Molecules, Vol. 27, Pages 7890: Angelica sinensis Polysaccharide and Astragalus membranaceus Polysaccharide Accelerate Liver Regeneration by Enhanced Glycolysis via Activation of JAK2/STAT3/HK2 Pathway
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Qiao-Bo Ye
The promotion of liver regeneration is crucial to avoid liver failure after hepatectomy. Angelica sinensis polysaccharide (ASP) and Astragalus membranaceus polysaccharide (AMP) have been identified as being associated with hepatoprotective effects. However, their roles and specific mechanisms in liver regeneration remain to be elucidated. In the present study, it suggested that the respective use of ASP or AMP strikingly promoted hepatocyte proliferation in vitro with a wide range of concentrations (from 12.5 μg/mL to 3200 μg/mL), and a stronger promoting effect was observed in com...
Source: Molecules - November 15, 2022 Category: Chemistry Authors: Xu-Dong Wen Yao-Lei Zhang Ling Yang Zhen Ye Guo-Chuan Fu Yong-He Hu Tao Pan Qiao-Bo Ye Tags: Article Source Type: research
Supercritical fluid extract of Angelica sinensis promotes the anti-colorectal cancer effect of oxaliplatin
In conclusion, A-SFE has the potential to become an adjuvant drug for OXA in the treatment of CRC, which provides new strategies for anti-colorectal cancer research. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 4, 2022 Category: Drugs & Pharmacology Source Type: research
Astragalus and its formulas as a therapeutic option for fibrotic diseases: Pharmacology and mechanisms
Fibrosis is the abnormal deposition of extracellular matrix, characterized by accumulation of collagen and other extracellular matrix components, which causes organ dysfunction and even death. Despite advances in understanding fibrosis pathology and clinical management, there is no treatment for fibrosis that can prevent or reverse it, existing treatment options may lead to diarrhea, nausea, bleeding, anorexia, and liver toxicity. Thus, effective drugs are needed for fibrotic diseases. Traditional Chinese medicine has played a vital role in fibrotic diseases, accumulating evidence has demonstrated that Astragalus (Astragal...
Source: Frontiers in Pharmacology - November 3, 2022 Category: Drugs & Pharmacology Source Type: research
Angelica sinensis polysaccharides prevents hematopoietic regression in D-Galactose-Induced aging model via attenuation of oxidative stress in hematopoietic microenvironment
CONCLUSION: The antioxidant property of ASP may provide a stroma-mediated potential therapeutic strategy for HSPC aging.PMID:36315330 | DOI:10.1007/s11033-022-07898-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - October 31, 2022 Category: Molecular Biology Authors: Pengwei Jing Xiaoying Song Lirong Xiong Biyao Wang Yaping Wang Lu Wang Source Type: research
Angelica sinensis polysaccharides prevents hematopoietic regression in D-Galactose-Induced aging model via attenuation of oxidative stress in hematopoietic microenvironment
CONCLUSION: The antioxidant property of ASP may provide a stroma-mediated potential therapeutic strategy for HSPC aging.PMID:36315330 | DOI:10.1007/s11033-022-07898-w (Source: Mol Biol Cell)
Source: Mol Biol Cell - October 31, 2022 Category: Molecular Biology Authors: Pengwei Jing Xiaoying Song Lirong Xiong Biyao Wang Yaping Wang Lu Wang Source Type: research
Angelica sinensis polysaccharides prevents hematopoietic regression in D-Galactose-Induced aging model via attenuation of oxidative stress in hematopoietic microenvironment
CONCLUSION: The antioxidant property of ASP may provide a stroma-mediated potential therapeutic strategy for HSPC aging.PMID:36315330 | DOI:10.1007/s11033-022-07898-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - October 31, 2022 Category: Molecular Biology Authors: Pengwei Jing Xiaoying Song Lirong Xiong Biyao Wang Yaping Wang Lu Wang Source Type: research
Effects of Danggui Buxue decoction on host gut microbiota and metabolism in GK rats with type 2 diabetes
In this study, a T2DM model was established in Goto-Kakizaki (GK) rats, which were then treated with a clinical dose of DBD (4 g/kg) through tube feeding for 6 weeks. Next, we used 16S rRNA sequencing and untargeted metabolomics by liquid chromatography with mass spectrometry (LC–MS) to detect changes in the composition of the microbiota and cecal metabolic products. Our data show that DBD mediates the continuous increase in blood glucose in GK rats, improves insulin sensitivity, reduces expression of inflammatory mediators, and improves systemic oxidative stress. Moreover, DBD also improves microbial diversity (e.g., ...
Source: Frontiers in Microbiology - October 24, 2022 Category: Microbiology Source Type: research
Retraction Note: Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia
(Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - October 20, 2022 Category: Complementary Medicine Authors: Zetao Chen, Li Cheng, Jing Zhang and Xing Cui Tags: Retraction Note Source Type: research
Network Pharmacology and Molecular Docking-Based Investigation of Potential Targets of Astragalus membranaceus and Angelica sinensis Compound Acting on Spinal Cord Injury
CONCLUSIONS: Altogether, it identified the mechanisms by which AM&AS was used for SCI treatment, namely, active ingredients, targets and signaling pathways. Consequently, further research into AM&AS treating SCI can be conducted on this scientific basis.PMID:36157206 | PMC:PMC9499798 | DOI:10.1155/2022/2141882 (Source: Disease Markers)
Source: Disease Markers - September 26, 2022 Category: Laboratory Medicine Authors: Shengnan Cao Guangjian Hou Ya Meng Yuanzhen Chen Liangyu Xie Bin Shi Source Type: research
Network Pharmacology and Molecular Docking-Based Investigation of Potential Targets of Astragalus membranaceus and Angelica sinensis Compound Acting on Spinal Cord Injury
CONCLUSIONS: Altogether, it identified the mechanisms by which AM&AS was used for SCI treatment, namely, active ingredients, targets and signaling pathways. Consequently, further research into AM&AS treating SCI can be conducted on this scientific basis.PMID:36157206 | PMC:PMC9499798 | DOI:10.1155/2022/2141882 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Shengnan Cao Guangjian Hou Ya Meng Yuanzhen Chen Liangyu Xie Bin Shi Source Type: research
Network Pharmacology and Molecular Docking-Based Investigation of Potential Targets of Astragalus membranaceus and Angelica sinensis Compound Acting on Spinal Cord Injury
CONCLUSIONS: Altogether, it identified the mechanisms by which AM&AS was used for SCI treatment, namely, active ingredients, targets and signaling pathways. Consequently, further research into AM&AS treating SCI can be conducted on this scientific basis.PMID:36157206 | PMC:PMC9499798 | DOI:10.1155/2022/2141882 (Source: Disease Markers)
Source: Disease Markers - September 26, 2022 Category: Laboratory Medicine Authors: Shengnan Cao Guangjian Hou Ya Meng Yuanzhen Chen Liangyu Xie Bin Shi Source Type: research
Rapid screening of 15 highly toxic pesticide residues in Angelica sinensis decoctions by thermal desorption electrospray ionization mass spectrometry
Volume 33, Issue 1, December 2022, Page 709-721 . (Source: Food and Agricultural Immunology)
Source: Food and Agricultural Immunology - September 20, 2022 Category: Food Science Authors: Hongyan Zhang Qiaoying Chang Xingzhi Wang Jian Li Guoyu Qiu Fuxiang Wu Renyuan Zhu Ming Su Source Type: research
Deep Fusion of Intelligent Meridian Sensing Technology and Huoluo Xiaoling Pills in the Treatment of Knee Osteoarthritis
Biomed Res Int. 2022 Sep 7;2022:8043674. doi: 10.1155/2022/8043674. eCollection 2022.ABSTRACTBased on the deep fusion of intelligent meridian sensing technology and Huoluo Xiaoling Pill (HXP) in the treatment of knee osteoarthritis (KOA), firstly, the effective components and targets of Salvia miltiorrhiza, Angelica sinensis, frankincense, and myrrh were obtained by using TCMSP, SwissADME, and Swisstarget databases. Similarly, relevant targets of KOA were collected through GeneCards, OMIM, TTD, PharmGKB, and DrugBank databases. Next, the potential targets of ZXP in the treatment of KOA were obtained by intersection of drug...
Source: Biomed Res - September 19, 2022 Category: Research Authors: Jiye Sun Ziou Wang Piao Wu Jinxuan Wei Xiaowei Sun Hongtao Li Source Type: research
Sodium Ferulate Inhibits Rat Cardiomyocyte Hypertrophy Induced by Angiotensin II Through Enhancement of Endothelial Nitric Oxide Synthase/Nitric Oxide/Cyclic Guanosine Monophosphate Signaling Pathway
In this study, myocardial hypertrophy was induced by angiotensin II 0.1 μmol/L in neonatal Sprague–Dawley rat ventricular myocytes. Nine groups were designed, that is, normal, normal administration, model, L-arginine (L-arg 1000 μmol/L), SF (50, 100, 200 μmol/L) group, and NG-nitro-L-arg-methyl ester 1500 μmol/L combined with SF 200 μmol/L or L-arg 1000 μmol/L group, respectively. Cardiomyocyte hypertrophy was confirmed by observing histological changes and measurements of cell diameter, protein content and atrial natriuretic factor, and β-myosin heavy chain levels of the cells. Notably, SF could inhibit significa...
Source: Journal of Cardiovascular Pharmacology - August 1, 2022 Category: Cardiology Tags: Original Article Source Type: research
