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Transcriptomic Analysis Reveals LncRNAs Associated with Flowering of < em > Angelica sinensis < /em > during Vernalization
Curr Issues Mol Biol. 2022 Apr 26;44(5):1867-1888. doi: 10.3390/cimb44050128.ABSTRACTAngelica sinensis is a "low-temperature and long-day" perennial plant that produces bioactive compounds such as phthalides, organic acids, and polysaccharides for various types of clinical agents, including those with cardio-cerebrovascular, hepatoprotective, and immunomodulatory effects. To date, the regulatory mechanism of flowering under the photoperiod has been revealed, while the regulatory network of flowering genes during vernalization, especially in the role of lncRNAs, has yet to be identified. Here, lncRNAs associated with flower...
Source: Current Issues in Molecular Biology - June 9, 2022 Category: Molecular Biology Authors: Xiaoxia Liu Mimi Luo Mengfei Li Jianhe Wei Source Type: research

Effects of Xiao Chengqi Formula on slow transit constipation by assessing gut microbiota and metabolomics analysis in vitro and in vivo 1
In conclusion, XCQ formula can protect ICC activity and effectively promote intestinal peristalsis by promoting the colonization of Roseburia and increasing the content of BAB after metabolism, thus improving the defecation status of STC patients. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 8, 2022 Category: Drugs & Pharmacology Source Type: research

Interactions Between Natural Products and Tamoxifen in Breast Cancer: A Comprehensive Literature Review
Conclusion: There is evidence for potential interactions of various natural products with TAM in pre-clinical studies, although the relevant clinical evidence is still lacking. Further studies are warranted to evaluate the potential interactions of natural products with TAM in clinical settings. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 2, 2022 Category: Drugs & Pharmacology Source Type: research

Z-Ligustilide Induces c-Myc-Dependent Apoptosis via Activation of ER-Stress Signaling in Hypoxic Oral Cancer Cells
This study focuses on the molecular mechanism of ligustilide-induced apoptosis in hypoxic oral cancer cells. We found that in hypoxic TW2.6 cells, ligustilide inhibited cell migration and induced caspase-dependent apoptosis. Accumulation of c-Myc accompanied by BH3-only members suggests that ligustilide may induce c-Myc-dependent apoptosis. In addition, we reported that ligustilide has an effect on ER-stress signaling. By using inhibitors of c-Myc, IRE1α, and ER-stress inhibitors, we found that cell morphologies or cell viability were rescued to some degree. Moreover, ligustilide is able to increase the expression of γ-H...
Source: Frontiers in Oncology - April 13, 2022 Category: Cancer & Oncology Source Type: research

Metabonomics Study on the hepatoprotective effect mechanism of polysaccharides from different processed products of Angelica Sinensis on the layer chickens based on UPLC-Q/TOF-MS/MS, multivariate statistical analysis and conjoint analysis
Biomed Chromatogr. 2022 Apr 7:e5362. doi: 10.1002/bmc.5362. Online ahead of print.ABSTRACTChicken Colibacillosis (CC) is one of the most severe diseases in the chicken industry. Ceftiofur sodium (CS) is often used to treat CC in clinical practice, and lipopolysaccharide (LPS) accumulates in the chicken body. Previous experimental studies found that CS combined with LPS could induce liver injury in layer chickens, and polysaccharides from charred Angelica Sinensis (CASP) had a better hepatoprotective effect than polysaccharides from unprocessed Angelica Sinensis (UASP). However, the intervention mechanism was unclear. Thus,...
Source: Biomedical Chromatography : BMC - April 8, 2022 Category: Biomedical Science Authors: Fan-Lin Wu Yong-Hao Hu Peng Ji Chen-Chen Li Jian He Source Type: research