Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan
Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) is beneficial to AA patients as a complementary therapy using a nationwide population-based database in Taiwan between 2000–2016. Patient survival was estimated by Kaplan‒Meier survival analyses and Cox proportional-hazard model. CHM-users presented lower risks of overall and anemia-related mortalities when compared to non-users. The risk of overall mortality for CHM-users in AA patients was 0.70-fold [adjusted hazard ratio (aHR): 0.70, 95% confidenc...
Source: Frontiers in Pharmacology - October 8, 2021 Category: Drugs & Pharmacology Source Type: research
A new method for giving complementary explanation on the blood enriching function and mechanism of unprocessed Angelica sinensis and its 4 kinds of processed products with tissue integrated metabolomics and confirmatory analysis
This study gives a complementary explanation on the blood supplementation effect and mechanism of ASs.PMID:34591996 | DOI:10.1002/bmc.5252 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - September 30, 2021 Category: Biomedical Science Authors: Peng Ji Chen-Chen Li Yan-Ming Wei Yong-Li Hua Wan-Ling Yao Fan-Lin Wu Xiao-Song Zhang Zi-Wen Yuan Nian-Shou Zhao Ya-Hui Zhang Yan-Qiao Wen Source Type: research
A new method for giving complementary explanation on the blood enriching function and mechanism of unprocessed Angelica sinensis and its 4 kinds of processed products with tissue integrated metabolomics and confirmatory analysis
This study gives a complementary explanation on the blood supplementation effect and mechanism of ASs.PMID:34591996 | DOI:10.1002/bmc.5252 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - September 30, 2021 Category: Biomedical Science Authors: Peng Ji Chen-Chen Li Yan-Ming Wei Yong-Li Hua Wan-Ling Yao Fan-Lin Wu Xiao-Song Zhang Zi-Wen Yuan Nian-Shou Zhao Ya-Hui Zhang Yan-Qiao Wen Source Type: research
A rapid and sensitive LC-MS/MS method for the determination of vanillic acid in rat plasma with application to pharmacokinetic study
In this study, a rapid and sensitive ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-ESI-MS/MS) method was established and validated for the determination of vanillic acid in rat plasma. Plasma samples were prepared by protein precipitation with acetonitrile. Chromatographic separation was performed on a ZORBAX RRHD Eclipse Plus C18 column (2.1 × 100 mm, 1.8 μm) with gradient elution at a flow rate of 0.3 mL/min, using mobile phase consisting of 0.1% formic acid (A) and acetonitrile (B). Vanillic acid and caffeic acid (internal standard, IS) were quantified by multiple reaction monitoring (MR...
Source: Biomedical Chromatography : BMC - September 23, 2021 Category: Biomedical Science Authors: Yuan Liang Tiancheng Ma Yuwei Li Na Cai Source Type: research
A rapid and sensitive LC-MS/MS method for the determination of vanillic acid in rat plasma with application to pharmacokinetic study
In this study, a rapid and sensitive ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-ESI-MS/MS) method was established and validated for the determination of vanillic acid in rat plasma. Plasma samples were prepared by protein precipitation with acetonitrile. Chromatographic separation was performed on a ZORBAX RRHD Eclipse Plus C18 column (2.1 × 100 mm, 1.8 μm) with gradient elution at a flow rate of 0.3 mL/min, using mobile phase consisting of 0.1% formic acid (A) and acetonitrile (B). Vanillic acid and caffeic acid (internal standard, IS) were quantified by multiple reaction monitoring (MR...
Source: Biomedical Chromatography : BMC - September 23, 2021 Category: Biomedical Science Authors: Yuan Liang Tiancheng Ma Yuwei Li Na Cai Source Type: research
A rapid and sensitive LC-MS/MS method for the determination of vanillic acid in rat plasma with application to pharmacokinetic study
In this study, a rapid and sensitive ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-ESI-MS/MS) method was established and validated for the determination of vanillic acid in rat plasma. Plasma samples were prepared by protein precipitation with acetonitrile. Chromatographic separation was performed on a ZORBAX RRHD Eclipse Plus C18 column (2.1 × 100 mm, 1.8 μm) with gradient elution at a flow rate of 0.3 mL/min, using mobile phase consisting of 0.1% formic acid (A) and acetonitrile (B). Vanillic acid and caffeic acid (internal standard, IS) were quantified by multiple reaction monitoring (MR...
Source: Biomedical Chromatography : BMC - September 23, 2021 Category: Biomedical Science Authors: Yuan Liang Tiancheng Ma Yuwei Li Na Cai Source Type: research
A rapid and sensitive LC-MS/MS method for the determination of vanillic acid in rat plasma with application to pharmacokinetic study
In this study, a rapid and sensitive ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-ESI-MS/MS) method was established and validated for the determination of vanillic acid in rat plasma. Plasma samples were prepared by protein precipitation with acetonitrile. Chromatographic separation was performed on a ZORBAX RRHD Eclipse Plus C18 column (2.1 × 100 mm, 1.8 μm) with gradient elution at a flow rate of 0.3 mL/min, using mobile phase consisting of 0.1% formic acid (A) and acetonitrile (B). Vanillic acid and caffeic acid (internal standard, IS) were quantified by multiple reaction monitoring (MR...
Source: Biomedical Chromatography : BMC - September 23, 2021 Category: Biomedical Science Authors: Yuan Liang Tiancheng Ma Yuwei Li Na Cai Source Type: research
Comparative Efficacy of Jaungo, A Traditional Herbal Ointment, and the Water-in-Oil Type Non-Steroidal Moisturizer for Radiation-Induced Dermatitis in Patients With Breast Cancer: A Study Protocol for a Prospective, Randomized, Single-Blinded, Pilot Study
This study aims to evaluate whether topical use of Jaungo (Shiunko), a traditional herbal ointment mainly composed of Lithospermi radix and Angelica sinensis, could reduce RID compared to the water-in-oil type non-steroidal moisturizer in patients with breast cancer.Methods: This is a prospective, single-blinded, randomized controlled pilot trial that investigates the effect of topical application of Jaungo for the prevention of RID in postoperative breast cancer patients scheduled for RT, in comparison with the non-steroidal moisturizer, with a random distribution of 50 patients across the two groups. RT will be administe...
Source: Frontiers in Pharmacology - September 21, 2021 Category: Drugs & Pharmacology Source Type: research
Angelica sinensis Polysaccharide Alleviates Myocardial Fibrosis and Oxidative Stress in the Heart of Hypertensive Rats
Comput Math Methods Med. 2021 Sep 3;2021:6710006. doi: 10.1155/2021/6710006. eCollection 2021.ABSTRACTThis research is aimed at studying the effect of Angelica sinensis polysaccharide (ASP) extracted from the Lixinshui prescription on cardiac disease induced by hypertension in rats. Rat models of cardiovascular disease were established, and the associated factors were measured. The data showed that ASP treatment increased the ejection fraction and short axis shortening rate, while decreasing the LV end-diastolic diameter, LV end-systolic diameter, LV end-diastolic volume, and LV end-systolic volume in HHD rats. ASP downreg...
Source: Computational and Mathematical Methods in Medicine - September 16, 2021 Category: Statistics Authors: Xiaolong Song Junhong Kong Jun Song Renyou Pan Lei Wang Source Type: research
N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes
In this report, we demonstrated that BP improved the metabolic profiles of mice with high fat diet-induced obesity (DIO) by preventing weight gain, improving serum blood parameters, enhancing energy expenditure, stimulating white fat browning, and reversing hepatic steatosis. Further investigations demonstrated that BP administration upregulated the mRNA expression of beige (CD137, TMEM26) and brown fat selected genes (UCP1, PRDM16, PGC-1α, PPARγ) in white adipose tissues. In vitro studies, BP treatment increased multilocular lipid droplet levels, induced β-adrenergic receptor (cAMP/PKA) and AMP-activated protein kinase...
Source: Mol Biol Cell - September 6, 2021 Category: Molecular Biology Authors: Kang-Yun Lu Kingsley Theras Primus Dass Shinn-Zong Lin Yu-Hua Tseng Shih-Ping Liu Horng-Jyh Harn Source Type: research
N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes
In this report, we demonstrated that BP improved the metabolic profiles of mice with high fat diet-induced obesity (DIO) by preventing weight gain, improving serum blood parameters, enhancing energy expenditure, stimulating white fat browning, and reversing hepatic steatosis. Further investigations demonstrated that BP administration upregulated the mRNA expression of beige (CD137, TMEM26) and brown fat selected genes (UCP1, PRDM16, PGC-1α, PPARγ) in white adipose tissues. In vitro studies, BP treatment increased multilocular lipid droplet levels, induced β-adrenergic receptor (cAMP/PKA) and AMP-activated protein kinase...
Source: Biochimica et Biophysica Acta - September 6, 2021 Category: Biochemistry Authors: Kang-Yun Lu Kingsley Theras Primus Dass Shinn-Zong Lin Yu-Hua Tseng Shih-Ping Liu Horng-Jyh Harn Source Type: research
Insights into the mechanism of the effects of rhizosphere microorganisms on the quality of authentic Angelica sinensis under different soil microenvironments
Angelica sinensis (Oliv.) Diels (A. sinensis) is a Chinese herb grown in different geographical locations. It contains numerous active components with therapeutic value. Rhizosphere microbiomes affect various asp... (Source: BMC Plant Biology)
Source: BMC Plant Biology - June 22, 2021 Category: Biology Authors: Lei Zhu, Hui Yan, Gui-sheng Zhou, Chun-hao Jiang, Pei Liu, Guang Yu, Sheng Guo, Qi-Nan Wu and Jin-ao Duan Tags: Research Source Type: research
Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide
Int J Biol Macromol. 2021 Jun 3:S0141-8130(21)01197-1. doi: 10.1016/j.ijbiomac.2021.05.213. Online ahead of print.ABSTRACTAngelica sinensis polysaccharide (ASP) is one of the main active components of Angelica sinensis (AS) that is widely used in traditional Chinese medicine. ASP is water-soluble polysaccharides, and it is mainly composed of glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl) and galacturonic acid (GalUA). The extraction methods of ASP include hot water extraction and ultrasonic wave extraction, and different extraction methods can affect the yield of ASP. ASP has a ...
Source: International Journal of Biological Macromolecules - June 6, 2021 Category: Biochemistry Authors: Jijuan Nai Chao Zhang Huili Shao Bingqian Li Huan Li Lei Gao Mengmeng Dai Liqiao Zhu Huagang Sheng Source Type: research
Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide
Int J Biol Macromol. 2021 Jun 3:S0141-8130(21)01197-1. doi: 10.1016/j.ijbiomac.2021.05.213. Online ahead of print.ABSTRACTAngelica sinensis polysaccharide (ASP) is one of the main active components of Angelica sinensis (AS) that is widely used in traditional Chinese medicine. ASP is water-soluble polysaccharides, and it is mainly composed of glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl) and galacturonic acid (GalUA). The extraction methods of ASP include hot water extraction and ultrasonic wave extraction, and different extraction methods can affect the yield of ASP. ASP has a ...
Source: International Journal of Biological Macromolecules - June 6, 2021 Category: Biochemistry Authors: Jijuan Nai Chao Zhang Huili Shao Bingqian Li Huan Li Lei Gao Mengmeng Dai Liqiao Zhu Huagang Sheng Source Type: research
Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK–mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats
Publication date: Available online 4 June 2021Source: Journal of EthnopharmacologyAuthor(s): Chin-Yi Cheng, Hui-Chi Huang, Shung-Te Kao, Yu-Chen Lee (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - June 5, 2021 Category: Drugs & Pharmacology Source Type: research
