Phthalide-derived oxaspiroangelioic acids A–C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head
Publication date: Available online 3 March 2021Source: Chinese Chemical LettersAuthor(s): Youzhe Chen, Chengbo Xu, Weiping Wang, Xiaoliang Wang, Qinglan Guo, Jiangong Shi (Source: Chinese Chemical Letters)
Source: Chinese Chemical Letters - March 3, 2021 Category: Chemistry Source Type: research
The Species Identification in Traditional Herbal Patent Medicine, Wuhu San, Based on Shotgun Metabarcoding
This study employed shotgun metabarcoding for the species identification of biological ingredients in traditional herbal patent medicine, Wuhu San. The five prescribed herbal materials found in Wuhu San were collected, and their reference sequences were obtained by traditional DNA barcoding using Sanger sequencing. Two lab-made and three commercial Wuhu San samples were collected, and a total of 37.14 Gb of shotgun sequencing data was obtained for these five samples using the Illumina sequencing platform. A total of 1,421,013 paired-end reads were enriched for the Internal Transcribed Spacer 2 (ITS2), psbA and trnH interg...
Source: Frontiers in Pharmacology - February 16, 2021 Category: Drugs & Pharmacology Source Type: research
Ethnobotanical Survey of Natural Galactagogues Prescribed in Traditional Chinese Medicine Pharmacies in Taiwan
We examined their botanical origins, biological classifications, traditional usage, and modern pharmacological properties. We used the TCM Inheritance Support System to identify core medicinal materials in galactogenous prescriptions. We collected 81 medicinal materials from 90 galactogenous prescriptions. Leguminosae accounted for 12%, whereas Apiaceae accounted for 7% of all materials examined. The primary medicinal plant parts used were roots and seeds. Nineteen frequently used medicinal materials had a relative frequency of citation of greater than or equal to 0.2. According to their efficacy, 58% were warm, 54% were s...
Source: Frontiers in Pharmacology - February 12, 2021 Category: Drugs & Pharmacology Source Type: research
Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway
Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), a traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties in ch... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 30, 2021 Category: Rheumatology Authors: Chao Xu, Su Ni, Chao Zhuang, Chenkai Li, Gongyin Zhao, Shijie Jiang, Liangliang Wang, Ruixia Zhu, Andre J. van Wijnen and Yuji Wang Tags: Research article Source Type: research
Combination of Astragalus membranaceous and Angelica sinensis Ameliorates Vascular Endothelial Cell Dysfunction by Inhibiting Oxidative Stress.
Authors: Yin Y, Li H, Chen Y, Zhu R, Li L, Zhang X, Zhou J, Wang Z, Li X
Abstract
Vascular endothelial dysfunction is an essential and early sign of diabetic macroangiopathy, a primary complication of diabetes mellitus. Astragalus membranaceous-Angelica sinensis is a classic medical combination applied in China to treat diabetes mellitus. The aim of this study was to investigate the effect of the granule form of the extract produced from the dried root of Astragalus membranaceous (AM) combination with the granule form of the extract produced from the dried Angelica sinensis (AS) on diabetic macroangiopathy...
Source: Evidence-based Complementary and Alternative Medicine - December 10, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Progress in Traditional Chinese Medicine for the Treatment of Migraine.
Abstract
Migraine is a recurrent disease with complex pathogenesis and is difficult to cure. At present, commercially available western migraine drugs are prone to generate side effects while treating the disease. Traditional Chinese medicine (TCM) avoids side effects via treatment with the principles of "treating both symptoms and root causes", "overall adjustment", and "treatment based on syndrome differentiation". Three strategies of drug treatment were developed based on the syndromes, i.e., removing stasis, calming liver Yang, and reinforcing deficiency. Prescriptions of removing stasis mostly contain...
Source: The American Journal of Chinese Medicine - December 10, 2020 Category: Complementary Medicine Authors: Huang Y, Ni N, Hong Y, Lin X, Feng Y, Shen L Tags: Am J Chin Med Source Type: research
(+)-/(―)-Angelignanine, a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head
Publication date: Available online 4 December 2020Source: Chinese Chemical LettersAuthor(s): Youzhe Chen, Qinglan Guo, Chengbo Xu, Chenggen Zhu, Jianjun Zhang, Jiangong Shi (Source: Chinese Chemical Letters)
Source: Chinese Chemical Letters - December 4, 2020 Category: Chemistry Source Type: research
Screening study of blood-supplementing active components in water decoction of Angelica sinensis processed with yellow rice wine based on response surface methodology.
CONCLUSIONS: The optimum preparation technology of WASD was obtained, and the water, n-butanol fractions were blood-supplementing fractions. This study provides a theoretical foundation for further application of WAS in the pharmaceutical industry.
PMID: 33222580 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - November 25, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism.
Abstract
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related death worldwide. The abnormal activation of glycolytic metabolism and PTEN/AKT signaling in NSCLC cells are highly correlated with their proliferation abilities and viability. Ligustilide is one of the major bioactive components of multiple Chinese traditional medicine including Angelica sinensis and Ligusticum. Ligustilide exposure inhibits the proliferation and viability of multiple cancer cell lines in vitro. However, the impact of ligustilide to the progression of NSCLC and its detailed pharmacological mechanisms...
Source: Toxicology and Applied Pharmacology - November 16, 2020 Category: Toxicology Authors: Jiang X, Zhao W, Zhu F, Wu H, Ding X, Bai J, Zhang X, Qian M Tags: Toxicol Appl Pharmacol Source Type: research
Comprehensive Analysis of Transcriptomics and Metabolomics between the Heads and Tails of Angelica Sinensis: Genes Related to Phenylpropanoid Biosynthesis Pathway.
CONCLUSION: Our work demonstrated that overexpressed genes and accumulated metabolites derived from PB pathway might be responsible for the discrepant pharmaceutical efficacies between AS heads and tails.
PMID: 33155889 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Yang J, Zhang C, Li WH, Zhang TE, Fan GZ, Guo BF, Yao WY, Gong DH, Peng QL, Ding WJ Tags: Comb Chem High Throughput Screen Source Type: research
Polyethylenimine-coated PLGA nanoparticles-encapsulated Angelica sinensis polysaccharide as an adjuvant for H9N2 vaccine to improve immune responses in chickens compared to Alum and oil-based adjuvants
Publication date: Available online 16 October 2020Source: Veterinary MicrobiologyAuthor(s): Pengfei Gu, Adelijiang Wusiman, Yue Zhang, Gaofeng Cai, Shuwen Xu, Shaowu Zhu, Zhenguang Liu, Yuanliang Hu, Jiaguo Liu, Deyun Wang (Source: Veterinary Microbiology)
Source: Veterinary Microbiology - October 16, 2020 Category: Veterinary Research Source Type: research
Z-Ligustilide Ameliorates Diabetic Rat Retinal Dysfunction Through Anti-Apoptosis and an Antioxidation Pathway.
CONCLUSIONS Z-LIG can inhibit inflammatory response and cell apoptosis in retinas of diabetic rats by repressing the VEGF-alpha pathway. Therefore, it may serve as a potential therapeutic agent for DR.
PMID: 33011733 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Study on the Fingerprints and Quality Evaluation of Angelica Sinensis Radix by HPLC Coupled With Chemometrics Based on Traditional Decoction Process of ACPTCM
CONCLUSIONS: These results demonstrated that the combination of HPLC chromatographic fingerprint and chemometrics offers an efficient and reliable approach for quality evaluation of ASR from different sources as Ancient Classical Prescriptions ingredients.PMID:33013250 | PMC:PMC7513407 | DOI:10.1177/1559325820951730 (Source: Dose Response)
Source: Dose Response - October 5, 2020 Category: Drugs & Pharmacology Authors: Zhang Qian Chen Yiyang Ma Lixia Jiang Yue Chen Jun Dong Jie Ma Yifan Zhang Jingjing Yan Guojun Source Type: research
