Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score  ≥ 7
Dis Markers. 2021 Feb 4;2021:8858905. doi: 10.1155/2021/8858905. eCollection 2021.ABSTRACTEpigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hypermethylated genes by the methyl-CpG targeted transcriptional activation (MeTA) method. The MeTA suppressed the growth of LNCaP-derived cells and induced apoptosis. Microarray analysis indicated that PYCARD (PYD and CARD domain containing) e...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Toshiya Miyauchi Masahiro Takahashi Koji Mitsuzuka Yuriko Saiki Teppei Okubo Paula M Vertino Akiteru Goto Yoichi Arai Akira Horii Shinichi Fukushige Source Type: research

Prevalence and Nonpharmacological Interventions for Sarcopenia among Cirrhotic Patients
Dis Markers. 2021 Feb 4;2021:8866093. doi: 10.1155/2021/8866093. eCollection 2021.ABSTRACTSarcopenia is the most common feature of hepatic cirrhosis characterized by progressive loss of muscle mass and function and increases permanently the mortality and morbidity rates among those patients. The incidence of sarcopenia in cirrhotic patients ranged 40-70% associating with impaired quality of life and augmented rates of infection. Based on these issues, this review is aimed at determining the prevalence and main causes of sarcopenia among cirrhotic patients and recognizing the recent diagnostic and physical treatment modalit...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Walid Kamal Abdelbasset Gopal Nambi Shereen H Elsayed Samah A Moawd Ahmed A Ibrahim Anju Verma Sayed A Tantawy Dalia M Kamel Ayman K Saleh Osama R Aldhafian Naif Bin Nwihadh Source Type: research

Serum Levels of BDNF in Patients with Adenoma and Colorectal Cancer
Dis Markers. 2021 Feb 12;2021:8867368. doi: 10.1155/2021/8867368. eCollection 2021.ABSTRACTThe present study is aimed at examining the serum levels of brain-derived neurotrophic factor (BDNF) and investigating its role in differential diagnosis of colorectal cancer (CRC). Materials and Methods. In a Chinese population, we conducted a case-control study to compare the diagnostic performance of serum levels of BDNF and carcinoembryonic antigen (CEA) for CRC. We enrolled 61 healthy controls, 31 patients with adenomas, and 81 patients with CRC. We explored the correlation between serum levels of BDNF and several pathological f...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Zhe Wang Shuang Wang Yu Liu Shan Gao Yunqing Yu Zhaolan Hu Source Type: research

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients
CONCLUSION: PIVKA-II is superior to AFP in HCC screening, and AFP in combination with PIVKA-II significantly improves the diagnostic value for Chinese HCC patients. PIVKA-II could effectively indicate HCC accompanied by PVTT and help to optimize the therapeutic strategy.PMID:33628341 | PMC:PMC7884179 | DOI:10.1155/2021/8868370 (Source: Disease Markers)
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Fei Xu Lulu Zhang Wenting He Di Song Xiaomeng Ji Jianyong Shao Source Type: research

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes
This study is aimed at identifying the spectrum of rare and novel variation in known pediatric asthma susceptibility genes using whole exome sequencing analysis in nine individual cases of childhood onset allergic asthma. DNA samples from the nine children with a history of bronchial asthma diagnosis underwent whole exome sequencing on Ion Proton. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified, and 8 were novel. Also, among of which, nineteen were nonsynonymous and 2 were ...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Neda M Bogari Amr A Amin Husni H Rayes Ahmed Abdelmotelb Mohiuddin M Taher Faisal A Al-Allaf Abdellatif Bouazzaoui Luke O'Gorman John W Holloway Source Type: research

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score  ≥ 7
Dis Markers. 2021 Feb 4;2021:8858905. doi: 10.1155/2021/8858905. eCollection 2021.ABSTRACTEpigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hypermethylated genes by the methyl-CpG targeted transcriptional activation (MeTA) method. The MeTA suppressed the growth of LNCaP-derived cells and induced apoptosis. Microarray analysis indicated that PYCARD (PYD and CARD domain containing) e...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Toshiya Miyauchi Masahiro Takahashi Koji Mitsuzuka Yuriko Saiki Teppei Okubo Paula M Vertino Akiteru Goto Yoichi Arai Akira Horii Shinichi Fukushige Source Type: research

Prevalence and Nonpharmacological Interventions for Sarcopenia among Cirrhotic Patients
Dis Markers. 2021 Feb 4;2021:8866093. doi: 10.1155/2021/8866093. eCollection 2021.ABSTRACTSarcopenia is the most common feature of hepatic cirrhosis characterized by progressive loss of muscle mass and function and increases permanently the mortality and morbidity rates among those patients. The incidence of sarcopenia in cirrhotic patients ranged 40-70% associating with impaired quality of life and augmented rates of infection. Based on these issues, this review is aimed at determining the prevalence and main causes of sarcopenia among cirrhotic patients and recognizing the recent diagnostic and physical treatment modalit...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Walid Kamal Abdelbasset Gopal Nambi Shereen H Elsayed Samah A Moawd Ahmed A Ibrahim Anju Verma Sayed A Tantawy Dalia M Kamel Ayman K Saleh Osama R Aldhafian Naif Bin Nwihadh Source Type: research

Serum Levels of BDNF in Patients with Adenoma and Colorectal Cancer
Dis Markers. 2021 Feb 12;2021:8867368. doi: 10.1155/2021/8867368. eCollection 2021.ABSTRACTThe present study is aimed at examining the serum levels of brain-derived neurotrophic factor (BDNF) and investigating its role in differential diagnosis of colorectal cancer (CRC). Materials and Methods. In a Chinese population, we conducted a case-control study to compare the diagnostic performance of serum levels of BDNF and carcinoembryonic antigen (CEA) for CRC. We enrolled 61 healthy controls, 31 patients with adenomas, and 81 patients with CRC. We explored the correlation between serum levels of BDNF and several pathological f...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Zhe Wang Shuang Wang Yu Liu Shan Gao Yunqing Yu Zhaolan Hu Source Type: research

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients
CONCLUSION: PIVKA-II is superior to AFP in HCC screening, and AFP in combination with PIVKA-II significantly improves the diagnostic value for Chinese HCC patients. PIVKA-II could effectively indicate HCC accompanied by PVTT and help to optimize the therapeutic strategy.PMID:33628341 | PMC:PMC7884179 | DOI:10.1155/2021/8868370 (Source: Disease Markers)
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Fei Xu Lulu Zhang Wenting He Di Song Xiaomeng Ji Jianyong Shao Source Type: research

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes
This study is aimed at identifying the spectrum of rare and novel variation in known pediatric asthma susceptibility genes using whole exome sequencing analysis in nine individual cases of childhood onset allergic asthma. DNA samples from the nine children with a history of bronchial asthma diagnosis underwent whole exome sequencing on Ion Proton. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified, and 8 were novel. Also, among of which, nineteen were nonsynonymous and 2 were ...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Neda M Bogari Amr A Amin Husni H Rayes Ahmed Abdelmotelb Mohiuddin M Taher Faisal A Al-Allaf Abdellatif Bouazzaoui Luke O'Gorman John W Holloway Source Type: research

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score  ≥ 7
Dis Markers. 2021 Feb 4;2021:8858905. doi: 10.1155/2021/8858905. eCollection 2021.ABSTRACTEpigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hypermethylated genes by the methyl-CpG targeted transcriptional activation (MeTA) method. The MeTA suppressed the growth of LNCaP-derived cells and induced apoptosis. Microarray analysis indicated that PYCARD (PYD and CARD domain containing) e...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Toshiya Miyauchi Masahiro Takahashi Koji Mitsuzuka Yuriko Saiki Teppei Okubo Paula M Vertino Akiteru Goto Yoichi Arai Akira Horii Shinichi Fukushige Source Type: research

Prevalence and Nonpharmacological Interventions for Sarcopenia among Cirrhotic Patients
Dis Markers. 2021 Feb 4;2021:8866093. doi: 10.1155/2021/8866093. eCollection 2021.ABSTRACTSarcopenia is the most common feature of hepatic cirrhosis characterized by progressive loss of muscle mass and function and increases permanently the mortality and morbidity rates among those patients. The incidence of sarcopenia in cirrhotic patients ranged 40-70% associating with impaired quality of life and augmented rates of infection. Based on these issues, this review is aimed at determining the prevalence and main causes of sarcopenia among cirrhotic patients and recognizing the recent diagnostic and physical treatment modalit...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Walid Kamal Abdelbasset Gopal Nambi Shereen H Elsayed Samah A Moawd Ahmed A Ibrahim Anju Verma Sayed A Tantawy Dalia M Kamel Ayman K Saleh Osama R Aldhafian Naif Bin Nwihadh Source Type: research

Serum Levels of BDNF in Patients with Adenoma and Colorectal Cancer
Dis Markers. 2021 Feb 12;2021:8867368. doi: 10.1155/2021/8867368. eCollection 2021.ABSTRACTThe present study is aimed at examining the serum levels of brain-derived neurotrophic factor (BDNF) and investigating its role in differential diagnosis of colorectal cancer (CRC). Materials and Methods. In a Chinese population, we conducted a case-control study to compare the diagnostic performance of serum levels of BDNF and carcinoembryonic antigen (CEA) for CRC. We enrolled 61 healthy controls, 31 patients with adenomas, and 81 patients with CRC. We explored the correlation between serum levels of BDNF and several pathological f...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Zhe Wang Shuang Wang Yu Liu Shan Gao Yunqing Yu Zhaolan Hu Source Type: research

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients
CONCLUSION: PIVKA-II is superior to AFP in HCC screening, and AFP in combination with PIVKA-II significantly improves the diagnostic value for Chinese HCC patients. PIVKA-II could effectively indicate HCC accompanied by PVTT and help to optimize the therapeutic strategy.PMID:33628341 | PMC:PMC7884179 | DOI:10.1155/2021/8868370 (Source: Disease Markers)
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Fei Xu Lulu Zhang Wenting He Di Song Xiaomeng Ji Jianyong Shao Source Type: research

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes
This study is aimed at identifying the spectrum of rare and novel variation in known pediatric asthma susceptibility genes using whole exome sequencing analysis in nine individual cases of childhood onset allergic asthma. DNA samples from the nine children with a history of bronchial asthma diagnosis underwent whole exome sequencing on Ion Proton. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified, and 8 were novel. Also, among of which, nineteen were nonsynonymous and 2 were ...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Neda M Bogari Amr A Amin Husni H Rayes Ahmed Abdelmotelb Mohiuddin M Taher Faisal A Al-Allaf Abdellatif Bouazzaoui Luke O'Gorman John W Holloway Source Type: research

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score  ≥ 7
Dis Markers. 2021 Feb 4;2021:8858905. doi: 10.1155/2021/8858905. eCollection 2021.ABSTRACTEpigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hypermethylated genes by the methyl-CpG targeted transcriptional activation (MeTA) method. The MeTA suppressed the growth of LNCaP-derived cells and induced apoptosis. Microarray analysis indicated that PYCARD (PYD and CARD domain containing) e...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Toshiya Miyauchi Masahiro Takahashi Koji Mitsuzuka Yuriko Saiki Teppei Okubo Paula M Vertino Akiteru Goto Yoichi Arai Akira Horii Shinichi Fukushige Source Type: research

Prevalence and Nonpharmacological Interventions for Sarcopenia among Cirrhotic Patients
Dis Markers. 2021 Feb 4;2021:8866093. doi: 10.1155/2021/8866093. eCollection 2021.ABSTRACTSarcopenia is the most common feature of hepatic cirrhosis characterized by progressive loss of muscle mass and function and increases permanently the mortality and morbidity rates among those patients. The incidence of sarcopenia in cirrhotic patients ranged 40-70% associating with impaired quality of life and augmented rates of infection. Based on these issues, this review is aimed at determining the prevalence and main causes of sarcopenia among cirrhotic patients and recognizing the recent diagnostic and physical treatment modalit...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Walid Kamal Abdelbasset Gopal Nambi Shereen H Elsayed Samah A Moawd Ahmed A Ibrahim Anju Verma Sayed A Tantawy Dalia M Kamel Ayman K Saleh Osama R Aldhafian Naif Bin Nwihadh Source Type: research

Serum Levels of BDNF in Patients with Adenoma and Colorectal Cancer
Dis Markers. 2021 Feb 12;2021:8867368. doi: 10.1155/2021/8867368. eCollection 2021.ABSTRACTThe present study is aimed at examining the serum levels of brain-derived neurotrophic factor (BDNF) and investigating its role in differential diagnosis of colorectal cancer (CRC). Materials and Methods. In a Chinese population, we conducted a case-control study to compare the diagnostic performance of serum levels of BDNF and carcinoembryonic antigen (CEA) for CRC. We enrolled 61 healthy controls, 31 patients with adenomas, and 81 patients with CRC. We explored the correlation between serum levels of BDNF and several pathological f...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Zhe Wang Shuang Wang Yu Liu Shan Gao Yunqing Yu Zhaolan Hu Source Type: research

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients
CONCLUSION: PIVKA-II is superior to AFP in HCC screening, and AFP in combination with PIVKA-II significantly improves the diagnostic value for Chinese HCC patients. PIVKA-II could effectively indicate HCC accompanied by PVTT and help to optimize the therapeutic strategy.PMID:33628341 | PMC:PMC7884179 | DOI:10.1155/2021/8868370 (Source: Disease Markers)
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Fei Xu Lulu Zhang Wenting He Di Song Xiaomeng Ji Jianyong Shao Source Type: research

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes
This study is aimed at identifying the spectrum of rare and novel variation in known pediatric asthma susceptibility genes using whole exome sequencing analysis in nine individual cases of childhood onset allergic asthma. DNA samples from the nine children with a history of bronchial asthma diagnosis underwent whole exome sequencing on Ion Proton. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified, and 8 were novel. Also, among of which, nineteen were nonsynonymous and 2 were ...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Neda M Bogari Amr A Amin Husni H Rayes Ahmed Abdelmotelb Mohiuddin M Taher Faisal A Al-Allaf Abdellatif Bouazzaoui Luke O'Gorman John W Holloway Source Type: research

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score  ≥ 7
Dis Markers. 2021 Feb 4;2021:8858905. doi: 10.1155/2021/8858905. eCollection 2021.ABSTRACTEpigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hypermethylated genes by the methyl-CpG targeted transcriptional activation (MeTA) method. The MeTA suppressed the growth of LNCaP-derived cells and induced apoptosis. Microarray analysis indicated that PYCARD (PYD and CARD domain containing) e...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Toshiya Miyauchi Masahiro Takahashi Koji Mitsuzuka Yuriko Saiki Teppei Okubo Paula M Vertino Akiteru Goto Yoichi Arai Akira Horii Shinichi Fukushige Source Type: research

Prevalence and Nonpharmacological Interventions for Sarcopenia among Cirrhotic Patients
Dis Markers. 2021 Feb 4;2021:8866093. doi: 10.1155/2021/8866093. eCollection 2021.ABSTRACTSarcopenia is the most common feature of hepatic cirrhosis characterized by progressive loss of muscle mass and function and increases permanently the mortality and morbidity rates among those patients. The incidence of sarcopenia in cirrhotic patients ranged 40-70% associating with impaired quality of life and augmented rates of infection. Based on these issues, this review is aimed at determining the prevalence and main causes of sarcopenia among cirrhotic patients and recognizing the recent diagnostic and physical treatment modalit...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Walid Kamal Abdelbasset Gopal Nambi Shereen H Elsayed Samah A Moawd Ahmed A Ibrahim Anju Verma Sayed A Tantawy Dalia M Kamel Ayman K Saleh Osama R Aldhafian Naif Bin Nwihadh Source Type: research

Serum Levels of BDNF in Patients with Adenoma and Colorectal Cancer
Dis Markers. 2021 Feb 12;2021:8867368. doi: 10.1155/2021/8867368. eCollection 2021.ABSTRACTThe present study is aimed at examining the serum levels of brain-derived neurotrophic factor (BDNF) and investigating its role in differential diagnosis of colorectal cancer (CRC). Materials and Methods. In a Chinese population, we conducted a case-control study to compare the diagnostic performance of serum levels of BDNF and carcinoembryonic antigen (CEA) for CRC. We enrolled 61 healthy controls, 31 patients with adenomas, and 81 patients with CRC. We explored the correlation between serum levels of BDNF and several pathological f...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Zhe Wang Shuang Wang Yu Liu Shan Gao Yunqing Yu Zhaolan Hu Source Type: research

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients
CONCLUSION: PIVKA-II is superior to AFP in HCC screening, and AFP in combination with PIVKA-II significantly improves the diagnostic value for Chinese HCC patients. PIVKA-II could effectively indicate HCC accompanied by PVTT and help to optimize the therapeutic strategy.PMID:33628341 | PMC:PMC7884179 | DOI:10.1155/2021/8868370 (Source: Disease Markers)
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Fei Xu Lulu Zhang Wenting He Di Song Xiaomeng Ji Jianyong Shao Source Type: research

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes
This study is aimed at identifying the spectrum of rare and novel variation in known pediatric asthma susceptibility genes using whole exome sequencing analysis in nine individual cases of childhood onset allergic asthma. DNA samples from the nine children with a history of bronchial asthma diagnosis underwent whole exome sequencing on Ion Proton. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified, and 8 were novel. Also, among of which, nineteen were nonsynonymous and 2 were ...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Neda M Bogari Amr A Amin Husni H Rayes Ahmed Abdelmotelb Mohiuddin M Taher Faisal A Al-Allaf Abdellatif Bouazzaoui Luke O'Gorman John W Holloway Source Type: research

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score  ≥ 7
Dis Markers. 2021 Feb 4;2021:8858905. doi: 10.1155/2021/8858905. eCollection 2021.ABSTRACTEpigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hypermethylated genes by the methyl-CpG targeted transcriptional activation (MeTA) method. The MeTA suppressed the growth of LNCaP-derived cells and induced apoptosis. Microarray analysis indicated that PYCARD (PYD and CARD domain containing) e...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Toshiya Miyauchi Masahiro Takahashi Koji Mitsuzuka Yuriko Saiki Teppei Okubo Paula M Vertino Akiteru Goto Yoichi Arai Akira Horii Shinichi Fukushige Source Type: research

Prevalence and Nonpharmacological Interventions for Sarcopenia among Cirrhotic Patients
Dis Markers. 2021 Feb 4;2021:8866093. doi: 10.1155/2021/8866093. eCollection 2021.ABSTRACTSarcopenia is the most common feature of hepatic cirrhosis characterized by progressive loss of muscle mass and function and increases permanently the mortality and morbidity rates among those patients. The incidence of sarcopenia in cirrhotic patients ranged 40-70% associating with impaired quality of life and augmented rates of infection. Based on these issues, this review is aimed at determining the prevalence and main causes of sarcopenia among cirrhotic patients and recognizing the recent diagnostic and physical treatment modalit...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Walid Kamal Abdelbasset Gopal Nambi Shereen H Elsayed Samah A Moawd Ahmed A Ibrahim Anju Verma Sayed A Tantawy Dalia M Kamel Ayman K Saleh Osama R Aldhafian Naif Bin Nwihadh Source Type: research

Serum Levels of BDNF in Patients with Adenoma and Colorectal Cancer
Dis Markers. 2021 Feb 12;2021:8867368. doi: 10.1155/2021/8867368. eCollection 2021.ABSTRACTThe present study is aimed at examining the serum levels of brain-derived neurotrophic factor (BDNF) and investigating its role in differential diagnosis of colorectal cancer (CRC). Materials and Methods. In a Chinese population, we conducted a case-control study to compare the diagnostic performance of serum levels of BDNF and carcinoembryonic antigen (CEA) for CRC. We enrolled 61 healthy controls, 31 patients with adenomas, and 81 patients with CRC. We explored the correlation between serum levels of BDNF and several pathological f...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Zhe Wang Shuang Wang Yu Liu Shan Gao Yunqing Yu Zhaolan Hu Source Type: research

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients
CONCLUSION: PIVKA-II is superior to AFP in HCC screening, and AFP in combination with PIVKA-II significantly improves the diagnostic value for Chinese HCC patients. PIVKA-II could effectively indicate HCC accompanied by PVTT and help to optimize the therapeutic strategy.PMID:33628341 | PMC:PMC7884179 | DOI:10.1155/2021/8868370 (Source: Disease Markers)
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Fei Xu Lulu Zhang Wenting He Di Song Xiaomeng Ji Jianyong Shao Source Type: research

Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes
This study is aimed at identifying the spectrum of rare and novel variation in known pediatric asthma susceptibility genes using whole exome sequencing analysis in nine individual cases of childhood onset allergic asthma. DNA samples from the nine children with a history of bronchial asthma diagnosis underwent whole exome sequencing on Ion Proton. For each patient, the entire complement of rare variation within strongly associated candidate genes was catalogued. The analysis showed 21 variants in the subjects, 13 had been previously identified, and 8 were novel. Also, among of which, nineteen were nonsynonymous and 2 were ...
Source: Disease Markers - February 25, 2021 Category: Laboratory Medicine Authors: Neda M Bogari Amr A Amin Husni H Rayes Ahmed Abdelmotelb Mohiuddin M Taher Faisal A Al-Allaf Abdellatif Bouazzaoui Luke O'Gorman John W Holloway Source Type: research

Assessment and Management of Cardiotoxicity in Hematologic Malignancies
Dis Markers. 2021 Feb 3;2021:6616265. doi: 10.1155/2021/6616265. eCollection 2021.ABSTRACTWith the increasing overall survival of cancer patients due to recent discoveries in oncology, the incidence of side effects is also rising, and along with secondary malignancies, cardiotoxicity is one of the most concerning side effects, affecting the quality of life of cancer survivors. There are two types of cardiotoxicity associated with chemotherapy; the first one is acute, life-threatening but, fortunately, in most of the cases, reversible; and the second one is with late onset and mostly irreversible. The most studied drugs ass...
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Anca Bojan Tunde Torok-Vistai Andrada Parvu Source Type: research

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review
CONCLUSION: IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.PMID:33613789 | PMC:PMC7875647 | DOI:10.1155/2021/8834822 (Source: Disease Markers)
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Sara Diana Lolansen Nina Rostgaard Eva Kjer Oernbo Marianne Juhler Anja Hviid Simonsen Nanna MacAulay Source Type: research

Next-Generation Sequencing for Molecular Diagnosis of Cystic Fibrosis in a Brazilian Cohort
In this study, complete screening of CFTR was performed through next-generation sequencing (NGS) to gain insight into the variants circulating in the population of Rio de Janeiro and to provide patient access to treatment through genotype-specific therapies. Samples from 93 patients with an inconclusive molecular diagnosis were subjected to full-length screening of CFTR using an Illumina NGS HiSeq platform. Among these patients, 46 had two pathogenic variants, whereas 12 had only one CFTR variant. Twenty-four variants were not part of our routine screening. Of these 24 variants, V938Gfs∗37 had not been described in ...
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Amanda Cambraia Mario Campos Junior Ver ônica Marques Zembrzuski Ricardo Magrani Junqueira Pedro Hern án Cabello Giselda Maria Kalil de Cabello Source Type: research

Assessment and Management of Cardiotoxicity in Hematologic Malignancies
Dis Markers. 2021 Feb 3;2021:6616265. doi: 10.1155/2021/6616265. eCollection 2021.ABSTRACTWith the increasing overall survival of cancer patients due to recent discoveries in oncology, the incidence of side effects is also rising, and along with secondary malignancies, cardiotoxicity is one of the most concerning side effects, affecting the quality of life of cancer survivors. There are two types of cardiotoxicity associated with chemotherapy; the first one is acute, life-threatening but, fortunately, in most of the cases, reversible; and the second one is with late onset and mostly irreversible. The most studied drugs ass...
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Anca Bojan Tunde Torok-Vistai Andrada Parvu Source Type: research

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review
CONCLUSION: IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.PMID:33613789 | PMC:PMC7875647 | DOI:10.1155/2021/8834822 (Source: Disease Markers)
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Sara Diana Lolansen Nina Rostgaard Eva Kjer Oernbo Marianne Juhler Anja Hviid Simonsen Nanna MacAulay Source Type: research

Next-Generation Sequencing for Molecular Diagnosis of Cystic Fibrosis in a Brazilian Cohort
In this study, complete screening of CFTR was performed through next-generation sequencing (NGS) to gain insight into the variants circulating in the population of Rio de Janeiro and to provide patient access to treatment through genotype-specific therapies. Samples from 93 patients with an inconclusive molecular diagnosis were subjected to full-length screening of CFTR using an Illumina NGS HiSeq platform. Among these patients, 46 had two pathogenic variants, whereas 12 had only one CFTR variant. Twenty-four variants were not part of our routine screening. Of these 24 variants, V938Gfs∗37 had not been described in ...
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Amanda Cambraia Mario Campos Junior Ver ônica Marques Zembrzuski Ricardo Magrani Junqueira Pedro Hern án Cabello Giselda Maria Kalil de Cabello Source Type: research

Assessment and Management of Cardiotoxicity in Hematologic Malignancies
Dis Markers. 2021 Feb 3;2021:6616265. doi: 10.1155/2021/6616265. eCollection 2021.ABSTRACTWith the increasing overall survival of cancer patients due to recent discoveries in oncology, the incidence of side effects is also rising, and along with secondary malignancies, cardiotoxicity is one of the most concerning side effects, affecting the quality of life of cancer survivors. There are two types of cardiotoxicity associated with chemotherapy; the first one is acute, life-threatening but, fortunately, in most of the cases, reversible; and the second one is with late onset and mostly irreversible. The most studied drugs ass...
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Anca Bojan Tunde Torok-Vistai Andrada Parvu Source Type: research

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review
CONCLUSION: IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.PMID:33613789 | PMC:PMC7875647 | DOI:10.1155/2021/8834822 (Source: Disease Markers)
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Sara Diana Lolansen Nina Rostgaard Eva Kjer Oernbo Marianne Juhler Anja Hviid Simonsen Nanna MacAulay Source Type: research

Next-Generation Sequencing for Molecular Diagnosis of Cystic Fibrosis in a Brazilian Cohort
In this study, complete screening of CFTR was performed through next-generation sequencing (NGS) to gain insight into the variants circulating in the population of Rio de Janeiro and to provide patient access to treatment through genotype-specific therapies. Samples from 93 patients with an inconclusive molecular diagnosis were subjected to full-length screening of CFTR using an Illumina NGS HiSeq platform. Among these patients, 46 had two pathogenic variants, whereas 12 had only one CFTR variant. Twenty-four variants were not part of our routine screening. Of these 24 variants, V938Gfs∗37 had not been described in ...
Source: Disease Markers - February 22, 2021 Category: Laboratory Medicine Authors: Amanda Cambraia Mario Campos Junior Ver ônica Marques Zembrzuski Ricardo Magrani Junqueira Pedro Hern án Cabello Giselda Maria Kalil de Cabello Source Type: research

Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer.
Authors: Han Y, Zhang Z, Wang Z, Sun S Abstract DNA double-strand break (DSB) repaired by homologous recombination (HR) is an essential process for breast cancer cells to survive. DNA2 nuclease acts parallel to homologous recombination (HR). Here, we investigated the detailed clinical attribute of DNA2 in breast cancer and the role of DNA2 in breast cancer cells' growth. We found that elevated expression of DNA2 was obviously linked to poor prognosis in breast cancer. Further, DNA2 expression was increased in the ER-negative group, PR-negative group, HER2-positive group, and high-grade group via analyzing 2,509 bre...
Source: Disease Markers - February 13, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Prognostic Value of Soluble Suppression of Tumorigenicity 2 in Chronic Kidney Disease Patients: A Meta-Analysis.
Conclusions: Our results show that high levels of sST2 could predict the all-cause mortality, CVD mortality, and CVD events in CKD patients. PMID: 33574967 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 13, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group.
Conclusions: This study demonstrated the role of circRNA expression profiling in the formation of IA and revealed that the mTOR pathway can be a latent therapeutic strategy for IA. PMID: 33574968 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 13, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease.
Conclusions: FokI polymorphism is may be associated with FH of P-CAD. FokI polymorphism may predispose to the development of P-CAD among healthy people over the next years. PMID: 33564343 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 12, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Role, Function, and Mechanism of Long Intergenic Noncoding RNA1184 (linc01184) in Colorectal Cancer.
Conclusions: The findings reveal for the first time that linc01184 is an enhancer for the proliferation and invasion of CRC by functioning as a ceRNA through the linc01184-miR-331-HER2-p-Akt/ERK1/2 pathway regulatory network. PMID: 33564344 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 12, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Inflammatory and Adipokine Status from Early to Midpregnancy in Arab Women and Its Associations with Gestational Diabetes Mellitus.
Conclusion: Inflammatory and adipocytokine profiles are altered in Arab women with GDM, TNF-α in particular. Further studies are needed to establish whether maternal inflammatory and adipocytokine profile influence fetal levels in the same manner. PMID: 33552314 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 9, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.
Authors: Sainaghi PP, Bellan M, Nerviani A PMID: 33532004 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 5, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

ECG Markers of Cardiovascular Toxicity in Adult and Pediatric Cancer Treatment.
Authors: Spînu Ș, Cismaru G, Boarescu PM, Istratoaie S, Negru AG, Lazea C, Căinap SS, Iacob D, Grosu AI, Saraci G, Burz C, Cismaru AC Abstract When a cardiologist is asked to evaluate the cardiac toxic effects of chemotherapy, he/she can use several tools: ECG, echocardiography, coronary angiography, ventriculography, and cardiac MRI. Of all these, the fastest and easiest to use is the ECG, which can provide information on the occurrence of cardiac toxic effects and can show early signs of subclinical cardiac damage. These warning signs are the most desired to be recognized by the cardiologist, because the ...
Source: Disease Markers - February 5, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Characteristics of Three Different Chemiluminescence Assays for Testing for SARS-CoV-2 Antibodies.
Authors: Weber MC, Risch M, Thiel SL, Grossmann K, Nigg S, Wohlwend N, Lung T, Hillmann D, Ritzler M, Ferrara F, Bigler S, Egli K, Bodmer T, Imperiali M, Salimi Y, Fleisch F, Cusini A, Heer S, Renz H, Paprotny M, Kohler P, Vernazza P, Risch L, Kahlert CR Abstract Several tests based on chemiluminescence immunoassay techniques have become available to test for SARS-CoV-2 antibodies. There is currently insufficient data on serology assay performance beyond 35 days after symptoms onset. We aimed to evaluate SARS-CoV-2 antibody tests on three widely used platforms. A chemiluminescent microparticle immunoassay (CMIA; Ab...
Source: Disease Markers - February 5, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Systemic Coagulation Markers Especially Fibrinogen Are Closely Associated with the Aggressiveness of Prostate Cancer in Patients Who Underwent Transrectal Ultrasound-Guided Prostate Biopsy.
Authors: Wang FM, Xing NZ Abstract Objective: It has been well elucidated that multiple types of cancers are at high risk of thrombosis. Several studies have indicated the prognostic value of fibrinogen (Fib) and D-dimer (DD) in prostate cancer (PCa). However, it remains unclear regarding the association of the comprehensive coagulation markers with the clinicopathological features of PCa. Methods: A total of 423 pathologically diagnosed patients with PCa were consecutively collected and stratified as low-intermediate-risk or high-risk groups. The association of coagulation parameters including Fib, DD, prothro...
Source: Disease Markers - February 5, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

15-lncRNA-Based Classifier-Clinicopathologic Nomogram Improves the Prediction of Recurrence in Patients with Hepatocellular Carcinoma.
Conclusion: Compared to the TNM stage, the 15-lncRNAs-based classifier-clinicopathologic nomogram is a more effective and valuable tool to identify HCC recurrence and may aid in clinical decision-making. PMID: 33520012 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 2, 2021 Category: Laboratory Medicine Tags: Dis Markers Source Type: research