Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors
CONCLUSIONS: Overall, relatively high CRP/Alb ratios, fibrinogen, and distant metastasis were associated with a poor prognosis of Xp11.2 tRCC adult patients; among them, only baseline fibrinogen levels independently predicted the progression of Xp11.2 tRCC; thus, it may help to identify patients with worse progression or death risk.PMID:34512814 | PMC:PMC8426103 | DOI:10.1155/2021/5647933 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jie Dong Weifeng Xu Zhigang Ji Boju Pan Source Type: research

EAD-Net: A Novel Lesion Segmentation Method in Diabetic Retinopathy Using Neural Networks
Dis Markers. 2021 Sep 1;2021:6482665. doi: 10.1155/2021/6482665. eCollection 2021.ABSTRACTDiabetic retinopathy (DR) is a common chronic fundus disease, which has four different kinds of microvessel structure and microvascular lesions: microaneurysms (MAs), hemorrhages (HEs), hard exudates, and soft exudates. Accurate detection and counting of them are a basic but important work. The manual annotation of these lesions is a labor-intensive task in clinical analysis. To solve the problem, we proposed a novel segmentation method for different lesions in DR. Our method is based on a convolutional neural network and can be divid...
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Cheng Wan Yingsi Chen Han Li Bo Zheng Nan Chen Weihua Yang Chenghu Wang Yan Li Source Type: research

Construction of a Novel Immune-Related lncRNA Pair Signature with Prognostic Significance for Kidney Clear Cell Renal Cell Carcinoma
CONCLUSIONS: This signature was proven to have a potential predictive significance for the prognosis of patients with ccRCC and the efficacy of immunotherapy.PMID:34512816 | PMC:PMC8429034 | DOI:10.1155/2021/8800358 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jian-Xuan Sun Qi-Dong Xia Chen-Qian Liu Jin-Zhou Xu Yang Xun Jun-Lin Lu Jia Hu Shao-Gang Wang Source Type: research

Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Cancer Progression via Activating PI3K/AKT/mTOR Pathway
CONCLUSION: PYCR2 was highly expressed in CRC, and its knockdown suppressed CRC tumorigenesis via inhibiting the activation of PI3K/AKT/mTOR pathway. This finding provides a new theoretical foundation for the treatment of CRC.PMID:34512817 | PMC:PMC8429024 | DOI:10.1155/2021/9950663 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Feng Yin Xiaoxia Huang Yi Xuan Source Type: research

Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors
CONCLUSIONS: Overall, relatively high CRP/Alb ratios, fibrinogen, and distant metastasis were associated with a poor prognosis of Xp11.2 tRCC adult patients; among them, only baseline fibrinogen levels independently predicted the progression of Xp11.2 tRCC; thus, it may help to identify patients with worse progression or death risk.PMID:34512814 | PMC:PMC8426103 | DOI:10.1155/2021/5647933 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jie Dong Weifeng Xu Zhigang Ji Boju Pan Source Type: research

EAD-Net: A Novel Lesion Segmentation Method in Diabetic Retinopathy Using Neural Networks
Dis Markers. 2021 Sep 1;2021:6482665. doi: 10.1155/2021/6482665. eCollection 2021.ABSTRACTDiabetic retinopathy (DR) is a common chronic fundus disease, which has four different kinds of microvessel structure and microvascular lesions: microaneurysms (MAs), hemorrhages (HEs), hard exudates, and soft exudates. Accurate detection and counting of them are a basic but important work. The manual annotation of these lesions is a labor-intensive task in clinical analysis. To solve the problem, we proposed a novel segmentation method for different lesions in DR. Our method is based on a convolutional neural network and can be divid...
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Cheng Wan Yingsi Chen Han Li Bo Zheng Nan Chen Weihua Yang Chenghu Wang Yan Li Source Type: research

Construction of a Novel Immune-Related lncRNA Pair Signature with Prognostic Significance for Kidney Clear Cell Renal Cell Carcinoma
CONCLUSIONS: This signature was proven to have a potential predictive significance for the prognosis of patients with ccRCC and the efficacy of immunotherapy.PMID:34512816 | PMC:PMC8429034 | DOI:10.1155/2021/8800358 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jian-Xuan Sun Qi-Dong Xia Chen-Qian Liu Jin-Zhou Xu Yang Xun Jun-Lin Lu Jia Hu Shao-Gang Wang Source Type: research

Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Cancer Progression via Activating PI3K/AKT/mTOR Pathway
CONCLUSION: PYCR2 was highly expressed in CRC, and its knockdown suppressed CRC tumorigenesis via inhibiting the activation of PI3K/AKT/mTOR pathway. This finding provides a new theoretical foundation for the treatment of CRC.PMID:34512817 | PMC:PMC8429024 | DOI:10.1155/2021/9950663 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Feng Yin Xiaoxia Huang Yi Xuan Source Type: research

Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors
CONCLUSIONS: Overall, relatively high CRP/Alb ratios, fibrinogen, and distant metastasis were associated with a poor prognosis of Xp11.2 tRCC adult patients; among them, only baseline fibrinogen levels independently predicted the progression of Xp11.2 tRCC; thus, it may help to identify patients with worse progression or death risk.PMID:34512814 | PMC:PMC8426103 | DOI:10.1155/2021/5647933 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jie Dong Weifeng Xu Zhigang Ji Boju Pan Source Type: research

EAD-Net: A Novel Lesion Segmentation Method in Diabetic Retinopathy Using Neural Networks
Dis Markers. 2021 Sep 1;2021:6482665. doi: 10.1155/2021/6482665. eCollection 2021.ABSTRACTDiabetic retinopathy (DR) is a common chronic fundus disease, which has four different kinds of microvessel structure and microvascular lesions: microaneurysms (MAs), hemorrhages (HEs), hard exudates, and soft exudates. Accurate detection and counting of them are a basic but important work. The manual annotation of these lesions is a labor-intensive task in clinical analysis. To solve the problem, we proposed a novel segmentation method for different lesions in DR. Our method is based on a convolutional neural network and can be divid...
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Cheng Wan Yingsi Chen Han Li Bo Zheng Nan Chen Weihua Yang Chenghu Wang Yan Li Source Type: research

Construction of a Novel Immune-Related lncRNA Pair Signature with Prognostic Significance for Kidney Clear Cell Renal Cell Carcinoma
CONCLUSIONS: This signature was proven to have a potential predictive significance for the prognosis of patients with ccRCC and the efficacy of immunotherapy.PMID:34512816 | PMC:PMC8429034 | DOI:10.1155/2021/8800358 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jian-Xuan Sun Qi-Dong Xia Chen-Qian Liu Jin-Zhou Xu Yang Xun Jun-Lin Lu Jia Hu Shao-Gang Wang Source Type: research

Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Cancer Progression via Activating PI3K/AKT/mTOR Pathway
CONCLUSION: PYCR2 was highly expressed in CRC, and its knockdown suppressed CRC tumorigenesis via inhibiting the activation of PI3K/AKT/mTOR pathway. This finding provides a new theoretical foundation for the treatment of CRC.PMID:34512817 | PMC:PMC8429024 | DOI:10.1155/2021/9950663 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Feng Yin Xiaoxia Huang Yi Xuan Source Type: research

Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors
CONCLUSIONS: Overall, relatively high CRP/Alb ratios, fibrinogen, and distant metastasis were associated with a poor prognosis of Xp11.2 tRCC adult patients; among them, only baseline fibrinogen levels independently predicted the progression of Xp11.2 tRCC; thus, it may help to identify patients with worse progression or death risk.PMID:34512814 | PMC:PMC8426103 | DOI:10.1155/2021/5647933 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jie Dong Weifeng Xu Zhigang Ji Boju Pan Source Type: research

EAD-Net: A Novel Lesion Segmentation Method in Diabetic Retinopathy Using Neural Networks
Dis Markers. 2021 Sep 1;2021:6482665. doi: 10.1155/2021/6482665. eCollection 2021.ABSTRACTDiabetic retinopathy (DR) is a common chronic fundus disease, which has four different kinds of microvessel structure and microvascular lesions: microaneurysms (MAs), hemorrhages (HEs), hard exudates, and soft exudates. Accurate detection and counting of them are a basic but important work. The manual annotation of these lesions is a labor-intensive task in clinical analysis. To solve the problem, we proposed a novel segmentation method for different lesions in DR. Our method is based on a convolutional neural network and can be divid...
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Cheng Wan Yingsi Chen Han Li Bo Zheng Nan Chen Weihua Yang Chenghu Wang Yan Li Source Type: research

Construction of a Novel Immune-Related lncRNA Pair Signature with Prognostic Significance for Kidney Clear Cell Renal Cell Carcinoma
CONCLUSIONS: This signature was proven to have a potential predictive significance for the prognosis of patients with ccRCC and the efficacy of immunotherapy.PMID:34512816 | PMC:PMC8429034 | DOI:10.1155/2021/8800358 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Jian-Xuan Sun Qi-Dong Xia Chen-Qian Liu Jin-Zhou Xu Yang Xun Jun-Lin Lu Jia Hu Shao-Gang Wang Source Type: research

Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Cancer Progression via Activating PI3K/AKT/mTOR Pathway
CONCLUSION: PYCR2 was highly expressed in CRC, and its knockdown suppressed CRC tumorigenesis via inhibiting the activation of PI3K/AKT/mTOR pathway. This finding provides a new theoretical foundation for the treatment of CRC.PMID:34512817 | PMC:PMC8429024 | DOI:10.1155/2021/9950663 (Source: Disease Markers)
Source: Disease Markers - September 13, 2021 Category: Laboratory Medicine Authors: Feng Yin Xiaoxia Huang Yi Xuan Source Type: research

Development and Validation of Diagnostic Models for Hand-Foot-and-Mouth Disease in Children
CONCLUSION: By analyzing clinical indicators, we have found the risk markers of HFMD and established suitable predictive models.PMID:34504626 | PMC:PMC8423554 | DOI:10.1155/2021/1923636 (Source: Disease Markers)
Source: Disease Markers - September 10, 2021 Category: Laboratory Medicine Authors: Feng Zhuo Mengjie Yu Qiang Chen Nuoya Li Li Luo Meiying Hu Qi Dong Liang Hong Shouhua Zhang Qiang Tao Source Type: research

Decreased Serum NCAM Levels Associated with Cognitive Impairment in Vascular Dementia
Dis Markers. 2021 Aug 31;2021:2792884. doi: 10.1155/2021/2792884. eCollection 2021.ABSTRACTOBJECTIVE: Neural cell adhesion molecule (NCAM), a glycoprotein widely distributed in the brain, has recently been shown to regulate neuroplasticity. However, the role of NCAM in vascular dementia (VaD) is still unclear. The purpose of this study is to determine whether NCAM is involved in the course of VaD.METHODS: Continuous recruitment of VaD patients and control population to join this study. Doctors or nurses are responsible for collecting their clinical characteristics including age, gender, formal education, heart rate, supine...
Source: Disease Markers - September 10, 2021 Category: Laboratory Medicine Authors: Jun Zhao Wei Lu Junshan Li Lei Liu Xiumin Zhao Source Type: research

Multiomics Differences in Lung Squamous Cell Carcinoma Patients with High Radiosensitivity Index Compared with Those with Low Radiosensitivity Index
CONCLUSIONS: Patients with lung squamous cell carcinoma have different multiomics characteristics between two groups. These differences may have an essential significance with radiotherapy effect.PMID:34504628 | PMC:PMC8423540 | DOI:10.1155/2021/3766659 (Source: Disease Markers)
Source: Disease Markers - September 10, 2021 Category: Laboratory Medicine Authors: Yajing Du Sujuan Yuan Xibing Zhuang Qi Zhang Tiankui Qiao Source Type: research

Development and Validation of Diagnostic Models for Hand-Foot-and-Mouth Disease in Children
CONCLUSION: By analyzing clinical indicators, we have found the risk markers of HFMD and established suitable predictive models.PMID:34504626 | PMC:PMC8423554 | DOI:10.1155/2021/1923636 (Source: Disease Markers)
Source: Disease Markers - September 10, 2021 Category: Laboratory Medicine Authors: Feng Zhuo Mengjie Yu Qiang Chen Nuoya Li Li Luo Meiying Hu Qi Dong Liang Hong Shouhua Zhang Qiang Tao Source Type: research

Decreased Serum NCAM Levels Associated with Cognitive Impairment in Vascular Dementia
Dis Markers. 2021 Aug 31;2021:2792884. doi: 10.1155/2021/2792884. eCollection 2021.ABSTRACTOBJECTIVE: Neural cell adhesion molecule (NCAM), a glycoprotein widely distributed in the brain, has recently been shown to regulate neuroplasticity. However, the role of NCAM in vascular dementia (VaD) is still unclear. The purpose of this study is to determine whether NCAM is involved in the course of VaD.METHODS: Continuous recruitment of VaD patients and control population to join this study. Doctors or nurses are responsible for collecting their clinical characteristics including age, gender, formal education, heart rate, supine...
Source: Disease Markers - September 10, 2021 Category: Laboratory Medicine Authors: Jun Zhao Wei Lu Junshan Li Lei Liu Xiumin Zhao Source Type: research

Multiomics Differences in Lung Squamous Cell Carcinoma Patients with High Radiosensitivity Index Compared with Those with Low Radiosensitivity Index
CONCLUSIONS: Patients with lung squamous cell carcinoma have different multiomics characteristics between two groups. These differences may have an essential significance with radiotherapy effect.PMID:34504628 | PMC:PMC8423540 | DOI:10.1155/2021/3766659 (Source: Disease Markers)
Source: Disease Markers - September 10, 2021 Category: Laboratory Medicine Authors: Yajing Du Sujuan Yuan Xibing Zhuang Qi Zhang Tiankui Qiao Source Type: research

Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration
CONCLUSION: The molecular and expression profiles of the YTH family were dysregulated in LUAD. YTH family members (especially YTHDC2) were promising biomarkers and potential therapeutic targets that may bring benefit for the patients with LUAD.PMID:34497675 | PMC:PMC8420974 | DOI:10.1155/2021/2789481 (Source: Disease Markers)
Source: Disease Markers - September 9, 2021 Category: Laboratory Medicine Authors: Kuan Hu Lei Yao Yuanliang Yan Lei Zhou Juanni Li Source Type: research

Signal Pathways and Markers Involved in Acute Lung Injury Induced by Acute Pancreatitis
Dis Markers. 2021 Aug 28;2021:9947047. doi: 10.1155/2021/9947047. eCollection 2021.ABSTRACTAcute pancreatitis (AP) is a common acute abdominal disease with a mortality rate of about 30%. Acute lung injury (ALI) is a common systemic complication of acute pancreatitis, with progressive hypoxemia and respiratory distress as the main manifestations, which can develop into acute respiratory distress syndrome or even multiple organ dysfunction syndrome (MODS) in severe cases, endangering human health. In the model of AP, pathophysiological process of the lung can be summarized as oxidative stress injury, inflammatory factor infi...
Source: Disease Markers - September 9, 2021 Category: Laboratory Medicine Authors: Jialin Zhou Pengcheng Zhou Yingyi Zhang Guangzhi Wang Zhe Fan Source Type: research

Analysis of Glomerular IgG Subclasses Switch in Idiopathic Membranous Nephropathy Classified by Glomerular Phospholipase A2 Receptor Antigen and Serum Antibody
CONCLUSIONS: Pre/co-rate of IgG3 declined with EM stage in total and PLA2R-related subgroup. We did not find IgG subclass switches from IgG1 to IgG4 in either IMN patients or subgroups.PMID:34497677 | PMC:PMC8421165 | DOI:10.1155/2021/9965343 (Source: Disease Markers)
Source: Disease Markers - September 9, 2021 Category: Laboratory Medicine Authors: Hao-Yuan Cui Chao Li Hang Li Yu-Bing Wen Lin Duan Yan Li Xi-Wei Yan Yu-Ting Hu Li-Meng Chen Xue-Mei Li Source Type: research

Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration
CONCLUSION: The molecular and expression profiles of the YTH family were dysregulated in LUAD. YTH family members (especially YTHDC2) were promising biomarkers and potential therapeutic targets that may bring benefit for the patients with LUAD.PMID:34497675 | PMC:PMC8420974 | DOI:10.1155/2021/2789481 (Source: Disease Markers)
Source: Disease Markers - September 9, 2021 Category: Laboratory Medicine Authors: Kuan Hu Lei Yao Yuanliang Yan Lei Zhou Juanni Li Source Type: research

Signal Pathways and Markers Involved in Acute Lung Injury Induced by Acute Pancreatitis
Dis Markers. 2021 Aug 28;2021:9947047. doi: 10.1155/2021/9947047. eCollection 2021.ABSTRACTAcute pancreatitis (AP) is a common acute abdominal disease with a mortality rate of about 30%. Acute lung injury (ALI) is a common systemic complication of acute pancreatitis, with progressive hypoxemia and respiratory distress as the main manifestations, which can develop into acute respiratory distress syndrome or even multiple organ dysfunction syndrome (MODS) in severe cases, endangering human health. In the model of AP, pathophysiological process of the lung can be summarized as oxidative stress injury, inflammatory factor infi...
Source: Disease Markers - September 9, 2021 Category: Laboratory Medicine Authors: Jialin Zhou Pengcheng Zhou Yingyi Zhang Guangzhi Wang Zhe Fan Source Type: research

Analysis of Glomerular IgG Subclasses Switch in Idiopathic Membranous Nephropathy Classified by Glomerular Phospholipase A2 Receptor Antigen and Serum Antibody
CONCLUSIONS: Pre/co-rate of IgG3 declined with EM stage in total and PLA2R-related subgroup. We did not find IgG subclass switches from IgG1 to IgG4 in either IMN patients or subgroups.PMID:34497677 | PMC:PMC8421165 | DOI:10.1155/2021/9965343 (Source: Disease Markers)
Source: Disease Markers - September 9, 2021 Category: Laboratory Medicine Authors: Hao-Yuan Cui Chao Li Hang Li Yu-Bing Wen Lin Duan Yan Li Xi-Wei Yan Yu-Ting Hu Li-Meng Chen Xue-Mei Li Source Type: research

ANGPTL3 Overexpression Suppresses the Development of Oncogenic Properties in Renal Cell Carcinoma via the Wnt/ < em > β < /em > -Catenin Signaling Pathway and Predicts Good Prognosis
In this study, we observed that ANGPTL3 expression was distinctly downregulated in both RCC specimens from TCGA datasets and cell lines. Survival assays also revealed that patients with low ANGPTL3 expression exhibited a shorter overall survival and disease-free survival than those with high ANGPTL3 expression. Cell counting kit-8 (CCK-8) assay, Colony formation assay, and flow cytometry showed that overexpression of ANGPTL3 distinctly suppressed the proliferation of RCC cells, and promoted apoptosis. Transwell assays and Wound healing assays revealed that ANGPTL3 upregulation suppressed the migration and invasion of RCC c...
Source: Disease Markers - September 6, 2021 Category: Laboratory Medicine Authors: Yu-Jian Zhang Lin Zhang Fei Feng Qi-Feng Cao Source Type: research

Differences in Immunological Landscape between < em > EGFR < /em > -Mutated and Wild-Type Lung Adenocarcinoma
Dis Markers. 2021 Aug 26;2021:3776854. doi: 10.1155/2021/3776854. eCollection 2021.ABSTRACTRecent clinical trials of lung adenocarcinoma with immune checkpoint inhibitors revealed that lung adenocarcinoma patients with EGFR mutations have a poor response to immunotherapy. However, the mechanisms have not been addressed. We performed immunohistochemistry analyses of resected lung adenocarcinoma tissues with and without EGFR mutations to investigate and compare the characteristics of the tumor microenvironment (TME). We retrospectively enrolled a total of 323 lung adenocarcinoma patients (164 had EGFR mutations), and their c...
Source: Disease Markers - September 6, 2021 Category: Laboratory Medicine Authors: Jia-Wei Luo Yan-Hua Guo Feng-Ying Wu Xue-Fei Li Xue-Cheng Sun Jia-Lu Wang Cai-Cun Zhou Source Type: research

Expression of Four Autophagy-Related Genes Accurately Predicts the Prognosis of Gastrointestinal Cancer in Asian Patients
This study, evaluated the prognostic value of autophagy-related genes in gastrointestinal cancer. Expression profile of autophagy-related genes for 296 gastrointestinal cancer patients of Asian ancestry was downloaded from the TCGA database (TCGA-LIHC, TCGA-STAD, TCGA-ESCA, TCGA-PAAD, TCGA-COAD, TCGA-CHOL, and TCGA-READ). The prognostic value of the autophagy-related genes was evaluated using univariate Cox, LASSO, and multivariate Cox regression analyses. The risk score of the autophagy-related gene signature was calculated to assess its predictive prognostic value for GI cancers. Forty-seven differentially expressed auto...
Source: Disease Markers - September 6, 2021 Category: Laboratory Medicine Authors: Hua Tang Yinyin Liang Shuyu Xu Rong Xia Jiemiao Shen Yuxin Zhang Xing Gong Yue Min Di Zhang Tie Zhao Shoulin Wang Yi Zhang Chao Wang Source Type: research

Albumin-Globulin Ratio Is an Independent Determinant of 28-Day Mortality in Patients with Critical Illness
CONCLUSION: The AGR might be an independent predictor of prognosis in critically ill patients.PMID:34484470 | PMC:PMC8413056 | DOI:10.1155/2021/9965124 (Source: Disease Markers)
Source: Disease Markers - September 6, 2021 Category: Laboratory Medicine Authors: Bin Liu Kun Xiao Peng Yan Tianyu Sun Jiang Wang Fei Xie Guoxin Mo Lixin Xie Source Type: research

Targeting lncRNA PSMA3-AS1, a Prognostic Marker, Suppresses Malignant Progression of Oral Squamous Cell Carcinoma
CONCLUSION: Collectively, PSMA3-AS1 as a risk factor facilitated malignant behaviors of OSCC cells, related to the miR-136-5p/FN1 axis. Hence, PSMA3-AS1 as a potential therapeutic target for OSCC deserved further exploration.PMID:34457087 | PMC:PMC8397548 | DOI:10.1155/2021/3138046 (Source: Disease Markers)
Source: Disease Markers - August 30, 2021 Category: Laboratory Medicine Authors: Xinghua Cao Kefeng Luan Jie Yang Yundong Huang Source Type: research

Biomarkers of Inflammation and Inflammation-Related Indexes upon Emergency Department Admission Are Predictive for the Risk of Intensive Care Unit Hospitalization and Mortality in Acute Poisoning: A 6-Year Prospective Observational Study
Dis Markers. 2021 Aug 19;2021:4696156. doi: 10.1155/2021/4696156. eCollection 2021.ABSTRACTPatients poisoned with drugs and nonpharmaceutical substances are frequently admitted from the emergency department (ED) to a medical or ICU department. We hypothesized that biomarkers of inflammation and inflammation-related indexes based on the complete blood cell (CBC) count can identify acutely poisoned patients at increased risk for ICU hospitalization and death. We performed a 6-year prospective cohort study on 1548 adult patients. The demographic data, the levels of hs-CRP (high-sensitivity C-reactive protein), CBC, and inflam...
Source: Disease Markers - August 30, 2021 Category: Laboratory Medicine Authors: Catalina Lionte Cristina Bologa Victorita Sorodoc Ovidiu Rusalim Petris Gabriela Puha Alexandra Stoica Alexandr Ceasovschih Elisabeta Jaba Laurentiu Sorodoc Source Type: research

Association of Red Blood Cell Distribution Width Levels with Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)
Dis Markers. 2021 Aug 6;2021:5536360. doi: 10.1155/2021/5536360. eCollection 2021.ABSTRACTOBJECTIVE: The aim of this study was to evaluate the diagnostic and prognostic value of red blood cell distribution width (RDW) in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).METHODS: We retrospectively reviewed 213 CTD-ILD patients and 97 CTD patients without ILD from February 2017 to February 2020. Hospital and office records were used as data sources. CTD-ILD patients were followed up.RESULTS: Patients with CTD-ILD had significantly higher RDW than those with CTD without ILD (p
Source: Disease Markers - August 30, 2021 Category: Laboratory Medicine Authors: Shenyun Shi Ling Chen Xianhua Gui Lulu Chen Xiaohua Qiu Min Yu Yonglong Xiao Source Type: research

High mRNA Expression of < em > CENPL < /em > and Its Significance in Prognosis of Hepatocellular Carcinoma Patients
In this study, we used databases of Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), the Kaplan-Meier Plotter, cBioPortal, the Human Protein Atlas (HPA), and TIMER (Tumor Immune Estimation Resource) and immunohistochemical staining of clinical specimens to investigate the expression of 15 major centromere proteins in HCC to evaluate their potential prognostic value. We found that the mRNA levels of 4 out of 15 centromere proteins (CENPL, CENPQ, CENPR, and CENPU) were significantly higher in HCC than in normal tissues, and their mRNA levels were associated with the tumor stages (p values
Source: Disease Markers - August 30, 2021 Category: Laboratory Medicine Authors: Zhongyuan Cui Lijia Xiao Fengsui Chen Jielong Wang Haiyan Lin Dongliang Li Zhixian Wu Source Type: research

Immune Checkpoints: Therapeutic Targets for Pituitary Tumors
Dis Markers. 2021 Aug 16;2021:5300381. doi: 10.1155/2021/5300381. eCollection 2021.ABSTRACTPituitary tumors are the third most common intracranial tumors in adults. Treatment of refractory pituitary tumors is known to be difficult due to limited treatment options. As a promising therapeutic method, tumor immunotherapy has been applied in the treatment of many tumors, including pituitary tumors. Immune checkpoint blocking is one of the effective strategies to activate antitumor immunity. Immune checkpoints prevent tissue damage by regulating the immune response of peripheral tissues and participate in the maintenance of a n...
Source: Disease Markers - August 27, 2021 Category: Laboratory Medicine Authors: Ding Nie Yimeng Xue Qiuyue Fang Jianhua Cheng Bin Li Dawei Wang Chuzhong Li Songbai Gui Yazhuo Zhang Peng Zhao Source Type: research

RNA-Binding Motif Protein 11 (RBM11) Serves as a Prognostic Biomarker and Promotes Ovarian Cancer Progression
Dis Markers. 2021 Aug 14;2021:3037337. doi: 10.1155/2021/3037337. eCollection 2021.ABSTRACTOvarian cancer is one of the most lethal gynecologic malignancies for women. Due to the lack of efficient target therapy, the overall survival rate for patients with advanced ovarian cancer is still low. Illustrating the molecular mechanisms dictating ovarian cancer progression is critically important to develop novel therapeutic agents. Here, we found that RNA-binding motif protein 11 (RBM11) was highly elevated in ovarian cancer tissues compared with normal ovary, while RBM11 depletion in ovarian cancer cells resulted in impaired c...
Source: Disease Markers - August 26, 2021 Category: Laboratory Medicine Authors: Chunhong Fu Ming Yuan Jie Sun Gang Liu Xiaojuan Zhao Wei Chang Zhongling Ma Source Type: research

Identification of Six Autophagy-Related-lncRNA Prognostic Biomarkers in Uveal Melanoma
Dis Markers. 2021 Aug 12;2021:2401617. doi: 10.1155/2021/2401617. eCollection 2021.ABSTRACTCurrently, no autophagy-related long noncoding RNA (lncRNA) has been reported to predict the prognosis of uveal melanoma patients. Our study screened for autophagy-related lncRNAs in 80 samples downloaded from The Cancer Genome Atlas (TCGA) database through lncRNA-mRNA coexpression. We used univariate Cox to further filter the lncRNAs. Multivariate Cox regression and LASSO regression were applied to construct an autophagy-associated lncRNA predictive model and calculate the risk score. Clinical risk factors were validated using Cox r...
Source: Disease Markers - August 24, 2021 Category: Laboratory Medicine Authors: Yao Chen Lu Chen Jinwei Wang Jia Tan Sha Wang Source Type: research

Long Noncoding RNA LINC01554 as a Novel Biomarker for Diagnosis and Prognosis Prediction of Epithelial Ovarian Cancer
This study was aimed at exploring the diagnostic and prognostic value of long noncoding RNA LINC01554 (LINC01554) in epithelial ovarian cancer (EOC) patients. Patients and Methods. The expressions of LINC01554 in 161 EOC patients were analyzed using RT-PCR. The area under the ROC curve (AUC) was used to estimate the effectiveness of LINC01554 for prediction. The chi-square test was performed to explore the association between LINC01554 expressions and clinical characteristics in EOC patients. Kaplan-Meier assays were conducted for the examination of the influence of LINC01554 expression on the overall survival of EOC patie...
Source: Disease Markers - August 23, 2021 Category: Laboratory Medicine Authors: Ting Luo Yan Jiang Jing Yang Source Type: research

APOA-5 Genetic Variant rs662799: Role in Lipid Changes and Insulin Resistance after a Mediterranean Diet in Caucasian Obese Subjects
CONCLUSIONS: C allele carriers of rs662799 of the APOA5 gene did not show an improvement in triglyceride, insulin, and HOMA-IR levels after a significant weight loss due to a hypocaloric diet with a Mediterranean pattern.PMID:34422134 | PMC:PMC8378982 | DOI:10.1155/2021/1257145 (Source: Disease Markers)
Source: Disease Markers - August 23, 2021 Category: Laboratory Medicine Authors: Daniel de Luis Olatz Izaola David Primo Source Type: research

Construction and Validation of a Novel Prognostic Signature for Intestinal Type of Gastric Cancer
CONCLUSION: We identified and verified a nine-gene signature for the prognostic prediction of IGC patients, which might identify subgroups of IGC patients and select more suitable therapeutic options.PMID:34422135 | PMC:PMC8376432 | DOI:10.1155/2021/5567392 (Source: Disease Markers)
Source: Disease Markers - August 23, 2021 Category: Laboratory Medicine Authors: Fan Zhang Ewetse Paul Maswikiti Yucai Wei Wenzhang Wu Yumin Li Source Type: research

A Review of Novel Cardiac Biomarkers in Acute or Chronic Cardiovascular Diseases: The Role of Soluble ST2 (sST2), Lipoprotein-Associated Phospholipase A2 (Lp-PLA2), Myeloperoxidase (MPO), and Procalcitonin (PCT)
Dis Markers. 2021 Aug 9;2021:6258865. doi: 10.1155/2021/6258865. eCollection 2021.ABSTRACTWhile the received traditional predictors are still the mainstay in the diagnosis and prognosis of CVD events, increasing studies have focused on exploring the ancillary effect of biomarkers for the aspiring of precision. Under which circumstances, soluble ST2 (sST2), lipoprotein-associated phospholipase A2 (Lp-PLA2), myeloperoxidase (MPO), and procalcitonin (PCT) have recently emerged as promising markers in the field of both acute and chronic cardiovascular diseases. Existent clinical studies have demonstrated the significant associ...
Source: Disease Markers - August 23, 2021 Category: Laboratory Medicine Authors: Junpei Li Tianyu Cao Yaping Wei Nan Zhang Ziyi Zhou Zhuo Wang Jingyi Li Yue Zhang Sijia Wang Ping Wang Nannan Cheng Lijing Ye Minghui Li Yu Yu Congcong Ding Ziheng Tan Biming Zhan Qiangqiang He Huihui Bao Yanqing Wu Lishun Liu Jianping Li Xiping Xu Xiaosh Source Type: research

Hyponatremia and Renal Venous Congestion in Heart Failure Patients
Dis Markers. 2021 Aug 12;2021:6499346. doi: 10.1155/2021/6499346. eCollection 2021.ABSTRACTOBJECTIVE: The interrelationship between the heart and kidneys has a great importance in the homeostasis of the cardiovascular system. Heart failure patients present intrarenal arterial hypoperfusion and intrarenal venous congestion due to reduced left ventricle ejection fraction, which triggers numerous neurohormonal factors. The aim of this study was to investigate intrarenal vascularization (arterial and venous), as well as the links between it and systemic congestion and, on the other side, with the mortality in patients with hea...
Source: Disease Markers - August 23, 2021 Category: Laboratory Medicine Authors: Alexandru Caraba Stela Iurciuc Andreea Munteanu Mircea Iurciuc Source Type: research

Gender-Related Difference in D-Dimer Level Predicts In-Hospital Heart Failure after Primary PCI for ST-Segment Elevation Myocardial Infarction
Dis Markers. 2021 Aug 10;2021:7641138. doi: 10.1155/2021/7641138. eCollection 2021.ABSTRACTAIMS: The prognostic value of plasma D-dimer in patients with coronary artery disease (CAD) remains controversial. The study is aimed at investigating the relationship between plasma D-dimer levels and in-hospital heart failure (HF) in ST-segment elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention (pPCI).METHODS: STEMI patients who underwent pPCI were enrolled in this study. Venous blood samples were collected from patients on admission before pPCI procedure. The study endpoint wa...
Source: Disease Markers - August 23, 2021 Category: Laboratory Medicine Authors: Li Li Wei Wang Tai Li Ying Sun Yanjun Gao Lin Wang Heng-Chen Yao Source Type: research

Serum Neuropeptide Y: A Potential Prognostic Marker of Intracerebral Hemorrhage
Dis Markers. 2021 Aug 10;2021:7957013. doi: 10.1155/2021/7957013. eCollection 2021.ABSTRACTOBJECTIVE: Neuropeptide Y (NPY), a 36-amino acid neuromodulator, is mainly secreted by neurons in the central and peripheral nervous systems, which participate in the regulation of a series of physiological processes. However, there are few studies on its correlation with intracranial hemorrhage (ICH). The purpose of this study is to determine whether the serum NPY level is related to the prognosis of ICH.METHODS: 364 patients diagnosed with ICH were included in the current study. The demographics, anthropometrics, medical history, c...
Source: Disease Markers - August 23, 2021 Category: Laboratory Medicine Authors: Weiming Sun Zhenxing Zhang Xu Feng Xin Sui Ye Miao Source Type: research