Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis
Biomed Pharmacother. 2021 May 24;140:111696. doi: 10.1016/j.biopha.2021.111696. Online ahead of print.ABSTRACTGlutamate-induced neurotoxicity is one of the most important pathogenic mechanisms in neurological diseases and is widely used as an in vitro model for ischemic stroke. Senkyunolide I (SEI), an active constituent derived from traditional Chinese medicine Ligusticum chuanxiong Hort. and Angelica sinensis (Oliv.) Diels, has been shown to have beneficial effects against focal cerebral ischemia-reperfusion in rats. However, the mechanisms underlying SEI-mediated neuroprotection remain not well understood. Thus, we expl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2021 Category: Drugs & Pharmacology Authors: Min Wang Hideki Hayashi Ichiro Horinokita Mayumi Asada Yui Iwatani Jian-Xun Liu Norio Takagi Source Type: research
Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis
Biomed Pharmacother. 2021 May 25;140:111696. doi: 10.1016/j.biopha.2021.111696. Online ahead of print.ABSTRACTGlutamate-induced neurotoxicity is one of the most important pathogenic mechanisms in neurological diseases and is widely used as an in vitro model for ischemic stroke. Senkyunolide I (SEI), an active constituent derived from traditional Chinese medicine Ligusticum chuanxiong Hort. and Angelica sinensis (Oliv.) Diels, has been shown to have beneficial effects against focal cerebral ischemia-reperfusion in rats. However, the mechanisms underlying SEI-mediated neuroprotection remain not well understood. Thus, we expl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2021 Category: Drugs & Pharmacology Authors: Min Wang Hideki Hayashi Ichiro Horinokita Mayumi Asada Yui Iwatani Jian-Xun Liu Norio Takagi Source Type: research
Ultrafiltration Extract of Radix Angelica Sinensis and Radix Hedysari Attenuates Risk of Low-Dose X-Ray Radiation-Induced Myocardial Fibrosis In Vitro
Evid Based Complement Alternat Med. 2021 Apr 28;2021:5580828. doi: 10.1155/2021/5580828. eCollection 2021.ABSTRACTThe risk of radiation-induced heart damage (RIHD) is a growing concern since recent advances in radiation therapy (RT) for cancer treatments have significantly improved the number of survivors. Radiation-induced myocardial fibrosis (RIMF) is the final pathological condition of RIHD and main change leading to serious cardiovascular complications following RT. The aim of this study was to investigate the effect of ultrafiltration extract of Radix Angelica Sinensis and Radix Hedysari (RAS-RH) on the proliferation,...
Source: Evidence-based Complementary and Alternative Medicine - May 19, 2021 Category: Complementary Medicine Authors: Juan Chang Chengxu Ma Huan Guo Haiqiong Ran Guolian Chen Yingdong Li Source Type: research
Antidepressant-like effects of Z-ligustilide on chronic unpredictable mild stress-induced depression in rats
Exp Ther Med. 2021 Jul;22(1):677. doi: 10.3892/etm.2021.10109. Epub 2021 Apr 25.ABSTRACTDepression is a significant public health issue and its neuropathogenesis is associated with the dysfunction of progesterone and allopregnanolone biosynthesis. Z-ligustilide (LIG), one of the main components of the herb Angelica sinensis (Oliv.) Diels (AS), is reported to have antidepressant activities. The present study aimed to evaluate the antidepressant-like effects of LIG via behavioral tests and to measure the levels of progesterone and allopregnanolone in the prefrontal cortex and hippocampus. The results demonstrated that LIG (2...
Source: Experimental and Therapeutic Medicine - May 14, 2021 Category: General Medicine Authors: Jian-Chun Ma Hao-Liang Zhang Hui-Ping Huang Zao-Liang Ma Su-Fang Chen Zhi-Kun Qiu Ji-Sheng Chen Source Type: research
Structures and anti-melanoma activities of two polysaccharides from Angelica sinensis (Oliv.) Diels
In this study, two homogeneous polysaccharides (APS-4I and APS-4II) were isolated from Angelica sinensis (Oliv.) Diels. APS-4I was a linear glucan with molecular weight of 16.1 kDa, which was composed of 88.4% α-1,6-Glcp, 4.1% α-1,2-Glcp, 3.9% α-1,3-Glcp, and 2.8% α-T-Glcp. APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% α-1,6-Glcp, 10.4% α-1,3,5-Araf, 8.7% α-T-Araf, 9.2% α-1,5-Araf, 4.0% α-1,3-Araf, 3.6% α-1,4-Galp, and 9.1% β-1,3-Galp. NMR results demonstrated that APS-4II has a backbone composed of →6)-α-Glcp-(1 → 6)-α-Glcp-(1 → 5)-α-Araf-. (1 → 5)-α-...
Source: International Journal of Biological Macromolecules - May 9, 2021 Category: Biochemistry Authors: Tian Zhang Wenjuan Liu Chengyang Fu Yuhe Qiao Kaimin Xiao Li Ren Caixia Feng Jingmei Wang Weixia Yang Xiao-Qiang Li Wei Cao Source Type: research
Structures and anti-melanoma activities of two polysaccharides from Angelica sinensis (Oliv.) Diels
In this study, two homogeneous polysaccharides (APS-4I and APS-4II) were isolated from Angelica sinensis (Oliv.) Diels. APS-4I was a linear glucan with molecular weight of 16.1 kDa, which was composed of 88.4% α-1,6-Glcp, 4.1% α-1,2-Glcp, 3.9% α-1,3-Glcp, and 2.8% α-T-Glcp. APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% α-1,6-Glcp, 10.4% α-1,3,5-Araf, 8.7% α-T-Araf, 9.2% α-1,5-Araf, 4.0% α-1,3-Araf, 3.6% α-1,4-Galp, and 9.1% β-1,3-Galp. NMR results demonstrated that APS-4II has a backbone composed of →6)-α-Glcp-(1 → 6)-α-Glcp-(1 → 5)-α-Araf-. (1 → 5)-α-...
Source: International Journal of Biological Macromolecules - May 9, 2021 Category: Biochemistry Authors: Tian Zhang Wenjuan Liu Chengyang Fu Yuhe Qiao Kaimin Xiao Li Ren Caixia Feng Jingmei Wang Weixia Yang Xiao-Qiang Li Wei Cao Source Type: research
(+)-/(−)-Angelignanine, a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head
Publication date: May 2021Source: Chinese Chemical Letters, Volume 32, Issue 5Author(s): Youzhe Chen, Qinglan Guo, Chengbo Xu, Chenggen Zhu, Jianjun Zhang, Jiangong Shi (Source: Chinese Chemical Letters)
Source: Chinese Chemical Letters - May 6, 2021 Category: Chemistry Source Type: research
[ASAP] Administration Routes of Polyethylenimine-Coated PLGA Nanoparticles Encapsulating Angelica Sinensis Polysaccharide Vaccine Delivery System Affect Immune Responses
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.1c00090 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - April 30, 2021 Category: Drugs & Pharmacology Authors: Pengfei Gu, Yue Zhang, Gaofeng Cai, Zhenguang Liu, Yuanliang Hu, Jiaguo Liu, and Deyun Wang Source Type: research
Structural characterization of an alkali-soluble polysaccharide from Angelica sinensis and its antitumor activity in vivo
Chem Biodivers. 2021 Apr 23. doi: 10.1002/cbdv.202100089. Online ahead of print.ABSTRACTA novel alkali-soluble polysaccharide (AASP) was isolated from Angelica sinensis (Oliv.) Diels under aqueous alkali treatment, and its structural characterization and antitumor activity in vivo were evaluated in present study. Results of HPGPC and IC revealed that AASP was a neutral polysaccharide containing Ara, Gal and Glc in the mole ratio of 1.00: 2.26: 24.43, with the average molecular weight of 4.7 kDa. Periodate oxidation, Smith degradation, methylation, FT-IR and NMR analyses further demonstrated that a preliminary structure of ...
Source: Chemistry and Biodiversity - April 24, 2021 Category: Biochemistry Authors: Yan Zhao Yingying Feng Xue Jing Yining Liu Anjun Liu Source Type: research
Structural characterization of an alkali-soluble polysaccharide from Angelica sinensis and its antitumor activity in vivo
Chem Biodivers. 2021 Apr 23. doi: 10.1002/cbdv.202100089. Online ahead of print.ABSTRACTA novel alkali-soluble polysaccharide (AASP) was isolated from Angelica sinensis (Oliv.) Diels under aqueous alkali treatment, and its structural characterization and antitumor activity in vivo were evaluated in present study. Results of HPGPC and IC revealed that AASP was a neutral polysaccharide containing Ara, Gal and Glc in the mole ratio of 1.00: 2.26: 24.43, with the average molecular weight of 4.7 kDa. Periodate oxidation, Smith degradation, methylation, FT-IR and NMR analyses further demonstrated that a preliminary structure of ...
Source: Chemistry and Biodiversity - April 24, 2021 Category: Biochemistry Authors: Yan Zhao Yingying Feng Xue Jing Yining Liu Anjun Liu Source Type: research
Structural characterization of an alkali-soluble polysaccharide from Angelica sinensis and its antitumor activity in vivo
Chem Biodivers. 2021 Apr 23. doi: 10.1002/cbdv.202100089. Online ahead of print.ABSTRACTA novel alkali-soluble polysaccharide (AASP) was isolated from Angelica sinensis (Oliv.) Diels under aqueous alkali treatment, and its structural characterization and antitumor activity in vivo were evaluated in present study. Results of HPGPC and IC revealed that AASP was a neutral polysaccharide containing Ara, Gal and Glc in the mole ratio of 1.00: 2.26: 24.43, with the average molecular weight of 4.7 kDa. Periodate oxidation, Smith degradation, methylation, FT-IR and NMR analyses further demonstrated that a preliminary structure of ...
Source: Chemistry and Biodiversity - April 24, 2021 Category: Biochemistry Authors: Yan Zhao Yingying Feng Xue Jing Yining Liu Anjun Liu Source Type: research
Observation of the Expression of Vascular Endothelial Growth Factor and the Potential Effect of Promoting Hair Growth Treated with Chinese Herbal BeauTop
Evid Based Complement Alternat Med. 2021 Feb 17;2021:6667011. doi: 10.1155/2021/6667011. eCollection 2021.ABSTRACTDespite minoxidil and finasteride already being approved by the Food and Drug Administration (FDA) for the treatment of hair loss, it is important to identify new and innovative treatments for hair loss, such as looking for a solution in Chinese herbal medicine. One such treatment to consider is BeauTop (BT), whose primary ingredients include Panax japonicus (T.Nees), C.A. Mey. (Araliaceae), Astragalus membranaceus (Fisch) Bunge (Fabaceae), Angelica sinensis (Oliv.) Diels (Apiaceae), Ligustrum lucidum W.T. Aito...
Source: Evidence-based Complementary and Alternative Medicine - March 8, 2021 Category: Complementary Medicine Authors: Chien-Ying Lee Chun-Hung Su Chien-Ying Chiang Chun-Nan Wu Yu-Hsiang Kuan Source Type: research
