Diversity and Bioactivity of Endophytes From Angelica sinensis in China
Plant seeds are not merely reproductive organs, they are also carriers of microorganism, particularly, inherent and non-invasive characteristic endophytes in host plant. Therefore, in this study, the endophytic diversity of Angelica seeds was studied and compared with endophytes isolated from healthy leaves, stems, roots, and seeds of A. sinensis using 20 different media. The metabolites of endophytic strains were evaluated with six different methods for their antioxidant activity and the paper disc diffusion method for antimicrobial activities. As a result, 226 endophytes were isolated. Compared with the biodiversity and ...
Source: Frontiers in Microbiology - August 17, 2020 Category: Microbiology Source Type: research
Molecules, Vol. 25, Pages 3356: Determination of Ferulic Acid in Angelica sinensis by Temperature-Controlled Hydrophobic Ionic Liquids-Based Ultrasound/Heating-Assisted Extraction Coupled with High Performance Liquid Chromatography
Shang
Yan Zhu
Hydrophilic ionic liquids are often used to extract the active ingredients of medicinal plants, while hydrophobic ionic liquids are rarely used to directly extract solid samples. In this paper, a simple, novel and efficient temperature-controlled hydrophobic ionic liquids-based ultrasound/heating-assisted extraction (TC-ILs-UHAE) procedure coupled with high-performance liquid chromatography (HPLC) was developed and applied to the determination of ferulic acid (FA) in Chinese herbal medicine Angelica sinensis. During the extraction procedure, hydrophobic ionic liquids (ILs) were dispersed into water to f...
Source: Molecules - July 23, 2020 Category: Chemistry Authors: Hongwei Wu Qianqian Huang Shujun Chao Jie Yu Shengrui Xu Feng Wang Xuefang Shang Yan Zhu Tags: Article Source Type: research
Changes of Anti-tuberculosis Herbs Formula During Past Three Decades in Contrast to Ancient Ones
ConclusionsAlthough there were wide variations in the herb groups and herb combinations in the formulae, half of the top 30 herbs were found in both modern and ancient prescriptions. The core herb combinations in modern and ancient prescriptions could help us to improve the priscription for treatment of TB. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 8, 2020 Category: Internal Medicine Source Type: research
Molecules, Vol. 25, Pages 3096: A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy
Hong Yang
Combination of chemotherapy and immunotherapy has been a promising strategy in cancer treatment. Polysaccharides from Angelica sinensis (AP), a well-known Chinese herbal medicine, have been proved to have good immunomodulatory activity. In the present study, an enzyme-sensitive tumor-targeting nano drug delivery system (AP-PP-DOX (doxorubicin), PP stood for peptide) was constructed. In this system, Angelica polysaccharides act as not only carriers to targeted delivery of drugs to tumor tissue but also effectors to improve tumor microenvironment and enhance immune function, resulting in synergistic antitumor e...
Source: Molecules - July 6, 2020 Category: Chemistry Authors: Min-Zhe Wang Xin He Zhe Yu Hong Wu Tie-Hong Yang Tags: Article Source Type: research
The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury.
Conclusions: Our results reflect the regulation of multiple targets and links in herb pairs and provide an important basis for the use of AR and ASR combinations in the treatment of MI.
PMID: 32608342 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 2, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Study on the Fingerprints and Quality Evaluation of Angelica Sinensis Radix by HPLC Coupled With Chemometrics Based on Traditional Decoction Process of ACPTCM.
Conclusions: These results demonstrated that the combination of HPLC chromatographic fingerprint and chemometrics offers an efficient and reliable approach for quality evaluation of ASR from different sources as Ancient Classical Prescriptions ingredients.
PMID: 33013250 [PubMed] (Source: Dose Response)
Source: Dose Response - June 30, 2020 Category: Drugs & Pharmacology Authors: Qian Z, Yiyang C, Lixia M, Yue J, Jun C, Jie D, Yifan M, Jingjing Z, Guojun Y Tags: Dose Response Source Type: research
Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia
Angelica sinensis polysaccharide (ASP) is an effective medicine for aplastic anemia (AA). The present study aims to investigate whether mitochondrial apoptosis in aplastic anemia could be corrected by ASP by a... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - June 22, 2020 Category: Complementary Medicine Authors: Zetao Chen, Li Cheng, Jing Zhang and Xing Cui Tags: Research article Source Type: research
Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22/STAT3 pathway.
In conclusion, ASP effectively alleviates chronic liver fibrosis by inhibiting HSC activation through the IL-22/STAT3 pathway.
PMID: 32569681 [PubMed - as supplied by publisher] (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - June 18, 2020 Category: Biochemistry Authors: Wang K, Wang J, Song M, Wang H, Xia N, Zhang Y Tags: Int J Biol Macromol Source Type: research
Pharmacokinetic Study of Ferulic Acid Following Transdermal or Intragastric Administration in Rats.
Abstract
Ferulic acid is contained in some Chinese herbal medicines such as Ligusticum chuanxiong or Angelica sinensis. Studies have focused on the treatment of inflammatory diseases and pain using ferulic acid. However, little is known about its pharmacokinetics after transdermal administration. The present research investigated the pharmacokinetic behavior of ferulic acid in rat plasma and skin microdialysate after ferulic acid transdermal or intragastric administration. Samples collected at predetermined time points were determined by a simple and sensitive HPLC-UV method. The pharmacokinetic parameters...
Source: AAPS PharmSciTech - June 7, 2020 Category: Drugs & Pharmacology Authors: Yan N, Tang Z, Xu Y, Li X, Wang Q Tags: AAPS PharmSciTech Source Type: research
The combination of Panax ginseng and Angelica sinensis alleviates ischemia brain injury by suppressing NLRP3 inflammasome activation and microglial pyroptosis
Publication date: Available online 29 May 2020Source: PhytomedicineAuthor(s): Jia Hu, Cheng Zeng, Jie Wei, Fengqi Duan, Sijun Liu, Yonghua Zhao, Hongmei Tan (Source: Phytomedicine)
Source: Phytomedicine - May 30, 2020 Category: Drugs & Pharmacology Source Type: research
Experimental Study on the Effect of Aconite and Angelica sinensis on Myocardial Ischemia Rats with Yang Deficiency and Blood Stasis.
Conclusions: The method of preparing a rat model of myocardial ischemia with Yang deficiency and blood stasis was feasible. The compatibility of Aconite and Angelica sinensis reduced myocardial fibrosis and inflammatory reaction, protected ischemic cardiomyocytes, and reduced myocardial injury, whose mechanism may be related to the regulation of PI3K/Akt pathway. The compatible group had better intervention effects than Aconite or Angelica sinensis alone. The best one was high-dose FG (1 : 2).
PMID: 32419818 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 20, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Radix Angelica Sinensis and Radix Hedysari Ultrafiltration Extract Protects against X-Irradiation-Induced Cardiac Fibrosis in Rats.
In this study, we first found that the RAS-RH antifibrosis effect was associated with the upregulation of microRNA-200a and the downregulation of TGF-β1/smad3 and COL1α. In addition, we also found that the antifibrosis effect of RAS-RH was related to the induction of apoptosis in primary rat cardiac fibroblasts and to the prevention of damage caused by reactive oxygen species (ROS). Interestingly, primary rat cardiac fibroblasts exposed to X-ray radiation underwent apoptosis less frequently in the absence of RAS-RH. Therefore, RAS-RH has the ability to protect against fibrosis, which could be occurring through the induct...
Source: Evidence-based Complementary and Alternative Medicine - May 10, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Leukemia cells apoptosis by a newly discovered heterogeneous polysaccharide from Angelica sinensis (Oliv.) Diels
Publication date: Available online 30 April 2020Source: Carbohydrate PolymersAuthor(s): Wenjuan Liu, Kaimin Xiao, Li Ren, Yi Sui, Jie Chen, Tian Zhang, Xiao-Qiang Li, Wei Cao (Source: Carbohydrate Polymers)
Source: Carbohydrate Polymers - May 2, 2020 Category: Biomedical Science Source Type: research
Radix Astragali and Radix Angelicae Sinensis in the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-analysis
ConclusionRA and RAS are effective and safe in the treatment of IPF, which is beneficial to pulmonary function and exercise tolerance of these patients. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 29, 2020 Category: Drugs & Pharmacology Source Type: research
The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review.
Abstract
The Th17/Treg axis plays a crucial role in immune-mediated inflammatory diseases (IMID) and might represent an interesting drug target of treatment strategy for these diseases. Accumulating evidence suggests a role for traditional Chinese medicine (TCM) in the modulation of Th17/Treg axis, but a comprehensive overview which summarizes this field hitherto is lacked. This paper performs a systematic literature review of the regulatory effects of TCM on the imbalance of Th17/Treg axis and its potential mechanisms. In addition, the frequency analysis and network pharmacology for the collected TCM herb...
Source: The American Journal of Chinese Medicine - April 28, 2020 Category: Complementary Medicine Authors: Xu YY, Wang DM, Liang HS, Liu ZH, Li JX, Wang MJ, Chen XM, Balak DMW, Radstake TRDJ, Huang RY, Lu CJ Tags: Am J Chin Med Source Type: research
