Adverse Cardiac Remodelling after Acute Myocardial Infarction: Old and New Biomarkers.
Authors: Berezin AE, Berezin AA Abstract The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous studies have examined the diagnostic and prognostic potencies of circulating cardiac biomarkers in acute coronary syndrome/AMI and heart failure after AMI, and even fewer have depicted the utility of biomarkers in AMI patients undergoing primary PCI. Although c...
Source: Disease Markers - July 7, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Circulating Sestrin Levels Are Increased in Hypertension Patients.
Conclusions: Circulating Sesn levels are increased in patients with hypertension and may be a target for the prevention and treatment of clinical hypertension. PMID: 32626541 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Evaluation of a Novel Missense Mutation in ABCB4 Gene Causing Progressive Familial Intrahepatic Cholestasis Type 3.
Authors: Saleem K, Cui Q, Zaib T, Zhu S, Qin Q, Wang Y, Dam J, Ji W, Liu P, Jia X, Wu J, Bai J, Fu S, Sun W Abstract Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a hepatic disorder occurring predominantly in childhood and is difficult to diagnose. PFIC3, being a rare autosomal recessive disease, is caused by genetic mutations in both alleles of ABCB4, resulting in the disruption of the bile secretory pathway. The identification of pathogenic effects resulting from different mutations in ABCB4 is the key to revealing the internal cause of disease. These mutations cause truncation, instability, mis...
Source: Disease Markers - July 7, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients.
Conclusion: I131 radiotherapy might exert therapeutic effects by targeting CDH5, KDR, CD34, FLT4, EMCN, FLT1, ROBO4, PTPRB, and CD93 in THCA patients. PMID: 32626543 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - July 7, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Pentraxin 3 (PTX-3) Levels in Bronchoalveolar Lavage Fluid as a Lung Cancer Biomarker.
In this study, we investigated the utility of pentraxin 3 (PTX-3) in bronchoalveolar lavage fluid (BALF) as lung cancer (LCa) diagnostic. A total of 89 LCa patients and 84 non-LCa patients who received bronchoscopy in the First Affiliated Hospital of Xi'an Jiaotong University from December 2014 to February 2015 were enrolled. LCa was subdivided according to pathological type (scale, gland, and small cell lung cancer). BALF samples were obtained during bronchoscopy and PTX-3 levels assayed by ELISA. t-tests, Mann-Whitney, and Kruskal-Wallis tests were performed for the comparison of PTX-3 levels between the different groups...
Source: Disease Markers - June 27, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Clinical Predictive Factors of Lower Extremity Deep Vein Thrombosis in Relative High-Risk Patients after Neurosurgery: A Retrospective Study.
Conclusion: The combined factor was constructed by hypertension, postoperative D-dimer, gender, and GCS score, and it might be a more handy and reliable marker to stratify patients at risk of DVT after neurosurgery. PMID: 32587639 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 27, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Identification of PDL1-Related Biomarkers to Select Lung Adenocarcinoma Patients for PD1/PDL1 Inhibitors.
Authors: Wu Y, Lin L, Liu X Abstract PD1/PDL1 inhibitors have been adopted for the treatment of advanced non-small-cell lung cancer, and PDL1 expression has been investigated as a predictive biomarker for PD1/PDL1 inhibitor therapy. However, PDL1 lacks diagnostic accuracy in differentiating patients who are likely or unlikely to benefit. So, it is urgent and clinically significant to identify other associated predictive biomarkers for PD1/PDL1 inhibitor therapy. Our work was to identify PDL1-related biomarkers that could improve the patient selection for PD1/PDL1 inhibitor treatment. We obtained 500 genes coexpress...
Source: Disease Markers - June 27, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

High Plasma Levels of Soluble Talin-1 in Patients with Coronary Artery Disease.
Authors: Aoyama M, Kishimoto Y, Saita E, Ikegami Y, Ohmori R, Nakamura M, Kondo K, Momiyama Y Abstract Aims: Talin-1 is a cytoskeletal protein that binds integrin, thereby leading to integrin activation and affecting focal adhesions. Recently, talin-1 expression was reported to be downregulated in human atherosclerotic plaques. However, blood levels of soluble talin-1 (sTalin-1) in patients with atherosclerotic disease, such as coronary artery disease (CAD), have not been elucidated. Methods: We measured plasma sTalin-1 levels in 349 patients undergoing elective coronary angiography. The severity of CAD was rep...
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Clinical Significance of M1/M2 Macrophages and Related Cytokines in Patients with Spinal Tuberculosis.
Conclusion: The report here highlights that two types of macrophage polarization (M1 and M2) are present in the tissues and peripheral blood of patients with spinal TB. Macrophages also play proinflammatory and anti-inflammatory roles. Macrophage polarization is involved in spinal TB infection. PMID: 32566036 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

MicroRNA-7 as a Potential Biomarker for Prognosis in Pancreatic Cancer.
Authors: Ye ZQ, Zou CL, Chen HB, Jiang MJ, Mei Z, Gu DN Abstract MicroRNAs play critical roles in tumor progression. Our recent study has indicated that microRNA-7 (miR-7) impairs autophagy-derived pools of glucose to suppress the glycolysis in pancreatic cancer progression. However, the roles of miR-7 in clinical significance and chemoresistance of pancreatic cancer remain unexplored. The aim of this study was to assess the expression of miR-7 in patients with pancreatic cancer and to evaluate the possibility of its usage as a prognostic molecular biomarker. MicroRNA array-based quantification analysis of 372 miRN...
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Clinical Significance and Prognostic Value of miR-28-5p in Colon Cancer.
This study aimed to determine the clinical significance and prognostic value of miR-28-5p in colon cancer. Methods: We retrospectively analyzed the data of miR-28-5p in colon adenocarcinoma data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), and the data was divided into cancer group and normal group, respectively. Forty colon cancer tissues and adjacent normal tissues were collected and tested by qRT-PCR methods. The difference of the miR-28-5p expression between colon cancer and normal tissues was compared. The clinical significance of miR-28-5p in colon cancer and the association with the sur...
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Strong-LAMP Assay Based on a Strongyloides spp.-Derived Partial Sequence in the 18S rRNA as Potential Biomarker for Strongyloidiasis Diagnosis in Human Urine Samples.
This study was thus aimed at comparing, for the first time, the use of a new loop-mediated isothermal amplification (LAMP) molecular assay (Strong-LAMP) to traditional methods on patients' urine samples. Twenty-four urine samples were taken from patients included in a study involving two Spanish hospitals for strongyloidiasis screening using parasitological and serological tests. Strongyloides larvae were found in 11 patients' faecal samples, thereby ascertaining that they had the disease. Other patients had high antibody titres but no larvae were found in their faeces. All urine samples were analysed by PCR and Strong-LAM...
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Prospecting for Breast Cancer Blood Biomarkers: Death-Associated Protein Kinase 1 (DAPK1) as a Potential Candidate.
Conclusion: DAPK1 is highly expressed in sera and breast tissues of breast cancer patients than nonbreast cancer participants. The elevated expression of DAKP1 in circulation rather than in breast tissues makes it a candidate for use as a blood biomarker and potential use as therapeutic target in drug development. PMID: 32566040 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Predicting Liver Disease Risk Using a Combination of Common Clinical Markers: A Screening Model from Routine Health Check-Up.
Authors: Wang Y, Li Y, Wang X, Gacesa R, Zhang J, Zhou L, Wang B Abstract Background: Early detection is crucial for the prognosis of patients with autoimmune liver disease (AILD). Due to the relatively low incidence, developing screening tools for AILD remain a challenge. Aims: To analyze clinical characteristics of AILD patients at initial presentation and identify clinical markers, which could be useful for disease screening and early detection. Methods: We performed observational retrospective study and analyzed 581 AILD patients who were hospitalized in the gastroenterology department and 1000 healthy ...
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

A First Step to a Biomarker of Curative Surgery in Colorectal Cancer by Liquid Biopsy of Methylated Septin 9 Gene.
Conclusions: Our study shows that circulating hypermethylated SEPT9 is a specific colorectal cancer biomarker. This hypermethylated SEPT9 DNA disappears around three months after surgery and that circulating hypermethylated SEPT9 may be the first noninvasive marker for postsurgical diagnosis; this conclusion must be confirmed with a more significant number of patients. PMID: 32566042 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 24, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Associations of Small Fiber Neuropathy with Geriatric Nutritional Risk Index and Arterial Stiffness in Hemodialysis.
Conclusions: Lower GNRI and arterial stiffness were significantly associated with small fiber neuropathy in patients undergoing HD. Malnutrition risk and vascular factors might play important roles in small fiber neuropathy among patients undergoing HD. PMID: 32509039 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - June 10, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

A Meta-Analysis of Robotic Surgery in Endometrial Cancer: Comparison with Laparoscopy and Laparotomy.
Authors: Wang J, Li X, Wu H, Zhang Y, Wang F Abstract Background: The safety and effectiveness of robotic surgery are evaluated by comparing perioperative outcomes with laparoscopy and laparotomy in endometrial cancer. Method: PubMed, MEDLINE, Embase, Cochrane, and other databases were searched for eligible studies up to April 2019. Studies that compared robotic surgery with laparoscopy or laparotomy in surgical staging of endometrial cancer were included. The pooled odds ratio and weighted mean difference were calculated using a random-effects or a fixed-effects model to summarize the results. Results: Twe...
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Role of Gas6 and TAM Receptors in the Identification of Cardiopulmonary Involvement in Systemic Sclerosis and Scleroderma Spectrum Disorders.
Authors: Bellan M, Dimagli A, Piccinino C, Giubertoni A, Ianniello A, Grimoldi F, Sguazzotti M, Nerviani A, Barini M, Carriero A, Smirne C, Burlone ME, Rigamonti C, Minisini R, Salmi L, Barbaglia MN, Castello LM, Sola D, Marino P, Avanzi GC, Pirisi M, Sainaghi PP Abstract Background: Few biomarkers are available for early identification of pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) in systemic sclerosis (SS) and scleroderma spectrum disorders (SSD). Aims: To evaluate Gas6, sAxl, and sMer as biomarkers for cardiopulmonary complications of SS and SSD. Methods: In a cross-section...
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Use of the Nuclear Matrix Protein 22 BladderChek Test for the Detection of Primary and Recurrent Urothelial Carcinoma.
Conclusions: The NMP22 BladderChek test has a low sensitivity for detecting primary and recurrent UC. Urine cytology is superior to the NMP22 BladderChek test, and combined use of the two tests improves the sensitivity in the detection of primary UC. PMID: 32454904 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA.
In conclusion, we identified that PTPN6 may be a novel prognostic biomarker in BC based on the TCGA database. Further clinical trials are needed to confirm our observations and mechanisms underlying the prognostic value of PTPN6 in BC also deserve further experimental exploration. PMID: 32454905 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Association of IL-1 β, IL-6, TNF-α, and TGFβ1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome.
Association of IL-1β, IL-6, TNF-α, and TGFβ1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome. Dis Markers. 2020;2020:6076274 Authors: Alkhuriji AF, Al Omar SY, Babay ZA, El-Khadragy MF, Mansour LA, Alharbi WG, Khalil MI Abstract Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and ...
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Septin 9 Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma.
Authors: Lyu JY, Chen JY, Zhang XJ, Zhang MW, Yu GS, Zhang L, Wen Z Abstract Nasopharyngeal carcinoma (NPC) is highly prevalent in Southeast Asia, and an unfavorable outcome is usually attributed to advanced stage NPC. Current methods for the early diagnosis of NPC have limitations in clinical practice. The aim of this study was to investigate the diagnostic ability of Septin 9 methylation for NPC. A quantitative methylation-sensitive PCR (qMS-PCR) assay was developed to measure the methylation status and levels of Septin 9 in nasopharyngeal tissues and paired swabs from patients with NPC, chronic nasopharyngitis, ...
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Comprehensive Analysis of Tumor-Infiltrating Immune Cells and Relevant Therapeutic Strategy in Esophageal Cancer.
In conclusion, the proportions of TIICs may be important to the progression, prognosis, and treatment of EC. PMID: 32454908 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis.
Conclusions: NLR has a moderately high diagnostic value in predicting the severity of acute pancreatitis. PMID: 32454909 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Relationship between Long Noncoding RNA H19 Polymorphisms and Risk of Coronary Artery Disease in a Chinese Population: A Case-Control Study.
Conclusion: Our study demonstrated that some genotypes of H19 rs2735971 and rs3024270 polymorphisms, as well as rs2735971-rs2839698-rs3024270 A-C-C haplotype, were associated with the risk of CAD in a Chinese population, and these genotypes have the potential to be biomarkers for predicting CAD risk. We also found that rs2735971-rs2839698-rs3024270 A-C-C may have a significantly lower risk of CAD. The recessive genetic model of rs3024270 could predict the severity of CAD. PMID: 32454910 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma.
Conclusion: Our study indicated that high FEN1 expression might function as a biomarker for diagnosis and prognosis. In addition, the study confirms that FEN1 is an oncogene in HCC progression. PMID: 32399086 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 15, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

scFv against HSP60 of Strongyloides sp. and Its Application in the Evaluation of Parasite Frequency in the Elderly.
Authors: Miguel CB, Levenhagen MA, Costa-Cruz JM, Goulart LR, Alves PT, Ueira-Vieira C, Brito PKMO, Gomes AO, Lazo-Chica JE, Oliveira CJF, Rodrigues WF Abstract The present study is aimed at evaluating serological method using scFv anti-Strongyloides sp. and reporting the frequencies of the results with conventional parasitological technique (faeces) in elderly individuals. Among 112 elderly individuals (≥60 years of age), 14.28% were positive for at least one enteroparasite, with one individual positive for S. stercoralis. Sera were evaluated for the presence of anti-Strongyloides sp. antibodies using total or ...
Source: Disease Markers - May 15, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes.
Authors: Singh PP, Bhandari S, Sharma RK, Singh N, Bharti PK Abstract Malaria in pregnancy causes adverse birth outcomes due to sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Angiopoietins are critical regulators of vascular development and formation of placental villous vasculature. Angiopoietin-1 and Angiopoietin-2 concentrations were measured in peripheral and placental plasma samples from 70 malaria-infected and 216 control women using commercially available DuoSet ELISA development kit. Angiopoietins increased in placental plasma (ANG1-5833.5 pg/ml and ANG2-9580.6 p...
Source: Disease Markers - May 15, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Diagnostic Value of Low-Dose 256-Slice Spiral CT Angiography, MR Angiography, and 3D-DSA in Cerebral Aneurysms.
Conclusion: CTA, DSA, and MRA have their own advantages and disadvantages in the diagnosis of cerebral aneurysms. They all have the diagnostic value for aneurysms. PMID: 32399089 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 15, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Optimized CyberKnife Lung Treatment: Effect of Fractionated Tracking Volume Change on Tracking Results.
Authors: Li GQ, Wang Y, Qiu MJ, Yang J, Peng ZJ, Zhang S, Fang X, Yang SL Abstract Objectives: To explore the impact of volume change in the fractionated tracking of stereotactic radiotherapy on the results of synchronous, respiratory tracking algorithm using CyberKnife. Methods: A total of 38 lung tumor patients receiving stereotactic radiotherapy at our center from March 2018 to October 2019 were counted. Photoshop CS4 image processing software was used to obtain the pixels and the average value of brightness of the tracking volume in the image and calculate the grayscale within the contour of the tracking vo...
Source: Disease Markers - May 15, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

miR-1291 Functions as a Potential Serum Biomarker for Bullous Pemphigoid.
Authors: Qiu L, Zhang L, Qi R, Gao X, Chen H, Xiao T Abstract Background: Bullous pemphigoid (BP) is a common T helper 2- (Th2-) dominated autoimmune blistering skin disease with significant mortality. MicroRNAs (miRNAs), which are endogenous noncoding RNA molecules, have been reported to be potential biomarkers for some autoimmune diseases; however, to date, there exist no reports on serum expression profiles of miRNAs in BP patients. Methods: A RNA quantitative PCR- (qPCR-) based array was conducted on sera from 20 active BP patients and 20 healthy controls for screening of miRNAs. Significantly dysregulated ...
Source: Disease Markers - May 15, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Absolute Neutrophil Count and Mean Platelet Volume in the Blood as Biomarkers to Detect Lung Cancer.
This study analyzed data from lung cancer patients and healthy individuals in Wuxi People's Hospital Affiliated with Nanjing Medical University. The Mann-Whitney U-test was performed to compare differences between lung cancer patients and healthy individuals. Spearman's correlation analysis was used to assess correlations. Receiver operating characteristic (ROC) curves were performed to determine diagnostic accuracy. Results: 209 patients diagnosed with lung cancer and 236 healthy subjects were enrolled in this study. Levels of ANC and MPV increased in lung cancer patients compared with healthy individuals (P
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection.
Conclusions: LMRc is a promising prognostic predictor for predicting the worse clinical outcome in patients with ESCC undergoing curative operation. PMID: 32377268 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Construction of ceRNA Coexpression Network and Screening of Molecular Targets in Colorectal Cancer.
Conclusion: The identified RNAs and constructed ceRNA network could provide great sources for the researches of therapy of the CRC. And the lncRNA RP11-108K3.2 and mRNA ONECUT2 may serve as a novel prognostic predictor of CRC. PMID: 32377269 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women.
Conclusions: WISP1 may be critical for the prediction, diagnosis, and therapeutic strategies against obesity and GDM in pregnant women. PMID: 32377270 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3K/Akt/mTOR Signaling Pathway in HER2+ Breast Cancer.
This study submits that SGLT1 is promising not only as a novel biomarker of HER2+ breast cancer subtype but also as a potential drug target. PMID: 32377271 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer.
In this study, we used immunohistochemistry to quantitate PNUTS expression on a tissue microarray containing 17,747 clinical prostate cancer specimens. As compared to normal prostate epithelium, PNUTS expression was often higher in cancer. Among 12,235 interpretable tumors, PNUTS staining was negative in 21%, weak in 34%, moderate in 35%, and strong in 10% of cases. High PNUTS expression was associated with higher tumor stage, classical and quantitative Gleason grade, nodal stage, surgical margin, Ki67 labeling index, and early biochemical recurrence (p
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Combination of CD147 and MMP-9 Serum Levels Is Identified as Novel Chemotherapy Response Markers of Advanced Non-Small-Cell Lung Cancer.
Authors: Qiao X, Gu Y, Yu J, Wang J, Liu X, Gu M, Ma L, Jia Y, Zhang S Abstract To evaluate the correlation between the changes in serum concentrations of cluster of differentiation-147 (scCD147) and chemotherapy outcome in patients with NSCLC and evaluate the combination of scCD147 with serum matrix metalloproteinase-9 (scMMP-9) levels in the prediction of chemotherapy response, eighty-two patients with advanced LC were enrolled. Newly diagnosed cases were treated with platinum-based chemotherapy. We measured scCD147 protein levels in LC cases by ELISA and used receiver operating characteristic (ROC) curves to ana...
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis.
Conclusions: Serum RANKL levels were potentially associated with better cognitive function in hemodialysis patients. Further large-scale and prospective studies are needed to confirm our findings. PMID: 32377274 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism.
Authors: Suchanek-Raif R, Raif P, Kowalczyk M, Paul-Samojedny M, Zielińska A, Kucia K, Merk W, Kowalski J Abstract Aim: The BDNF dysfunction in the schizophrenia has been soundly documented. The TrkB gene is a high-affinity receptor of the BDNF that is changed in schizophrenia and mood disorders. The study had two aims: first, to identify whether the five nucleotide polymorphisms (SNPs) in TrkB gene are associated with a diagnosis of schizophrenia; and the latter, if any association exists between the TrkB SNPs and psychopathology, suicide attempts, and family history of schizophrenia in a Caucasian population. ...
Source: Disease Markers - May 1, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis.
Conclusions: The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk. PMID: 32300378 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - April 18, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Comparative Proteomic Investigation of Plasma Reveals Novel Potential Biomarker Groups for Acute Aortic Dissection.
Authors: Cheng N, Wang H, Zhang W, Wang H, Jin X, Ma X, Ma Y Abstract Acute aortic dissection (AAD) is a catastrophic cardiovascular disease with high disability and mortality due to multiple fatal complications. However, the molecular changes of the serum proteome after AAD are not very clear. Here, we performed isobaric tags for relative and absolute quantitation- (iTRAQ-) based comparative proteomic analysis to investigate the proteome profile changes after AAD by collecting plasma samples from 20 AAD patients and 20 controls. Out of the 345 identified proteins, 266 were considered as high-quality quantified pro...
Source: Disease Markers - April 8, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients.
Conclusions: These results demonstrated that there was no evidence of a relationship between ApoE and PAD. PMID: 32211081 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - March 28, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis.
Conclusion: Our meta-analysis showed that HSF assay could provide high accuracy in predicting BA patients and non-BA individuals. However, further studies with better design and larger sample size are required to support the results of the present study. PMID: 32190130 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - March 21, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

A Trypanosoma cruzi Genome Tandem Repetitive Satellite DNA Sequence as a Molecular Marker for a LAMP Assay for Diagnosing Chagas' Disease.
Authors: Ordóñez D, Fernández-Soto P, Fernández-Martín AM, Crego-Vicente B, Febrer-Sendra B, Diego JG, Vicente B, López-Abán J, Belhassen-García M, Muro A, Patarroyo MA Abstract Chagas' disease is a neglected tropical disease caused by Trypanosoma cruzi which is endemic throughout Latin America and is spread by worldwide migration. Diagnosis is currently limited to serological and molecular techniques having variations regarding their sensitivity and specificity. This work was aimed at developing a new sensitive, applicable, and cost-effective molecular diagno...
Source: Disease Markers - March 19, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

A 17-Gene Signature Predicted Prognosis in Renal Cell Carcinoma.
In conclusion, the 17-gene signature model was related to the survival of RCC patients and could help predict the prognosis with significant clinical implications. PMID: 32184905 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - March 19, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Assessing the Prognostic Performance of the Child-Pugh, Model for End-Stage Liver Disease, and Albumin-Bilirubin Scores in Patients with Decompensated Cirrhosis: A Large Asian Cohort from Gastroenterology Department.
Conclusion: All five methods (Child-Pugh score, MELD score, MELD-Na score, iMELD score, and ALBI score) provided a reliable prediction of mortality for both the short-term and long-term prognosis of patients with DeCi. The ALBI score may be particularly useful for assessing short-term outcomes, whereas the MELD score may be particularly useful for assessing long-term outcomes. PMID: 32148566 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - March 11, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Upregulated Seizure-Related 6 Homolog-Like 2 Is a Prognostic Predictor of Hepatocellular Carcinoma.
This study suggests a significant correlation between SEZ6L2 and HCC, which means that SEZ6L2 may potentially serve as a useful prognostic biomarker for HCC patients. PMID: 32148567 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - March 11, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy.
Conclusions: In IgAN patients, an elevated serum HD5 level at the time of renal biopsy was associated with poor renal outcomes. HD5 rather than HD6 was probably associated with renal function of IgAN patients. PMID: 32089753 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - February 25, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Serum Golgi Protein 73 as a Potential Biomarker for Hepatic Necroinflammation in Population with Nonalcoholic Steatohepatitis.
In this study, we evaluated the diagnostic value of serum Golgi protein 73 (GP73) for hepatic necroinflammatory damage in patients with NASH. Methods: The clinical data of 201 patients with NASH diagnosed by liver biopsy according to the Brunt staging system were collected retrospectively. The in situ expression of GP73 protein was measured by immunohistochemistry. The receiver operating characteristic (ROC) curve was used to calculate the area under the ROC curve (AUROC) of serum GP73 for diagnosing hepatic necroinflammatory damage. Results: The serum GP73 levels of NASH patients increased with the aggravation of ...
Source: Disease Markers - February 25, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research