Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans
CONCLUSIONS: This study showed that SMYAD improves TAO symptoms and inhibits the development of TAO. The mechanism could be associated with anti-inflammatory and therapeutic angiogenesis.PMID:37318081 | DOI:10.1080/07853890.2023.2218105 (Source: Annals of Medicine)
Source: Annals of Medicine - June 15, 2023 Category: Internal Medicine Authors: Jiaxi Zou Weiming Xu Ziyun Li Ping Gao Fangyuan Zhang Yuting Cui Jingqing Hu Source Type: research
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification
In this study, we combined network pharmacological methods with experimental verification to investigate the anti-neuroinflammatory effects and mechanisms of ligustilide and LIGc. Based on our network pharmacology analysis, we identified four key targets of ligustilide involved in exerting an anti-inflammatory effect, with the nuclear factor (NF)-κB signal pathway suggested as the main signalling pathway. To verify these results, we examined the expression of inflammatory cytokines and inflammation-related proteins, analysed the phosphorylation level of NF-κB, inhibitor of κBα (IκBα) and inhibitor of κB kinase α an...
Source: Clinical and Experimental Pharmacology and Physiology - June 12, 2023 Category: Drugs & Pharmacology Authors: Juan Gao Gang Su Wei Chen Qionghui Wu Junxi Liu Jifei Liu Miao Chai Ying Dong He Wang Lixia Chen Zhenchang Zhang Manxia Wang Source Type: research
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification
In this study, we combined network pharmacological methods with experimental verification to investigate the anti-neuroinflammatory effects and mechanisms of ligustilide and LIGc. Based on our network pharmacology analysis, we identified four key targets of ligustilide involved in exerting an anti-inflammatory effect, with the nuclear factor (NF)-κB signal pathway suggested as the main signalling pathway. To verify these results, we examined the expression of inflammatory cytokines and inflammation-related proteins, analysed the phosphorylation level of NF-κB, inhibitor of κBα (IκBα) and inhibitor of κB kinase α an...
Source: Clinical and Experimental Pharmacology and Physiology - June 12, 2023 Category: Drugs & Pharmacology Authors: Juan Gao Gang Su Wei Chen Qionghui Wu Junxi Liu Jifei Liu Miao Chai Ying Dong He Wang Lixia Chen Zhenchang Zhang Manxia Wang Source Type: research
Molecules, Vol. 28, Pages 4384: Apiaceae Medicinal Plants in China: A Review of Traditional Uses, Phytochemistry, Bolting and Flowering (BF), and BF Control Methods
ianhe Wei
Apiaceae plants have been widely used in traditional Chinese medicine (TCM) for the removing dampness, relieving superficies, and dispelling cold, etc. In order to exploit potential applications as well as improve the yield and quality of Apiaceae medicinal plants (AMPs), the traditional use, modern pharmacological use, phytochemistry, effect of bolting and flowering (BF), and approaches for controlling BF were summarized. Currently, about 228 AMPs have been recorded as TCMs, with 6 medicinal parts, 72 traditional uses, 62 modern pharmacological uses, and 5 main kinds of metabolites. Three different degrees (...
Source: Molecules - May 27, 2023 Category: Chemistry Authors: Meiling Li Min Li Li Wang Mengfei Li Jianhe Wei Tags: Review Source Type: research
[ASAP] Colon-Targeting < named-content content-type="genus-species" xlink:type="simple" > Angelica sinensis < /named-content > Polysaccharide Nanoparticles with Dual Responsiveness for Alleviation of Ulcerative Colitis
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.3c02128 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - May 26, 2023 Category: Materials Science Authors: Yu Xu, Bei-Wei Zhu, Rong Sun, Xiang Li, Di Wu, and Jiang-Ning Hu Source Type: research
Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF- κB pathway
Int J Biol Macromol. 2023 May 4:124689. doi: 10.1016/j.ijbiomac.2023.124689. Online ahead of print.ABSTRACTThe roots of Angelica sinensis have been used in Traditional Chinese Medicine for thousands of years. However, tons of aerial parts of this herb (aboveground part) are commonly discarded during the process of root preparations. A polysaccharide (ASP-Ag-AP) in the aboveground parts of A. sinensis was isolated and preliminarily characterized as typical plant pectin. ASP-Ag-AP exhibited noticeable protective effects against dextran sodium sulfate (DSS)-induced colitis, including reduction of colonic inflammation, modulat...
Source: International Journal of Biological Macromolecules - May 6, 2023 Category: Biochemistry Authors: Yuan-Feng Zou Cen-Yu Li Yu-Ping Fu Xiao-Ping JiZe Yu-Zhe Zhao Xi Peng Jing-Yi Wang Zhong-Qiong Yin Yang-Ping Li Xu Song Li-Xia Li Xing-Hong Zhao Bin Feng Chao Huang Gang Ye Hua-Qiao Tang Ji Chen Rui Li Xing-Fu Chen Meng-Liang Tian Source Type: research
< em > Angelica sinensis < /em > polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells
CONCLUSIONS: ASP delayed oxidative stress-induced premature senescence of 5-FU-treated feeder co-cultured hematopoietic cells via down-regulation of overactivated Wnt/β-catenin signaling. These findings provide a new strategy for alleviating myelosuppressive stress.PMID:37148130 | DOI:10.1080/13880209.2023.2207592 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 6, 2023 Category: Drugs & Pharmacology Authors: Yilin Niu Hanxianzhi Xiao Biyao Wang Ziling Wang Kunhang Du Yaping Wang Lu Wang Source Type: research
Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF- κB pathway
Int J Biol Macromol. 2023 May 4:124689. doi: 10.1016/j.ijbiomac.2023.124689. Online ahead of print.ABSTRACTThe roots of Angelica sinensis have been used in Traditional Chinese Medicine for thousands of years. However, tons of aerial parts of this herb (aboveground part) are commonly discarded during the process of root preparations. A polysaccharide (ASP-Ag-AP) in the aboveground parts of A. sinensis was isolated and preliminarily characterized as typical plant pectin. ASP-Ag-AP exhibited noticeable protective effects against dextran sodium sulfate (DSS)-induced colitis, including reduction of colonic inflammation, modulat...
Source: International Journal of Biological Macromolecules - May 6, 2023 Category: Biochemistry Authors: Yuan-Feng Zou Cen-Yu Li Yu-Ping Fu Xiao-Ping JiZe Yu-Zhe Zhao Xi Peng Jing-Yi Wang Zhong-Qiong Yin Yang-Ping Li Xu Song Li-Xia Li Xing-Hong Zhao Bin Feng Chao Huang Gang Ye Hua-Qiao Tang Ji Chen Rui Li Xing-Fu Chen Meng-Liang Tian Source Type: research
