Protective effect of Angelica sinensis polysaccharide on pregnant rats suffering from iron deficiency anemia via regulation of the hepcidin-FPN1 axis
Int J Biol Macromol. 2023 Nov 13:128016. doi: 10.1016/j.ijbiomac.2023.128016. Online ahead of print.ABSTRACTIron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with deleterious maternal and fetal outcomes. Angelica sinensis polysaccharide (ASP) has been shown to reduce hepcidin expression in IDA rats. However, the role of ASP in the treatment of IDA during pregnancy and its potential mechanisms have not been investigated. Moreover, the effect of ASP on duodenal iron absorption is not clear. The aim of this study was to investigate the preventive efficacy of ASP against IDA during pregnanc...
Source: International Journal of Biological Macromolecules - November 15, 2023 Category: Biochemistry Authors: Yu Zhang Tingting Guo Lei Huang Zihao He Jinglin Wang Hao Mei Xiao Huang Kaiping Wang Source Type: research
Protective effect of Angelica sinensis polysaccharide on pregnant rats suffering from iron deficiency anemia via regulation of the hepcidin-FPN1 axis
Int J Biol Macromol. 2023 Nov 13:128016. doi: 10.1016/j.ijbiomac.2023.128016. Online ahead of print.ABSTRACTIron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with deleterious maternal and fetal outcomes. Angelica sinensis polysaccharide (ASP) has been shown to reduce hepcidin expression in IDA rats. However, the role of ASP in the treatment of IDA during pregnancy and its potential mechanisms have not been investigated. Moreover, the effect of ASP on duodenal iron absorption is not clear. The aim of this study was to investigate the preventive efficacy of ASP against IDA during pregnanc...
Source: International Journal of Biological Macromolecules - November 15, 2023 Category: Biochemistry Authors: Yu Zhang Tingting Guo Lei Huang Zihao He Jinglin Wang Hao Mei Xiao Huang Kaiping Wang Source Type: research
Molecules, Vol. 28, Pages 7292: The Dynamic Accumulation Rules of Chemical Components during the Medicine Formation Period of Angelica sinensis and Chemometric Classifying Analysis for Different Bolting Times Using ATR-FTIR
This study explored and compared the accumulation dynamics of primary and secondary metabolites in AS and EB roots during the vegetative growth stage (from May to September) by light microscopy, ultraviolet spectrometry, and HPLC methods. Under a microscope, the amount of free starch granules and oil chamber in the AS root increased. On the contrary, they decreased further from EB-Jul to EB-Sep. By comparison, the wall of the xylem vessel was slightly thickened and stacked, and the cell walls of parenchyma and root cortex tissue were thickened in the EB root. Early underground bolting reduces soluble sugar, soluble protein...
Source: Molecules - October 27, 2023 Category: Chemistry Authors: Fang Ma Yuan Jiang Baoshan Li Yuxin Zeng Hushan Shang Fusheng Wang Zhirong Sun Tags: Article Source Type: research
Role of senkyunolide I in the promotion of neural stem/progenitor cell proliferation via the Akt/ β-catenin pathway
This study examined the effects of SEI on the proliferation and neuronal lineage differentiation of prepared neural stem/progenitor cells (NS/PCs). The NS/PC proliferation was determined by 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt, and neurosphere formation assays. The NS/PC differentiation was also investigated by immunocytochemistry, and western blotting was employed to measure phosphorylated Akt (pAkt) and GSK-3β (pGSK-3β), and active-β-catenin protein levels. We showed that the NS/PC proliferation was enhanced after SEI exposure. Elevated cell numbers were also observe...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 13, 2023 Category: Drugs & Pharmacology Authors: Min Wang Hideki Hayashi Ichiro Horinokita Mayumi Asada Yui Iwatani Jun-Guo Ren Jian-Xun Liu Norio Takagi Source Type: research
Role of senkyunolide I in the promotion of neural stem/progenitor cell proliferation via the Akt/ β-catenin pathway
This study examined the effects of SEI on the proliferation and neuronal lineage differentiation of prepared neural stem/progenitor cells (NS/PCs). The NS/PC proliferation was determined by 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt, and neurosphere formation assays. The NS/PC differentiation was also investigated by immunocytochemistry, and western blotting was employed to measure phosphorylated Akt (pAkt) and GSK-3β (pGSK-3β), and active-β-catenin protein levels. We showed that the NS/PC proliferation was enhanced after SEI exposure. Elevated cell numbers were also observe...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 13, 2023 Category: Drugs & Pharmacology Authors: Min Wang Hideki Hayashi Ichiro Horinokita Mayumi Asada Yui Iwatani Jun-Guo Ren Jian-Xun Liu Norio Takagi Source Type: research
Antifungal mechanism of Angelica sinensis essential oil against Penicillium roqueforti and its application in extending the shelf life of bread
This study provides new evidence for the antifungal activity of ASEO against P. roqueforti and will promote the use of ASEO in the preservation of food and agricultural products.PMID:37827052 | DOI:10.1016/j.ijfoodmicro.2023.110427 (Source: International Journal of Food Microbiology)
Source: International Journal of Food Microbiology - October 12, 2023 Category: Food Science Authors: Qingchao Gao Jingjing Qi Yulong Tan Jian Ju Source Type: research
Antifungal mechanism of Angelica sinensis essential oil against Penicillium roqueforti and its application in extending the shelf life of bread
This study provides new evidence for the antifungal activity of ASEO against P. roqueforti and will promote the use of ASEO in the preservation of food and agricultural products.PMID:37827052 | DOI:10.1016/j.ijfoodmicro.2023.110427 (Source: International Journal of Food Microbiology)
Source: International Journal of Food Microbiology - October 12, 2023 Category: Food Science Authors: Qingchao Gao Jingjing Qi Yulong Tan Jian Ju Source Type: research
Host genetic background rather than diet-induced gut microbiota shifts of sympatric black-necked crane, common crane and bar-headed goose
ConclusionThe host genetic background is the dominant factor determining the composition of the microbiota. Monitoring the changes in gut microbiota and feeding types of wild birds through bird feces is of great reference value for the conservation of other endangered species. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - October 12, 2023 Category: Microbiology Source Type: research
Yantiao Formula intervention in Rats with Sepsis: Network Pharmacology and Experimental Analysis
CONCLUSION: YTF has a multi-component, multi-target, and multi-channel role in treating sepsis. The primary mechanisms may involve inhibiting the p38MAPK pathway to reduce the inflammatory response.PMID:37817514 | DOI:10.2174/0113862073262718230921113659 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 11, 2023 Category: Chemistry Authors: Leilei Zhu Deng Liu Menghan Xu Wenqing Wang Xudong Xiong Qianmei Zhou Rong Shi Source Type: research
Yantiao Formula intervention in Rats with Sepsis: Network Pharmacology and Experimental Analysis
CONCLUSION: YTF has a multi-component, multi-target, and multi-channel role in treating sepsis. The primary mechanisms may involve inhibiting the p38MAPK pathway to reduce the inflammatory response.PMID:37817514 | DOI:10.2174/0113862073262718230921113659 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - October 11, 2023 Category: Chemistry Authors: Leilei Zhu Deng Liu Menghan Xu Wenqing Wang Xudong Xiong Qianmei Zhou Rong Shi Source Type: research
Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells
Biomed Pharmacother. 2023 Sep 30;167:115599. doi: 10.1016/j.biopha.2023.115599. Online ahead of print.ABSTRACTB-lymphocytopenia among myelosuppression is the most intractable side effect of chemotherapy. Here, we investigated ways to alleviate 5-fluorouracil-caused stress hematopoietic impairment. We found that intraperitoneally injected ASP (Angelica sinensis polysaccharides) (100 mg/kg per day), one main active ingredient of Angelica sinensis, for consecutive 7 days, significantly recovered mouse bone marrow pro-B and pre-B cells, reversed the capacity of CFU-PreB colony forming, thus alleviating B cell reduction in the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 2, 2023 Category: Drugs & Pharmacology Authors: Hanxianzhi Xiao Yaping Wang Ziling Wang Biyao Wang Ling Hu Jiying Hou Kunhang Du Nianci Sun Lu Wang Source Type: research
Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells
Biomed Pharmacother. 2023 Sep 30;167:115599. doi: 10.1016/j.biopha.2023.115599. Online ahead of print.ABSTRACTB-lymphocytopenia among myelosuppression is the most intractable side effect of chemotherapy. Here, we investigated ways to alleviate 5-fluorouracil-caused stress hematopoietic impairment. We found that intraperitoneally injected ASP (Angelica sinensis polysaccharides) (100 mg/kg per day), one main active ingredient of Angelica sinensis, for consecutive 7 days, significantly recovered mouse bone marrow pro-B and pre-B cells, reversed the capacity of CFU-PreB colony forming, thus alleviating B cell reduction in the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 2, 2023 Category: Drugs & Pharmacology Authors: Hanxianzhi Xiao Yaping Wang Ziling Wang Biyao Wang Ling Hu Jiying Hou Kunhang Du Nianci Sun Lu Wang Source Type: research
Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells
Biomed Pharmacother. 2023 Sep 30;167:115599. doi: 10.1016/j.biopha.2023.115599. Online ahead of print.ABSTRACTB-lymphocytopenia among myelosuppression is the most intractable side effect of chemotherapy. Here, we investigated ways to alleviate 5-fluorouracil-caused stress hematopoietic impairment. We found that intraperitoneally injected ASP (Angelica sinensis polysaccharides) (100 mg/kg per day), one main active ingredient of Angelica sinensis, for consecutive 7 days, significantly recovered mouse bone marrow pro-B and pre-B cells, reversed the capacity of CFU-PreB colony forming, thus alleviating B cell reduction in the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 2, 2023 Category: Drugs & Pharmacology Authors: Hanxianzhi Xiao Yaping Wang Ziling Wang Biyao Wang Ling Hu Jiying Hou Kunhang Du Nianci Sun Lu Wang Source Type: research
Preparation and evaluation of Angelica sinensis polysaccharide-modified chitosan sponge for acute liver injury protection
In this study, a porous sponge material was formed by physically mixing chitosan (CS) and Angelica sinensis polysaccharide (ASP). After removing the water by freeze-drying, the CS/ASP sponge was obtained. The prepared sponges exhibited excellent swelling properties, thermal stability and biocompatibility as well as improvements over the insufficient mechanical properties of pure chitosan sponges. Notably, the ASP released from the CS/ASP sponge could be effectively absorbed by the liver, which endowed the CS/ASP sponge with effective liver-protective effects against CCl4-induced acute liver injury; these protective effects...
Source: International Journal of Biological Macromolecules - October 1, 2023 Category: Biochemistry Authors: Kaiping Wang Wangtianzi Teng Nire Wu SaiSai Gu Tao Zhou Yu Zhang Source Type: research
Preparation and evaluation of Angelica sinensis polysaccharide-modified chitosan sponge for acute liver injury protection
In this study, a porous sponge material was formed by physically mixing chitosan (CS) and Angelica sinensis polysaccharide (ASP). After removing the water by freeze-drying, the CS/ASP sponge was obtained. The prepared sponges exhibited excellent swelling properties, thermal stability and biocompatibility as well as improvements over the insufficient mechanical properties of pure chitosan sponges. Notably, the ASP released from the CS/ASP sponge could be effectively absorbed by the liver, which endowed the CS/ASP sponge with effective liver-protective effects against CCl4-induced acute liver injury; these protective effects...
Source: International Journal of Biological Macromolecules - October 1, 2023 Category: Biochemistry Authors: Kaiping Wang Wangtianzi Teng Nire Wu SaiSai Gu Tao Zhou Yu Zhang Source Type: research
