong-Li Hua Wan-Ling Yao Zi-Wen Yuan Yan-Ming Wei Source Type: research
Screening of polysaccharides from the differently processed products of Angelica sinensis with the best liver protection effect on chicken and the intervention mechanism study based on tandem mass tag proteomics and multiple reaction monitoring approach
This study aims to investigate the protective effect of PDPPAS on chicken liver injury caused by CS combined with LPS buildup and further identify the polysaccharides with the highest hepatoprotective activity in chickens. Furthermore, the study elucidates polysaccharides' intervention mechanism using tandem mass tag (TMT) proteomics and multiple reaction monitoring (MRM) methods. A total of 190 1-day-old layer chickens were randomly assigned into 12 groups, of which 14 chickens were in the control group and 16 in other groups, for a 10-day trial. The screening results showed that charred A. sinensis polysaccharide (CASP) ...
Source: Biomedical Chromatography : BMC - February 25, 2024 Category: Biomedical Science Authors: Chen-Chen Li Peng Ji Jian He You-Sheng Peng Fan-Lin Wu Yong-Li Hua Wan-Ling Yao Zi-Wen Yuan Yan-Ming Wei Source Type: research
Angelica sinensis polysaccharides modified selenium nanoparticles for effective prevention of acute liver injury
Int J Biol Macromol. 2024 Feb 20;263(Pt 1):130321. doi: 10.1016/j.ijbiomac.2024.130321. Online ahead of print.ABSTRACTAs a global public health issue, the treatment of acute liver injury (ALI) is severely limited due to the lack of specific drugs. In order to address the challenges, innovative strategies for selenium nanoparticles (Se NPs) with excellent antioxidant properties have been actively developed to effectively prevent ALI. However, the functional activity of Se NPs is severely affected by poor stability and bioavailability. The aim of this work is to develop a stabilization system (ASP-Se NPs) for Angelica sinens...
Source: International Journal of Biological Macromolecules - February 21, 2024 Category: Biochemistry Authors: Yu Xu Xin-Chuang Wang Wen Jiang Jiang-Ning Hu Source Type: research
A comprehensive review of the anticancer effects of decursin
Cancer is a globally complex disease with a plethora of genetic, physiological, metabolic, and environmental variations. With the increasing resistance to current anticancer drugs, efforts have been made to develop effective cancer treatments. Currently, natural products are considered promising cancer therapeutic agents due to their potent anticancer activity and low intrinsic toxicity. Decursin, a coumarin analog mainly derived from the roots of the medicinal plant Angelica sinensis, has a wide range of biological activities, including anti-inflammatory, antioxidant, neuroprotective, and especially anticancer activities....
Source: Frontiers in Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 29, Pages 912: Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson & rsquo;s Disease
Molecules, Vol. 29, Pages 912: Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson’s Disease
Molecules doi: 10.3390/molecules29040912
Authors:
Mingjie Zhang
Congyan Duan
Weifang Lin
Honghua Wu
Lu Chen
Hong Guo
Minyu Yu
Qi Liu
Yaling Nie
Hong Wang
Shaoxia Wang
The microglia, displaying diverse phenotypes, play a significant regulatory role in the development, progression, and prognosis of Parkinson’s disease. Research has established that glycolytic reprogrammi...
Source: Molecules - February 19, 2024 Category: Chemistry Authors: Mingjie Zhang Congyan Duan Weifang Lin Honghua Wu Lu Chen Hong Guo Minyu Yu Qi Liu Yaling Nie Hong Wang Shaoxia Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 731: Angelica Sinensis Polysaccharide-Based Nanoparticles for Liver-Targeted Delivery of Oridonin
ng
Liqiao Zhu
The present work aimed to study the feasibility of Angelica sinensis polysaccharide (ASP) as an instinctive liver targeting drug delivery carrier for oridonin (ORI) in the treatment of hepatocellular carcinoma (HCC). ASP was reacted with deoxycholic acid (DOCA) via an esterification reaction to form an ASP-DOCA conjugate. ORI-loaded ASP-DOCA nanoparticles (ORI/ASP-DOCA NPs) were prepared by the thin-film water method, and their size was about 195 nm in aqueous solution. ORI/ASP-DOCA NPs had a drug loading capacity of up to 9.2%. The release of ORI in ORI/ASP-DOCA NPs was pH-dependent, resulting in rapid...
Source: Molecules - February 5, 2024 Category: Chemistry Authors: Henglai Sun Jijuan Nai Biqi Deng Zhen Zheng Xuemei Chen Chao Zhang Huagang Sheng Liqiao Zhu Tags: Article Source Type: research
Traditional Chinese medicine Zhusha Anshen Wan: protective effects on liver, kidney, and intestine of the individual drugs using 1H NMR metabolomics
Discussion: The metabolic mechanism of single drug detoxification in compound prescriptions has been elucidated. Coptis chinensis and Glycyrrhiza uralensis serve as the primary detoxification agents within ZSASW for mitigating liver, kidney, and intestinal damage caused by cinnabar. Detoxification can be observed through changes in the levels of various endogenous metabolites and related metabolic pathways. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Source Type: research
Anti-platelet aggregation activities of different grades of Angelica sinensis and their therapeutic mechanisms in rats with blood deficiency: insights from metabolomics and lipidomics analyses
This study investigated anti-platelet aggregation activities were used by New Zealand rabbits, and high-performance liquid chromatography data were obtained to determine the spectrum–effect relationship for different commercial grades of RAS. Plasma and urine metabolites were examined using ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry-based metabolomics to elucidate the mechanisms underlying the role of these metabolites in a rat model of blood deficiency (BD). Plasma and spleen metabolites were additionally examined using ultra-performance liquid chromatography ...
Source: Frontiers in Pharmacology - January 3, 2024 Category: Drugs & Pharmacology Source Type: research
