Polysaccharides Extracted from < em > Angelica sinensis < /em > (Oliv.) Diels Relieve the Malignant Characteristics of Glioma Cells through Regulating the MiR-373-3p-Mediated TGF- < em > β < /em > /Smad4 Signaling Pathway
CONCLUSIONS: ASP suppresses the malignant progression of glioma via regulating the miR-373-3p-mediated TGF-β/Smad4 pathway.PMID:35855826 | PMC:PMC9288290 | DOI:10.1155/2022/7469774 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2022 Category: Complementary Medicine Authors: Chunhong Qu Weifeng Dong Source Type: research
Molecules, Vol. 27, Pages 4617: The Dynamic Accumulation Rules of Chemical Components in Different Medicinal Parts of Angelica sinensis by GC-MS
This study demonstrated that the differences of composition accumulation in different medicinal parts of Angelica sinensis were mainly reflected in the types and relative contents of compounds. The study found that the number of compounds in different medicinal parts of Angelica sinensis in each period were different and the change rules of the same compound in different medicinal parts were also different. The number of compounds in the tail of Angelica sinensis was the least in April, and the largest in October. The content of ligustilide in the body of Angelica sinensis was higher in April and was the highest in the tai...
Source: Molecules - July 20, 2022 Category: Chemistry Authors: Yuying Chen Qian Li Daiyu Qiu Tags: Article Source Type: research
An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis
Angiogenesis, the formation of new capillaries from pre-existing vascular networks, plays an important role in many physiological and pathological processes. The use of pro-angiogenic agents has been proposed as an attractive approach for promoting wound healing and treating vascular insufficiency-related problems, such as ischemic heart disease and stroke, which are the leading causes of death worldwide. Traditional herbal medicine has a long history; however, there is still a need for more in-depth studies and evidence-based confirmation from controlled and validated trials. Many in vitro and in vivo studies have reporte...
Source: Frontiers in Pharmacology - July 19, 2022 Category: Drugs & Pharmacology Source Type: research
Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies
Polycystic ovary syndrome (PCOS) is a very common, complex, and heterogeneous endocrine disorder of women that involves a combination of environmental and genetic factors. PCOS affects women of growing age particularly at the early to late reproductive stage (15–35 years). Currently, PCOS affects 1 in every 10 women worldwide. It is characterized majorly by a raised level of androgens such as testosterone and a large number of ovarian cysts (more than 10) that cause anovulation, infertility, and irregular menstrual cycle. PCOS is also related to other endocrine and metabolic abnormalities, such as obesity, hirsutism, ac...
Source: Frontiers in Pharmacology - July 18, 2022 Category: Drugs & Pharmacology Source Type: research
Unusual Presentation of Acute Hydroxychloroquine Retinopathy
CONCLUSIONS AND IMPORTANCE: Although rare, acute hydroxychloroquine maculopathy could occur in patients with concomitant usage of medications that could interfere with P450 enzymes system. Careful acquisition of drug history and serial ophthalmological examinations are advised in using hydroxychloroquine for disease management even for a short period of time.PMID:35802352 | DOI:10.1080/09273948.2022.2088563 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - July 8, 2022 Category: Allergy & Immunology Authors: You-Yang Lian Yi-Cih Ma Cheng-Kuo Cheng Source Type: research
Prediction and validation of potential molecular targets for the combination of Astragalus membranaceus and Angelica sinensis in the treatment of atherosclerosis based on network pharmacology
This study was conducted to predict and validate the potential molecular targets and pathways of Astragalus membranaceus and Angelica sinensis (A&A) in the treatment of atherosclerosis using network pharmacology. The active ingredients of A&A were obtained using the TCMSP database, while the target genes of atherosclerosis were acquired using 2 databases, namely GeneCards and DrugBank. The disease-target-component model map and the core network were obtained using Cytoscape 3.8.2 and MCODE plug-in, respectively. The core network was then imported into the STRING database to obtain the protein-protein interaction (P...
Source: Atherosclerosis - July 1, 2022 Category: Cardiology Authors: Tianyue Wang Yaqiong Zhou Kaina Wang Xinyu Jiang Jingbo Wang Jing Chen Source Type: research
Prediction and validation of potential molecular targets for the combination of Astragalus membranaceus and Angelica sinensis in the treatment of atherosclerosis based on network pharmacology
This study was conducted to predict and validate the potential molecular targets and pathways of Astragalus membranaceus and Angelica sinensis (A&A) in the treatment of atherosclerosis using network pharmacology. The active ingredients of A&A were obtained using the TCMSP database, while the target genes of atherosclerosis were acquired using 2 databases, namely GeneCards and DrugBank. The disease-target-component model map and the core network were obtained using Cytoscape 3.8.2 and MCODE plug-in, respectively. The core network was then imported into the STRING database to obtain the protein-protein interaction (PPI) netw...
Source: Medicine - July 1, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Novel Integrated Tiered Cumulative Risk Assessment of Heavy Metals in Food Homologous Traditional Chinese Medicine Based on a Real-Life-Exposure Scenario
In order to serve population health better, the first integrated tiered decision tree for cumulative risk assessment of co-exposure of Pb-, Cd-, and As-associated health risks in food homologous traditional Chinese medicine (TCM) was designed, after measuring their concentrations by inductively coupled plasma-mass spectroscopy (ICP-MS). Basically, our three-step decision tree involving hazard quotient (HQ), hazard index (HI), and target-organ toxicity dose (TTD) modification of the HI method was developed to evaluate the potential risks of 949 batches of 15 types of food homologous TCM. To acquire a real-life exposure scen...
Source: Frontiers in Pharmacology - June 24, 2022 Category: Drugs & Pharmacology Source Type: research
Exploring the Q-markers of Angelica sinensis (Oliv.) Diels of anti-platelet aggregation activity based on spectrum-effect relationships
In this study, the RAS from geoherb regions showed better efficacy in inhibiting ADP-induced or AA-induced platelet aggregation than those in non-geoherbs. In addition, the HPLC fingerprints of 30 batches of RAS, realizing the comprehensive evaluation of RAS, were established and used for spectral efficiency to screen the quality markers (Q-Markers) on anti-platelet aggregation activities. Five compounds in RAS, senkyunolide I, uridine, guanine, ferulic acid, and adenosine, were demonstrated to contribute significantly to the anti-platelet aggregation activity. These bioactive compounds, especially senkyunolide I and ferul...
Source: Biomedical Chromatography : BMC - June 9, 2022 Category: Biomedical Science Authors: Kaixue Zhang Xue Shen Li Yang Qin Chen Ningning Wang Yimeng Li Pingshun Song Min Jiang Gang Bai Pingrong Yang Zhigang Yang Source Type: research
Transcriptomic Analysis Reveals LncRNAs Associated with Flowering of < em > Angelica sinensis < /em > during Vernalization
Curr Issues Mol Biol. 2022 Apr 26;44(5):1867-1888. doi: 10.3390/cimb44050128.ABSTRACTAngelica sinensis is a "low-temperature and long-day" perennial plant that produces bioactive compounds such as phthalides, organic acids, and polysaccharides for various types of clinical agents, including those with cardio-cerebrovascular, hepatoprotective, and immunomodulatory effects. To date, the regulatory mechanism of flowering under the photoperiod has been revealed, while the regulatory network of flowering genes during vernalization, especially in the role of lncRNAs, has yet to be identified. Here, lncRNAs associated with flower...
Source: Current Issues in Molecular Biology - June 9, 2022 Category: Molecular Biology Authors: Xiaoxia Liu Mimi Luo Mengfei Li Jianhe Wei Source Type: research
Exploring the Q-markers of Angelica sinensis (Oliv.) Diels of anti-platelet aggregation activity based on spectrum-effect relationships
In this study, the RAS from geoherb regions showed better efficacy in inhibiting ADP-induced or AA-induced platelet aggregation than those in non-geoherbs. In addition, the HPLC fingerprints of 30 batches of RAS, realizing the comprehensive evaluation of RAS, were established and used for spectral efficiency to screen the quality markers (Q-Markers) on anti-platelet aggregation activities. Five compounds in RAS, senkyunolide I, uridine, guanine, ferulic acid, and adenosine, were demonstrated to contribute significantly to the anti-platelet aggregation activity. These bioactive compounds, especially senkyunolide I and ferul...
Source: Biomedical Chromatography : BMC - June 9, 2022 Category: Biomedical Science Authors: Kaixue Zhang Xue Shen Li Yang Qin Chen Ningning Wang Yimeng Li Pingshun Song Min Jiang Gang Bai Pingrong Yang Zhigang Yang Source Type: research
Transcriptomic Analysis Reveals LncRNAs Associated with Flowering of < em > Angelica sinensis < /em > during Vernalization
Curr Issues Mol Biol. 2022 Apr 26;44(5):1867-1888. doi: 10.3390/cimb44050128.ABSTRACTAngelica sinensis is a "low-temperature and long-day" perennial plant that produces bioactive compounds such as phthalides, organic acids, and polysaccharides for various types of clinical agents, including those with cardio-cerebrovascular, hepatoprotective, and immunomodulatory effects. To date, the regulatory mechanism of flowering under the photoperiod has been revealed, while the regulatory network of flowering genes during vernalization, especially in the role of lncRNAs, has yet to be identified. Here, lncRNAs associated with flower...
Source: Current Issues in Molecular Biology - June 9, 2022 Category: Molecular Biology Authors: Xiaoxia Liu Mimi Luo Mengfei Li Jianhe Wei Source Type: research
Transcriptomic Analysis Reveals LncRNAs Associated with Flowering of < em > Angelica sinensis < /em > during Vernalization
Curr Issues Mol Biol. 2022 Apr 26;44(5):1867-1888. doi: 10.3390/cimb44050128.ABSTRACTAngelica sinensis is a "low-temperature and long-day" perennial plant that produces bioactive compounds such as phthalides, organic acids, and polysaccharides for various types of clinical agents, including those with cardio-cerebrovascular, hepatoprotective, and immunomodulatory effects. To date, the regulatory mechanism of flowering under the photoperiod has been revealed, while the regulatory network of flowering genes during vernalization, especially in the role of lncRNAs, has yet to be identified. Here, lncRNAs associated with flower...
Source: Current Issues in Molecular Biology - June 9, 2022 Category: Molecular Biology Authors: Xiaoxia Liu Mimi Luo Mengfei Li Jianhe Wei Source Type: research
