< em > Angelica sinensis < /em > polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells
CONCLUSIONS: ASP delayed oxidative stress-induced premature senescence of 5-FU-treated feeder co-cultured hematopoietic cells via down-regulation of overactivated Wnt/β-catenin signaling. These findings provide a new strategy for alleviating myelosuppressive stress.PMID:37148130 | DOI:10.1080/13880209.2023.2207592 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 6, 2023 Category: Drugs & Pharmacology Authors: Yilin Niu Hanxianzhi Xiao Biyao Wang Ziling Wang Kunhang Du Yaping Wang Lu Wang Source Type: research
Plant-beneficial Streptomyces dioscori SF1 potential biocontrol and plant growth promotion in saline soil within the arid and semi-arid areas
In conclusion, the strain SF1 can be used to develop environmental protection biological control agents, improve the anti-disease activity of plants, and promote plant growth in salinity soil within arid and semi-arid regions.PMID:37145360 | DOI:10.1007/s11356-023-27362-x (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - May 5, 2023 Category: Environmental Health Authors: Xiaokang Li Duoyong Lang Jianhuan Wang Wenjin Zhang Xinhui Zhang Source Type: research
Plant-beneficial Streptomyces dioscori SF1 potential biocontrol and plant growth promotion in saline soil within the arid and semi-arid areas
In conclusion, the strain SF1 can be used to develop environmental protection biological control agents, improve the anti-disease activity of plants, and promote plant growth in salinity soil within arid and semi-arid regions.PMID:37145360 | DOI:10.1007/s11356-023-27362-x (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - May 5, 2023 Category: Environmental Health Authors: Xiaokang Li Duoyong Lang Jianhuan Wang Wenjin Zhang Xinhui Zhang Source Type: research
Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila
Int J Biol Macromol. 2023 Apr 28:124639. doi: 10.1016/j.ijbiomac.2023.124639. Online ahead of print.ABSTRACTAngelica sinensis polysaccharide (ASP) is one of the principal active components of Angelica sinensis (AS) that is widely used in natural medicine and has various pharmacological activities, including antioxidant, anti-inflammatory, and enhancing immunity. However, its pharmacological role of anti-aging needs to be clarified. Here, we detected the beneficial effect and mechanism of ASP on healthy aging and aging-related diseases using the Drosophila melanogaster model. The results showed that oral administration of A...
Source: International Journal of Biological Macromolecules - April 30, 2023 Category: Biochemistry Authors: Wenjuan Tuo Shuwei Wang Yan Shi Wangjie Cao Yongqi Liu Yun Su Minghui Xiu Jianzheng He Source Type: research
Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila
Int J Biol Macromol. 2023 Apr 28:124639. doi: 10.1016/j.ijbiomac.2023.124639. Online ahead of print.ABSTRACTAngelica sinensis polysaccharide (ASP) is one of the principal active components of Angelica sinensis (AS) that is widely used in natural medicine and has various pharmacological activities, including antioxidant, anti-inflammatory, and enhancing immunity. However, its pharmacological role of anti-aging needs to be clarified. Here, we detected the beneficial effect and mechanism of ASP on healthy aging and aging-related diseases using the Drosophila melanogaster model. The results showed that oral administration of A...
Source: International Journal of Biological Macromolecules - April 30, 2023 Category: Biochemistry Authors: Wenjuan Tuo Shuwei Wang Yan Shi Wangjie Cao Yongqi Liu Yun Su Minghui Xiu Jianzheng He Source Type: research
Dose- and time-dependent renoprotection of Angelica sinensis in patients with chronic kidney disease: A longitudinal cohort study
Conclusion: This study suggests dose- and time-dependent renoprotection and dose-dependent survival benefits of the S herb in compounds and no increased hyperkalemia risk of the prescribed CHMs in CKD patients. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 25, 2023 Category: Drugs & Pharmacology Source Type: research
A comprehensive review of antitumor properties of Angelica species and their antitumor-responsible constituents and the underlying molecular mechanisms involved in tumor inhibition
Phytother Res. 2023 Apr 22. doi: 10.1002/ptr.7841. Online ahead of print.ABSTRACTAngelica species have been traditionally used for their medicinal properties. Recent studies have suggested their potential use as anticancer agents, making them an area of interest for further research. The review aims to summarize the current understanding of the potential anticancer effects of Angelica species and to provide insights for further research in this area. We searched for "Angelica" related information on Google Scholar, PubMed, ScienceDirect, Wiley, Science Citation Index Finder, and Springer link by searching keywords such as ...
Source: Cell Research - April 22, 2023 Category: Cytology Authors: Zufa Sabeel Youfeng Liang Mingxuan Hao Lu Ying Rui Guo Ruolan Chen Xiaoning Li Changyuan Yu Zhao Yang Source Type: research
Angelica Sinensis polysaccharide antagonizes 5-Fluorouracil-induced spleen injury and dysfunction by suppressing oxidative stress and apoptosis
In conclusion, the protective effect of ASP on spleens and splenocytes may be related to the reduction of oxidative stress and apoptosis via reactivation of Nrf2 and PI3K/AKT pathways. This study has provided a new protective agent for minimizing the spleen injury caused by 5-FU and a new idea for improving the prognosis of chemotherapy patients.PMID:37018993 | DOI:10.1016/j.biopha.2023.114602 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 5, 2023 Category: Drugs & Pharmacology Authors: Kunhang Du Lu Wang Ziling Wang Hanxianzhi Xiao Jiying Hou Ling Hu Ningke Fan Yaping Wang Source Type: research
Angelica Sinensis polysaccharide antagonizes 5-Fluorouracil-induced spleen injury and dysfunction by suppressing oxidative stress and apoptosis
In conclusion, the protective effect of ASP on spleens and splenocytes may be related to the reduction of oxidative stress and apoptosis via reactivation of Nrf2 and PI3K/AKT pathways. This study has provided a new protective agent for minimizing the spleen injury caused by 5-FU and a new idea for improving the prognosis of chemotherapy patients.PMID:37018993 | DOI:10.1016/j.biopha.2023.114602 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 5, 2023 Category: Drugs & Pharmacology Authors: Kunhang Du Lu Wang Ziling Wang Hanxianzhi Xiao Jiying Hou Ling Hu Ningke Fan Yaping Wang Source Type: research
Multi-Function of a New Bioactive Secondary Metabolite Derived from Endophytic Fungus < em > Colletotrichum acutatum < /em > of < em > Angelica sinensis < /em >
J Microbiol Biotechnol. 2023 Jan 6;33(6):1-17. doi: 10.4014/jmb.2206.06010. Online ahead of print.ABSTRACTIn the current study we assessed a new crystallized compound, 5-(1-hydroxybutyl)-4-methoxy-3- methyl-2H-pyran-2-one (C-HMMP), from the endophytic fungus Colletotrichum acutatum residing in the medicinal plant Angelica sinensis for its in vitro antimicrobial, antibiofilm, antioxidant, antimalarial, and anti-proliferative properties. The promising compound was identified as C-HMMP through antimicrobial-guided fraction. The structure of C-HMMP was unambiguously confirmed by 2D NMR and HIRS spectroscopic analysis. Antimicr...
Source: Journal of Microbiology and Biotechnology - March 13, 2023 Category: Biotechnology Authors: Ramy S Yehia Source Type: research
Multi-Function of a New Bioactive Secondary Metabolite Derived from Endophytic Fungus < em > Colletotrichum acutatum < /em > of < em > Angelica sinensis < /em >
J Microbiol Biotechnol. 2023 Jan 6;33(6):1-17. doi: 10.4014/jmb.2206.06010. Online ahead of print.ABSTRACTIn the current study we assessed a new crystallized compound, 5-(1-hydroxybutyl)-4-methoxy-3- methyl-2H-pyran-2-one (C-HMMP), from the endophytic fungus Colletotrichum acutatum residing in the medicinal plant Angelica sinensis for its in vitro antimicrobial, antibiofilm, antioxidant, antimalarial, and anti-proliferative properties. The promising compound was identified as C-HMMP through antimicrobial-guided fraction. The structure of C-HMMP was unambiguously confirmed by 2D NMR and HIRS spectroscopic analysis. Antimicr...
Source: Journal of Microbiology and Biotechnology - March 13, 2023 Category: Biotechnology Authors: Ramy S Yehia Source Type: research
Multi-Function of a New Bioactive Secondary Metabolite Derived from Endophytic Fungus < em > Colletotrichum acutatum < /em > of < em > Angelica sinensis < /em >
J Microbiol Biotechnol. 2023 Jan 6;33(6):1-17. doi: 10.4014/jmb.2206.06010. Online ahead of print.ABSTRACTIn the current study we assessed a new crystallized compound, 5-(1-hydroxybutyl)-4-methoxy-3- methyl-2H-pyran-2-one (C-HMMP), from the endophytic fungus Colletotrichum acutatum residing in the medicinal plant Angelica sinensis for its in vitro antimicrobial, antibiofilm, antioxidant, antimalarial, and anti-proliferative properties. The promising compound was identified as C-HMMP through antimicrobial-guided fraction. The structure of C-HMMP was unambiguously confirmed by 2D NMR and HIRS spectroscopic analysis. Antimicr...
Source: Journal of Microbiology and Biotechnology - March 13, 2023 Category: Biotechnology Authors: Ramy S Yehia Source Type: research
Multi-Function of a New Bioactive Secondary Metabolite Derived from Endophytic Fungus < em > Colletotrichum acutatum < /em > of < em > Angelica sinensis < /em >
J Microbiol Biotechnol. 2023 Jan 6;33(6):1-17. doi: 10.4014/jmb.2206.06010. Online ahead of print.ABSTRACTIn the current study we assessed a new crystallized compound, 5-(1-hydroxybutyl)-4-methoxy-3- methyl-2H-pyran-2-one (C-HMMP), from the endophytic fungus Colletotrichum acutatum residing in the medicinal plant Angelica sinensis for its in vitro antimicrobial, antibiofilm, antioxidant, antimalarial, and anti-proliferative properties. The promising compound was identified as C-HMMP through antimicrobial-guided fraction. The structure of C-HMMP was unambiguously confirmed by 2D NMR and HIRS spectroscopic analysis. Antimicr...
Source: Journal of Microbiology and Biotechnology - March 13, 2023 Category: Biotechnology Authors: Ramy S Yehia Source Type: research
Multi-Function of a New Bioactive Secondary Metabolite Derived from Endophytic Fungus < em > Colletotrichum acutatum < /em > of < em > Angelica sinensis < /em >
J Microbiol Biotechnol. 2023 Jan 6;33(6):1-17. doi: 10.4014/jmb.2206.06010. Online ahead of print.ABSTRACTIn the current study we assessed a new crystallized compound, 5-(1-hydroxybutyl)-4-methoxy-3- methyl-2H-pyran-2-one (C-HMMP), from the endophytic fungus Colletotrichum acutatum residing in the medicinal plant Angelica sinensis for its in vitro antimicrobial, antibiofilm, antioxidant, antimalarial, and anti-proliferative properties. The promising compound was identified as C-HMMP through antimicrobial-guided fraction. The structure of C-HMMP was unambiguously confirmed by 2D NMR and HIRS spectroscopic analysis. Antimicr...
Source: Journal of Microbiology and Biotechnology - March 13, 2023 Category: Biotechnology Authors: Ramy S Yehia Source Type: research
Multi-Function of a New Bioactive Secondary Metabolite Derived from Endophytic Fungus < em > Colletotrichum acutatum < /em > of < em > Angelica sinensis < /em >
J Microbiol Biotechnol. 2023 Jan 6;33(6):1-17. doi: 10.4014/jmb.2206.06010. Online ahead of print.ABSTRACTIn the current study we assessed a new crystallized compound, 5-(1-hydroxybutyl)-4-methoxy-3- methyl-2H-pyran-2-one (C-HMMP), from the endophytic fungus Colletotrichum acutatum residing in the medicinal plant Angelica sinensis for its in vitro antimicrobial, antibiofilm, antioxidant, antimalarial, and anti-proliferative properties. The promising compound was identified as C-HMMP through antimicrobial-guided fraction. The structure of C-HMMP was unambiguously confirmed by 2D NMR and HIRS spectroscopic analysis. Antimicr...
Source: Journal of Microbiology and Biotechnology - March 13, 2023 Category: Biotechnology Authors: Ramy S Yehia Source Type: research
