Association between Mutation in SMARCAD1 and Basan Syndrome with Cutaneous Squamous Cell Carcinoma
CONCLUSION: To the best of our knowledge, this is the first study reported Basan syndrome with family history of cSCC. Despite in this study we cannot draw any conclusion about the association between Basan syndrome and cSCC at the genetic level, this study encourages future works to substantiate this potential but important issue.PMID:35592705 | PMC:PMC9113868 | DOI:10.1155/2022/7840710 (Source: Disease Markers)
Source: Disease Markers - May 20, 2022 Category: Laboratory Medicine Authors: Ying Xiong Ting Chen Jia Yu He Zhou Baozhen Lu Lijie Chen Liwei Sun Can Wang Sujun Li Bo Wu Source Type: research

PI3K/AKT/mTOR Pathway-Associated Genes Reveal a Putative Prognostic Signature Correlated with Immune Infiltration in Hepatocellular Carcinoma
CONCLUSION: A putative and differential dataset-validated prognostic signature on the basis of integrated bioinformatic analysis was established in our study, providing the immunotherapeutic targets as well as the personalized treatment in HCC with neoteric insight.PMID:35592706 | PMC:PMC9112180 | DOI:10.1155/2022/7545666 (Source: Disease Markers)
Source: Disease Markers - May 20, 2022 Category: Laboratory Medicine Authors: Zhihuai Wang Adeel Ur Rehman Xihu Qin Chunfu Zhu Siyuan Wu Source Type: research

Alarm Signal S100-Related Signature Is Correlated with Tumor Microenvironment and Predicts Prognosis in Glioma
Dis Markers. 2022 May 10;2022:4968555. doi: 10.1155/2022/4968555. eCollection 2022.ABSTRACTGlioma are the most common malignant central nervous system tumor and are characterized by uncontrolled proliferation and resistance to therapy. Dysregulation of S100 proteins may augment tumor initiation, proliferation, and metastasis by modulating immune response. However, the comprehensive function and prognostic value of S100 proteins in glioma remain unclear. Here, we explored the expression profiles of 17 S100 family genes and constructed a high-efficient prediction model for glioma based on CGGA and TCGA datasets. Immune lands...
Source: Disease Markers - May 20, 2022 Category: Laboratory Medicine Authors: Lin-Jian Wang Peipei Lv Yongli Lou Source Type: research

The ceRNA Crosstalk between mRNAs and lncRNAs in Diabetes Myocardial Infarction
Dis Markers. 2022 May 9;2022:4283534. doi: 10.1155/2022/4283534. eCollection 2022.ABSTRACTCompetitive endogenous RNA regulation suggests an intricate network of all transcriptional RNAs that have the function of repressing miRNA function and regulating mRNA expression. Today, the specific ceRNA regulatory mechanisms of lncRNA-miRNA-mRNA in patients who have diabetes mellitus (DM) and myocardial infarction (MI) are still unknown. Two data sets, GSE34198 and GSE112690, were rooted in the Gene Expression Omnibus database to search for changes of lncRNA, miRNA, and mRNA in MI patients with diabetes. Weighted gene correlation n...
Source: Disease Markers - May 20, 2022 Category: Laboratory Medicine Authors: Yun Zhou Chengjun Zhou Lilong Wei Chengwu Han Yongtong Cao Source Type: research

Curcumin Inhibits the Growth and Metastasis of Melanoma via miR-222-3p/SOX10/Notch Axis
CONCLUSION: Curcumin enhances the miR-222-3p level to reduce SOX10 expression, and ultimately inactivates the Notch pathway in repressing melanoma proliferation, migration, and invasion.PMID:35585935 | PMC:PMC9110126 | DOI:10.1155/2022/3129781 (Source: Disease Markers)
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Youqun Tang Yanming Cao Source Type: research

Endothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction
In this study, we aimed to determine endothelial dysfunction and ischemia-modified albumin (IMA) levels in patients diagnosed with erectile dysfunction (ED) and to examine the relationship between these and diabetes disease. 86 male patients (46 patients with diabetes, age: 51.5 ± 9.2 and 40 patients with nondiabetes (control group), age: 54.78 ± 12.2) were included in the study. IMA, a new indicator of tissue ischemia and oxidative stress, was checked. Superoxide dismutase (SOD) activity, another oxidative stress indicator, was examined. Endothelin-1 (ET-1), one of the parameters of endothelial dysfunction, was measured...
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Hasan An ıl Kurt Emrah Demirci Cabir Alan Source Type: research

Muscle Energy Technique plus Neurac Method in Stroke Patients with Hemiplegia Complicated by Diabetes Mellitus and Assessment of Quality of Life
CONCLUSION: Neurac method plus MET improves the independent mobility of stroke patients with hemiplegia and diabetes, relieves pain, enhances balance and stability, mitigates limb dysfunction, and boosts patients' quality of life, so it is worthy of clinical application.PMID:35585937 | PMC:PMC9110136 | DOI:10.1155/2022/6318721 (Source: Disease Markers)
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Jingyan Wang Shuang Wang Hongmei Wu Shuxin Dong Baojun Zhang Source Type: research

Study on Circulating lncRNA Expression Profile in Patients with Cerebral Infarction
In conclusion, the expression profile of lncRNA in CI group was significantly different from that in healthy group, indicating that lncRNA might be closely related to the occurrence, development, and prognosis of CI.PMID:35585938 | PMC:PMC9110134 | DOI:10.1155/2022/3042105 (Source: Disease Markers)
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Man-Tang Li Cheng-Hong Luo Peng-Jie Xu Ya Jin Source Type: research

Curcumin Inhibits the Growth and Metastasis of Melanoma via miR-222-3p/SOX10/Notch Axis
CONCLUSION: Curcumin enhances the miR-222-3p level to reduce SOX10 expression, and ultimately inactivates the Notch pathway in repressing melanoma proliferation, migration, and invasion.PMID:35585935 | PMC:PMC9110126 | DOI:10.1155/2022/3129781 (Source: Disease Markers)
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Youqun Tang Yanming Cao Source Type: research

Endothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction
In this study, we aimed to determine endothelial dysfunction and ischemia-modified albumin (IMA) levels in patients diagnosed with erectile dysfunction (ED) and to examine the relationship between these and diabetes disease. 86 male patients (46 patients with diabetes, age: 51.5 ± 9.2 and 40 patients with nondiabetes (control group), age: 54.78 ± 12.2) were included in the study. IMA, a new indicator of tissue ischemia and oxidative stress, was checked. Superoxide dismutase (SOD) activity, another oxidative stress indicator, was examined. Endothelin-1 (ET-1), one of the parameters of endothelial dysfunction, was measured...
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Hasan An ıl Kurt Emrah Demirci Cabir Alan Source Type: research

Muscle Energy Technique plus Neurac Method in Stroke Patients with Hemiplegia Complicated by Diabetes Mellitus and Assessment of Quality of Life
CONCLUSION: Neurac method plus MET improves the independent mobility of stroke patients with hemiplegia and diabetes, relieves pain, enhances balance and stability, mitigates limb dysfunction, and boosts patients' quality of life, so it is worthy of clinical application.PMID:35585937 | PMC:PMC9110136 | DOI:10.1155/2022/6318721 (Source: Disease Markers)
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Jingyan Wang Shuang Wang Hongmei Wu Shuxin Dong Baojun Zhang Source Type: research

Study on Circulating lncRNA Expression Profile in Patients with Cerebral Infarction
In conclusion, the expression profile of lncRNA in CI group was significantly different from that in healthy group, indicating that lncRNA might be closely related to the occurrence, development, and prognosis of CI.PMID:35585938 | PMC:PMC9110134 | DOI:10.1155/2022/3042105 (Source: Disease Markers)
Source: Disease Markers - May 19, 2022 Category: Laboratory Medicine Authors: Man-Tang Li Cheng-Hong Luo Peng-Jie Xu Ya Jin Source Type: research

Identification of SMIM1 and SEZ6L2 as Potential Biomarkers for Genes Associated with Intervertebral Disc Degeneration in Pyroptosis
CONCLUSION: In conclusion, this research identifies SMIM1 and SEZ6L2 as important biomarkers of IDD associated with pyroptosis, which will help to unravel the development and pathogenesis of IDD and determine potential therapeutic targets.PMID:35578687 | PMC:PMC9107366 | DOI:10.1155/2022/9515571 (Source: Disease Markers)
Source: Disease Markers - May 17, 2022 Category: Laboratory Medicine Authors: Nan Wang Xiyu Liu Xiaoyang Fang Shuang Chen Zhipeng Xi Xiaoyu Zhang Congyang Xue Xin Liu Lin Xie Source Type: research

The Clinical Observation and Mechanism of Acupuncture on Cancer-Related Fatigue of Breast Cancer Based on "Gut-Brain Axis": Study Protocol for a Randomized Controlled Trial
This study will identify the effect and the mechanism of acupuncture therapy in CRF. And it will offer an alternative treatment modality for the treatment of CRF after chemotherapy for breast cancer. Furthermore, it will also provide the clinical and theoretical bases for the extensive application of acupuncture therapy in tumor rehabilitation. Trial Status. Protocol version number and date: V2.0, 6 May 2021. The trial is registered with the Chinese Clinical Trial Registry on 20 June 2021 (trial identifier: ChiCTR2100047510).PMID:35578688 | PMC:PMC9107368 | DOI:10.1155/2022/8099595 (Source: Disease Markers)
Source: Disease Markers - May 17, 2022 Category: Laboratory Medicine Authors: Zhuan Lv Yi-Ming Gu Rui-Dong Liu Kai-Qi Su Xiao-Di Ruan Yi-Niu Chang Jing Gao Rui-Qing Li Lu Fang Xiao-Dong Feng Source Type: research

Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
In this study, cognitive function was significantly impaired in the T2DM mice; aerobic exercise improved cognitive impairment through activating the AMPK/SIRT1 signalling pathway and inhibiting the JAK2/STAT3 signalling pathway in T2DM mice. However, after the application of RO8191 (JAK2 activator) or Compound C (AMPK inhibitor), the positive improvement of the exercise was evidently suppressed. Taken together, our data indicated that long-term aerobic exercise improves type 2 diabetes mellitus-related cognitive impairment by inhibiting JAK2/STAT3 and enhancing AMPK/SIRT1 pathways in mice.PMID:35578689 | PMC:PMC9107038 | D...
Source: Disease Markers - May 17, 2022 Category: Laboratory Medicine Authors: Lili Lin Yonghua Wang Wenli Xu Chaolu Huang Jinrong Hu Xixi Chen Xinhuang Lv Yuelin Qin Xiaoyong Zhao Haiyan Li Source Type: research