Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPAR γ/SOD2/ROS pathways
Phytother Res. 2023 Aug 26. doi: 10.1002/ptr.7979. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a common degenerative joint disease, which is characterized by wear of articular cartilage and narrow joint space, resulting in joint movement disorder. At present, accurate molecular mechanisms and effective interventions are still being explored. Here, we propose that angelica sinensis polysaccharide (ASP) alleviates OA progression by activating peroxisome proliferator-activated receptor gamma (PPARγ). Therapeutic effect of ASP improving mitochondrial metabolism of OA chondrocytes was evaluated in vitro and in vivo, r...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Su Ni Ning Yi Hang Yuan Dong Li Xu Chen Chao Zhuang Source Type: research
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPAR γ/SOD2/ROS pathways
Phytother Res. 2023 Aug 26. doi: 10.1002/ptr.7979. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a common degenerative joint disease, which is characterized by wear of articular cartilage and narrow joint space, resulting in joint movement disorder. At present, accurate molecular mechanisms and effective interventions are still being explored. Here, we propose that angelica sinensis polysaccharide (ASP) alleviates OA progression by activating peroxisome proliferator-activated receptor gamma (PPARγ). Therapeutic effect of ASP improving mitochondrial metabolism of OA chondrocytes was evaluated in vitro and in vivo, r...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Su Ni Ning Yi Hang Yuan Dong Li Xu Chen Chao Zhuang Source Type: research
The serum lipidomics reveal the action mechanism of Danggui-Yimucao herbal pair in abortion mice
In this study, serum lipidomics were adopted to dissect the mechanism of DY in promoting recovery after medical abortion. A total of 152 differential metabolites were screened by lipidomics. All metabolites were imported into MetaboAnalyst for analysis, and finally key metabolic pathways such as glycerophospholipid metabolism, linoleic acid metabolism and pentose and glucuronate interconversions were enriched. Our results indicated that metabolic disorders in abortion mice were alleviated by DY through glycerophospholipid metabolism, while prostaglandin and leukotriene metabolites might be the key targets of DY to promote ...
Source: Biomedical Chromatography : BMC - August 15, 2023 Category: Biomedical Science Authors: Feng-Yun Bai Shi-Jie Bi Shi-Jun Yue Ding-Qiao Xu Rui-Jia Fu Ying Sun Xiao-Hu Sun Yu-Ping Tang Source Type: research
The serum lipidomics reveal the action mechanism of Danggui-Yimucao herbal pair in abortion mice
In this study, serum lipidomics were adopted to dissect the mechanism of DY in promoting recovery after medical abortion. A total of 152 differential metabolites were screened by lipidomics. All metabolites were imported into MetaboAnalyst for analysis, and finally key metabolic pathways such as glycerophospholipid metabolism, linoleic acid metabolism and pentose and glucuronate interconversions were enriched. Our results indicated that metabolic disorders in abortion mice were alleviated by DY through glycerophospholipid metabolism, while prostaglandin and leukotriene metabolites might be the key targets of DY to promote ...
Source: Biomedical Chromatography : BMC - August 15, 2023 Category: Biomedical Science Authors: Feng-Yun Bai Shi-Jie Bi Shi-Jun Yue Ding-Qiao Xu Rui-Jia Fu Ying Sun Xiao-Hu Sun Yu-Ping Tang Source Type: research
Molecules, Vol. 28, Pages 6004: Phenolic Compounds and Antioxidant and Anti-Enzymatic Activities of Selected Adaptogenic Plants from South America, Asia, and Africa
lik
Aneta A. Ptaszyńska
Daniel Załuski
Despite the fact that there are many studies related to the adaptogenic and pro-healthy activities of plant-based compounds, there are some adaptogenic plants whose activities are not fully known, especially those coming from the wild regions of Asia, Africa, and South America. The aim of these studies was to examine the contents of non-nutritional compounds, such as polyphenols, flavonoids, and phenolic acids in ten adaptogenic species (Astragalus membranaceus (AM), Uncaria rhynchophylla (UR), Polygonum multiflorum (PM), Angelica sinensis (AS), Andrographis paniculatea (AP)...
Source: Molecules - August 10, 2023 Category: Chemistry Authors: Jakub G ębalski Milena Ma łkowska Filip Graczyk Artur S łomka El żbieta Piskorska Dorota Gawenda-Kempczy ńska Aneta Kondrzycka-D ąda Anna Bogucka-Kocka Maciej Strzemski Ireneusz Sowa Magdalena W ójciak Sebastian Grzyb Krystian Krolik Aneta A. Ptasz Tags: Article Source Type: research
Retracted: Network Pharmacology and Molecular Docking-Based Investigation of Potential Targets of Astragalus membranaceus and Angelica sinensis Compound Acting on Spinal Cord Injury
Dis Markers. 2023 Jul 26;2023:9824032. doi: 10.1155/2023/9824032. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/2141882.].PMID:37538092 | PMC:PMC10396634 | DOI:10.1155/2023/9824032 (Source: Disease Markers)
Source: Disease Markers - August 4, 2023 Category: Laboratory Medicine Authors: Disease Markers Source Type: research
Comparative efficacy of Jaungo, a traditional herbal ointment, and a water-in-oil type non-steroidal moisturizer for radiation-induced dermatitis in patients with breast cancer: a prospective, randomized, single-blind, pilot study
Conclusion: These findings suggest that Jaungo has preventive efficacy without severe side-effects against RID in patients with BC that is comparable to that of the water-in-oil type non-steroidal moisturizer. Further extensive randomized controlled trials with larger sample sizes are warranted to validate our findings.Clinical Trial Registration: Clinical Research Information Service (CRIS), https://cris.nih.go.kr, identifier KCT0005971. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 3, 2023 Category: Drugs & Pharmacology Source Type: research
< em > Angelica sinensis < /em > extract induces telomere dysfunction, cell cycle arrest, and mitochondria-mediated apoptosis in human glioblastoma cells
This study aimed to investigate the effect of AS-acetone extract (AS-A) on the progression of GB and the potential mechanisms underlying its effects. The results indicated that AS-A used in this study showed potency in growth inhibition of GB cells and reduction of telomerase activity. In addition, AS-A blocked the cell cycle at the G0/G1 phase by regulating the expression of p53 and p16. Furthermore, apoptotic morphology, such as chromatin condensation, DNA fragmentation, and apoptotic bodies, was observed in AS-A-treated cells, induced by the activation of the mitochondria-mediated pathway. In an animal study, AS-A reduc...
Source: The Chinese Journal of Physiology - June 16, 2023 Category: Physiology Authors: Tsung-Liang Ma Kai-Fu Chang Xiao-Fan Huang Hung-Chih Lai Chih-Yen Hsiao Nu-Man Tsai Source Type: research
Ligustilide, a novel SIRT1 agonist, alleviates lipopolysaccharide-induced acute lung injury through deacetylation of NICD
Int Immunopharmacol. 2023 Jun 14;121:110486. doi: 10.1016/j.intimp.2023.110486. Online ahead of print.ABSTRACTDevelopment and progression of sepsis-induced acute lung injury (ALI) involve apoptosis and oxidative stress in lung epithelial cells. Ligustilide (LIG) is one of the main bioactive constituents derived from the Angelica sinensis. As a novel SIRT1 agonist, LIG owns powerful anti-inflammatory and antioxidative properties, exerting remarkable therapeutic effects on cancers, neurological disorders, and diabetes mellitus. However, whether LIG could protect against lipopolysaccharide (LPS)-induced ALI by activating SIRT...
Source: International Immunopharmacology - June 16, 2023 Category: Allergy & Immunology Authors: Guang Li Chunxiao Hu Yan Liu Huiqing Lin Source Type: research
