Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes.
Conclusions: The SUA level is significantly associated with the severity of OSAHS and should be controlled when managing OSAHS. PMID: 31281547 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 11, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Triglyceride-Glucose Index Predicts Coronary Artery Disease Severity and Cardiovascular Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome.
Authors: Mao Q, Zhou D, Li Y, Wang Y, Xu SC, Zhao XH Abstract Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is the leading cause of morbidity and mortality from cardiovascular disease worldwide. Several recent studies have shown the relationship between the triglyceride-glucose (TyG) index and vascular disease; however, the role of the TyG index in NSTE-ACS has not been extensively assessed. Thus, we aimed to investigate the association of the TyG index with cardiovascular risk factors and outcomes in NSTE-ACS. Overall, 438 patients with NSTE-ACS were enrolled to examine the association of the TyG ind...
Source: Disease Markers - July 11, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway.
In conclusion, our study demonstrated that TFAP4 is a valuable prognostic biomarker in determining the likelihood of tumor metastasis and recurrence, as well as the long-term survival rates of HCC patients. Exploring the regulatory mechanism of TFAP4 will also contribute to the development of new prevention and treatment strategies for HCC. PMID: 31281549 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 11, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Use of Saliva in the Diagnosis of Oral and Systemic Diseases.
Authors: Zalewska A, Waszkiewicz N, López-Pintor RM PMID: 31281550 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 11, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Circulating Levels of miR-574-5p Are Associated with Neurological Outcome after Cardiac Arrest in Women: A Target Temperature Management (TTM) Trial Substudy.
Authors: Boileau A, Somoza AS, Dankiewicz J, Stammet P, Gilje P, Erlinge D, Hassager C, Wise MP, Kuiper M, Friberg H, Nielsen N, Devaux Y, TTM-Trial Investigators on behalf of Cardiolinc Network Abstract Purpose: Postresuscitation neuroprognostication is guided by neurophysiological tests, biomarker measurement, and clinical examination. Recent investigations suggest that circulating microRNAs (miRNA) may help in outcome prediction after cardiac arrest. We assessed the ability of miR-574-5p to predict neurological outcome after cardiac arrest, in a sex-specific manner. Methods: In this substudy of the Target T...
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

ELL2 Is Downregulated and Associated with Galactose-Deficient IgA1 in IgA Nephropathy.
Conclusion: Our findings implied that decreased ELL2 expression was negatively correlated with the numbers of B cells and aberrant glycosylation of IgA1 in IgAN. PMID: 31275443 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Circulating Noncoding RNAs Have a Promising Future Acting as Novel Biomarkers for Colorectal Cancer.
Authors: Wang JJ, Wang X, Song YX, Zhao JH, Sun JX, Shi JX, Wu ZH, Wang ZN Abstract Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, causing a large number of cancer-related deaths each year. Patients are usually diagnosed at advanced and incurable stages due to the lack of suitable screening methods for early detection. Noncoding RNAs (ncRNAs), including small and long noncoding RNAs (lncRNA), are known to have significant regulatory functions, and accumulating evidence suggests that circulating ncRNAs have potential applications as noninvasive biomarkers for diagnosing CRC, evaluating...
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

No Association between the rs1799836 Polymorphism of the Monoamine Oxidase B Gene and the Risk of Autism Spectrum Disorders in the Kazakhstani Population.
Authors: Perfilyeva AV, Bespalova KB, Skvortsova LA, Surdeanu A, Garshin AA, Perfilyeva YV, Khamdiyeva OK, Bekmanov BO, Djansugurova LB Abstract Autism spectrum disorders (ASDs) are heterogeneous diseases that are triggered by a number of environmental and genetic factors. The aim of the current study was to investigate an association of the rs1799836 genetic variant of the neurotransmitter-related gene MAOB with ASDs. In total, 262 patients diagnosed with ASDs and their 126 healthy siblings were included in the present study. All individuals represented a Kazakhstani population. The distributions of the rs1799836 ...
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Relationship between Plasma Soluble Receptor for Advanced Glycation End Products and Coronary Artery Disease.
Authors: Wang X, Xu T, Mungun D, Zhou C, Zha Z, Lu M, Fen C, Guo Y Abstract Background: Inflammation is involved in the development and progression of coronary artery disease (CAD). The role of the receptor for advanced glycation end products (RAGE) in the development of CAD has been recognized. The expression of sRAGE and S100A12 in patients with coronary artery disease from different studies was inconsistent. We attempted to determine the expression of sRAGE and S100A12 and their relationship in the subjects with different severity levels of CAD. Methods: A total of 259 patients undergoing coronary angiograph...
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders.
Conclusion: RDW is a promising candidate biomarker for the screening and the prognostic stratification of PAH in CTD patients. PMID: 31275447 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

High Level of Serum Tissue Kallikrein Is Associated with Favorable Outcome in Acute Ischemic Stroke Patients.
Conclusions: Serum TK can be a promising predictor of clinical outcome in AIS patients who received acute reperfusion therapy. PMID: 31275448 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Prognostic Role of Klotho in Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis.
Conclusion: Levels of sKlotho are positively correlated with the eGFR, and low sKlotho levels are significantly associated with an increased risk of poor kidney outcomes. Therefore, sKlotho could be used as a novel biomarker for early diagnosis and prognostic assessment for patients with chronic kidney disease. Studies with a larger sample size and longer follow-up period are warranted to validate our results. PMID: 31275449 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis.
Authors: Liu Z, Shi H Abstract Objective: To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. Methods: Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the quality of literature collected was assessed based on evaluation criteria. The heterogeneity, sensitivity, and specificity were detected using the StataSE12.0 software, and the correlation between SCC-Ag and cervical cancer prognosis as the effect variables was assess...
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure.
In conclusion, GSTP1 polymorphic variants may determine individual susceptibility to oxidative stress, inflammation, and endothelial dysfunction in HF. PMID: 31275451 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Prognostic Value of Pretreatment Serum Transthyretin Level in Patients with Gastrointestinal Cancers.
Conclusion: The low pretreatment serum transthyretin level implies an unfavorable prognosis for patients with GI cancers. The monitoring of pretreatment transthyretin level could contribute to the risk stratification and individualized therapy in GI cancers. PMID: 31275452 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Biomarkers of Inflammation in Left Ventricular Diastolic Dysfunction.
Authors: Mocan M, Mocan Hognogi LD, Anton FP, Chiorescu RM, Goidescu CM, Stoia MA, Farcas AD Abstract Left ventricular diastolic dysfunction (LVDD) is an important precursor to many different cardiovascular diseases. Diastolic abnormalities have been studied extensively in the past decade, and it has been confirmed that one of the mechanisms leading to heart failure is a chronic, low-grade inflammatory reaction. The triggers are classical cardiovascular risk factors, grouped under the name of metabolic syndrome (MetS), or other systemic diseases that have an inflammatory substrate such as chronic obstructive pulmon...
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Expression and Clinical Relevance of SOX9 in Gastric Cancer.
In conclusion, we have identified SOX9 as a biomarker of disease relapse in gastric cancer patients. Further experiments are needed to elucidate its biological relevance at the cellular level. PMID: 31275454 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm.
In this study, we aimed to examine whether BET1L rs2280543 and potentially functional polymorphisms in H19 influence the risk of IA. A hospital-based case-control study was performed involving 542 IA patients and 588 age- and gender-matched controls. The BET1L rs2280543 and H19 polymorphisms were genotyped using the TaqMan assay. The BET1L rs2280543 CT, CT/TT genotypes, and T allele were associated with an increased risk of IA (CT vs. CC, adjusted OR = 1.43, 95% CI: 1.08-1.90, P = 0.01; CT/TT vs. CC, adjusted OR = 1.48, 95% CI: 1.12-1.94, P = 0.005; and T vs. C, adjusted OR = 1.44, 95% CI: 1.13-1.83, P...
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis.
Conclusions: IDUA rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures. PMID: 31275456 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Early Discharge from the Emergency Department Based on Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels: A TRIAGE III Substudy.
Authors: Schultz M, Rasmussen LJH, Høi-Hansen T, Kjøller E, Jensen BN, Lind MN, Ravn L, Kallemose T, Lange T, Køber L, Rasmussen LS, Eugen-Olsen J, Iversen KK Abstract Objective: Using biomarkers for early and accurate identification of patients at low risk of serious illness may improve the flow in the emergency department (ED) by classifying these patients as nonurgent or even suitable for discharge. A potential biomarker for this purpose is soluble urokinase plasminogen activator receptor (suPAR). We hypothesized that availability of suPAR might lead to a higher proportion of early discharge...
Source: Disease Markers - June 28, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma.
Authors: Chai SJ, Ahmad Zabidi MM, Gan SP, Rajadurai P, Lim PVH, Ng CC, Yap LF, Teo SH, Lim KP, Patel V, Cheong SC Abstract Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer prevalent in Southern China and Southeast Asia. The current knowledge on the molecular pathogenesis of NPC is still inadequate to improve disease management. Using gene expression microarrays, we have identified the four-jointed box 1 (FJX1) gene to be upregulated in primary NPC tissues relative to nonmalignant tissues. An orthologue of human FJX1, the four-jointed (fj) gene in Drosophila and Fjx1 in mouse, has reported to be associa...
Source: Disease Markers - June 28, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Amino Acid-Based Metabolic Profile Provides Functional Assessment and Prognostic Value for Heart Failure Outpatients.
In conclusion, amino acid-based assessment of metabolic status correlates with functional capacity in HF outpatients and provides prognostic value for a variety of HF populations. PMID: 31236145 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 28, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Expression Concordance of 325 Novel RNA Biomarkers between Data Generated by NanoString nCounter and Affymetrix GeneChip.
Conclusion: The 325 RNA biomarkers showed reproducibility in two technology platforms with moderate to high concordance. Future directions include performing clinical validation studies and generating rationale for patient selection in clinical trials using the technically validated assay. PMID: 31217830 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 22, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Corrigendum to "Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma".
Corrigendum to "Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma". Dis Markers. 2019;2019:2434063 Authors: Sun S, Li B, Wang Y, Li X, Wang P, Wang F, Zhang W, Yang H Abstract [This corrects the article DOI: 10.1155/2018/6514795.]. PMID: 31210831 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 20, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Comment on "Sex Differences in the Association between Night Shift Work and the Risk of Cancers: A Meta-Analysis of 57 Articles".
Comment on "Sex Differences in the Association between Night Shift Work and the Risk of Cancers: A Meta-Analysis of 57 Articles". Dis Markers. 2019;2019:9263862 Authors: Sun P, Bi M, Su Y, Chen Z PMID: 31210832 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 20, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Evaluation of the Diagnostic Potential of uPAR as a Biomarker in Renal Biopsies of Patients with FSGS.
Authors: da Silva CA, Araújo LS, Dos Reis Monteiro MLG, de Morais Pereira LH, da Silva MV, Castellano LRC, Corrêa RRM, Dos Reis MA, Machado JR Abstract Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are primary glomerulopathies leading to proteinuria, known as podocytopathies, which share syndromic and morphological similarities. Morphological similarity occurs in cases of FSGS in which the sclerotic lesion was not sampled in renal biopsy, due to the focal nature of the disease. Differentiating these entities is very important, especially in cases of suspected FSGS but with ...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Evaluation of Matrix Metalloproteinase 9 Serum Concentration as a Biomarker in Malignant Mesothelioma.
Authors: Štrbac D, Goričar K, Dolžan V, Kovač V Abstract Background: Malignant mesothelioma (MM) is a rare, but fatal disease with few treatment options. The diagnosis and treatment response are challenging in MM. Therefore, the search for novel diagnostic and prognostic biomarkers is ongoing. The aim of our study was to investigate matrix metalloproteinase 9 (MMP9) as a potential serum biomarker of treatment response and survival in MM. We also investigated the influence of genetic polymorphisms on MMP9 serum levels. Methods: We included 110 patients with MM that have been previously genotyped for co...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

PTPN22 Gene Polymorphisms Are Associated with Susceptibility to Large Artery Atherosclerotic Stroke and Microembolic Signals.
Authors: Zhou L, Wang K, Wang J, Zhou Z, Cheng Y, Pan X, Ma A Abstract Large artery atherosclerotic stroke (LAAS) is the most common ischemic stroke (IS) subtype, and microemboli may be clinically important for indicating increased risk of IS. The inflammatory process of atherosclerosis is well known, and lymphoid phosphatase (Lyp), which is encoded by the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene, plays an important role in the inflammatory response. Our study was intended to evaluate the relationship between PTPN22 gene and LAAS and microembolic signals (MES). Three loci of the PTPN22 gene (r...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis.
Conclusion: Our studies suggested that miR-497 might be a prognostic biomarker in cancers. However, further multicenter prospective clinical researches are needed to confirm the association between miR-497 expression and cancer prognosis. PMID: 31191744 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Immune Exclusion Is Frequent in Small-Cell Carcinoma of the Bladder.
In conclusion, these data demonstrate that small-cell bladder cancer commonly exhibits an immune-excluded phenotype. PMID: 31191745 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

NFE2L3 Inhibition Induces Cell Cycle Arrest at the G0/G1 Phase in Colorectal Cancer Cells through Downregulating CCND1 and pRb1-ser807/811.
Authors: Zhang L, Hu DL, Tang B, Cheng Y, Jiao C, Cheng L, Tan ZR, Zhou HH Abstract The molecular mechanism for colorectal cancer to develop remains unelucidated. To find biomarkers related to colorectal cancer development, we analyzed the gene expression profile of 380 colorectal cancer patients and 51 healthy controls by R software. Finally, 1579 upregulated differential expression genes (DEGs) and 3218 downregulated DEGs were identified. Then, the top 20 upregulated DEGs were compared with 181 upregulated DEGs that we reported previously, and 11 overlapped DEGs were found. NFE2L3 (nuclear factor, erythroid 2-lik...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Plasma Osteoprotegerin Correlates with Stroke Severity and the Occurrence of Microembolic Signals in Patients with Acute Ischemic Stroke.
Authors: Cao Y, Cui C, Zhao H, Pan X, Li W, Wang K, Ma A Abstract Background: Instability of atherosclerotic plaques is associated with the occurrence of stroke. Microembolic signals (MESs) are an indicator of unstable plaque. A relationship between plasma osteoprotegerin (OPG) and ischemic stroke has already been identified. The aim of this study was to investigate whether plasma OPG levels have a relationship with MESs and to evaluate the feasibility of OPG as a biomarker of stroke severity and occurrence of MESs. Methods: Our study consisted of 127 patients with large artery atherosclerosis stroke and 56 con...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Investigating the Protein Signature of Adamantinomatous Craniopharyngioma Pediatric Brain Tumor Tissue: Towards the Comprehension of Its Aggressive Behavior.
Authors: Martelli C, Serra R, Inserra I, Rossetti DV, Iavarone F, Vincenzoni F, Castagnola M, Urbani A, Tamburrini G, Caldarelli M, Massimi L, Desiderio C Abstract Although histologically benign, adamantinomatous craniopharyngioma (AC) pediatric brain tumor is a locally aggressive disease that frequently determines symptoms and hormonal dysfunctions related to the mass effect on the surrounding structures. Another typical feature of this benign neoplasm is the presence of voluminous liquid cysts frequently associated with the solid component. Even if studies have been devoted to the proteomic characterization of th...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients.
Authors: Wajda J, Świat M, Owczarek AJ, Brzozowska A, Olszanecka-Glinianowicz M, Chudek J Abstract Background: Vitamin D (VD) deficiency is considered an independent risk factor for death due to cardiovascular events including ischemic stroke (IS). We assessed the hypothesis that decreased levels of 25-hydroxyvitamin D (25-OH-D) are associated with increased risk of mortality in patients with IS. Methods: Serum 25-OH-D, intact parathyroid hormone (iPTH), and intact fibroblast growth factor 23 (iFGF23) levels were assessed in serum of 240 consecutive patients admitted within the 24 hours after the onset of IS. ...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Diagnostic Value of Salivary Markers in Neuropsychiatric Disorders.
Authors: Kułak-Bejda A, Waszkiewicz N, Bejda G, Zalewska A, Maciejczyk M Abstract A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabolites. Saliva collection is noninvasive, and self-collection is possible. There is a lack of risk of injuries related to injection with needle, and it is generally safe. Human saliva has been successfully used, for exampl...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Biomarkers for Alzheimer's Disease in Saliva: A Systematic Review.
Conclusion: Aβ42 and tau seem to be worthy candidates for future salivary biomarkers for AD, but other biomarkers such as lactoferrin and selected metabolites also have potential. More studies must be carried out with larger sample sizes and a standardization of the sampling and processing method. Factors such as diurnal variation, AD patients' decreased ability of oral self-care, and salivary flowrates must be taken into consideration. PMID: 31191751 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

RAD51B (rs8017304 and rs2588809), TRIB1 (rs6987702, rs4351379, and rs4351376), COL8A1 (rs13095226), and COL10A1 (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
Conclusion: Our study revealed a strong association between a variant in COL8A1 (rs13095226) and exudative AMD development. PMID: 31191752 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Clinicopathological Characteristics and Prognosis of cT1N0M1 Gastric Cancer: A Population-Based Study.
Authors: Han J, Tu J, Tang C, Ma X, Huang C Abstract Background: Distant metastasis of early gastric cancer is a rare subgroup and poorly understood. The present study is aimed at summarizing the clinicopathological characteristics, prognosis, and management of clinical T1N0M1 (cT1N0M1) gastric cancer. Method: Between 2004 and 2015, patients diagnosed with cT1N0M1 gastric cancer were retrospectively analyzed using the Surveillance, Epidemiology, and End Results (SEER) database. Results: A total of 1093 cT1N0M1 gastric cancer patients were identified. 49 patients (4.5%) received cancer-directed surgery, and ...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Circulating MicroRNA-499 as a Diagnostic Biomarker for Acute Myocardial Infarction: A Meta-analysis.
Conclusion: The results showed that circulating microRNA-499 is a reliable biomarker for diagnosing AMI patients. PMID: 31191754 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Role of Circular RNAs in Preeclampsia.
Authors: Jia N, Li J Abstract Circular RNAs (circRNAs) are noncoding RNAs characterized by circular covalently closed structures, which are generated by back-splicing. circRNA is more stable and conserved than linear RNA and exists in various organisms. Preeclampsia (PE), a common hypertensive disorder of pregnancy, has a profound impact on maternal and neonatal mortality and morbidity. Recent studies demonstrated that circRNAs were differentially expressed in PE maternal-fetal interface compared with those in the control and might mediate pathological processes in pregnancy complications. However, the mechanisms o...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30  mm.
A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm. Dis Markers. 2019;2019:8435893 Authors: Zhu WY, Fang KX, He JY, Cui R, Zhang YK, Le HB Abstract We sought to develop and validate a clinical nomogram model for predicting overall survival (OS) in non-small-cell lung cancer (NSCLC) patients with resected tumors that were 30 mm or smaller, using clinical data and molecular marker findings. We retrospectively analyzed 786 NSCLC patients with a pathological tumor size less than 30 mm who underwent surgery betwee...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients?
Authors: Cuartero M, Betbesé AJ, Núñez K, Baldirà J, Ordonez-Llanos J Abstract Purpose: To analyse the capacity of whole-blood NGAL (wbNGAL) to stratify AKI in critically ill patients with and without sepsis. Methods: Whole-blood NGAL was measured with a point-of-care device at admission and 48 hours later in patients admitted to a general ICU. Patients were classified by the AKIN and KDIGO classifications at admission and 24 and 48 hours. We performed an ROC curve analysis. wbNGAL values at admission were compared in patients with sepsis and septic shock. Results: The study incl...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Coding Region Mutation Screening in Optineurin in Chinese Normal-Tension Glaucoma Patients.
Conclusions: This study confirmed the association of the OPTN T34T variant with NTG, suggesting that OPTN is a susceptibility gene for NTG in Chinese. Moreover, a variant with amino acid change (I407T) was identified in NTG but not in controls. Further studies are warranted to assess whether this variant is a causative mutation for NTG. PMID: 31198474 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

DNA Methylation Profiles and Their Diagnostic Utility in BC.
Authors: Shan M, Zhang L, Liu Y, Gao C, Kang W, Yang W, He Y, Zhang G Abstract Biomarkers, including DNA methylation, have shown a great potential for use in personalized medicine for BC and especially for the diagnosis of BC in developing countries. According to the bisulfite sequencing PCR in twelve specimens (BC and matched normal tissues), nine genetic probes were designed to detect the frequency of methylation of the promoters in a total of 302 paired cases of BC and matched normal breast tissues. Finally, a total of 900 serum samples were used to validate the use of these methylation biomarkers for clinical d...
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

A Preliminary Study of Uric Metabolomic Alteration for Postpartum Depression Based on Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry.
Authors: Zhang L, Zou W, Huang Y, Wen X, Huang J, Wang Y, Sheng X Abstract Postpartum depression affects about 10-20% of newly delivered women, which is harmful for both mothers and infants. However, the current diagnosis of postpartum depression depends on the subjective judgment of a practitioner, which may lead to misdiagnosis. Hence, an appended objective diagnosis index may help the practitioner to improve diagnosis. A metabolomic study can find biomarkers as an objective index to facilitate disease diagnosis. Forty-nine postpartum depressed patients and 50 healthy controls were recruited into this study. The ...
Source: Disease Markers - June 12, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Loss of SDC1 Expression Is Associated with Poor Prognosis of Colorectal Cancer Patients in Northern China.
In this study, SDC1 expression was detected in 65 adjacent non-neoplastic colorectal tissues, 477 CRCs, and 79 metastatic lymph nodes using tissue microarray. Results: The data show that SDC1 decreased in CRC tissues (p ≤ 0.001) and metastatic lymph node tissues (p ≤ 0.001) compared to that in adjacent non-neoplastic colorectal tissues. Loss of SDC1 protein expression is associated with poor overall (p
Source: Disease Markers - June 12, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Tumor Mutation Load: A Novel Independent Prognostic Factor in Stage IIIA-N2 Non-Small-Cell Lung Cancer.
In conclusion, differentiation, smoking, mutation frequency> 0.025, and mutation number> 2 are prognostic factors. The frequency and number of gene mutations in cfDNA are expected to be prognostic predictors of NSCLC. PMID: 31182981 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 12, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Expression and Concentration of Matrix Metalloproteinase 9 and Tissue Inhibitor of Matrix Metalloproteinases 1 in Laryngeal Squamous Cell Carcinoma.
Authors: Matulka M, Konopka A, Mroczko B, Pryczynicz A, Kemona A, Groblewska M, Sieskiewicz A, Olszewska E Abstract The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects. Twenty-seven patients who were diagnosed with laryngeal carcinoma and selected for total laryngectomy were included in the study group. MMP-9 and TIMP-1 expression in tissues was assessed using immunohistochemical assays. Immunoenzymatic E...
Source: Disease Markers - June 1, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population.
Authors: Li Q, Zhang P, Wang Y, Zhang Y, Li K, Song Y, Su M, Zhou B, Zhang L Abstract Background: Previous evidence has indicated that the reduction of axis inhibition protein 1 (AXIN1) expression is related with the poor differentiation of non-small-cell lung cancer (NSCLC). However, the potential association between AXIN1 and bladder cancer (BC) is unknown. We aimed to initially explore the relevance of AXIN1 gene polymorphisms (rs12921862 C/A, rs1805105 T/C, and rs370681 C/T) and BC. Methods: Three hundred and sixteen BC patients and 419 healthy controls had been enrolled. Polymerase chain reaction-restricti...
Source: Disease Markers - June 1, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

High Serum Uric Acid Is Associated with Tubular Damage and Kidney Inflammation in Patients with Type 2 Diabetes.
Authors: Guarda NS, Bollick YS, de Carvalho JAM, Premaor MO, Comim FV, Moresco RN Abstract Background: Uric acid presents different roles in an organism. High serum uric acid concentrations may induce inflammatory pathways and promote kidney damage through different mechanisms. Therefore, this study investigated the association among high serum uric acid concentrations, renal tubular damage, and renal inflammation assessed via estimation of urinary kidney injury molecule-1 (KIM-1) and inflammatory cytokines in patients with type 2 diabetes (T2D). Methods: Urinary concentrations of KIM-1, IL-1, IL-6, IL-10, and ...
Source: Disease Markers - May 23, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research