Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation
Dis Markers. 2021 Apr 27;2021:5530673. doi: 10.1155/2021/5530673. eCollection 2021.ABSTRACTBackground. Despite afatinib as a new first-line treatment for EGFR L858R and exon 19 deletion or other rare EGFR-mutation patients, the acquired resistance or toxic effects associated with it limited its use clinically. The controlling of acquired resistance or optimization of the afatinib dosage in EGFR/T790M mutation-positive non-small-cell lung cancer (NSCLC) is still an important fundamental problem. Ethacrynic acid (EA) has been proved as a dual inhibitor of GST and WNT, and the α, β-unsaturated-keto structure of it ...
Source: Disease Markers - June 14, 2021 Category: Laboratory Medicine Authors: Xuehui Zhang Chaoyuan Huang Biyu Cui Yebin Pang Rong Liang Xiaoling Luo Source Type: research

Prognostic Value of the Red Cell Distribution Width in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome: A Retrospective Cohort Study
This study is aimed at determining whether RDW is a prognostic indicator of sepsis-induced ARDS.METHODS: This retrospective cohort study included 1161 patients with sepsis-induced ARDS. The datasets were acquired from the Medical Information Mart for Intensive Care III database. The locally weighted scatter-plot smoothing technique, Cox regression, Kaplan-Meier estimator, and subgroup analysis were carried out to evaluate the association between RDW and 90-day mortality.RESULTS: The RDW and mortality had a roughly linear increasing relationship. The Cox regression model results were as follows: for level 2 (14.5%
Source: Disease Markers - June 14, 2021 Category: Laboratory Medicine Authors: Huabin Wang Junbin Huang Wenhua Liao Jiannan Xu Zhongyuan He Yong Liu Zhijie He Chun Chen Source Type: research

Cancer-Associated Fibroblasts Regulate Bladder Cancer Invasion and Metabolic Phenotypes through Autophagy
Dis Markers. 2021 May 25;2021:6645220. doi: 10.1155/2021/6645220. eCollection 2021.ABSTRACTRecently, both cancer-associated fibroblasts (CAFs) and autophagy have been proven to play an important role in tumor development, including bladder cancer (BCa). However, the real mechanisms remain largely unclear. Here, we reconstruct a mimic tumor microenvironment to explore the interaction between CAFs and the BCa cell line T24 using a coculture system. Autophagy in CAFs was induced or inhibited by rapamycin or siRNA, respectively. After coculture with CAFs, T24 cell proliferation, invasion, and aerobic glycolysis were tested in ...
Source: Disease Markers - June 14, 2021 Category: Laboratory Medicine Authors: Dahai Dong Yu Yao Jinlei Song Lijiang Sun Guiming Zhang Source Type: research

Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics
Dis Markers. 2021 May 19;2021:5558458. doi: 10.1155/2021/5558458. eCollection 2021.ABSTRACTThe aim of this study was to identify differences in serum metabolomics profiles of house-dust-mite (HDM)-induced allergic rhinitis (AR) patients compared to controls and to explore novel biomarkers reflecting disease severity. Serum samples were collected from 29 healthy controls and HDM-induced 72 AR patients, including 30 mild patients (MAR) and 42 moderate to severe AR patients (MSAR). Metabolomics detection was performed, and orthogonal partial least square discriminate analysis was applied to assess the differences between AR p...
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Shaobing Xie Hua Zhang Zhihai Xie Yongzhen Liu Kelei Gao Junyi Zhang Shumin Xie Fengjun Wang Ruohao Fan Weihong Jiang Source Type: research

Identification of Disease-Specific Hub Biomarkers and Immune Infiltration in Osteoarthritis and Rheumatoid Arthritis Synovial Tissues by Bioinformatics Analysis
This study is aimed at identifying disease-specific hub genes, exploring immune cell infiltration, and elucidating the underlying mechanisms associated with RA and OA synovial lesion.METHODS: Gene expression profiles (GSE55235, GSE55457, GSE55584, and GSE12021) were selected from Gene Expression Omnibus for analysis. Differentially expressed genes (DEGs) were identified by the "LIMMA" package in Bioconductor. The DEGs were identified by Gene Ontology (GO) and KEGG pathway analysis. A protein-protein interaction network was constructed to identify candidate hub genes by using STRING and Cytoscape. Hub genes were i...
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Fei Sun Jian Lin Zhou Pu Ji Peng Chen Qiu Jia Rui Cao Hao Peng Source Type: research

Combination Model of Thyrotrophin Receptor Antibody and Volumetric Orbital Apex Crowding Index as an Indicator of Dysthyroid Optic Neuropathy
CONCLUSION: A combination of TRAb and VACI is an effective indicator for DON.PMID:34113406 | PMC:PMC8154283 | DOI:10.1155/2021/9964232 (Source: Disease Markers)
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Zhihong Deng Lu Chen Jia Tan Sha Wang Dan Liu Jinwei Wang Chengzhi Jiang Jie Yang Bei Xu Source Type: research

Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics
Dis Markers. 2021 May 19;2021:5558458. doi: 10.1155/2021/5558458. eCollection 2021.ABSTRACTThe aim of this study was to identify differences in serum metabolomics profiles of house-dust-mite (HDM)-induced allergic rhinitis (AR) patients compared to controls and to explore novel biomarkers reflecting disease severity. Serum samples were collected from 29 healthy controls and HDM-induced 72 AR patients, including 30 mild patients (MAR) and 42 moderate to severe AR patients (MSAR). Metabolomics detection was performed, and orthogonal partial least square discriminate analysis was applied to assess the differences between AR p...
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Shaobing Xie Hua Zhang Zhihai Xie Yongzhen Liu Kelei Gao Junyi Zhang Shumin Xie Fengjun Wang Ruohao Fan Weihong Jiang Source Type: research

Identification of Disease-Specific Hub Biomarkers and Immune Infiltration in Osteoarthritis and Rheumatoid Arthritis Synovial Tissues by Bioinformatics Analysis
This study is aimed at identifying disease-specific hub genes, exploring immune cell infiltration, and elucidating the underlying mechanisms associated with RA and OA synovial lesion.METHODS: Gene expression profiles (GSE55235, GSE55457, GSE55584, and GSE12021) were selected from Gene Expression Omnibus for analysis. Differentially expressed genes (DEGs) were identified by the "LIMMA" package in Bioconductor. The DEGs were identified by Gene Ontology (GO) and KEGG pathway analysis. A protein-protein interaction network was constructed to identify candidate hub genes by using STRING and Cytoscape. Hub genes were i...
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Fei Sun Jian Lin Zhou Pu Ji Peng Chen Qiu Jia Rui Cao Hao Peng Source Type: research

Combination Model of Thyrotrophin Receptor Antibody and Volumetric Orbital Apex Crowding Index as an Indicator of Dysthyroid Optic Neuropathy
CONCLUSION: A combination of TRAb and VACI is an effective indicator for DON.PMID:34113406 | PMC:PMC8154283 | DOI:10.1155/2021/9964232 (Source: Disease Markers)
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Zhihong Deng Lu Chen Jia Tan Sha Wang Dan Liu Jinwei Wang Chengzhi Jiang Jie Yang Bei Xu Source Type: research

Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics
Dis Markers. 2021 May 19;2021:5558458. doi: 10.1155/2021/5558458. eCollection 2021.ABSTRACTThe aim of this study was to identify differences in serum metabolomics profiles of house-dust-mite (HDM)-induced allergic rhinitis (AR) patients compared to controls and to explore novel biomarkers reflecting disease severity. Serum samples were collected from 29 healthy controls and HDM-induced 72 AR patients, including 30 mild patients (MAR) and 42 moderate to severe AR patients (MSAR). Metabolomics detection was performed, and orthogonal partial least square discriminate analysis was applied to assess the differences between AR p...
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Shaobing Xie Hua Zhang Zhihai Xie Yongzhen Liu Kelei Gao Junyi Zhang Shumin Xie Fengjun Wang Ruohao Fan Weihong Jiang Source Type: research

Identification of Disease-Specific Hub Biomarkers and Immune Infiltration in Osteoarthritis and Rheumatoid Arthritis Synovial Tissues by Bioinformatics Analysis
This study is aimed at identifying disease-specific hub genes, exploring immune cell infiltration, and elucidating the underlying mechanisms associated with RA and OA synovial lesion.METHODS: Gene expression profiles (GSE55235, GSE55457, GSE55584, and GSE12021) were selected from Gene Expression Omnibus for analysis. Differentially expressed genes (DEGs) were identified by the "LIMMA" package in Bioconductor. The DEGs were identified by Gene Ontology (GO) and KEGG pathway analysis. A protein-protein interaction network was constructed to identify candidate hub genes by using STRING and Cytoscape. Hub genes were i...
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Fei Sun Jian Lin Zhou Pu Ji Peng Chen Qiu Jia Rui Cao Hao Peng Source Type: research

Combination Model of Thyrotrophin Receptor Antibody and Volumetric Orbital Apex Crowding Index as an Indicator of Dysthyroid Optic Neuropathy
CONCLUSION: A combination of TRAb and VACI is an effective indicator for DON.PMID:34113406 | PMC:PMC8154283 | DOI:10.1155/2021/9964232 (Source: Disease Markers)
Source: Disease Markers - June 11, 2021 Category: Laboratory Medicine Authors: Zhihong Deng Lu Chen Jia Tan Sha Wang Dan Liu Jinwei Wang Chengzhi Jiang Jie Yang Bei Xu Source Type: research

Fibronectin 1: A Potential Biomarker for Ovarian Cancer
Dis Markers. 2021 May 22;2021:5561651. doi: 10.1155/2021/5561651. eCollection 2021.ABSTRACTMETHODS: OVCAR3 and A2780 are the two common cell lines that are used for ovarian cancer studies. The different invasion and migration abilities were observed by scratch tests and transwell experiments in our preliminary study. Gene chip was used to screen the expression gene in these two different cell lines, and then, the differentially expressed genes (at least 2-fold difference, P value
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huijing Bao Qianyu Huo Qin Yuan Chen Xu Source Type: research

Association of Polymorphisms in Vitamin D-Metabolizing Enzymes < em > DHCR7 < /em > and < em > CYP2R1 < /em > with Cancer Susceptibility: A Systematic Review and Meta-Analysis
Dis Markers. 2021 May 22;2021:6615001. doi: 10.1155/2021/6615001. eCollection 2021.ABSTRACTThe deficiency of vitamin D has been reported to be relevant to cancer risk. DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes. Thus, accumulating researchers are concerned with the correlation between polymorphisms of DHCR7 and CYP2R1 genes and cancer susceptibility. Nevertheless, the conclusions of literatures are inconsistent. We conducted an integrated review for the correlation of DHCR7 and CYP2R1 SNPs with cancer susceptibility. In the meanwhile, a meta-analysis was performed using accessible data to cla...
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Jing Wen Jia Li Xinyuan Liang Aiping Wang Source Type: research

Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma in South China-Clinical Features, Treatment, Immunopathology, and Surgical Outcomes of 21 Cases
CONCLUSION: The disease is of high prevalence in autumn and winter. The central hypoventilation symptom and mature ovarian teratomas were associated with surgical outcome. NMDAR-positive neural tissue is not the only etiological factor of encephalitis. We speculate that encephalitis development in some patients may result from NMDAR expression in sebaceous glands and squamous epithelial tissues.PMID:34093900 | PMC:PMC8163540 | DOI:10.1155/2021/9990382 (Source: Disease Markers)
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huiyun Jiang Huixia Ye Yifeng Wang Yunhui Li Ying Wang Xiaomao Li Source Type: research

Fibronectin 1: A Potential Biomarker for Ovarian Cancer
Dis Markers. 2021 May 22;2021:5561651. doi: 10.1155/2021/5561651. eCollection 2021.ABSTRACTMETHODS: OVCAR3 and A2780 are the two common cell lines that are used for ovarian cancer studies. The different invasion and migration abilities were observed by scratch tests and transwell experiments in our preliminary study. Gene chip was used to screen the expression gene in these two different cell lines, and then, the differentially expressed genes (at least 2-fold difference, P value
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huijing Bao Qianyu Huo Qin Yuan Chen Xu Source Type: research

Association of Polymorphisms in Vitamin D-Metabolizing Enzymes < em > DHCR7 < /em > and < em > CYP2R1 < /em > with Cancer Susceptibility: A Systematic Review and Meta-Analysis
Dis Markers. 2021 May 22;2021:6615001. doi: 10.1155/2021/6615001. eCollection 2021.ABSTRACTThe deficiency of vitamin D has been reported to be relevant to cancer risk. DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes. Thus, accumulating researchers are concerned with the correlation between polymorphisms of DHCR7 and CYP2R1 genes and cancer susceptibility. Nevertheless, the conclusions of literatures are inconsistent. We conducted an integrated review for the correlation of DHCR7 and CYP2R1 SNPs with cancer susceptibility. In the meanwhile, a meta-analysis was performed using accessible data to cla...
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Jing Wen Jia Li Xinyuan Liang Aiping Wang Source Type: research

Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma in South China-Clinical Features, Treatment, Immunopathology, and Surgical Outcomes of 21 Cases
CONCLUSION: The disease is of high prevalence in autumn and winter. The central hypoventilation symptom and mature ovarian teratomas were associated with surgical outcome. NMDAR-positive neural tissue is not the only etiological factor of encephalitis. We speculate that encephalitis development in some patients may result from NMDAR expression in sebaceous glands and squamous epithelial tissues.PMID:34093900 | PMC:PMC8163540 | DOI:10.1155/2021/9990382 (Source: Disease Markers)
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huiyun Jiang Huixia Ye Yifeng Wang Yunhui Li Ying Wang Xiaomao Li Source Type: research

Fibronectin 1: A Potential Biomarker for Ovarian Cancer
Dis Markers. 2021 May 22;2021:5561651. doi: 10.1155/2021/5561651. eCollection 2021.ABSTRACTMETHODS: OVCAR3 and A2780 are the two common cell lines that are used for ovarian cancer studies. The different invasion and migration abilities were observed by scratch tests and transwell experiments in our preliminary study. Gene chip was used to screen the expression gene in these two different cell lines, and then, the differentially expressed genes (at least 2-fold difference, P value
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huijing Bao Qianyu Huo Qin Yuan Chen Xu Source Type: research

Association of Polymorphisms in Vitamin D-Metabolizing Enzymes < em > DHCR7 < /em > and < em > CYP2R1 < /em > with Cancer Susceptibility: A Systematic Review and Meta-Analysis
Dis Markers. 2021 May 22;2021:6615001. doi: 10.1155/2021/6615001. eCollection 2021.ABSTRACTThe deficiency of vitamin D has been reported to be relevant to cancer risk. DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes. Thus, accumulating researchers are concerned with the correlation between polymorphisms of DHCR7 and CYP2R1 genes and cancer susceptibility. Nevertheless, the conclusions of literatures are inconsistent. We conducted an integrated review for the correlation of DHCR7 and CYP2R1 SNPs with cancer susceptibility. In the meanwhile, a meta-analysis was performed using accessible data to cla...
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Jing Wen Jia Li Xinyuan Liang Aiping Wang Source Type: research

Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma in South China-Clinical Features, Treatment, Immunopathology, and Surgical Outcomes of 21 Cases
CONCLUSION: The disease is of high prevalence in autumn and winter. The central hypoventilation symptom and mature ovarian teratomas were associated with surgical outcome. NMDAR-positive neural tissue is not the only etiological factor of encephalitis. We speculate that encephalitis development in some patients may result from NMDAR expression in sebaceous glands and squamous epithelial tissues.PMID:34093900 | PMC:PMC8163540 | DOI:10.1155/2021/9990382 (Source: Disease Markers)
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huiyun Jiang Huixia Ye Yifeng Wang Yunhui Li Ying Wang Xiaomao Li Source Type: research

Fibronectin 1: A Potential Biomarker for Ovarian Cancer
Dis Markers. 2021 May 22;2021:5561651. doi: 10.1155/2021/5561651. eCollection 2021.ABSTRACTMETHODS: OVCAR3 and A2780 are the two common cell lines that are used for ovarian cancer studies. The different invasion and migration abilities were observed by scratch tests and transwell experiments in our preliminary study. Gene chip was used to screen the expression gene in these two different cell lines, and then, the differentially expressed genes (at least 2-fold difference, P value
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huijing Bao Qianyu Huo Qin Yuan Chen Xu Source Type: research

Association of Polymorphisms in Vitamin D-Metabolizing Enzymes < em > DHCR7 < /em > and < em > CYP2R1 < /em > with Cancer Susceptibility: A Systematic Review and Meta-Analysis
Dis Markers. 2021 May 22;2021:6615001. doi: 10.1155/2021/6615001. eCollection 2021.ABSTRACTThe deficiency of vitamin D has been reported to be relevant to cancer risk. DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes. Thus, accumulating researchers are concerned with the correlation between polymorphisms of DHCR7 and CYP2R1 genes and cancer susceptibility. Nevertheless, the conclusions of literatures are inconsistent. We conducted an integrated review for the correlation of DHCR7 and CYP2R1 SNPs with cancer susceptibility. In the meanwhile, a meta-analysis was performed using accessible data to cla...
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Jing Wen Jia Li Xinyuan Liang Aiping Wang Source Type: research

Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma in South China-Clinical Features, Treatment, Immunopathology, and Surgical Outcomes of 21 Cases
CONCLUSION: The disease is of high prevalence in autumn and winter. The central hypoventilation symptom and mature ovarian teratomas were associated with surgical outcome. NMDAR-positive neural tissue is not the only etiological factor of encephalitis. We speculate that encephalitis development in some patients may result from NMDAR expression in sebaceous glands and squamous epithelial tissues.PMID:34093900 | PMC:PMC8163540 | DOI:10.1155/2021/9990382 (Source: Disease Markers)
Source: Disease Markers - June 7, 2021 Category: Laboratory Medicine Authors: Huiyun Jiang Huixia Ye Yifeng Wang Yunhui Li Ying Wang Xiaomao Li Source Type: research

HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in Diabetic Patients with Acute Coronary Syndrome
CONCLUSION: A higher HDL-C/apoA-I ratio is associated with increased severity of coronary artery stenosis in DM patients with ACS but not with the rate of major adverse cardiovascular events at the end of the 2-year follow-up.PMID:34055102 | PMC:PMC8149224 | DOI:10.1155/2021/6689056 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Lizhe Sun Manyun Guo Chenbo Xu Xiangrui Qiao Yiming Hua Gulinigaer Tuerhongjiang Bowen Lou Ruifeng Li Xiaofang Bai Juan Zhou Yue Wu Jianqing She Zuyi Yuan Source Type: research

FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Dis Markers. 2021 May 17;2021:8821292. doi: 10.1155/2021/8821292. eCollection 2021.ABSTRACTFGF23 is a hormone secreted mainly by osteocytes and osteoblasts in bone. Its pivotal role concerns the maintenance of mineral ion homeostasis. It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases. Multiple studies have shown that FGF23 level increases in the very early stages of chronic kidney disease (CKD), and its concentration may also be highly associated with cardiac complications. The present review is limited to some...
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Anna Kurpas Karolina Supe ł Karolina Idzikowska Marzenna Zieli ńska Source Type: research

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19
CONCLUSION: Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.PMID:34055104 | PMC:PMC8123088 | DOI:10.1155/2021/8863053 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Mattia Bellan Danila Azzolina Eyal Hayden Gianluca Gaidano Mario Pirisi Antonio Acquaviva Gianluca Aimaretti Paolo Aluffi Valletti Roberto Angilletta Roberto Arioli Gian Carlo Avanzi Gianluca Avino Piero Emilio Balbo Giulia Baldon Francesca Baorda Emanuel Source Type: research

HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in Diabetic Patients with Acute Coronary Syndrome
CONCLUSION: A higher HDL-C/apoA-I ratio is associated with increased severity of coronary artery stenosis in DM patients with ACS but not with the rate of major adverse cardiovascular events at the end of the 2-year follow-up.PMID:34055102 | PMC:PMC8149224 | DOI:10.1155/2021/6689056 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Lizhe Sun Manyun Guo Chenbo Xu Xiangrui Qiao Yiming Hua Gulinigaer Tuerhongjiang Bowen Lou Ruifeng Li Xiaofang Bai Juan Zhou Yue Wu Jianqing She Zuyi Yuan Source Type: research

FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Dis Markers. 2021 May 17;2021:8821292. doi: 10.1155/2021/8821292. eCollection 2021.ABSTRACTFGF23 is a hormone secreted mainly by osteocytes and osteoblasts in bone. Its pivotal role concerns the maintenance of mineral ion homeostasis. It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases. Multiple studies have shown that FGF23 level increases in the very early stages of chronic kidney disease (CKD), and its concentration may also be highly associated with cardiac complications. The present review is limited to some...
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Anna Kurpas Karolina Supe ł Karolina Idzikowska Marzenna Zieli ńska Source Type: research

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19
CONCLUSION: Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.PMID:34055104 | PMC:PMC8123088 | DOI:10.1155/2021/8863053 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Mattia Bellan Danila Azzolina Eyal Hayden Gianluca Gaidano Mario Pirisi Antonio Acquaviva Gianluca Aimaretti Paolo Aluffi Valletti Roberto Angilletta Roberto Arioli Gian Carlo Avanzi Gianluca Avino Piero Emilio Balbo Giulia Baldon Francesca Baorda Emanuel Source Type: research

HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in Diabetic Patients with Acute Coronary Syndrome
CONCLUSION: A higher HDL-C/apoA-I ratio is associated with increased severity of coronary artery stenosis in DM patients with ACS but not with the rate of major adverse cardiovascular events at the end of the 2-year follow-up.PMID:34055102 | PMC:PMC8149224 | DOI:10.1155/2021/6689056 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Lizhe Sun Manyun Guo Chenbo Xu Xiangrui Qiao Yiming Hua Gulinigaer Tuerhongjiang Bowen Lou Ruifeng Li Xiaofang Bai Juan Zhou Yue Wu Jianqing She Zuyi Yuan Source Type: research

FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Dis Markers. 2021 May 17;2021:8821292. doi: 10.1155/2021/8821292. eCollection 2021.ABSTRACTFGF23 is a hormone secreted mainly by osteocytes and osteoblasts in bone. Its pivotal role concerns the maintenance of mineral ion homeostasis. It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases. Multiple studies have shown that FGF23 level increases in the very early stages of chronic kidney disease (CKD), and its concentration may also be highly associated with cardiac complications. The present review is limited to some...
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Anna Kurpas Karolina Supe ł Karolina Idzikowska Marzenna Zieli ńska Source Type: research

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19
CONCLUSION: Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.PMID:34055104 | PMC:PMC8123088 | DOI:10.1155/2021/8863053 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Mattia Bellan Danila Azzolina Eyal Hayden Gianluca Gaidano Mario Pirisi Antonio Acquaviva Gianluca Aimaretti Paolo Aluffi Valletti Roberto Angilletta Roberto Arioli Gian Carlo Avanzi Gianluca Avino Piero Emilio Balbo Giulia Baldon Francesca Baorda Emanuel Source Type: research

HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in Diabetic Patients with Acute Coronary Syndrome
CONCLUSION: A higher HDL-C/apoA-I ratio is associated with increased severity of coronary artery stenosis in DM patients with ACS but not with the rate of major adverse cardiovascular events at the end of the 2-year follow-up.PMID:34055102 | PMC:PMC8149224 | DOI:10.1155/2021/6689056 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Lizhe Sun Manyun Guo Chenbo Xu Xiangrui Qiao Yiming Hua Gulinigaer Tuerhongjiang Bowen Lou Ruifeng Li Xiaofang Bai Juan Zhou Yue Wu Jianqing She Zuyi Yuan Source Type: research

FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Dis Markers. 2021 May 17;2021:8821292. doi: 10.1155/2021/8821292. eCollection 2021.ABSTRACTFGF23 is a hormone secreted mainly by osteocytes and osteoblasts in bone. Its pivotal role concerns the maintenance of mineral ion homeostasis. It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases. Multiple studies have shown that FGF23 level increases in the very early stages of chronic kidney disease (CKD), and its concentration may also be highly associated with cardiac complications. The present review is limited to some...
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Anna Kurpas Karolina Supe ł Karolina Idzikowska Marzenna Zieli ńska Source Type: research

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19
CONCLUSION: Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.PMID:34055104 | PMC:PMC8123088 | DOI:10.1155/2021/8863053 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Mattia Bellan Danila Azzolina Eyal Hayden Gianluca Gaidano Mario Pirisi Antonio Acquaviva Gianluca Aimaretti Paolo Aluffi Valletti Roberto Angilletta Roberto Arioli Gian Carlo Avanzi Gianluca Avino Piero Emilio Balbo Giulia Baldon Francesca Baorda Emanuel Source Type: research

HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in Diabetic Patients with Acute Coronary Syndrome
CONCLUSION: A higher HDL-C/apoA-I ratio is associated with increased severity of coronary artery stenosis in DM patients with ACS but not with the rate of major adverse cardiovascular events at the end of the 2-year follow-up.PMID:34055102 | PMC:PMC8149224 | DOI:10.1155/2021/6689056 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Lizhe Sun Manyun Guo Chenbo Xu Xiangrui Qiao Yiming Hua Gulinigaer Tuerhongjiang Bowen Lou Ruifeng Li Xiaofang Bai Juan Zhou Yue Wu Jianqing She Zuyi Yuan Source Type: research

FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Dis Markers. 2021 May 17;2021:8821292. doi: 10.1155/2021/8821292. eCollection 2021.ABSTRACTFGF23 is a hormone secreted mainly by osteocytes and osteoblasts in bone. Its pivotal role concerns the maintenance of mineral ion homeostasis. It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases. Multiple studies have shown that FGF23 level increases in the very early stages of chronic kidney disease (CKD), and its concentration may also be highly associated with cardiac complications. The present review is limited to some...
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Anna Kurpas Karolina Supe ł Karolina Idzikowska Marzenna Zieli ńska Source Type: research

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19
CONCLUSION: Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.PMID:34055104 | PMC:PMC8123088 | DOI:10.1155/2021/8863053 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Mattia Bellan Danila Azzolina Eyal Hayden Gianluca Gaidano Mario Pirisi Antonio Acquaviva Gianluca Aimaretti Paolo Aluffi Valletti Roberto Angilletta Roberto Arioli Gian Carlo Avanzi Gianluca Avino Piero Emilio Balbo Giulia Baldon Francesca Baorda Emanuel Source Type: research

HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in Diabetic Patients with Acute Coronary Syndrome
CONCLUSION: A higher HDL-C/apoA-I ratio is associated with increased severity of coronary artery stenosis in DM patients with ACS but not with the rate of major adverse cardiovascular events at the end of the 2-year follow-up.PMID:34055102 | PMC:PMC8149224 | DOI:10.1155/2021/6689056 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Lizhe Sun Manyun Guo Chenbo Xu Xiangrui Qiao Yiming Hua Gulinigaer Tuerhongjiang Bowen Lou Ruifeng Li Xiaofang Bai Juan Zhou Yue Wu Jianqing She Zuyi Yuan Source Type: research

FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Dis Markers. 2021 May 17;2021:8821292. doi: 10.1155/2021/8821292. eCollection 2021.ABSTRACTFGF23 is a hormone secreted mainly by osteocytes and osteoblasts in bone. Its pivotal role concerns the maintenance of mineral ion homeostasis. It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases. Multiple studies have shown that FGF23 level increases in the very early stages of chronic kidney disease (CKD), and its concentration may also be highly associated with cardiac complications. The present review is limited to some...
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Anna Kurpas Karolina Supe ł Karolina Idzikowska Marzenna Zieli ńska Source Type: research

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19
CONCLUSION: Our findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.PMID:34055104 | PMC:PMC8123088 | DOI:10.1155/2021/8863053 (Source: Disease Markers)
Source: Disease Markers - May 31, 2021 Category: Laboratory Medicine Authors: Mattia Bellan Danila Azzolina Eyal Hayden Gianluca Gaidano Mario Pirisi Antonio Acquaviva Gianluca Aimaretti Paolo Aluffi Valletti Roberto Angilletta Roberto Arioli Gian Carlo Avanzi Gianluca Avino Piero Emilio Balbo Giulia Baldon Francesca Baorda Emanuel Source Type: research

Elevated Serum Small Dense Low-Density Lipoprotein Cholesterol May Increase the Risk and Severity of Coronary Heart Disease and Predict Cardiovascular Events in Patients with Type 2 Diabetes Mellitus
Dis Markers. 2021 May 10;2021:5597028. doi: 10.1155/2021/5597028. eCollection 2021.ABSTRACTBACKGROUND: Coronary heart disease (CHD) is a common and severe complication in type 2 diabetes mellitus (T2DM) patients. Increased amount of circulatory small dense low-density lipoprotein cholesterol (sdLDL-C) particles is known to be a sign of dyslipidemia and can result in atherosclerosis. However, the association between serum sdLDL-C levels and CHD in T2DM patients remains unclear.METHODS: A total of 3684 T2DM patients who received selective coronary angiography (CAG) were selected. For analyzing the association between sdLDL-C...
Source: Disease Markers - May 28, 2021 Category: Laboratory Medicine Authors: Juan Huang Jun-Xu Gu Hui-Zhang Bao Shan-Shan Li Xiao-Qin Yao Ming Yang Yang Li Ai-Min Zhang Yue Yin Na Zhang Mei Jia Ming Su Source Type: research

A Risk Signature with Autophagy-Related Long Noncoding RNAs for Predicting the Prognosis of Clear Cell Renal Cell Carcinoma: Based on the TCGA Database and Bioinformatics
Dis Markers. 2021 May 7;2021:8849977. doi: 10.1155/2021/8849977. eCollection 2021.ABSTRACTBACKGROUND: Disorders of autophagic processes have been reported to affect the survival outcome of clear cell renal cell carcinoma (ccRCC) patients. The purpose of our study was to identify and validate the candidate prognostic long noncoding RNA signature of autophagy.METHODS: Transcriptome profiles were obtained from The Cancer Genome Atlas. The autophagy gene list was obtained from the Human Autophagy Database. Based on coexpression analysis, we obtained a list of autophagy-related lncRNAs (ARlncRNAs). GO enrichment analysis and KE...
Source: Disease Markers - May 27, 2021 Category: Laboratory Medicine Authors: Yundong Xuan Weihao Chen Kan Liu Yu Gao Shidong Zuo Baojun Wang Xin Ma Xu Zhang Source Type: research

Fibrinogen Level Predicts Outcomes in Critically Ill Patients with Acute Exacerbation of Chronic Heart Failure
Dis Markers. 2021 Apr 30;2021:6639393. doi: 10.1155/2021/6639393. eCollection 2021.ABSTRACTBACKGROUND: Heart failure (HF) is a common cardiovascular disease, which is related to systemic inflammation for decades. Fibrinogen (FIB) is a sign of thrombosis and inflammation, which is associated with the prognosis of many diseases. Nevertheless, the role of fibrinogen level in the prognosis of critically ill patients with acute exacerbation of chronic heart failure is unclear.METHODS: The data are from the Medical Information Mart for Intensive Care III (MIMIC III) database, which is a freely accessible critical care database. ...
Source: Disease Markers - May 20, 2021 Category: Laboratory Medicine Authors: Zhongyuan Meng Yaxin Zhao Yan He Source Type: research

Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population
CONCLUSIONS: Aluminum might contribute to the development of COPD in the road-working population. CBR3 and AOC3 seem expressed in different patterns than previously reported, evidenced by their correlation with proinflammatory and anti-inflammatory cytokines.PMID:34012494 | PMC:PMC8105110 | DOI:10.1155/2021/9953234 (Source: Disease Markers)
Source: Disease Markers - May 20, 2021 Category: Laboratory Medicine Authors: Yumin Zhou Man Wang Weiyan Yang Jianjun Li Jialin Li Yueying Hu Wei Wang Chunli Che Hong Qi Source Type: research

Fibrinogen Level Predicts Outcomes in Critically Ill Patients with Acute Exacerbation of Chronic Heart Failure
Dis Markers. 2021 Apr 30;2021:6639393. doi: 10.1155/2021/6639393. eCollection 2021.ABSTRACTBACKGROUND: Heart failure (HF) is a common cardiovascular disease, which is related to systemic inflammation for decades. Fibrinogen (FIB) is a sign of thrombosis and inflammation, which is associated with the prognosis of many diseases. Nevertheless, the role of fibrinogen level in the prognosis of critically ill patients with acute exacerbation of chronic heart failure is unclear.METHODS: The data are from the Medical Information Mart for Intensive Care III (MIMIC III) database, which is a freely accessible critical care database. ...
Source: Disease Markers - May 20, 2021 Category: Laboratory Medicine Authors: Zhongyuan Meng Yaxin Zhao Yan He Source Type: research

Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population
CONCLUSIONS: Aluminum might contribute to the development of COPD in the road-working population. CBR3 and AOC3 seem expressed in different patterns than previously reported, evidenced by their correlation with proinflammatory and anti-inflammatory cytokines.PMID:34012494 | PMC:PMC8105110 | DOI:10.1155/2021/9953234 (Source: Disease Markers)
Source: Disease Markers - May 20, 2021 Category: Laboratory Medicine Authors: Yumin Zhou Man Wang Weiyan Yang Jianjun Li Jialin Li Yueying Hu Wei Wang Chunli Che Hong Qi Source Type: research